ATE416170T1 - Substituierte 2-phenyl benzofurane als oestrogenwirksame substanzen - Google Patents
Substituierte 2-phenyl benzofurane als oestrogenwirksame substanzenInfo
- Publication number
- ATE416170T1 ATE416170T1 AT02805170T AT02805170T ATE416170T1 AT E416170 T1 ATE416170 T1 AT E416170T1 AT 02805170 T AT02805170 T AT 02805170T AT 02805170 T AT02805170 T AT 02805170T AT E416170 T1 ATE416170 T1 AT E416170T1
- Authority
- AT
- Austria
- Prior art keywords
- benzofuranes
- phenyl
- substituted
- estrogenic substances
- estrogenic
- Prior art date
Links
- 229940106582 estrogenic substances Drugs 0.000 title 1
- JKKFKPJIXZFSSB-CBZIJGRNSA-N estrone 3-sulfate Chemical compound OS(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 JKKFKPJIXZFSSB-CBZIJGRNSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/18—Feminine contraceptives
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- A—HUMAN NECESSITIES
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- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61P9/12—Antihypertensives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Toxicology (AREA)
- Gynecology & Obstetrics (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34163801P | 2001-12-18 | 2001-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE416170T1 true ATE416170T1 (de) | 2008-12-15 |
Family
ID=23338402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02805170T ATE416170T1 (de) | 2001-12-18 | 2002-12-17 | Substituierte 2-phenyl benzofurane als oestrogenwirksame substanzen |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US6774248B2 (de) |
| EP (1) | EP1458700B1 (de) |
| JP (1) | JP2006506315A (de) |
| CN (1) | CN1606551A (de) |
| AR (1) | AR037883A1 (de) |
| AT (1) | ATE416170T1 (de) |
| AU (1) | AU2002366356A1 (de) |
| BR (1) | BR0215058A (de) |
| CA (1) | CA2470352A1 (de) |
| DE (1) | DE60230187D1 (de) |
| MX (1) | MXPA04005784A (de) |
| TW (1) | TW200301106A (de) |
| WO (1) | WO2003051860A2 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6653346B1 (en) * | 2002-02-07 | 2003-11-25 | Galileo Pharmaceuticals, Inc. | Cytoprotective benzofuran derivatives |
| US7078541B2 (en) * | 2002-02-07 | 2006-07-18 | Galileo Pharmaceuticals, Inc. | Benzofuran derivatives |
| TW200409759A (en) | 2002-09-25 | 2004-06-16 | Wyeth Corp | Substituted 4-(indazol-3-yl)phenols |
| GB0225548D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Compounds |
| DK1633699T3 (da) * | 2003-05-16 | 2007-03-26 | Wyeth Corp | Aryl-carbaldehydroximderivater og deres anvendelse som östrogene midler |
| CL2004000985A1 (es) * | 2003-05-16 | 2005-01-14 | Wyeth Corp | Compuestos derivados de fenilquinolinas; composicion farmaceutica, proceso de preparacion; y uso para tratar osteoporosis, enfermedad de paget, dano vascular, osteoartritis, cancer oseo, cancer ovarico, cancer prostatico, hipercolesterolemia, aterosc |
| ATE487475T1 (de) * | 2003-08-01 | 2010-11-15 | Chugai Pharmaceutical Co Ltd | Heterocyclische verbindungen als nützliche malonyl-coa decarboxylase-hemmer |
| JP2008505095A (ja) * | 2004-07-01 | 2008-02-21 | ワイス | エストロゲンリガンドとしての四環式化合物 |
| RU2007120254A (ru) * | 2004-12-17 | 2009-01-27 | Вайет (Us) | Новые способы применения агонистов эстрогена бета |
| EP1984028A2 (de) * | 2006-02-14 | 2008-10-29 | Wyeth a Corporation of the State of Delaware | Wässrige pharmazeutische formulierungen er-selektiver liganden |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| US9623021B2 (en) * | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| KR101638035B1 (ko) | 2007-01-22 | 2016-07-11 | 지티엑스, 인코포레이티드 | 핵 수용체에 결합하는 물질 |
| MX2009008121A (es) * | 2007-01-31 | 2009-08-12 | Wyeth Corp | Uso de ligados selectivos de receptores de estrogeno beta para tratar lesiones de pulmon agudas. |
