ATE416766T1 - Verfahren zur herstellung von 4-(2- dipropylaminoethyl)-1,3-dihydro-2h-indol-2-on- hydrochlorid - Google Patents
Verfahren zur herstellung von 4-(2- dipropylaminoethyl)-1,3-dihydro-2h-indol-2-on- hydrochloridInfo
- Publication number
- ATE416766T1 ATE416766T1 AT04806731T AT04806731T ATE416766T1 AT E416766 T1 ATE416766 T1 AT E416766T1 AT 04806731 T AT04806731 T AT 04806731T AT 04806731 T AT04806731 T AT 04806731T AT E416766 T1 ATE416766 T1 AT E416766T1
- Authority
- AT
- Austria
- Prior art keywords
- indol
- dihydro
- dipropylaminoethyl
- hydrochloride
- producing
- Prior art date
Links
- XDXHAEQXIBQUEZ-UHFFFAOYSA-N Ropinirole hydrochloride Chemical compound Cl.CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2 XDXHAEQXIBQUEZ-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- UHSKFQJFRQCDBE-UHFFFAOYSA-N ropinirole Chemical compound CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2 UHSKFQJFRQCDBE-UHFFFAOYSA-N 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960001879 ropinirole Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN60MU2004 | 2004-01-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE416766T1 true ATE416766T1 (de) | 2008-12-15 |
Family
ID=34746665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04806731T ATE416766T1 (de) | 2004-01-20 | 2004-07-16 | Verfahren zur herstellung von 4-(2- dipropylaminoethyl)-1,3-dihydro-2h-indol-2-on- hydrochlorid |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7378439B2 (de) |
| EP (1) | EP1706113B1 (de) |
| JP (1) | JP2007518793A (de) |
| KR (1) | KR20060130108A (de) |
| CN (1) | CN1909901A (de) |
| AT (1) | ATE416766T1 (de) |
| AU (1) | AU2004313729A1 (de) |
| CA (1) | CA2548982A1 (de) |
| DE (1) | DE602004018386D1 (de) |
| PL (1) | PL1706113T3 (de) |
| WO (1) | WO2005067922A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120253051A1 (en) | 2009-12-16 | 2012-10-04 | Pharmathen S.A. | Process for the preparation of ropinirole and salts thereof |
| ES2608782T3 (es) | 2010-04-30 | 2017-04-17 | Teikoku Pharma Usa, Inc. | Composiciones transdérmicas de propinilaminoindano |
| EP2688561B1 (de) | 2011-03-24 | 2018-08-22 | Teikoku Pharma USA, Inc. | Transdermale zusammensetzungen mit einer wirkstoffschicht und einer wirkstoffumwandlungsschicht |
| JP5913614B2 (ja) | 2011-11-09 | 2016-04-27 | テイコク ファーマ ユーエスエー インコーポレーテッド | 皮膚新生物の処置方法 |
| WO2013102142A1 (en) | 2011-12-28 | 2013-07-04 | Global Blood Therapeutics, Inc. | Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation |
| HK1203412A1 (en) | 2011-12-28 | 2015-10-30 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
| AU2013338243B2 (en) | 2012-11-02 | 2016-09-29 | Teikoku Seiyaku Co., Ltd. | Propynylaminoindan transdermal compositions |
| CN103086946B (zh) * | 2013-01-17 | 2018-10-23 | 浙江华海药业股份有限公司 | 一种盐酸罗匹尼罗纯化的方法 |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| SG10201802911RA (en) | 2013-03-15 | 2018-05-30 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| AP2015008718A0 (en) | 2013-03-15 | 2015-09-30 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| WO2014145040A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
| US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
| EP3919056B1 (de) | 2013-03-15 | 2024-08-28 | Global Blood Therapeutics, Inc. | Verbindungen und verwendungen davon zur modulation von hämoglobin |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| EA202092627A1 (ru) | 2013-11-18 | 2021-09-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| ES2860648T5 (es) | 2014-02-07 | 2024-11-27 | Global Blood Therapeutics Inc | Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1H-pirazol-5-il)piridin-3-il)metoxi)benzaldehído |
| MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
| US11020382B2 (en) | 2015-12-04 | 2021-06-01 | Global Blood Therapeutics, Inc. | Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
| TWI825524B (zh) | 2016-05-12 | 2023-12-11 | 美商全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
| TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
| CN110621660B (zh) * | 2017-06-16 | 2022-06-28 | 浙江华海立诚药业有限公司 | 盐酸罗匹尼罗的纯化方法 |
| EP3860975B1 (de) | 2018-10-01 | 2023-10-18 | Global Blood Therapeutics, Inc. | Modulatoren von hämoglobin zur behandlung von sichelzellenanämie |
| US12479816B2 (en) | 2019-02-08 | 2025-11-25 | University of Pittsburgh—of the Commonwealth System of Higher Education | 20-HETE formation inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4452808A (en) * | 1982-12-07 | 1984-06-05 | Smithkline Beckman Corporation | 4-Aminoalkyl-2(3H)-indolones |
| GB8712073D0 (en) * | 1987-05-21 | 1987-06-24 | Smith Kline French Lab | Medicament |
| GB8714371D0 (en) * | 1987-06-19 | 1987-07-22 | Smith Kline French Lab | Process |
| GB9008605D0 (en) * | 1990-04-17 | 1990-06-13 | Smith Kline French Lab | Process |
| US5958965A (en) * | 1996-08-27 | 1999-09-28 | American Home Products Corporation | 4-aminoethoxy indoles |
-
2004
- 2004-07-09 US US10/888,901 patent/US7378439B2/en not_active Expired - Fee Related
- 2004-07-16 EP EP04806731A patent/EP1706113B1/de not_active Expired - Lifetime
- 2004-07-16 CN CNA2004800406984A patent/CN1909901A/zh active Pending
- 2004-07-16 KR KR1020067014523A patent/KR20060130108A/ko not_active Withdrawn
- 2004-07-16 DE DE602004018386T patent/DE602004018386D1/de not_active Expired - Lifetime
- 2004-07-16 JP JP2006550494A patent/JP2007518793A/ja not_active Withdrawn
- 2004-07-16 AU AU2004313729A patent/AU2004313729A1/en not_active Abandoned
- 2004-07-16 WO PCT/IN2004/000214 patent/WO2005067922A1/en not_active Ceased
- 2004-07-16 AT AT04806731T patent/ATE416766T1/de not_active IP Right Cessation
- 2004-07-16 CA CA002548982A patent/CA2548982A1/en not_active Abandoned
- 2004-07-16 PL PL04806731T patent/PL1706113T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1909901A (zh) | 2007-02-07 |
| JP2007518793A (ja) | 2007-07-12 |
| US20050159605A1 (en) | 2005-07-21 |
| EP1706113A1 (de) | 2006-10-04 |
| US7378439B2 (en) | 2008-05-27 |
| CA2548982A1 (en) | 2005-07-28 |
| WO2005067922A1 (en) | 2005-07-28 |
| KR20060130108A (ko) | 2006-12-18 |
| DE602004018386D1 (de) | 2009-01-22 |
| PL1706113T3 (pl) | 2009-07-31 |
| EP1706113B1 (de) | 2008-12-10 |
| AU2004313729A1 (en) | 2005-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |