ATE417058T1 - Derivate der z-domäne des proteins a von staphylococcus (spa), welche mit mindestens einer domäne des humanen faktors viii interagieren - Google Patents

Derivate der z-domäne des proteins a von staphylococcus (spa), welche mit mindestens einer domäne des humanen faktors viii interagieren

Info

Publication number
ATE417058T1
ATE417058T1 AT00921293T AT00921293T ATE417058T1 AT E417058 T1 ATE417058 T1 AT E417058T1 AT 00921293 T AT00921293 T AT 00921293T AT 00921293 T AT00921293 T AT 00921293T AT E417058 T1 ATE417058 T1 AT E417058T1
Authority
AT
Austria
Prior art keywords
domain
protein
spa
derivatives
factor viii
Prior art date
Application number
AT00921293T
Other languages
English (en)
Inventor
Charlotta Ljungqvist
Karin Nord
Per-Ake Nygren
Mathias Uhlen
Original Assignee
Biovitrum Ab Publ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovitrum Ab Publ filed Critical Biovitrum Ab Publ
Application granted granted Critical
Publication of ATE417058T1 publication Critical patent/ATE417058T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT00921293T 1999-04-19 2000-04-17 Derivate der z-domäne des proteins a von staphylococcus (spa), welche mit mindestens einer domäne des humanen faktors viii interagieren ATE417058T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9901379A SE9901379D0 (sv) 1999-04-19 1999-04-19 Receptor structures

Publications (1)

Publication Number Publication Date
ATE417058T1 true ATE417058T1 (de) 2008-12-15

Family

ID=20415254

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00921293T ATE417058T1 (de) 1999-04-19 2000-04-17 Derivate der z-domäne des proteins a von staphylococcus (spa), welche mit mindestens einer domäne des humanen faktors viii interagieren

Country Status (8)

Country Link
EP (1) EP1179014B1 (de)
JP (1) JP4578690B2 (de)
AT (1) ATE417058T1 (de)
AU (1) AU4162400A (de)
DE (1) DE60041052D1 (de)
DK (1) DK1179014T3 (de)
SE (1) SE9901379D0 (de)
WO (1) WO2000063243A1 (de)

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WO2004003019A2 (en) * 2002-06-28 2004-01-08 Domantis Limited Immunoglobin single variant antigen-binding domains and dual-specific constructs
WO2003093821A1 (en) * 2002-04-29 2003-11-13 Affibody Ab Sandwich assay and kit
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
SE0301936D0 (sv) * 2003-06-30 2003-06-30 Affibody Ab New polypeptide
SE0301987D0 (sv) * 2003-07-04 2003-07-04 Affibody Ab New polypeptide
DE602004018141D1 (de) * 2003-07-04 2009-01-15 Affibody Ab Polypeptide mit bindungsaffinität für her2
GB0524788D0 (en) 2005-12-05 2006-01-11 Affibody Ab Polypeptides
WO2008127457A2 (en) 2006-12-06 2008-10-23 Repligen Corporation Nucleic acids encoding recombinant protein a
US7977118B2 (en) 2006-12-08 2011-07-12 General Electric Company Two helix binders
US8198043B2 (en) 2006-12-08 2012-06-12 General Electric Company Two helix binders
US7989216B2 (en) 2006-12-08 2011-08-02 General Electric Company Two helix binders
US7981691B2 (en) 2006-12-08 2011-07-19 General Electric Company Two helix binders
IN2009DN05758A (de) 2007-03-12 2015-07-24 Esbatech Ag
KR101530723B1 (ko) 2007-06-25 2015-06-22 에스바테크 - 어 노바티스 컴파니 엘엘씨 단일 쇄 항체의 서열에 기초한 공학처리 및 최적화
CN111253484A (zh) 2007-06-25 2020-06-09 艾斯巴技术-诺华有限责任公司 修饰抗体的方法和具有改善的功能性质的修饰抗体
US8426557B2 (en) 2007-08-03 2013-04-23 Affibody Ab IGF-1R binding polypeptides and their use
GB2453589A (en) 2007-10-12 2009-04-15 King S College London Protease inhibition
MX346024B (es) 2008-06-25 2017-03-02 Esbatech Alcon Biomed Res Unit Optimización de solubilidad de inmuno-aglutinantes.
US8592555B2 (en) 2008-08-11 2013-11-26 Emd Millipore Corporation Immunoglobulin-binding proteins with improved specificity
WO2010019233A1 (en) 2008-08-11 2010-02-18 Nektar Therapeutics Multi-arm polymeric alkanoate conjugates
WO2010021720A1 (en) 2008-08-19 2010-02-25 Nektar Therapeutics Conjugates of small-interfering nucleic acids
SG195555A1 (en) 2008-12-24 2013-12-30 Emd Millipore Corp Caustic stable chromatography ligands
JP5917417B2 (ja) 2010-03-05 2016-05-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗体の選択的強化
DK2591099T3 (da) 2010-07-09 2021-02-15 Bioverativ Therapeutics Inc Kimære koagulationsfaktorer
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
US20140088021A1 (en) 2011-05-27 2014-03-27 Nektar Therapeutics Water-Soluble Polymer-Linked Binding Moiety and Drug Compounds
SG10201604559TA (en) 2011-06-08 2016-07-28 Emd Millipore Corp Chromatography matrices including novel staphylococcus aureus protein a based ligands
US9701749B2 (en) 2011-08-11 2017-07-11 Ono Pharmaceutical Co., Ltd. Therapeutic agent for autoimmune diseases comprising PD-1 agonist
WO2013106577A2 (en) 2012-01-10 2013-07-18 Biogen Idec Ma Inc. Enhancement of transport of therapeutic molecules across the blood brain barrier
WO2013175276A1 (en) 2012-05-23 2013-11-28 Argen-X B.V Il-6 binding molecules
US9897611B2 (en) 2012-12-27 2018-02-20 National Institute Of Advanced Industrial Science And Technology Molecule library constructed on the basis of backbone structure of microprotein
EP3019520B1 (de) * 2013-07-10 2019-12-11 GE Healthcare BioProcess R&D AB Mutierte immunglobulinbindende polypeptide
ES2742505T3 (es) * 2013-08-28 2020-02-14 Affibody Ab Polipéptidos de unión que tienen un andamio mutado
KR20220002325A (ko) 2019-04-29 2022-01-06 씨티바 바이오프로세스 알＆디 에이비 단백질 A에 결합할 수 있는 Fc 영역이 없는 항체 또는 항체 단편을 분리하는 방법
TWI889320B (zh) 2019-07-05 2025-07-01 日商小野藥品工業股份有限公司 以pd-1/cd3雙特異性蛋白質所進行之血液性癌症治療
WO2021025140A1 (ja) 2019-08-08 2021-02-11 小野薬品工業株式会社 二重特異性タンパク質
TW202346359A (zh) 2022-04-15 2023-12-01 美商凱維那醫療公司 用於治療自體免疫疾病之方法及組合物
US20250249112A1 (en) * 2022-04-29 2025-08-07 Craig RAMIREZ Macropinocytosis selective non-binding protein-drug conjugates
US20250223326A1 (en) 2022-05-10 2025-07-10 Institut National de la Santé et de la Recherche Médicale Syncitin-1 fusion proteins and uses thereof for cargo delivery into target cells
WO2025041077A1 (en) 2023-08-23 2025-02-27 Sanofi Ctla-4-based lysosomal degraders and uses thereof

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Publication number Priority date Publication date Assignee Title
IL74909A (en) 1984-04-20 1992-01-15 Genentech Inc Preparation of functional human factor viii and dna sequences,expression vectors,transformed microorganisms and cell lines used therein
SE8501050D0 (sv) 1985-03-05 1985-03-05 Kabivitrum Ab Biologically active fragments of human antihemophilic factor and method for preparation thereof
SE465222C5 (sv) 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
SE468050C (sv) 1991-03-15 1998-04-27 Pharmacia & Upjohn Ab Rekombinant derivat av human faktor VIII
SE9400088D0 (sv) 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures

Also Published As

Publication number Publication date
WO2000063243A1 (en) 2000-10-26
SE9901379D0 (sv) 1999-04-19
DE60041052D1 (de) 2009-01-22
AU4162400A (en) 2000-11-02
EP1179014A1 (de) 2002-02-13
JP4578690B2 (ja) 2010-11-10
JP2002542259A (ja) 2002-12-10
DK1179014T3 (da) 2009-04-06
EP1179014B1 (de) 2008-12-10

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