ATE415411T1 - Reinigungsprozess für igf-i - Google Patents

Reinigungsprozess für igf-i

Info

Publication number
ATE415411T1
ATE415411T1 AT96912727T AT96912727T ATE415411T1 AT E415411 T1 ATE415411 T1 AT E415411T1 AT 96912727 T AT96912727 T AT 96912727T AT 96912727 T AT96912727 T AT 96912727T AT E415411 T1 ATE415411 T1 AT E415411T1
Authority
AT
Austria
Prior art keywords
igf
unfolding
refolding
reverse phase
cation exchange
Prior art date
Application number
AT96912727T
Other languages
English (en)
Inventor
Russell Brierley
Joan Abrams
John Hanson
Francis Maslanka
Cynthia Cowgill
Luis G Juarbe-Osorio
Patricio Riquelme
Glenn Dorin
Original Assignee
Cephalon Inc
Novartis Vaccines & Diagnostic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon Inc, Novartis Vaccines & Diagnostic filed Critical Cephalon Inc
Application granted granted Critical
Publication of ATE415411T1 publication Critical patent/ATE415411T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT96912727T 1995-04-14 1996-04-12 Reinigungsprozess für igf-i ATE415411T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/422,436 US5650496A (en) 1995-04-14 1995-04-14 IGF-I purification process

Publications (1)

Publication Number Publication Date
ATE415411T1 true ATE415411T1 (de) 2008-12-15

Family

ID=23674879

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96912727T ATE415411T1 (de) 1995-04-14 1996-04-12 Reinigungsprozess für igf-i

Country Status (11)

Country Link
US (2) US5650496A (de)
EP (1) EP0820463B1 (de)
JP (1) JP3894570B2 (de)
AT (1) ATE415411T1 (de)
AU (2) AU696516B2 (de)
CA (1) CA2218111C (de)
DE (1) DE69637760D1 (de)
ES (1) ES2321242T3 (de)
NO (1) NO322326B1 (de)
NZ (1) NZ306782A (de)
WO (1) WO1996032407A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996007744A1 (en) * 1994-09-08 1996-03-14 Chiron Corporation A method of improved production of insulin-like growth factor
US6756484B1 (en) 1995-04-14 2004-06-29 Cephalon, Inc. IGF-I purification process
US7071313B1 (en) * 1995-06-07 2006-07-04 Cephalon, Inc. Methods of purifying authentic IGF from yeast hosts
US7193042B1 (en) 1995-06-07 2007-03-20 Chiron Corporation Methods for purifying authentic IGF from yeast hosts
WO1996040776A1 (en) * 1995-06-07 1996-12-19 Chiron Corporation Methods for purifying authentic igf from yeast hosts
AU729459B2 (en) * 1996-11-15 2001-02-01 Genentech Inc. Purification of neurotrophins
JP2003530316A (ja) 1999-12-22 2003-10-14 ノボ ノルディスク アクティーゼルスカブ スクランブルした一本鎖ポリペプチドの抽出的再生法
GB0011278D0 (en) 2000-05-10 2000-06-28 Univ London Repair of nerve damage
WO2002009738A1 (en) 2000-07-28 2002-02-07 Murphy Christopher J Transplant media
US20040203115A1 (en) * 2001-10-09 2004-10-14 Giardina Steven L Methods and compositions for production and purification of recombinant staphylococcal enterotoxin b (rseb)
KR20030044696A (ko) * 2001-11-30 2003-06-09 정종문 피키아 파스토리스에서 재조합 인슐린 유사 성장인자-1단백질을 연속적으로 생산하는 방법
GB0202906D0 (en) * 2002-02-07 2002-03-27 Univ London Prevention of myocardial damage
US7229554B2 (en) * 2002-09-25 2007-06-12 Novo Nordisk A/S Purification process comprising microfiltration at elevated temperatures
US20070207209A1 (en) * 2004-08-27 2007-09-06 Murphy Christopher J Trophic factor combinations for nervous system treatment
WO2006097682A1 (en) * 2005-03-18 2006-09-21 Ucl Business Plc Mechano growth factor peptides and their use
KR102178191B1 (ko) 2008-09-02 2020-11-13 머크 밀리포어 리미티드 크로마토그래피 막, 이를 포함하는 장치 및 이의 이용방법
ES2543457T5 (es) * 2009-02-19 2021-12-22 Xellia Pharmaceuticals Aps Procedimiento para purificar lipopéptidos
CA2780095C (en) * 2009-11-13 2018-12-11 Merck Millipore Ltd. Hydrophobic interaction chromatography membranes, and methods of use thereof
US9873088B2 (en) 2011-05-17 2018-01-23 Natrix Separations Inc. Layered tubular membranes for chromatography, and methods of use thereof
CA3233933A1 (en) * 2017-01-30 2018-08-02 Regeneron Pharmaceuticals, Inc. Compositions and methods for reducing bioburden in chromatography
JP2020099909A (ja) * 2020-03-17 2020-07-02 ＨＯＹＡ Ｔｅｃｈｎｏｓｕｒｇｉｃａｌ株式会社 処理方法、生産方法およびハイドロキシアパタイト充填剤
KR102933055B1 (ko) * 2020-11-05 2026-02-27 시믹 홀딩스 씨오., 엘티디. 재조합 인슐린 유사 성장 인자 i의 제조 방법
CN116754678B (zh) * 2023-06-19 2025-09-16 杭州度安医学检验实验室有限公司 一种血液中胰岛素样生长因子检测样本的处理及检测方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5093317A (en) * 1989-06-05 1992-03-03 Cephalon, Inc. Treating disorders by application of insulin-like growth factor
WO1992003477A1 (en) * 1990-08-20 1992-03-05 Novo Nordisk A/S Biologically active compound, a process for the preparation thereof and use of the same
CA2090969C (en) * 1990-09-04 2001-08-21 Russell Arthur Brierley Production of insulin-like growth factor-1 in methylotrophic yeast cells
US5231178A (en) * 1991-01-16 1993-07-27 The Salk Institute Biotechnology/Industrial Associates, Inc. Method for the purification of intact, correctly-folded insulin-like growth factor-1
US5288931A (en) * 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
AU3812993A (en) * 1992-03-24 1993-10-21 Synergen, Inc. Refolding and purification of insulin-like growth factor I
US5407810A (en) * 1993-08-20 1995-04-18 Genentech, Inc. Aqueous multiple-phase isolation of polypeptide
US5663304A (en) * 1993-08-20 1997-09-02 Genentech, Inc. Refolding of misfolded insulin-like growth factor-I
US5451660A (en) * 1993-12-13 1995-09-19 Genentech, Inc. Method for purifying polypeptides
US5446024A (en) * 1993-12-17 1995-08-29 Genentech, Inc. Purification of insulin-like growth factor

Also Published As

Publication number Publication date
EP0820463A4 (de) 2001-08-08
CA2218111C (en) 2008-07-08
AU2007201259A1 (en) 2007-04-05
EP0820463B1 (de) 2008-11-26
EP0820463A1 (de) 1998-01-28
AU5543396A (en) 1996-10-30
AU696516B2 (en) 1998-09-10
NO974740D0 (no) 1997-10-13
DE69637760D1 (de) 2009-01-08
CA2218111A1 (en) 1996-10-17
NO974740L (no) 1997-12-12
ES2321242T3 (es) 2009-06-03
NZ306782A (en) 1998-11-25
US6207806B1 (en) 2001-03-27
NO322326B1 (no) 2006-09-18
JPH11503733A (ja) 1999-03-30
WO1996032407A1 (en) 1996-10-17
JP3894570B2 (ja) 2007-03-22
US5650496A (en) 1997-07-22

Similar Documents

Publication Publication Date Title
DE69637760D1 (de) Reinigungsprozess für igf-i
DK0582790T3 (da) Ny fremgangsmåde til fremstilling af 7-substituerede-9-[(substitueret glycyl)-amino]-6-demethyl-6-deoxytetracycliner
DE69432704D1 (de) Verfahren zur Herstellung von humanen Relaxin
HU9201551D0 (en) Method for producing biologically active compounds
CA2098183A1 (en) Method for the purification of intact, correctly-folded insulin-like growth factor-1
DE69433692D1 (de) Verfahren zur herstellung von poly-beta-1-4-n-acetylglukosamin
AU4473597A (en) Novel expression vectors for production of foreign proteins as soluble forms
ATE232210T1 (de) Verfahren zur herstellung von erythromicin a-oxim
CA2220447A1 (en) Novel fusion protein recovery and purification methods
CA2170515A1 (en) Nucleotide sequences for novel protein tyrosine phosphatases
FI103974B1 (fi) Menetelmä proteiinin puhdistamiseksi
WO1996011951A3 (en) Keratinocyte growth factor analogs
DE69415345D1 (de) Verfahren zur herstellung von bisnoraldehyden aus bisnoralkohol
DK0775159T3 (da) Ny fremgangsmåde til fremstilling af biologisk aktivt dimert protein
ATE128447T1 (de) Verfahren zur herstellung von äthanderivaten.
DE69808771D1 (de) Ein verfahren zur herstellung von tetraaza makrocyclen
WO1997005159A3 (en) Method for the purification of proteins
ATE203408T1 (de) Verbessertes verfahren zur herstellung von 6,
陈仲英 Superconvergence of generalized difference method for elliptic boundary value problem
DE69513408D1 (de) Ein verbessertes verfahren für die herstellung von seitenketten-derivaten von cyclohexapeptidyl-lipopeptiden
AU5024490A (en) Method of recovering purified epi protein from a solution especially a fermentation solution
RU94017615A (ru) Способ получения пептида
KR940014438A (ko) 섬자리공의 잎에서 분리한 신규한 항바이러스 단백질 및 그의 정제 법
RU95105312A (ru) Способ получения пептида дельта - сна
DE69526992D1 (de) Fermentationsprozess für die Herstellung von Phenylessigsäure mit Phenylalanin als Ausgangskomponente

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties