ATE419369T1 - Chimäre mensch-rinder respiratory syncytial virus vakzinen - Google Patents

Chimäre mensch-rinder respiratory syncytial virus vakzinen

Info

Publication number: ATE419369T1
Authority: AT; Austria
Prior art keywords: rsv; genome; human; chimeric; bovine
Prior art date: 1999-07-09

Application number

AT00941756T

Other languages

English (en)

Inventor

Ursula Buchholz

Peter Collins

Brian Murphy

Stephen Whitehead

Christine Krempl

Original Assignee

Us Gov Health & Human Serv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-09

Filing date

2000-06-23

Publication date

2009-01-15

2000-06-23 Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv

2009-01-15 Application granted granted Critical

2009-01-15 Publication of ATE419369T1 publication Critical patent/ATE419369T1/de

Links

241000725643 Respiratory syncytial virus Species 0.000 title abstract 7
229960005486 vaccine Drugs 0.000 title abstract 2
241000711895 Bovine orthopneumovirus Species 0.000 abstract 2
241000711920 Human orthopneumovirus Species 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
241000282412 Homo Species 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
230000002238 attenuated effect Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
230000028993 immune response Effects 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
230000002458 infectious effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1
230000035772 mutation Effects 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
239000002157 polynucleotide Substances 0.000 abstract 1
102000040430 polynucleotide Human genes 0.000 abstract 1
108091033319 polynucleotide Proteins 0.000 abstract 1
239000013598 vector Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/544—Mucosal route to the airways
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18541—Use of virus, viral particle or viral elements as a vector
- C12N2760/18543—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18561—Methods of inactivation or attenuation
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Virology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
General Engineering & Computer Science (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Biophysics (AREA)
Mycology (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT00941756T 1999-07-09 2000-06-23 Chimäre mensch-rinder respiratory syncytial virus vakzinen ATE419369T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US14313299P	1999-07-09	1999-07-09

Publications (1)

Publication Number	Publication Date
ATE419369T1 true ATE419369T1 (de)	2009-01-15

Family

ID=22502738

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00941756T ATE419369T1 (de)	1999-07-09	2000-06-23	Chimäre mensch-rinder respiratory syncytial virus vakzinen

Country Status (13)

Country	Link
US (2)	US7829102B2 (de)
EP (1)	EP1287152B1 (de)
JP (1)	JP2003530073A (de)
KR (1)	KR100905450B1 (de)
CN (2)	CN100354425C (de)
AT (1)	ATE419369T1 (de)
AU (2)	AU784216B2 (de)
BR (1)	BR0013195A (de)
CA (1)	CA2378552A1 (de)
DE (1)	DE60041280D1 (de)
IL (2)	IL147447A0 (de)
MX (1)	MXPA02000220A (de)
WO (1)	WO2001004335A2 (de)

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US20030082209A1 (en)	2000-07-05	2003-05-01	Skiadopoulos Mario H.	Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines
US7662397B2 (en)	1997-07-15	2010-02-16	The United States Of America As Represented By The Department Of Health And Human Services	Respiratory syncytial virus vaccines expressing protective antigens from promoter-proximal genes
US20040005542A1 (en)	2001-06-22	2004-01-08	Krempl Christine D	Respiratory syncytial virus vaccines expressing protective antigens from promotor- proximal genes
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JP2007524372A (ja)	2003-02-28	2007-08-30	ザガバメントオブザユナイテッドステイツオブアメリカアズリプレゼンテッドバイザセクレタリーオブザデパートメントオブヘルスアンドヒューマンサービシーズ	組換えヒトメタニューモウイルスおよびその使用
CN1871355B (zh)	2003-06-09	2011-12-14	惠氏	从cDNA中回收非节段性负链RNA病毒的改进方法
WO2005080417A2 (en) *	2003-12-10	2005-09-01	The Uab Research Foundation	Recombinant viruses with heterologous envelope proteins
EP2471938A3 (de) *	2005-11-24	2013-04-24	The Research Foundation for Microbial Diseases of Osaka University	Rekombinanter polyvalenter Impfstoff
US20100260792A1 (en) *	2007-10-22	2010-10-14	University Of Rochester	Respiratory syncytial virus vaccine based on chimeric papillomavirus virus-like particles or capsomeres
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GB201019240D0 (en)	2010-11-15	2010-12-29	Vib Vzw	Respiratory syncytical virus vaccine
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CN102210859B (zh) *	2011-05-31	2012-11-21	昆明理工大学	一种结核分枝杆菌esat-6-f2融合蛋白亚单位疫苗及其制备方法
EP2836231B1 (de)	2012-04-13	2019-01-09	The United States of America, as represented by The Secretary, Department of Health and Human Services	Genetisch stabiler attenuierter lebendimpfstoff gegen das respiratorische-synzytial-virus und seine herstellung
JP2014236748A (ja) *	2014-08-26	2014-12-18	一般財団法人阪大微生物病研究会	組換え多価ワクチン
CN107406835A (zh)	2015-01-20	2017-11-28	美利坚合众国,由健康及人类服务部部长代表	表达嵌合rsv/bpiv3f蛋白的重组人/牛副流感病毒3(b/hpiv3)及其用途
MX2019011599A (es)	2017-03-30	2019-12-19	Univ Queensland	Moleculas quimericas y usos de las mismas.
US12071632B2 (en) *	2018-04-23	2024-08-27	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Chimeric vectors
WO2020076141A1 (ko) *	2018-10-12	2020-04-16	에스케이바이오사이언스 주식회사	재조합 rsv 생백신주 및 이의 제조 방법
CN110229219B (zh) *	2019-06-21	2021-03-30	中国科学院武汉病毒研究所	一种新型的呼吸道合胞病毒疫苗抗原的制备方法及其用途
US12311000B2 (en)	2019-08-16	2025-05-27	Mayo Foundation For Medical Education And Research	Chimeric vesiculoviruses and methods of use
CL2020000857A1 (es) *	2020-03-31	2021-11-05	Univ Pontificia Catolica Chile	Nuevo uso de formulación inmunogénica bcg que expresa una proteína del virus respiratorio sincicial humano contra bvrs en bovinos
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CN116676275B (zh) *	2023-03-17	2024-06-07	北京赛尔富森生物科技有限公司	A基因型嵌合腮腺炎病毒株和制备方法及用途

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CA2379362A1 (en)	1999-07-13	2001-01-18	Peter L. Collins	Respiratory syncytial viruses expressing immune modulatory molecules
MXPA02012818A (es) *	2000-06-23	2003-05-14	Gov Health & Human Serv	Vacunas de virus sincitales respiratoriso que expresan antigenos protectores a partir de genes proximos promotores.

2000
- 2000-06-23 CN CNB008101191A patent/CN100354425C/zh not_active Expired - Fee Related
- 2000-06-23 KR KR1020027000318A patent/KR100905450B1/ko not_active Expired - Fee Related
- 2000-06-23 BR BR0013195-4A patent/BR0013195A/pt not_active IP Right Cessation
- 2000-06-23 CN CNA2007101671126A patent/CN101260386A/zh active Pending
- 2000-06-23 WO PCT/US2000/017755 patent/WO2001004335A2/en not_active Ceased
- 2000-06-23 JP JP2001509539A patent/JP2003530073A/ja not_active Ceased
- 2000-06-23 AT AT00941756T patent/ATE419369T1/de not_active IP Right Cessation
- 2000-06-23 CA CA002378552A patent/CA2378552A1/en not_active Abandoned
- 2000-06-23 EP EP00941756A patent/EP1287152B1/de not_active Expired - Lifetime
- 2000-06-23 MX MXPA02000220A patent/MXPA02000220A/es not_active Application Discontinuation
- 2000-06-23 DE DE60041280T patent/DE60041280D1/de not_active Expired - Lifetime
- 2000-06-24 IL IL14744700A patent/IL147447A0/xx unknown
- 2000-06-24 AU AU56415/00A patent/AU784216B2/en not_active Ceased
2002
- 2002-01-03 IL IL147447A patent/IL147447A/en not_active IP Right Cessation
2005
- 2005-03-31 US US11/097,946 patent/US7829102B2/en not_active Expired - Fee Related
- 2005-08-11 US US11/203,620 patent/US7842798B2/en not_active Expired - Fee Related
2006
- 2006-05-23 AU AU2006202170A patent/AU2006202170B2/en not_active Ceased

Also Published As

Publication number	Publication date
AU2006202170B2 (en)	2009-10-08
BR0013195A (pt)	2002-07-23
WO2001004335A3 (en)	2002-12-19
IL147447A (en)	2010-05-31
IL147447A0 (en)	2002-08-14
AU2006202170A1 (en)	2006-06-15
CN100354425C (zh)	2007-12-12
DE60041280D1 (de)	2009-02-12
AU5641500A (en)	2001-01-30
CN1402792A (zh)	2003-03-12
KR100905450B1 (ko)	2009-07-02
AU784216B2 (en)	2006-02-23
CA2378552A1 (en)	2001-01-18
US20060057158A1 (en)	2006-03-16
US7829102B2 (en)	2010-11-09
JP2003530073A (ja)	2003-10-14
KR20020092343A (ko)	2002-12-11
WO2001004335A8 (en)	2003-02-06
WO2001004335A2 (en)	2001-01-18
MXPA02000220A (es)	2005-08-16
EP1287152B1 (de)	2008-12-31
US20070184069A1 (en)	2007-08-09
EP1287152A2 (de)	2003-03-05
CN101260386A (zh)	2008-09-10
US7842798B2 (en)	2010-11-30

Legal Events

Date	Code	Title	Description
2009-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE419369T1 (de)	2009-01-15	Chimäre mensch-rinder respiratory syncytial virus vakzinen
WO2001042445A3 (en)	2001-11-29	USE OF RECOMBINANT PARAINFLUENZA VIRUSES (PIVs) AS VECTORS TO PROTECT AGAINST INFECTION AND DISEASE CAUSED BY PIV AND OTHER HUMAN PATHOGENS
MXPA01013302A (es)	2004-03-10	Vacunas para el virus de la parainfluenza (piv) quimerico para humanos-bovinos atenuadas.
IL189766A0 (en)	2008-08-07	Methods for vaccine production and interferon deficient substrates
ATE85622T1 (de)	1993-02-15	Chimarenglykoproteine, enthaltend immunogene segmente des humanen respiratorischen synzytialvirus.
HU229101B1 (en)	2013-07-29	Dna transfection system for the generation of infectious influenza virus
DE69739689D1 (de)	2010-01-21	Herstellung von attenuierten respiratorischen syncytialvirus-impfstoffen aus klonierten nukleotidsequenzen
DE60139026D1 (de)	2009-07-30	Lebender influenza impfstoff und verfahren zu seiner herstellung
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WO2000061611A3 (en)	2001-01-04	Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences
DE60136811D1 (de)	2009-01-15	Respiratorische synzytialvirus impfstoffe, welche schützende antigene von promotor-proximalen genen exprimieren
WO2007046839A3 (en)	2007-07-19	New live virus vaccines
WO2002002605A3 (en)	2003-01-09	Attenuated human-bovine chimeric parainfluenza virus (piv) vaccines
WO2004092207A3 (en)	2005-04-07	Respiratory syncytial virus (rsv) peptides
Oxburgh	2001	Studies of the evolution of the haemagglutinin protein of equine influenza virus H3N8.
TH62970A (th)	2004-07-19	วัคซีนไวรัสโรคเบอร์ซาอักเสบติดต่อชนิดบรอดสเปคตรัม (broad spectrum)