ATE418085T1 - Nichtlineares echtzeit-3d-mikroskopmessystem und verfahren zu seiner anwendung - Google Patents

Nichtlineares echtzeit-3d-mikroskopmessystem und verfahren zu seiner anwendung

Info

Publication number
ATE418085T1
ATE418085T1 AT06710202T AT06710202T ATE418085T1 AT E418085 T1 ATE418085 T1 AT E418085T1 AT 06710202 T AT06710202 T AT 06710202T AT 06710202 T AT06710202 T AT 06710202T AT E418085 T1 ATE418085 T1 AT E418085T1
Authority
AT
Austria
Prior art keywords
examining
optical
optical signal
time
light source
Prior art date
Application number
AT06710202T
Other languages
English (en)
Inventor
Pal Maak
Julia Fekete
Laszlo Valenta
Gergely Katona
Peter Kallo
Karoly Osvay
E Szilveszter Vizi
Robert Szipocs
Balazs Rozsa
Original Assignee
E Szilveszter Vizi
Szipoecs Robert
Balazs Rozsa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E Szilveszter Vizi, Szipoecs Robert, Balazs Rozsa filed Critical E Szilveszter Vizi
Application granted granted Critical
Publication of ATE418085T1 publication Critical patent/ATE418085T1/de

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0068—Optical details of the image generation arrangements using polarisation
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036—Scanning details, e.g. scanning stages
    • G02B21/0048—Scanning details, e.g. scanning stages scanning mirrors, e.g. rotating or galvanomirrors, MEMS mirrors
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/18—Arrangements with more than one light path, e.g. for comparing two specimens
    • G02B21/20—Binocular arrangements
    • G02B21/22—Stereoscopic arrangements

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Stereoscopic And Panoramic Photography (AREA)
  • Length Measuring Devices By Optical Means (AREA)
AT06710202T 2005-01-27 2006-01-27 Nichtlineares echtzeit-3d-mikroskopmessystem und verfahren zu seiner anwendung ATE418085T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0500143A HU227859B1 (en) 2005-01-27 2005-01-27 Real-time 3d nonlinear microscope measuring system and its application

Publications (1)

Publication Number Publication Date
ATE418085T1 true ATE418085T1 (de) 2009-01-15

Family

ID=89985773

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06710202T ATE418085T1 (de) 2005-01-27 2006-01-27 Nichtlineares echtzeit-3d-mikroskopmessystem und verfahren zu seiner anwendung

Country Status (6)

Country Link
US (1) US7872748B2 (de)
EP (1) EP1851580B1 (de)
AT (1) ATE418085T1 (de)
DE (1) DE602006004311D1 (de)
HU (1) HU227859B1 (de)
WO (1) WO2006079861A1 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE454845T1 (de) 2000-10-30 2010-01-15 Gen Hospital Corp Optische systeme zur gewebeanalyse
US9295391B1 (en) 2000-11-10 2016-03-29 The General Hospital Corporation Spectrally encoded miniature endoscopic imaging probe
WO2002088705A2 (en) 2001-05-01 2002-11-07 The General Hospital Corporation Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties
US7355716B2 (en) 2002-01-24 2008-04-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US7643153B2 (en) 2003-01-24 2010-01-05 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
CA2519937C (en) 2003-03-31 2012-11-20 Guillermo J. Tearney Speckle reduction in optical coherence tomography by path length encoded angular compounding
ES2310744T3 (es) 2003-06-06 2009-01-16 The General Hospital Corporation Fuente de luz sintonizable en longitudes de onda.
EP2278287B1 (de) 2003-10-27 2016-09-07 The General Hospital Corporation Optische Abbildungsmethode und - vorrichtung mit Frequenzbereichsinterferometrie
US8018598B2 (en) 2004-05-29 2011-09-13 The General Hospital Corporation Process, system and software arrangement for a chromatic dispersion compensation using reflective layers in optical coherence tomography (OCT) imaging
AU2005270037B2 (en) 2004-07-02 2012-02-09 The General Hospital Corporation Endoscopic imaging probe comprising dual clad fibre
JP5053845B2 (ja) 2004-08-06 2012-10-24 ザ ジェネラル ホスピタル コーポレイション 光学コヒーレンス断層撮影法を使用して試料中の少なくとも１つの位置を決定するための方法、システムおよびソフトウェア装置
JP5324095B2 (ja) 2004-08-24 2013-10-23 ザ ジェネラル ホスピタル コーポレイション 血管セグメントを画像化する方法および装置
EP1989997A1 (de) 2004-08-24 2008-11-12 The General Hospital Corporation Verfahren, Vorrichtung und Software-Anordnung zur Messung einer mechanischen Belastung und elastischer Eigenschaften einer Probe
US7365859B2 (en) 2004-09-10 2008-04-29 The General Hospital Corporation System and method for optical coherence imaging
EP1804638B1 (de) 2004-09-29 2012-12-19 The General Hospital Corporation System und verfahren zur abbildung optischer kohärenz
WO2006058346A1 (en) 2004-11-29 2006-06-01 The General Hospital Corporation Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample
EP2325803A1 (de) 2005-04-28 2011-05-25 The General Hospital Corporation Beurteilung von optischen Kohärenztomographieinformationen für eine anatomische Struktur
EP1889037A2 (de) 2005-06-01 2008-02-20 The General Hospital Corporation Vorrichtung, verfahren und system zur abbildung phasenaufgelöster optischer frequenzdomänen
DE602006017558D1 (de) 2005-08-09 2010-11-25 Gen Hospital Corp Gerät und verfahren zur durchführung von polarisationsbasierter quadraturdemodulation bei optischer kohärenztomographie
EP1940286A1 (de) 2005-09-29 2008-07-09 General Hospital Corporation Verfahren und gerät für ein verfahren zur betrachtung und auswertung einer oder mehrerer biologischen proben mit progressiv zunehmender auflösung
CN101384212A (zh) 2006-01-19 2009-03-11 通用医疗公司 通过上皮内腔器官束扫描对上皮内腔器官进行光学成像的方法和系统
WO2007084903A2 (en) 2006-01-19 2007-07-26 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and method for producing one or more optical arrangements
US9186066B2 (en) 2006-02-01 2015-11-17 The General Hospital Corporation Apparatus for applying a plurality of electro-magnetic radiations to a sample
US10426548B2 (en) 2006-02-01 2019-10-01 The General Hosppital Corporation Methods and systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures
EP3143926B1 (de) 2006-02-08 2020-07-01 The General Hospital Corporation Verfahren, anordnungen und systeme zum abrufen von informationen im zusammenhang mit einer anatomischen probe mithilfe eines optischen mikroskops
JP2009527770A (ja) 2006-02-24 2009-07-30 ザ ジェネラル ホスピタル コーポレイション 角度分解型のフーリエドメイン光干渉断層撮影法を遂行する方法及びシステム
EP3150110B1 (de) 2006-05-10 2020-09-02 The General Hospital Corporation Verfahren, anordnungen und systeme zur bereitstellung von frequenzbereichsabbildung einer probe
WO2008049118A2 (en) 2006-10-19 2008-04-24 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample and effecting such portion(s)
EP2602651A3 (de) 2007-03-23 2014-08-27 The General Hospital Corporation Verfahren, Anordnungen und Vorrichtung zur Verwendung eines wellenlängengewobbelten Lasers anhand von Winkelabtastungs- und Dispersionsverfahren
US10534129B2 (en) 2007-03-30 2020-01-14 The General Hospital Corporation System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque
US8045177B2 (en) 2007-04-17 2011-10-25 The General Hospital Corporation Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy
US7566173B2 (en) * 2007-07-09 2009-07-28 Alcon, Inc. Multi-spot ophthalmic laser probe
JP5038094B2 (ja) * 2007-10-31 2012-10-03 オリンパス株式会社 レーザー走査型顕微鏡
US8059274B2 (en) * 2007-12-07 2011-11-15 The Spectranetics Corporation Low-loss polarized light diversion
US7898656B2 (en) 2008-04-30 2011-03-01 The General Hospital Corporation Apparatus and method for cross axis parallel spectroscopy
US8593619B2 (en) 2008-05-07 2013-11-26 The General Hospital Corporation System, method and computer-accessible medium for tracking vessel motion during three-dimensional coronary artery microscopy
JP5795531B2 (ja) 2008-06-20 2015-10-14 ザ ジェネラル ホスピタル コーポレイション フューズドファイバオプティックカプラ構造、及びその使用方法
WO2010009136A2 (en) 2008-07-14 2010-01-21 The General Hospital Corporation Apparatus and methods for color endoscopy
EP2359121A4 (de) 2008-12-10 2013-08-14 Gen Hospital Corp Systeme, vorrichtung und verfahren zur erweiterung der bildgebungstiefenbereichs bei der optischen kohärenztomopgrafie mittels optischer unterabtastung
WO2010090837A2 (en) 2009-01-20 2010-08-12 The General Hospital Corporation Endoscopic biopsy apparatus, system and method
JP2012515930A (ja) * 2009-01-26 2012-07-12 ザ ジェネラル ホスピタル コーポレーション 広視野の超解像顕微鏡を提供するためのシステム、方法及びコンピューターがアクセス可能な媒体
US9178330B2 (en) 2009-02-04 2015-11-03 The General Hospital Corporation Apparatus and method for utilization of a high-speed optical wavelength tuning source
BR112012001042A2 (pt) 2009-07-14 2016-11-22 Gen Hospital Corp equipamento e método de medição do fluxo de fluído dentro de estrutura anatômica.
ES2552799T3 (es) * 2009-11-24 2015-12-02 Alcon Research, Ltd. Sonda láser multipunto de una sola fibra para endoiluminación oftálmica
US9304308B2 (en) * 2009-12-09 2016-04-05 Advanced Micro Devices, Inc. Laser scanning module including an optical isolator
CN102655906B (zh) * 2009-12-15 2015-03-25 爱尔康研究有限公司 多点激光探针
EP2542145B1 (de) 2010-03-05 2020-08-12 The General Hospital Corporation Systeme zur bereitstellung mikroskopischer bilder von mindestens einer anatomischen struktur mit einer bestimmten auflösung
US9069130B2 (en) 2010-05-03 2015-06-30 The General Hospital Corporation Apparatus, method and system for generating optical radiation from biological gain media
EP2575597B1 (de) 2010-05-25 2022-05-04 The General Hospital Corporation Vorrichtung zur bereitstellung einer optischen bildgebung für strukturen und zusammensetzungen
US9795301B2 (en) 2010-05-25 2017-10-24 The General Hospital Corporation Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images
WO2011153434A2 (en) 2010-06-03 2011-12-08 The General Hospital Corporation Apparatus and method for devices for imaging structures in or at one or more luminal organs
JP2012042669A (ja) * 2010-08-18 2012-03-01 Sony Corp 顕微鏡制御装置及び光学的歪み補正方法
JP5883018B2 (ja) 2010-10-27 2016-03-09 ザ ジェネラル ホスピタル コーポレイション 少なくとも１つの血管内部の血圧を測定するための装置、システム、および方法
US9103721B2 (en) 2011-04-07 2015-08-11 Uwm Research Foundation, Inc. High speed microscope with spectral resolution
WO2013013049A1 (en) 2011-07-19 2013-01-24 The General Hospital Corporation Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography
EP2748587B1 (de) 2011-08-25 2021-01-13 The General Hospital Corporation Verfahren und anordnungen zur bereitstellung mikrooptischer kohärenztomographieverfahren
US9341783B2 (en) 2011-10-18 2016-05-17 The General Hospital Corporation Apparatus and methods for producing and/or providing recirculating optical delay(s)
US9629528B2 (en) 2012-03-30 2017-04-25 The General Hospital Corporation Imaging system, method and distal attachment for multidirectional field of view endoscopy
EP2852315A4 (de) 2012-05-21 2016-06-08 Gen Hospital Corp Einrichtung, vorrichtung und verfahren für kapselmikroskopie
JP6227652B2 (ja) 2012-08-22 2017-11-08 ザ ジェネラル ホスピタル コーポレイション ソフトリソグラフィを用いてミニチュア内視鏡を製作するためのシステム、方法、およびコンピュータ・アクセス可能媒体
US10245181B2 (en) 2012-12-21 2019-04-02 Alcon Research, Ltd. Grin fiber multi-spot laser probe
US9968261B2 (en) 2013-01-28 2018-05-15 The General Hospital Corporation Apparatus and method for providing diffuse spectroscopy co-registered with optical frequency domain imaging
US10893806B2 (en) 2013-01-29 2021-01-19 The General Hospital Corporation Apparatus, systems and methods for providing information regarding the aortic valve
WO2014121082A1 (en) 2013-02-01 2014-08-07 The General Hospital Corporation Objective lens arrangement for confocal endomicroscopy
WO2014144709A2 (en) 2013-03-15 2014-09-18 The General Hospital Corporation Methods and systems for characterizing an object
EP2997354A4 (de) 2013-05-13 2017-01-18 The General Hospital Corporation Erkennung einer selbstinterferierenden fluoreszenzphase und amplitude
WO2015009932A1 (en) 2013-07-19 2015-01-22 The General Hospital Corporation Imaging apparatus and method which utilizes multidirectional field of view endoscopy
EP3021735A4 (de) 2013-07-19 2017-04-19 The General Hospital Corporation Bestimmung der augenbewegung mittels netzhautabbildung mit rückkopplung
WO2015013651A2 (en) 2013-07-26 2015-01-29 The General Hospital Corporation System, apparatus and method utilizing optical dispersion for fourier-domain optical coherence tomography
WO2015105870A1 (en) 2014-01-08 2015-07-16 The General Hospital Corporation Method and apparatus for microscopic imaging
US10736494B2 (en) 2014-01-31 2020-08-11 The General Hospital Corporation System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device
US10228556B2 (en) 2014-04-04 2019-03-12 The General Hospital Corporation Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s)
JP2017525435A (ja) 2014-07-25 2017-09-07 ザ ジェネラル ホスピタル コーポレイション インビボ・イメージングおよび診断のための機器、デバイスならびに方法
US10989661B2 (en) 2015-05-01 2021-04-27 The Board Of Regents Of The University Of Texas System Uniform and scalable light-sheets generated by extended focusing
US9696255B2 (en) * 2015-10-16 2017-07-04 National Central University Image processing method of two-photon structured illumination point scanning microscopy
WO2017180680A1 (en) 2016-04-12 2017-10-19 The Board Of Regents Of The University Of Texas System LIGHT-SHEET MICROSCOPE WITH PARALLELIZED 3D lMAGE ACQUISITION
DE102017120317A1 (de) * 2017-09-04 2019-03-07 Leica Microsystems Cms Gmbh Optische Anordnung und Verfahren zur Beeinflussung einer Dispersion von Wellenlängen mindestens eines Lichtpulses oder Lichtstrahls
US20190101489A1 (en) * 2017-09-29 2019-04-04 Michael John Darwin Method and Apparatus for Simultaneously Measuring 3Dimensional Structures and Spectral Content of Said Structures
DE102017127424B3 (de) * 2017-11-21 2019-04-25 Bruker Optik Gmbh Mikroskop
CN116592775B (zh) * 2023-05-30 2023-12-22 北京国光领航科技有限公司 一种基于色散测量拉锥光纤芯径的测量装置及其测量方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034613A (en) * 1989-11-14 1991-07-23 Cornell Research Foundation, Inc. Two-photon laser microscopy
US5659642A (en) * 1992-10-23 1997-08-19 Optiscan Pty. Ltd. Confocal microscope and endoscope
US6411835B1 (en) * 1997-01-13 2002-06-25 Medispectra, Inc. Spectral volume microprobe arrays
US5713364A (en) * 1995-08-01 1998-02-03 Medispectra, Inc. Spectral volume microprobe analysis of materials
US5995281A (en) * 1997-04-09 1999-11-30 Carl Zeiss Jena Gmbh Device for coupling the radiation of short-pulse lasers in an optical beam path of a microscope
CA2398029A1 (en) * 2000-02-08 2001-08-16 Cornell Research Foundation, Inc. Multiphoton excitation through optical fibers for fluorescence spectroscopy
DE10044308A1 (de) * 2000-09-07 2002-03-21 Leica Microsystems Verfahren und Vorrichtung zur Detektion von Fluoreszenzlicht bei der konfokalen Rastermikroskopie

Also Published As

Publication number Publication date
EP1851580A1 (de) 2007-11-07
US7872748B2 (en) 2011-01-18
HU227859B1 (en) 2012-05-02
HUP0500143A2 (en) 2006-07-28
EP1851580B1 (de) 2008-12-17
DE602006004311D1 (de) 2009-01-29
WO2006079861A1 (en) 2006-08-03
HU0500143D0 (en) 2005-03-29
US20080308730A1 (en) 2008-12-18

Similar Documents

Publication Publication Date Title
ATE418085T1 (de) Nichtlineares echtzeit-3d-mikroskopmessystem und verfahren zu seiner anwendung
EP1664854B1 (de) Faseroptisches ablieferungs- und sammelsystem für biologische anwendungen
CN104330398B (zh) 一种多模式非线性光学显微成像方法及装置
Bader et al. Impact of pulse duration on Ho: YAG laser lithotripsy: fragmentation and dusting performance
Bauer-Marschallinger et al. All-optical photoacoustic projection imaging
US9791682B2 (en) Quantitative nonlinear optical microscopy using a shaped beam
WO2007090147A3 (en) Method and apparatus for measurement of optical properties in tissue
Chen et al. Review of advanced imaging techniques
AU2013220469A1 (en) Flow cytometer with digital holographic microscope
DE112015006288B4 (de) Optische Messvorrichtung und optisches Messverfahren
Mur et al. Multi-frame multi-exposure shock wave imaging and pressure measurements
Devi et al. A table-top compact multimodal nonlinear laser tweezer
Lai et al. Design and test of a rigid endomicroscopic system for multimodal imaging and femtosecond laser ablation
ATE545856T1 (de) Verfahren und vorrichtung zur polarisationsabhängigen und ortsaufgelösten untersuchung einer oberfläche oder einer schicht
Wang et al. Laser ultrasonic surface wave dispersion technique for non-destructive evaluation of human dental enamel
DE602004006396D1 (de) Analyse einer zusammenstellung mit beobachtung
Yu et al. Label-free chemical imaging in vivo: three-dimensional non-invasive microscopic observation of amphioxus notochord through stimulated Raman scattering (SRS)
CN104614349A (zh) 反射式分光瞳共焦-光声显微成像装置与方法
CN114689095B (zh) 基于多模光纤的超高速全光纤成像系统及方法
DE60227774D1 (de) Verfahren und Vorrichtung zur Messung des nichtlinearen Brechungskoeffizienten eines Lichtwellenleiters
Koukoulas et al. Towards a future primary method for microphone calibration: Optical measurement of acoustic velocity in low seeding conditions
Gu Femtosecond biophotonics: core technology and applications
CN211206261U (zh) 一种基于微结构光纤的拉曼测试辅助调节耦合的实时成像系统
CN101551327A (zh) 塑料模具钢抛光性能干涉测量仪
Chen et al. Recent advances in optical microscopy methods for subcellular imaging of thick biological tissues

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties