ATE419013T1 - Methoden und vektorenkonstrukte zur erzeugung von transgene nagetieren, welche ein heterologes gen ubiquitär exprimieren - Google Patents

Methoden und vektorenkonstrukte zur erzeugung von transgene nagetieren, welche ein heterologes gen ubiquitär exprimieren

Info

Publication number
ATE419013T1
ATE419013T1 AT99918541T AT99918541T ATE419013T1 AT E419013 T1 ATE419013 T1 AT E419013T1 AT 99918541 T AT99918541 T AT 99918541T AT 99918541 T AT99918541 T AT 99918541T AT E419013 T1 ATE419013 T1 AT E419013T1
Authority
AT
Austria
Prior art keywords
gene
general
deletor
recombinase
animals
Prior art date
Application number
AT99918541T
Other languages
English (en)
Inventor
Philippe Soriano
Elizabeth Robertson
Original Assignee
Hutchinson Fred Cancer Res
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hutchinson Fred Cancer Res, Harvard College filed Critical Hutchinson Fred Cancer Res
Application granted granted Critical
Publication of ATE419013T1 publication Critical patent/ATE419013T1/de

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/30—Animal model comprising expression system for selective cell killing, e.g. toxins, enzyme dependent prodrug therapy using ganciclovir

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT99918541T 1998-04-15 1999-04-14 Methoden und vektorenkonstrukte zur erzeugung von transgene nagetieren, welche ein heterologes gen ubiquitär exprimieren ATE419013T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8189498P 1998-04-15 1998-04-15

Publications (1)

Publication Number Publication Date
ATE419013T1 true ATE419013T1 (de) 2009-01-15

Family

ID=22167097

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99918541T ATE419013T1 (de) 1998-04-15 1999-04-14 Methoden und vektorenkonstrukte zur erzeugung von transgene nagetieren, welche ein heterologes gen ubiquitär exprimieren

Country Status (5)

Country Link
US (1) US6461864B1 (de)
EP (1) EP1071471B1 (de)
AT (1) ATE419013T1 (de)
DE (1) DE69940196D1 (de)
WO (1) WO1999053017A2 (de)

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US6692965B1 (en) * 1999-11-23 2004-02-17 Chromocell Corporation Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences
FR2810048A1 (fr) * 2000-06-07 2001-12-14 Centre Nat Rech Scient Construction d'acide nucleique utile pour l'expression de transgenes notamment dans les cellules souches embryonnaires
US20020099194A1 (en) * 2000-07-14 2002-07-25 The Trustees Of Columbia University Methods to overexpress a foreign gene in a cell or in an animal in vitro and in vivo
US20030003519A1 (en) * 2000-10-27 2003-01-02 Khodadoust Mehran M. Compositions and methods for the discovery and selection of biological information
US7473557B2 (en) 2001-06-06 2009-01-06 Regeneron Pharmaceuticals, Inc. Method for targeting transcriptionally active loci
EP1392111A4 (de) * 2001-06-06 2004-07-28 Regeneron Pharma Verfahren zum targetting transkriptionell aktiver stellen
WO2003020743A1 (en) * 2001-09-05 2003-03-13 Regeneron Pharmaceuticals, Inc. Methods of expressing transgenes
DE60335637D1 (de) * 2002-07-24 2011-02-17 Manoa Biosciences Inc Vektoren auf transposonbasis und verfahren zur integration von nukleinsäuren
US20050071893A1 (en) * 2002-10-17 2005-03-31 Jost Seibler SiRNA mediated gene silencing in transgenic animals
US20060218654A1 (en) * 2002-10-17 2006-09-28 Artemis Pharmaceuticals Gmbh Sirna mediated gene silencing in transgenic animals
WO2004042023A2 (en) * 2002-11-01 2004-05-21 Five Prime Therapeutics, Inc. Stem cell libraries
EP1439234A1 (de) * 2003-01-08 2004-07-21 ARTEMIS Pharmaceuticals GmbH Gezielte Transgenese unter Verwendung des rosa26-Lokus
US20050008618A1 (en) * 2003-02-27 2005-01-13 Howard Kaufman Composition for delivering an agent to a target cell and uses thereof
WO2005001087A2 (en) * 2003-06-11 2005-01-06 Regeneron Pharmaceuticals, Inc. Methods of modifying genes in eukaryotic cells
US20060084799A1 (en) * 2003-09-24 2006-04-20 Williams Lewis T Human cDNA clones comprising polynucleotides encoding polypeptides and methods of their use
KR20100063144A (ko) * 2004-02-18 2010-06-10 크로모셀 코포레이션 신호 프로브를 이용하는 방법 및 물질
CN101218348B (zh) 2004-04-02 2014-07-30 帝斯曼知识产权资产管理有限公司 具有提高的同源重组效率的丝状真菌突变体
EP2083081A1 (de) 2005-07-22 2009-07-29 Five Prime Therapeutics, Inc. Zusammensetzungen und Verfahren zur Behandlung von Krankheiten mit FGFR-Fusionsproteinen
JP2009511050A (ja) * 2005-10-13 2009-03-19 ジェネンテック・インコーポレーテッド バイオルミネセンス撮像のためのトランスジェニックｒｏｓａ２６−ルシフェラーゼマウス
JP5524610B2 (ja) 2006-04-07 2014-06-18 ザ リサーチ ファウンデーション オブ ステイト ユニバーシティー オブ ニューヨーク トランスコバラミン受容体ポリペプチド、核酸およびその調節因子、ならびに細胞の増殖の調節ならびにガンおよびコバラミン欠損症の処置に使用する関連方法
DE602007012846D1 (de) * 2006-04-08 2011-04-14 Dsm Ip Assets Bv Verbessertes verfahren zur homologen rekombination in eukaryontischen zellen
US9206397B2 (en) * 2006-07-07 2015-12-08 The Fred Hutchinson Cancer Research Center High efficiency FLP site-specific recombination in mammalian cells using an optimized FLP gene
WO2008088863A2 (en) * 2007-01-19 2008-07-24 Mount Sinai School Of Medicine Of New York University Stem cell gene targeting
CN101838329A (zh) * 2009-03-18 2010-09-22 嘉和生物药业有限公司 抗血管新生融合蛋白
AU2010282508B2 (en) 2009-08-13 2015-05-28 Crystal Bioscience Inc. Transgenic animal for production of antibodies having minimal CDRs
WO2012022723A1 (en) * 2010-08-16 2012-02-23 F. Hoffmann-La Roche Ag Reporter mouse for delivery of rnai
JP5999602B2 (ja) * 2011-05-27 2016-09-28 公立大学法人横浜市立大学 遺伝子ターゲティングベクター、その作製方法及び利用方法
GB201222881D0 (en) * 2012-12-19 2013-01-30 Univ Dundee Animal model
WO2015108102A1 (ja) * 2014-01-15 2015-07-23 国立大学法人 群馬大学 Ａｔｐ可視化動物およびその用途
EP4163374A1 (de) 2015-11-23 2023-04-12 The Regents of the University of California Verfolgung und manipulation von zellulärer rna über nukleare freisetzung von crispr/cas9
EP3622062A4 (de) 2017-05-10 2020-10-14 The Regents of the University of California Gerichtetes editing von zellulärer rna durch nukleare abgabe von crispr/cas9

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
WO1992015694A1 (en) * 1991-03-08 1992-09-17 The Salk Institute For Biological Studies Flp-mediated gene modification in mammalian cells, and compositions and cells useful therefor

Also Published As

Publication number Publication date
WO1999053017A3 (en) 1999-12-02
DE69940196D1 (de) 2009-02-12
EP1071471A4 (de) 2005-10-05
WO1999053017A2 (en) 1999-10-21
EP1071471B1 (de) 2008-12-31
EP1071471A2 (de) 2001-01-31
US6461864B1 (en) 2002-10-08

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