| GB0806656D0 (en) * | 2008-04-11 | 2008-05-14 | Karobio Ab | Novel estrogen receptor ligands |
| MX2012011504A (es) * | 2010-04-05 | 2013-01-18 | Mannkind Corp | Inhibidores de enzima 1 dependiente de inositol (ire-1 alfa). |
| GB201113538D0 (en) | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
| CN103724306B (zh) * | 2014-01-24 | 2015-03-11 | 温州大学 | 一种苯并呋喃衍生物的制备方法 |
| US10590100B2 (en) | 2015-11-11 | 2020-03-17 | Ambient Photonics, Inc. | Benzofuran derivatives for the treatment of CNS and other disorders |
| AU2019274580B2 (en) | 2018-05-23 | 2024-11-07 | The Board Of Trustees Of The University Of Illinois | Estrogen receptor beta ligands for the prevention and treatment of multiple sclerosis (MS) and other demyelinating, inflammatory and neurodegenerative diseases |
| CN112912073B (zh) * | 2018-07-10 | 2023-11-28 | 环境光子学公司 | 用于基于铜氧化还原的染料敏化太阳能电池的太阳能电池染料及其组合 |
| CN108997282B (zh) * | 2018-07-25 | 2022-04-29 | 安徽工程大学 | 具有α-葡萄糖苷酶抑制活性的芳基苯并呋喃类衍生物 |
| CN109030681B (zh) * | 2018-09-20 | 2021-10-01 | 广西壮族自治区药用植物园 | 鉴定山豆根真伪的方法 |
| CN118420688B (zh) * | 2024-05-18 | 2026-01-02 | 河南中医药大学 | 一种从麻黄根中制备麻黄根酚类化合物的方法及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4863958A (en) | 1984-06-20 | 1989-09-05 | Merck Frosst Canada, Inc. | Benzofuran derivatives useful as inhibitors of mammalian leukotriene biosynthesis |
| US5087638A (en) | 1984-06-20 | 1992-02-11 | Merck Frosst Canada, Inc. | Benzofuran derivatives |
| US5705507A (en) | 1995-03-10 | 1998-01-06 | Eli Lilly And Company | Aplha-substituted-3-benzyl-benzofurans |
| US20020099086A1 (en) | 1998-07-31 | 2002-07-25 | Proteome Sciences Plc | Use of extracts from aristolochia in the treatment of AIDS |
| RU2324686C2 (ru) | 2000-08-24 | 2008-05-20 | Юнивесити Оф Питсбэг | ПРОИЗВОДНЫЕ ТИОФЛАВИНА, СВЯЗЫВАЮЩИЕ АМИЛОИД, СПОСОБ ОБНАРУЖЕНИЯ in vivo ОТЛОЖЕНИЙ АМИЛОИДА И СПОСОБ РАСПОЗНАВАНИЯ БОЛЕЗНИ АЛЬЦГЕЙМЕРА |
-
2002
- 2002-12-16 US US10/320,207 patent/US6774248B2/en not_active Expired - Fee Related
- 2002-12-17 EP EP02805170A patent/EP1458700B1/de not_active Expired - Lifetime
- 2002-12-17 AT AT02805170T patent/ATE416170T1/de not_active IP Right Cessation
- 2002-12-17 DE DE60230187T patent/DE60230187D1/de not_active Expired - Fee Related
- 2002-12-17 CA CA002470352A patent/CA2470352A1/en not_active Abandoned
- 2002-12-17 AU AU2002366356A patent/AU2002366356A1/en not_active Abandoned
- 2002-12-17 JP JP2003552744A patent/JP2006506315A/ja active Pending
- 2002-12-17 TW TW091136367A patent/TW200301106A/zh unknown
- 2002-12-17 MX MXPA04005784A patent/MXPA04005784A/es active IP Right Grant
- 2002-12-17 WO PCT/US2002/040224 patent/WO2003051860A2/en not_active Ceased
- 2002-12-17 BR BRPI0215058-1A patent/BR0215058A/pt not_active IP Right Cessation
- 2002-12-17 CN CNA028255682A patent/CN1606551A/zh active Pending
- 2002-12-17 AR ARP020104914A patent/AR037883A1/es not_active Application Discontinuation
-
2004
- 2004-04-21 US US10/828,970 patent/US7022733B2/en not_active Expired - Fee Related
-
2005
- 2005-10-11 US US11/247,361 patent/US20060074128A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1606551A (zh) | 2005-04-13 |
| MXPA04005784A (es) | 2004-09-13 |
| US20060074128A1 (en) | 2006-04-06 |
| DE60230187D1 (de) | 2009-01-15 |
| EP1458700B1 (de) | 2008-12-03 |
| US20050038107A1 (en) | 2005-02-17 |
| BR0215058A (pt) | 2006-06-06 |
| JP2006506315A (ja) | 2006-02-23 |
| US7022733B2 (en) | 2006-04-04 |
| AR037883A1 (es) | 2004-12-09 |
| US6774248B2 (en) | 2004-08-10 |
| AU2002366356A1 (en) | 2003-06-30 |
| WO2003051860A3 (en) | 2003-12-04 |
| WO2003051860A2 (en) | 2003-06-26 |
| EP1458700A2 (de) | 2004-09-22 |
| TW200301106A (en) | 2003-07-01 |
| CA2470352A1 (en) | 2003-06-26 |
| US20030171428A1 (en) | 2003-09-11 |
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