ATE417639T1 - Gerät zur bestimmung der dialyse-effizienz - Google Patents
Gerät zur bestimmung der dialyse-effizienzInfo
- Publication number
- ATE417639T1 ATE417639T1 AT03759141T AT03759141T ATE417639T1 AT E417639 T1 ATE417639 T1 AT E417639T1 AT 03759141 T AT03759141 T AT 03759141T AT 03759141 T AT03759141 T AT 03759141T AT E417639 T1 ATE417639 T1 AT E417639T1
- Authority
- AT
- Austria
- Prior art keywords
- patient
- dialysis efficiency
- dialysis
- dialyzer
- treatment
- Prior art date
Links
- 238000000502 dialysis Methods 0.000 title abstract 4
- 238000012512 characterization method Methods 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
- A61M1/1603—Regulation parameters
- A61M1/1605—Physical characteristics of the dialysate fluid
- A61M1/1609—Physical characteristics of the dialysate fluid after use, i.e. downstream of dialyser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
- A61M1/1613—Profiling or modelling of patient or predicted treatment evolution or outcome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
- A61M1/1617—Control or regulation using measurements made during a temporary variation of a characteristic of the fresh dialysis fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
- A61M1/3406—Physical characteristics of the filtrate, e.g. urea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
- A61M1/341—Regulation parameters by measuring the filtrate rate or volume
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3607—Regulation parameters
- A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0496—Urine
- A61M2202/0498—Urea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/15—Detection of leaks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Optics & Photonics (AREA)
- Cardiology (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42241002P | 2002-10-30 | 2002-10-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE417639T1 true ATE417639T1 (de) | 2009-01-15 |
Family
ID=32230351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03759141T ATE417639T1 (de) | 2002-10-30 | 2003-10-28 | Gerät zur bestimmung der dialyse-effizienz |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7488447B2 (de) |
| EP (1) | EP1556101B1 (de) |
| AT (1) | ATE417639T1 (de) |
| AU (1) | AU2003274869A1 (de) |
| DE (1) | DE60325404D1 (de) |
| ES (1) | ES2318161T3 (de) |
| WO (1) | WO2004039436A1 (de) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005001051B4 (de) * | 2005-01-07 | 2007-10-31 | Fresenius Medical Care Deutschland Gmbh | Vorrichtung und Verfahren zur Erkennung von Komplikationen während einer extrakorporalen Blutbehandlung |
| US7815809B2 (en) * | 2005-12-13 | 2010-10-19 | Gambro Lundia Ab | Method for conductivity calculation in a treatment fluid upstream and downstream a filtration unit in apparatuses for the blood treatment |
| US8753515B2 (en) | 2009-12-05 | 2014-06-17 | Home Dialysis Plus, Ltd. | Dialysis system with ultrafiltration control |
| EP2514449A4 (de) * | 2009-12-17 | 2015-06-24 | Nipro Corp | Hämodialysator |
| US8501009B2 (en) | 2010-06-07 | 2013-08-06 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Fluid purification system |
| CN103096949B (zh) * | 2010-07-14 | 2015-09-02 | 旭化成医疗株式会社 | 血液透析系统 |
| US8945936B2 (en) | 2011-04-06 | 2015-02-03 | Fresenius Medical Care Holdings, Inc. | Measuring chemical properties of a sample fluid in dialysis systems |
| CN103842004B (zh) | 2011-08-22 | 2016-11-23 | 美敦力公司 | 双流吸附剂盒 |
| CA2851245C (en) | 2011-10-07 | 2019-11-26 | Home Dialysis Plus, Ltd. | Heat exchange fluid purification for dialysis system |
| US9713668B2 (en) | 2012-01-04 | 2017-07-25 | Medtronic, Inc. | Multi-staged filtration system for blood fluid removal |
| US11154648B2 (en) | 2013-01-09 | 2021-10-26 | Medtronic, Inc. | Fluid circuits for sorbent cartridge with sensors |
| US9713666B2 (en) | 2013-01-09 | 2017-07-25 | Medtronic, Inc. | Recirculating dialysate fluid circuit for blood measurement |
| US11565029B2 (en) | 2013-01-09 | 2023-01-31 | Medtronic, Inc. | Sorbent cartridge with electrodes |
| US9707328B2 (en) | 2013-01-09 | 2017-07-18 | Medtronic, Inc. | Sorbent cartridge to measure solute concentrations |
| US10850016B2 (en) | 2013-02-01 | 2020-12-01 | Medtronic, Inc. | Modular fluid therapy system having jumpered flow paths and systems and methods for cleaning and disinfection |
| US9623164B2 (en) | 2013-02-01 | 2017-04-18 | Medtronic, Inc. | Systems and methods for multifunctional volumetric fluid control |
| US10010663B2 (en) | 2013-02-01 | 2018-07-03 | Medtronic, Inc. | Fluid circuit for delivery of renal replacement therapies |
| US9827361B2 (en) | 2013-02-02 | 2017-11-28 | Medtronic, Inc. | pH buffer measurement system for hemodialysis systems |
| US9144640B2 (en) | 2013-02-02 | 2015-09-29 | Medtronic, Inc. | Sorbent cartridge configurations for improved dialysate regeneration |
| US9943780B2 (en) | 2013-11-26 | 2018-04-17 | Medtronic, Inc. | Module for in-line recharging of sorbent materials with optional bypass |
| US10052612B2 (en) | 2013-11-26 | 2018-08-21 | Medtronic, Inc. | Zirconium phosphate recharging method and apparatus |
| US9884145B2 (en) | 2013-11-26 | 2018-02-06 | Medtronic, Inc. | Parallel modules for in-line recharging of sorbents using alternate duty cycles |
| US10004839B2 (en) | 2013-11-26 | 2018-06-26 | Medtronic, Inc. | Multi-use sorbent cartridge |
| US10537875B2 (en) | 2013-11-26 | 2020-01-21 | Medtronic, Inc. | Precision recharging of sorbent materials using patient and session data |
| US9895477B2 (en) | 2013-11-26 | 2018-02-20 | Medtronic, Inc. | Detachable module for recharging sorbent materials with optional bypass |
| JP6657186B2 (ja) | 2014-04-29 | 2020-03-04 | アウトセット・メディカル・インコーポレイテッドOutset Medical, Inc. | 透析システムおよび方法 |
| EP3160533B1 (de) | 2014-06-24 | 2020-08-12 | Medtronic Inc. | Sorptionsmittelbeutel |
| US10357757B2 (en) | 2014-06-24 | 2019-07-23 | Medtronic, Inc. | Stacked sorbent assembly |
| EP3160531B1 (de) | 2014-06-24 | 2019-08-14 | Medtronic Inc. | Auffüllung von urease in dialysesystemen unter verwendung eines ureaseeinführers |
| WO2015199763A1 (en) | 2014-06-24 | 2015-12-30 | Medtronic, Inc. | A urease introduction system for replenishing urease in a sorbent cartridge |
| EP3160529B1 (de) | 2014-06-24 | 2019-11-13 | Medtronic Inc. | Ureasenachfüllung in dialysesystemen mit ureasebeutel |
| EP3160535B1 (de) | 2014-06-24 | 2024-10-02 | Mozarc Medical US LLC | Modulare dialysatregenerationsanordnung |
| DE102014012423A1 (de) | 2014-08-20 | 2016-02-25 | Fresenius Medical Care Deutschland Gmbh | Dialysemaschine mit der Fähigkeit zur Bestimmung einer prädialytischen Eigenschaft im Blut eines Dialysepatienten |
| US9713665B2 (en) | 2014-12-10 | 2017-07-25 | Medtronic, Inc. | Degassing system for dialysis |
| US10874787B2 (en) | 2014-12-10 | 2020-12-29 | Medtronic, Inc. | Degassing system for dialysis |
| US10098993B2 (en) | 2014-12-10 | 2018-10-16 | Medtronic, Inc. | Sensing and storage system for fluid balance |
| WO2018001996A1 (en) * | 2016-06-30 | 2018-01-04 | Gambro Lundia Ab | Connection test for blood treatment machines ii |
| WO2018035520A1 (en) | 2016-08-19 | 2018-02-22 | Outset Medical, Inc. | Peritoneal dialysis system and methods |
| US10981148B2 (en) | 2016-11-29 | 2021-04-20 | Medtronic, Inc. | Zirconium oxide module conditioning |
| US11167070B2 (en) | 2017-01-30 | 2021-11-09 | Medtronic, Inc. | Ganged modular recharging system |
| US10960381B2 (en) | 2017-06-15 | 2021-03-30 | Medtronic, Inc. | Zirconium phosphate disinfection recharging and conditioning |
| JP6997582B2 (ja) * | 2017-10-17 | 2022-01-17 | 日機装株式会社 | 血液浄化装置 |
| JP6914803B2 (ja) * | 2017-10-17 | 2021-08-04 | 日機装株式会社 | 血液浄化装置 |
| US11278654B2 (en) | 2017-12-07 | 2022-03-22 | Medtronic, Inc. | Pneumatic manifold for a dialysis system |
| US11033667B2 (en) | 2018-02-02 | 2021-06-15 | Medtronic, Inc. | Sorbent manifold for a dialysis system |
| US11110215B2 (en) | 2018-02-23 | 2021-09-07 | Medtronic, Inc. | Degasser and vent manifolds for dialysis |
| US12285552B2 (en) | 2018-08-14 | 2025-04-29 | Mozarc Medical Us Llc | Precision dialysis therapy based on sorbent effluent analysis |
| ES3028957T3 (en) | 2018-08-23 | 2025-06-20 | Outset Medical Inc | Dialysis system and methods |
| US11213616B2 (en) | 2018-08-24 | 2022-01-04 | Medtronic, Inc. | Recharge solution for zirconium phosphate |
| CN113795286A (zh) | 2019-04-30 | 2021-12-14 | 开端医疗公司 | 透析系统和方法 |
| US12128165B2 (en) | 2020-04-27 | 2024-10-29 | Mozarc Medical Us Llc | Dual stage degasser |
| EP3991764B1 (de) | 2020-10-27 | 2024-03-06 | Bellco S.r.l. | Durchflussmesser zum dosieren von wasser in einem dialysesystem |
| US12318528B2 (en) | 2020-10-30 | 2025-06-03 | Mozarc Medical Us Llc | Variable orifice fistula graft |
| EP3991770B1 (de) | 2020-10-30 | 2024-10-30 | Bellco S.r.l. | Dialysekassette mit pumpfunktionen |
| EP4008376A1 (de) | 2020-12-03 | 2022-06-08 | Medtronic, Inc. | Flexibles rohr-routing-zubehör für peritoneal dialysis system |
| US12569601B2 (en) | 2021-04-07 | 2026-03-10 | Mozarc Medical Us Llc | Increased operational capabilities of a dialysis system |
| US12397093B2 (en) | 2021-05-18 | 2025-08-26 | Mozarc Medical Us Llc | Sorbent cartridge designs |
| CN116148194A (zh) * | 2023-02-08 | 2023-05-23 | 成都威力生生物科技有限公司 | 在线尿素清除率检测方法、系统及电子设备 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE465404B (sv) * | 1988-03-03 | 1991-09-09 | Gambro Ab | Dialyssystem |
| EP0616540B1 (de) * | 1992-10-13 | 1998-08-26 | Baxter International Inc. | Hemodialyseueberwachungssystem fuer hemodialysatoren |
| US5685988A (en) * | 1993-09-15 | 1997-11-11 | Malchesky; Paul | Dialysis process and system |
| FR2713937B1 (fr) | 1993-12-17 | 1996-05-31 | Hospal Ind | Procédé de détermination d'un paramètre significatif du progrès d'un traitement extracorporel de sang. |
| SE9604370D0 (sv) * | 1996-11-28 | 1996-11-28 | Gambro Ab | Method and system for preventing intradialytic symptomatology |
| DE19746367C2 (de) * | 1996-11-30 | 1999-08-26 | Fresenius Medical Care De Gmbh | Verfahren zur in-vivo-Bestimmung von Parametern der Hämodialyse und Vorrichtung zur Durchführung des Verfahrens |
| SE513034C2 (sv) | 1997-06-02 | 2000-06-19 | Gambro Lundia Ab | Metod och anordning för beräkning av dialyseffektivitet |
| SE9702074D0 (sv) * | 1997-06-02 | 1997-06-02 | Gambro Ab | Method and device for calculating dialysis efficiency |
-
2003
- 2003-10-28 ES ES03759141T patent/ES2318161T3/es not_active Expired - Lifetime
- 2003-10-28 EP EP03759141A patent/EP1556101B1/de not_active Expired - Lifetime
- 2003-10-28 AU AU2003274869A patent/AU2003274869A1/en not_active Abandoned
- 2003-10-28 DE DE60325404T patent/DE60325404D1/de not_active Expired - Lifetime
- 2003-10-28 AT AT03759141T patent/ATE417639T1/de not_active IP Right Cessation
- 2003-10-28 WO PCT/SE2003/001666 patent/WO2004039436A1/en not_active Ceased
- 2003-10-28 US US10/533,251 patent/US7488447B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004039436A1 (en) | 2004-05-13 |
| EP1556101B1 (de) | 2008-12-17 |
| DE60325404D1 (de) | 2009-01-29 |
| US7488447B2 (en) | 2009-02-10 |
| ES2318161T3 (es) | 2009-05-01 |
| AU2003274869A1 (en) | 2004-05-25 |
| EP1556101A1 (de) | 2005-07-27 |
| US20060116624A1 (en) | 2006-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |