ATE417064T1 - Hab18g/cd147, dessen antagonist und anwendung - Google Patents
Hab18g/cd147, dessen antagonist und anwendungInfo
- Publication number
- ATE417064T1 ATE417064T1 AT02734987T AT02734987T ATE417064T1 AT E417064 T1 ATE417064 T1 AT E417064T1 AT 02734987 T AT02734987 T AT 02734987T AT 02734987 T AT02734987 T AT 02734987T AT E417064 T1 ATE417064 T1 AT E417064T1
- Authority
- AT
- Austria
- Prior art keywords
- hab18g
- antisense
- antisense nucleotide
- peptide antagonists
- expression plasmid
- Prior art date
Links
- 102100032412 Basigin Human genes 0.000 title abstract 13
- 101000798441 Homo sapiens Basigin Proteins 0.000 title abstract 13
- 239000005557 antagonist Substances 0.000 title abstract 4
- 230000000692 anti-sense effect Effects 0.000 abstract 5
- 239000002773 nucleotide Substances 0.000 abstract 4
- 125000003729 nucleotide group Chemical group 0.000 abstract 4
- 239000013613 expression plasmid Substances 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 208000030507 AIDS Diseases 0.000 abstract 2
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 2
- 206010027476 Metastases Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000007270 liver cancer Diseases 0.000 abstract 2
- 208000014018 liver neoplasm Diseases 0.000 abstract 2
- 230000009401 metastasis Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108020005544 Antisense RNA Proteins 0.000 abstract 1
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 241000206602 Eukaryota Species 0.000 abstract 1
- 238000001042 affinity chromatography Methods 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000002456 anti-arthritic effect Effects 0.000 abstract 1
- 230000036436 anti-hiv Effects 0.000 abstract 1
- 230000003356 anti-rheumatic effect Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000003435 antirheumatic agent Substances 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 239000003184 complementary RNA Substances 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 239000013600 plasmid vector Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01115274 CN1325907A (zh) | 2001-05-25 | 2001-05-25 | 肝癌转移相关因子HAb18G及其反义RNA表达质粒载体PCI-asHAb18G |
| CN 01131735 CN1186352C (zh) | 2001-09-28 | 2001-09-28 | HAb18G/CD147肽类拮抗剂及其制备方法和用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE417064T1 true ATE417064T1 (de) | 2008-12-15 |
Family
ID=25740375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02734987T ATE417064T1 (de) | 2001-05-25 | 2002-05-27 | Hab18g/cd147, dessen antagonist und anwendung |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20050026841A1 (de) |
| EP (1) | EP1403284B1 (de) |
| JP (1) | JP2005504516A (de) |
| AT (1) | ATE417064T1 (de) |
| DE (1) | DE60230269D1 (de) |
| WO (1) | WO2002094875A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1442203A (zh) * | 2003-05-15 | 2003-09-17 | 陈志南 | Sars冠状病毒和aids病毒(hiv-1)-cd147受体靶位拮抗剂 |
| WO2005092381A1 (en) * | 2004-03-25 | 2005-10-06 | Centocor, Inc. | Use of emmprin antagonists for the treatment of diseases associated with excessive angiogenesis |
| EP1796686A4 (de) * | 2004-09-30 | 2008-05-14 | Centocor Inc | Emmprin-antagonisten und ihre verwendungen |
| JP4911950B2 (ja) * | 2005-11-07 | 2012-04-04 | 晃 伊東 | Mmp−1の部分ペプチドを用いた癌浸潤・転移阻害薬 |
| AU2009296937B2 (en) * | 2008-09-29 | 2015-02-12 | Centocor Ortho Biotech Inc. | Anti-CD147 antibodies, methods, and uses |
| US9644019B2 (en) * | 2010-12-02 | 2017-05-09 | Carlos Zaragoza Sánchez | Compounds for treating cardiac damage after ischaemia/reperfusion |
| WO2013150518A1 (en) | 2012-04-01 | 2013-10-10 | Rappaport Family Institute For Research In The Medical Sciences | Extracellular matrix metalloproteinase inducer (emmprin) peptides and binding antibodies |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002505097A (ja) * | 1998-03-03 | 2002-02-19 | アブジェニックス インク. | 治療薬としてのcd147結合分子 |
-
2002
- 2002-05-27 JP JP2002592349A patent/JP2005504516A/ja active Pending
- 2002-05-27 DE DE60230269T patent/DE60230269D1/de not_active Expired - Lifetime
- 2002-05-27 EP EP02734987A patent/EP1403284B1/de not_active Expired - Lifetime
- 2002-05-27 US US10/478,647 patent/US20050026841A1/en not_active Abandoned
- 2002-05-27 AT AT02734987T patent/ATE417064T1/de not_active IP Right Cessation
- 2002-05-27 WO PCT/CN2002/000356 patent/WO2002094875A1/zh not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US20050026841A1 (en) | 2005-02-03 |
| EP1403284B1 (de) | 2008-12-10 |
| DE60230269D1 (de) | 2009-01-22 |
| EP1403284A4 (de) | 2005-12-28 |
| JP2005504516A (ja) | 2005-02-17 |
| EP1403284A1 (de) | 2004-03-31 |
| WO2002094875A1 (fr) | 2002-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |