ATE415959T1 - Herg1-kanal-öffner zur behandlung von herzarrythmien - Google Patents

Herg1-kanal-öffner zur behandlung von herzarrythmien

Info

Publication number
ATE415959T1
ATE415959T1 AT04766708T AT04766708T ATE415959T1 AT E415959 T1 ATE415959 T1 AT E415959T1 AT 04766708 T AT04766708 T AT 04766708T AT 04766708 T AT04766708 T AT 04766708T AT E415959 T1 ATE415959 T1 AT E415959T1
Authority
AT
Austria
Prior art keywords
treatment
channel opener
herg1 channel
arrythmia
heart
Prior art date
Application number
AT04766708T
Other languages
English (en)
Inventor
Soeren Olesen
Morten Grunnet
Palle Christophersen
Dorte Strobaek
Joachim Demnitz
Rie Hansen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of ATE415959T1 publication Critical patent/ATE415959T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Finger-Pressure Massage (AREA)
  • Surgical Instruments (AREA)
  • Processing Of Meat And Fish (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT04766708T 2003-09-04 2004-09-06 Herg1-kanal-öffner zur behandlung von herzarrythmien ATE415959T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200301264 2003-09-04

Publications (1)

Publication Number Publication Date
ATE415959T1 true ATE415959T1 (de) 2008-12-15

Family

ID=34259076

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04766708T ATE415959T1 (de) 2003-09-04 2004-09-06 Herg1-kanal-öffner zur behandlung von herzarrythmien

Country Status (10)

Country Link
US (2) US7851492B2 (de)
EP (1) EP1663192B1 (de)
JP (2) JP2007504202A (de)
CN (1) CN1845726A (de)
AT (1) ATE415959T1 (de)
AU (1) AU2004269924A1 (de)
CA (1) CA2537746A1 (de)
DE (1) DE602004018162D1 (de)
MX (1) MXPA06002315A (de)
WO (1) WO2005023237A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1827411A2 (de) * 2004-12-17 2007-09-05 Neurosearch A/S Als kaliumkanal-aktivatoren geeignete diphenyl-harnstoff-derivate
WO2006089871A2 (en) * 2005-02-23 2006-08-31 Neurosearch A/S Diphenylurea derivatives useful as erg channel openers for the treatment of cardiac arrhythmias
CA2630639A1 (en) * 2005-11-21 2007-05-31 Tap Pharmaceutical Products, Inc. Treatment of qt interval prolongation and diseases associated therewith
EP1996190A1 (de) 2006-03-14 2008-12-03 Neurosearch A/S Diphenyl-harnstoff-derivate und ihre anwendung als chloridkanalblocker oder bkca-kanal-modulatoren
WO2009068509A1 (en) * 2007-11-26 2009-06-04 Neurosearch A/S Novel benzamide derivatives useful as potassium channel modulators
WO2011119939A2 (en) * 2010-03-25 2011-09-29 The Uab Research Foundation Manipulation of calcium channels to regulate after-depolarization events in cardiac myocytes
US9255093B2 (en) * 2014-04-17 2016-02-09 Novartis Ag Polycyclic HERG activators
CN105343120A (zh) * 2015-11-19 2016-02-24 宁波市医疗中心李惠利医院 Amo-103在制备治疗心律失常药物中的应用
JP7111359B2 (ja) * 2018-02-08 2022-08-02 国立大学法人東北大学 植物のカリウムイオン輸送体の機能制御剤及び植物の育成方法
JP7336133B2 (ja) * 2019-08-07 2023-08-31 国立大学法人東北大学 ジフェニル尿素化合物誘導体

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104890A (en) * 1989-03-28 1992-04-14 Fujisawa Pharmaceutical Company, Ltd. Benzopyran derivatives and processes for preparation thereof
CN1060467A (zh) * 1990-09-25 1992-04-22 武田药品工业株式会社 1，3-苯并嗪衍生物、其生产方法和用途
US5164509A (en) * 1990-11-26 1992-11-17 E. R. Squibb & Sons, Inc. Benzodiazolo analogs
DK41193D0 (da) * 1993-04-07 1993-04-07 Neurosearch As Ionkanalaabnere
US5416097A (en) * 1993-05-19 1995-05-16 Berlex Laboratories, Inc. Potassium channel activators/openers
US5679706A (en) * 1994-09-30 1997-10-21 Bristol-Myers Squibb Company Combination of a potassium channel activator and an antiarrhythmic agent
JPH11503110A (ja) 1995-02-17 1999-03-23 スミスクライン・ビーチャム・コーポレイション Ｉｌ−８受容体拮抗剤
WO1996028537A1 (en) 1995-03-09 1996-09-19 University Of Utah Research Foundation Long qt genes and method for diagnosing or preventing the occurrence of long qt syndrome
EP0910358A1 (de) 1996-05-24 1999-04-28 Neurosearch A/S Phenylderivate als chloridkanalblocker
CA2255858C (en) 1996-05-24 2007-09-11 Neurosearch A/S Phenyl derivatives containing an acidic group, their preparation and their use as chloride channel blockers
US6297261B1 (en) * 1997-04-22 2001-10-02 Neurosearch A/S Substituted phenyl derivatives, their preparation and use
US5972894A (en) * 1997-08-07 1999-10-26 Cytran, Inc. Peptides having potassium channel opener activity
ATE295166T1 (de) * 1998-01-14 2005-05-15 Nippon Shinyaku Co Ltd Aktivatoren der kalium-kanäle
US6207383B1 (en) 1998-07-27 2001-03-27 University Of Utah Research Foundation Mutations in and genomic structure of HERG—a long QT syndrome gene
PL198852B1 (pl) 1998-10-22 2008-07-31 Neurosearch As Podstawione pochodne fenylu, kompozycja farmaceutyczna je zawierająca oraz ich zastosowanie
US20030013136A1 (en) * 2000-10-30 2003-01-16 Balser Jeffrey R. Human KCR1 regulation of HERG potassium channel block
JP2004535760A (ja) 2000-11-20 2004-12-02 メルク　エンド　カムパニー　インコーポレーテッド ヒトｅｒｇ２カリウムチャンネル
US20040077634A1 (en) * 2001-02-15 2004-04-22 Ulrik Lademann Treatment of diseases characterized by excessive or insufficient cell death
WO2003000245A1 (en) * 2001-06-22 2003-01-03 Poseidon Pharmaceuticals A/S Compounds for use in disorders associated with mast cell or basophil activity
CN100497302C (zh) 2002-09-05 2009-06-10 神经研究公司 二芳基脲衍生物和它们作为氯通道阻滞剂的用途
WO2005023238A1 (en) * 2003-09-04 2005-03-17 Poseidon Pharmaceuticals A/S Erg channel openers for the treatment of hyperexcitability-related neuronal diseases
CA2630639A1 (en) 2005-11-21 2007-05-31 Tap Pharmaceutical Products, Inc. Treatment of qt interval prolongation and diseases associated therewith
US20090047703A1 (en) * 2007-08-17 2009-02-19 University Of Maryland, Baltimore ERG-1 Peptides and Polynucleotides and Their Use in the Treatment and Diagnosis of Disease

Also Published As

Publication number Publication date
US20060281794A1 (en) 2006-12-14
EP1663192B1 (de) 2008-12-03
JP2011052004A (ja) 2011-03-17
MXPA06002315A (es) 2006-05-22
DE602004018162D1 (de) 2009-01-15
CA2537746A1 (en) 2005-03-17
JP2007504202A (ja) 2007-03-01
US20110071164A1 (en) 2011-03-24
AU2004269924A1 (en) 2005-03-17
CN1845726A (zh) 2006-10-11
US7851492B2 (en) 2010-12-14
EP1663192A1 (de) 2006-06-07
WO2005023237A1 (en) 2005-03-17

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties