ATE417058T1 - Derivate der z-domäne des proteins a von staphylococcus (spa), welche mit mindestens einer domäne des humanen faktors viii interagieren - Google Patents

Derivate der z-domäne des proteins a von staphylococcus (spa), welche mit mindestens einer domäne des humanen faktors viii interagieren

Info

Publication number
ATE417058T1
ATE417058T1 AT00921293T AT00921293T ATE417058T1 AT E417058 T1 ATE417058 T1 AT E417058T1 AT 00921293 T AT00921293 T AT 00921293T AT 00921293 T AT00921293 T AT 00921293T AT E417058 T1 ATE417058 T1 AT E417058T1
Authority
AT
Austria
Prior art keywords
domain
protein
spa
derivatives
factor viii
Prior art date
Application number
AT00921293T
Other languages
English (en)
Inventor
Charlotta Ljungqvist
Karin Nord
Per-Ake Nygren
Mathias Uhlen
Original Assignee
Biovitrum Ab Publ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovitrum Ab Publ filed Critical Biovitrum Ab Publ
Application granted granted Critical
Publication of ATE417058T1 publication Critical patent/ATE417058T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT00921293T 1999-04-19 2000-04-17 Derivate der z-domäne des proteins a von staphylococcus (spa), welche mit mindestens einer domäne des humanen faktors viii interagieren ATE417058T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9901379A SE9901379D0 (sv) 1999-04-19 1999-04-19 Receptor structures

Publications (1)

Publication Number Publication Date
ATE417058T1 true ATE417058T1 (de) 2008-12-15

Family

ID=20415254

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00921293T ATE417058T1 (de) 1999-04-19 2000-04-17 Derivate der z-domäne des proteins a von staphylococcus (spa), welche mit mindestens einer domäne des humanen faktors viii interagieren

Country Status (8)

Country Link
EP (1) EP1179014B1 (de)
JP (1) JP4578690B2 (de)
AT (1) ATE417058T1 (de)
AU (1) AU4162400A (de)
DE (1) DE60041052D1 (de)
DK (1) DK1179014T3 (de)
SE (1) SE9901379D0 (de)
WO (1) WO2000063243A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005504261A (ja) * 2001-01-12 2005-02-10 アフィボディ・アーベー 検出方法
CA2483408A1 (en) * 2002-04-29 2003-11-13 Affibody Ab Sandwich assay and kit
EP1600459A3 (de) * 2002-06-28 2005-12-07 Domantis Limited Ligand
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
SE0301936D0 (sv) * 2003-06-30 2003-06-30 Affibody Ab New polypeptide
SE0301987D0 (sv) * 2003-07-04 2003-07-04 Affibody Ab New polypeptide
EP1641818B1 (de) * 2003-07-04 2008-12-03 Affibody AB Polypeptide mit bindungsaffinität für her2
GB0524788D0 (en) * 2005-12-05 2006-01-11 Affibody Ab Polypeptides
EP2099932A4 (de) 2006-12-06 2009-11-18 Repligen Corp Nukleinsäuren zur kodierung des rekombinanten proteins a
US7989216B2 (en) 2006-12-08 2011-08-02 General Electric Company Two helix binders
US8198043B2 (en) 2006-12-08 2012-06-12 General Electric Company Two helix binders
US7977118B2 (en) 2006-12-08 2011-07-12 General Electric Company Two helix binders
US7981691B2 (en) 2006-12-08 2011-07-19 General Electric Company Two helix binders
CN103275216B (zh) 2007-03-12 2015-05-06 艾斯巴技术-诺华有限责任公司 单链抗体的基于序列的工程改造和最优化
DK2158315T3 (en) 2007-06-25 2016-06-06 Esbatech Alcon Biomed Res Unit Methods of modifying antibodies and modified antibodies with improved functional properties
KR101530723B1 (ko) 2007-06-25 2015-06-22 에스바테크 - 어 노바티스 컴파니 엘엘씨 단일 쇄 항체의 서열에 기초한 공학처리 및 최적화
US8426557B2 (en) 2007-08-03 2013-04-23 Affibody Ab IGF-1R binding polypeptides and their use
GB2453589A (en) 2007-10-12 2009-04-15 King S College London Protease inhibition
US9556265B2 (en) 2008-06-25 2017-01-31 Esbatech, An Alcon Biomedical Research Unit Llc Solubility optimization of immunobinders
US8592555B2 (en) 2008-08-11 2013-11-26 Emd Millipore Corporation Immunoglobulin-binding proteins with improved specificity
US8637466B2 (en) 2008-08-11 2014-01-28 Nektar Therapeutics Multi-arm polymeric alkanoate conjugates
US9089610B2 (en) 2008-08-19 2015-07-28 Nektar Therapeutics Complexes of small-interfering nucleic acids
SG195555A1 (en) 2008-12-24 2013-12-30 Emd Millipore Corp Caustic stable chromatography ligands
KR101855714B1 (ko) 2010-03-05 2018-05-10 베링거 인겔하임 인터내셔날 게엠베하 항체의 선택적 농축
HRP20191305T1 (hr) 2010-07-09 2019-10-18 Bioverativ Therapeutics Inc. Preradive jednolančane molekule i polipeptidi izrađeni koristeći iste
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
WO2012166555A1 (en) 2011-05-27 2012-12-06 Nektar Therapeutics Water - soluble polymer - linked binding moiety and drug compounds
SG10201604559TA (en) 2011-06-08 2016-07-28 Emd Millipore Corp Chromatography matrices including novel staphylococcus aureus protein a based ligands
US9701749B2 (en) 2011-08-11 2017-07-11 Ono Pharmaceutical Co., Ltd. Therapeutic agent for autoimmune diseases comprising PD-1 agonist
HUE039033T2 (hu) 2012-01-10 2018-12-28 Biogen Ma Inc Terápiás molekulák transzportjának fokozása a vér-agy gáton keresztül
WO2013175276A1 (en) 2012-05-23 2013-11-28 Argen-X B.V Il-6 binding molecules
US9897611B2 (en) 2012-12-27 2018-02-20 National Institute Of Advanced Industrial Science And Technology Molecule library constructed on the basis of backbone structure of microprotein
CN105377880B (zh) 2013-07-10 2020-08-07 通用电气医疗集团生物工艺研发股份公司 突变的免疫球蛋白结合多肽
KR102497083B1 (ko) * 2013-08-28 2023-02-07 애피바디 에이비 돌연변이된 스캐폴드를 갖는 결합 폴리펩티드
JP7715446B2 (ja) 2019-04-29 2025-07-30 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ プロテインＡと結合する能力があるＦｃ領域を欠いている抗体又は抗体断片の分離のための方法
KR20220030956A (ko) 2019-07-05 2022-03-11 오노 야꾸힝 고교 가부시키가이샤 Pd-1/cd3 이중 특이성 단백질에 의한 혈액암 치료
TW202120550A (zh) 2019-08-08 2021-06-01 日商小野藥品工業股份有限公司 雙特異性蛋白質
WO2023201339A1 (en) 2022-04-15 2023-10-19 Kyverna Therapeutics, Inc. Methods and compositions for treating autoimmune disease
WO2023212704A2 (en) * 2022-04-29 2023-11-02 Tezcat Biosciences, Inc. Macropinocytosis selective non-binding protein-drug conjugates
US20250223326A1 (en) 2022-05-10 2025-07-10 Institut National de la Santé et de la Recherche Médicale Syncitin-1 fusion proteins and uses thereof for cargo delivery into target cells
CN122029191A (zh) 2023-08-23 2026-05-12 赛诺菲 基于ctla-4的溶酶体降解剂及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL74909A (en) 1984-04-20 1992-01-15 Genentech Inc Preparation of functional human factor viii and dna sequences,expression vectors,transformed microorganisms and cell lines used therein
SE8501050D0 (sv) 1985-03-05 1985-03-05 Kabivitrum Ab Biologically active fragments of human antihemophilic factor and method for preparation thereof
SE465222C5 (sv) 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
SE468050C (sv) 1991-03-15 1998-04-27 Pharmacia & Upjohn Ab Rekombinant derivat av human faktor VIII
SE9400088D0 (sv) * 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures

Also Published As

Publication number Publication date
JP2002542259A (ja) 2002-12-10
WO2000063243A1 (en) 2000-10-26
DK1179014T3 (da) 2009-04-06
JP4578690B2 (ja) 2010-11-10
DE60041052D1 (de) 2009-01-22
EP1179014A1 (de) 2002-02-13
SE9901379D0 (sv) 1999-04-19
AU4162400A (en) 2000-11-02
EP1179014B1 (de) 2008-12-10

Similar Documents

Publication Publication Date Title
DE60041052D1 (de) Derivate der z-domäne des proteins a von staphylococcus (spa), welche mit mindestens einer domäne des humanen faktors viii interagieren
DK0397633T3 (da) Fibronectinbindende protein samt fremstilling deraf
DE60141546D1 (de) Polypeptide enthaltend extrazellulären Domäne von IL-20RA und/oderr IL-20RB
DE59708952D1 (de) Fusionspolypeptid zur beeinflussung von wechselwirkungen zwischen proteinen
SI1346034T1 (sl) POLIPEPTID PROTEAZE, KI CEPI VON WILLEBRANDOV FAKTOR (vWF), NUKLEINSKA KISLINA, KI KODIRA POLIPEPTID, IN UPORABA POLIPEPTIDA
CY1112875T1 (el) Sfrp και πεπτιδικα μοτιβα που διαντιδρουν με την sfrp και μεθοδοι χρησης τους
ATE320488T1 (de) Mutanten des lag-3 proteins, ihre expression und verwendung
NO882380D0 (no) Fibfonektin-bindende protein, samt fremstilling derav.
DE69840024D1 (de) Antimikrobielle Peptide, abstammend von Ubiquicidin
DE68924601D1 (de) Reinigung von q-beta-replicase.
SE9003374D0 (sv) A collagen binding protein as well as its preparation
DE69032258D1 (de) Antikoagulierende Peptide
SE8801723D0 (sv) Fibronectin binding protein as well as its preparation
FI943218A7 (fi) Kaseinomakropeptidin peptidit, mainittujen peptidien vasta-aineet ja k äytöt
DE68905097D1 (de) Peptid-molekuele, wirksam gegen gram-positive keime.
DK0540574T3 (da) Antikoagulationspeptider
DE69230614D1 (de) Protein-s polypeptide und deren verwendungen
DE59109235D1 (de) Peptide des HIV-gag Proteins, ihre Herstellung und Verwendung
DE69534738D1 (de) Leukocyten-aktivierender Faktor
DK0938555T3 (da) Konstruktioner og komplekser af cyclin E
DE59805677D1 (de) Froststabilisierung von wässrigen überzugsmitteln durch frostschutzproteine
DE60138885D1 (de) Polypeptide mit aktivität der stimulierung von neutrophilen
ATE199935T1 (de) Insulinbindendes polypeptid
WO1998038211A3 (en) Permuted hemoglobin-like proteins
DE60045078D1 (de) POLYNUKLEOTIDE, WELCHE FüR MITGLIEDER DER HUMANEN B LYMPHOZYTEN-AKTIVIERENDES ANTIGEN FAMILIE KODIEREN, UND VON DIESEN KODIERTE POLYPEPTIDE

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties