ATE419629T1 - Poröse ferro- oder ferrimagnetische glasteilchen für molekültrennung - Google Patents

Poröse ferro- oder ferrimagnetische glasteilchen für molekültrennung

Info

Publication number
ATE419629T1
ATE419629T1 AT01938032T AT01938032T ATE419629T1 AT E419629 T1 ATE419629 T1 AT E419629T1 AT 01938032 T AT01938032 T AT 01938032T AT 01938032 T AT01938032 T AT 01938032T AT E419629 T1 ATE419629 T1 AT E419629T1
Authority
AT
Austria
Prior art keywords
glass particles
ferro
porous
ferri
magnetic glass
Prior art date
Application number
AT01938032T
Other languages
English (en)
Inventor
Philippe Sauer
Bernd Springer
Thomas Manz
Christoph Ritt
Roland Fabis
Original Assignee
Qiagen Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22708215&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE419629(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Qiagen Gmbh filed Critical Qiagen Gmbh
Application granted granted Critical
Publication of ATE419629T1 publication Critical patent/ATE419629T1/de

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/005Pretreatment specially adapted for magnetic separation
    • B03C1/01Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/1013Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by using magnetic beads
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01FMAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0036Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H01F1/0045Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
    • H01F1/0054Coated nanoparticles, e.g. nanoparticles coated with organic surfactant
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991Coated
    • Y10T428/2993Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991Coated
    • Y10T428/2993Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y10T428/2996Glass particles or spheres
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991Coated
    • Y10T428/2998Coated including synthetic resin or polymer

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Power Engineering (AREA)
  • Biophysics (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Hard Magnetic Materials (AREA)
  • Saccharide Compounds (AREA)
  • Soft Magnetic Materials (AREA)
  • Surface Treatment Of Glass (AREA)
AT01938032T 2000-03-24 2001-03-22 Poröse ferro- oder ferrimagnetische glasteilchen für molekültrennung ATE419629T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19209300P 2000-03-24 2000-03-24

Publications (1)

Publication Number Publication Date
ATE419629T1 true ATE419629T1 (de) 2009-01-15

Family

ID=22708215

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01938032T ATE419629T1 (de) 2000-03-24 2001-03-22 Poröse ferro- oder ferrimagnetische glasteilchen für molekültrennung

Country Status (8)

Country Link
US (3) US7183002B2 (de)
EP (1) EP1266385B1 (de)
JP (2) JP4907030B2 (de)
AT (1) ATE419629T1 (de)
AU (2) AU6380001A (de)
CA (1) CA2400724C (de)
DE (1) DE60137203D1 (de)
WO (1) WO2001071732A2 (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6380001A (en) * 2000-03-24 2001-10-03 Qiagen Gmbh Porous ferro- or ferrimagnetic glass particles for isolating molecules
GB0116359D0 (en) * 2001-07-04 2001-08-29 Genovision As Preparation of polymer particles
US7192560B2 (en) 2001-12-20 2007-03-20 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using anion exchange
US7347976B2 (en) 2001-12-20 2008-03-25 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using a hydrophilic solid support in a hydrophobic matrix
DE10201084A1 (de) * 2002-01-14 2003-07-24 Bayer Ag Siliziumhaltige Magnetpartikel, Verfahren zu deren Herstellung und Verwendung der Partikel
GB0215185D0 (en) 2002-07-01 2002-08-07 Genovision As Binding a target substance
WO2004054625A2 (en) * 2002-12-12 2004-07-01 Mykrolis Corporation Porous sintered composite materials
US7981600B2 (en) 2003-04-17 2011-07-19 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using an anion exchange material that includes a polyoxyalkylene
WO2005054466A2 (en) 2003-07-25 2005-06-16 Ambion, Inc. Methods and compositions for preparing rna from a fixed sample
US20050059024A1 (en) 2003-07-25 2005-03-17 Ambion, Inc. Methods and compositions for isolating small RNA molecules
US8084457B2 (en) 2003-09-15 2011-12-27 Lead Discovery Center Gmbh Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases
DE10355409A1 (de) * 2003-11-25 2005-06-30 Magnamedics Gmbh Sphärische, magnetische Silicagel-Träger mit vergrößerter Oberfläche für die Aufreinigung von Nukleinsäuren
US7939249B2 (en) 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
US7727710B2 (en) 2003-12-24 2010-06-01 3M Innovative Properties Company Materials, methods, and kits for reducing nonspecific binding of molecules to a surface
JP2007522807A (ja) * 2004-02-18 2007-08-16 アプレラ コーポレイション 高分子電解質コーティングされたサイズ排除イオン交換粒子
AU2005200670B2 (en) * 2004-02-20 2007-05-03 F. Hoffmann-La Roche Ag Adsorption of nucleic acids to a solid phase
EP1690938A1 (de) * 2005-02-11 2006-08-16 Qiagen GmbH Verfahren zur Isolierung von Nukleinsäuren, wobei die Nukleinsäuren bei erhöhter Temperatur an einer Matrix immobilisiert werden
JP5007920B2 (ja) * 2005-08-31 2012-08-22 日立金属株式会社 核酸抽出方法、がん細胞検出方法および磁気ビーズ
JP4297148B2 (ja) 2006-09-22 2009-07-15 ソニー株式会社 核酸回収装置及び核酸回収方法
DE102006054173A1 (de) * 2006-11-16 2008-05-21 Qiagen Gmbh Verfahren zur Herstellung von magnetischen Kieselsäurepartikeln
EP1995316A1 (de) 2007-05-25 2008-11-26 Qiagen GmbH Verfahren zur schonenden Zellaufreinigung, Zellgewinnung und Transfektion von Zellen
CN101279246B (zh) * 2007-12-28 2011-07-27 华侨大学 一种嗜硫性磁性复合微球的制备方法和用此复合微球分离免疫球蛋白g的方法
KR101053023B1 (ko) * 2008-02-14 2011-08-01 (주)바이오니아 구형 실리카 자성입자 및 이의 제조방법
US20090218711A1 (en) * 2008-02-28 2009-09-03 David Dasher Method of increasing ceramic paste stiffening/gelation temperature by using a salt and precursor batch
DE102008026058A1 (de) 2008-05-30 2009-12-03 Qiagen Gmbh Lyse, Binde- und/oder Waschreagenz verwendbar zur Isolierung und/oder Reinigung von Nukleinsäuren
EP2128169A1 (de) 2008-05-30 2009-12-02 Qiagen GmbH Verfahren zur Isolierung von kurzkettigen Nukleinsäuren
EP2264168B1 (de) 2009-06-18 2014-12-17 Qiagen GmbH Verfahren zur Isolierung von Nukleinsäuren
TWI407994B (zh) 2009-10-22 2013-09-11 Ind Tech Res Inst 分離核酸的方法、試劑及套組
EP2345719A1 (de) 2010-01-18 2011-07-20 Qiagen GmbH Verfahren zur Isolierung kleiner RNA
RU2444011C1 (ru) * 2010-07-06 2012-02-27 Учреждение Российской академии медицинских наук научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова РАМН (НИИВС им. И.И. Мечникова РАМН) Способ выявления кишечных вирусов в воде
EP2407540A1 (de) 2010-07-15 2012-01-18 Qiagen GmbH Verfahren zur Reinigung von Nukleinsäure
DE102010034083A1 (de) 2010-08-12 2012-02-16 Süd-Chemie AG Magnetische Glaspartikel zum Einsatz in Biogasanlagen, Fermentations- und Separationsprozessen
DE102010039232B4 (de) 2010-08-12 2013-02-21 Dennert Poraver Gmbh Verfahren zur Herstellung von magnetischem Blähglasgranulat
CN102179230B (zh) * 2011-04-01 2012-09-19 中国科学院生态环境研究中心 一种赋磁二氧化硅气凝胶的制备方法
CN103764827B (zh) 2011-07-04 2018-04-24 恰根有限公司 可用于分离和/或纯化核酸的试剂
EP3789500A1 (de) 2011-08-12 2021-03-10 QIAGEN GmbH Verfahren zur isolierung von nukleinsäuren
DE102012201774A1 (de) 2012-02-07 2013-08-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Magnetisch abtrennbare Mikropartikel mit einer silikatischen Hülle, Verfahren zu ihrer Herstellung sowie ihre Verwendung
EP2634254A1 (de) 2012-02-29 2013-09-04 QIAGEN GmbH Verfahren zur Isolierung von Nukleinsäuren aus Nahrungsmittelproben
WO2013181651A1 (en) * 2012-06-01 2013-12-05 Omega Bio-Tek, Inc. Selective nucleic acid fragment recovery
FR2994184B1 (fr) 2012-08-02 2017-12-08 Biomerieux Sa Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride aza-isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits
EP2888363B1 (de) 2012-08-21 2018-06-06 Qiagen GmbH Verfahren zur isolierung von nukleinsäuren aus einer stabilisierten probe mit formaldehydfreigabe
WO2014029792A1 (en) 2012-08-21 2014-02-27 Qiagen Gmbh Virus particle stabilisation and method for isolating viral nucleic acids
WO2014033326A1 (en) 2012-09-03 2014-03-06 Qiagen Gmbh Method for isolating rna including small rna with high yield
WO2014090838A1 (en) * 2012-12-11 2014-06-19 Qiagen Gmbh Preparation of silica particles
US10745686B2 (en) 2013-02-08 2020-08-18 Qiagen Gmbh Method for separating DNA by size
EP3828284A1 (de) 2013-03-15 2021-06-02 Abbott Molecular Inc. Einstufiges verfahren zur aufreinigung von nukleinsäuren
CN105916962B (zh) 2013-11-19 2019-02-05 三星电子株式会社 发光颗粒、包含其的材料和产品、以及方法
CN103903827B (zh) * 2014-03-20 2018-01-23 哈尔滨益材新材料有限公司 一种磁性二氧化硅复合微球的制备方法及其应用
CN103908945B (zh) * 2014-03-31 2015-09-16 洛阳惠尔纳米科技有限公司 一种核酸提取磁珠的制备方法及应用
CN104465008A (zh) * 2014-11-18 2015-03-25 成都理想财富投资咨询有限公司 一种用于dna纯化的磁流体的制备方法
FR3031063B1 (fr) 2014-12-30 2017-02-10 Biomerieux Sa Complexe multicouches, procede de fabrication et utilisation du complexe
EP3059312A1 (de) 2015-02-20 2016-08-24 QIAGEN GmbH Nukleinsäureextraktionsverfahren
KR101646610B1 (ko) 2015-05-28 2016-08-09 (주)바이오니아 생체 물질 정제용 고활성 실리카 자성나노입자 및 이의 제조 방법
EP3303582A1 (de) 2015-06-01 2018-04-11 Qiagen GmbH Elektrophoreseunterstütztes verfahren und vorrichtung zur reinigung eines geladenen zielmoleküls aus einer probe
US10711265B2 (en) 2015-06-01 2020-07-14 Qiagen Gmbh Electrophoresis assisted method for purifying a target nucleic acid using a delayed elution approach
JP7007197B2 (ja) 2015-06-05 2022-01-24 キアゲン ゲーエムベーハー サイズによってdnaを分離する方法
WO2016198519A1 (en) * 2015-06-09 2016-12-15 Biocartis N.V. Automatable method for nucleic acid isolation
WO2017013102A1 (en) 2015-07-23 2017-01-26 Biocartis Nv Optimized clinical sample sequencing
US20180135040A1 (en) 2016-02-16 2018-05-17 Life Magnetics, Inc. Methods for separating nucleic acids with graphene coated magnetic beads
CA3029178C (en) 2016-06-30 2022-07-19 Biois Co.,Ltd Double-stranded nucleic acid signal probe and method for detecting target molecule using same
DE102016121483B4 (de) 2016-11-09 2020-06-18 Axagarius Gmbh & Co. Kg Partikelförmiges Feststoff-Kompositmaterial zur Nukleinsäureaufreinigung, enthaltend magnetische Nanopartikel , Verfahren zu dessen Herstellung und dessen Verwendung
US20200080074A1 (en) 2016-12-15 2020-03-12 Qiagen Gmbh Method for isolating highly pure nucleic acid with magnetic particles
WO2019063071A1 (en) 2017-09-27 2019-04-04 Qiagen Gmbh METHOD FOR HIGH-PERFORMANCE RNA ISOLATION
TR201903564A2 (tr) 2019-03-08 2019-03-21 Safas Saf Plastik Sanayi Ve Ticaret Anonim Sirketi Stres ve ağri azaltici bi̇r malzeme olarak magneti̇t parti̇külleri̇ i̇çeren sürekli̇ blok esnek poli̇üretan köpük üretmek i̇çi̇n yöntem
WO2021119043A2 (en) * 2019-12-09 2021-06-17 Corning Incorporated Bioactive glass as nucleic acid carriers with ph switch control-releasing
CN115698282A (zh) 2020-01-13 2023-02-03 福路伦特生物科学公司 单细胞测序
US11866782B2 (en) 2020-03-16 2024-01-09 Fluent Biosciences Inc. Multi-omic analysis in monodisperse droplets
WO2021195169A1 (en) 2020-03-24 2021-09-30 Fluent Biosciences Inc. Viral detection using template emulsification
DK4128287T3 (da) * 2020-04-03 2024-06-10 Lybe Scient As Fremgangsmåde til fremstillingen af produkter til isolering af nukleinsyrer
EP4182477A4 (de) 2020-07-15 2024-09-11 Fluent Biosciences Inc. Abgestufte ligationsoligos
CN112563016B (zh) * 2020-12-23 2024-06-25 四川安可瑞新材料技术有限公司 核酸提取用磁性微球的制备方法、所制备的产品及用途
CA3209578A1 (en) * 2021-01-25 2022-07-28 Fluent Biosciences Inc. Emulsification with magnetic hydrogels
CN112891986B (zh) * 2021-01-30 2022-05-03 哈尔滨工业大学 一种集成封闭式核酸自动提取装置
CN118922718A (zh) * 2021-10-19 2024-11-08 菲诺米耐斯公司 使用磁珠进行简单的可自动化的蛋白质消化的系统和方法
US12534721B2 (en) 2022-10-06 2026-01-27 Illumina, Inc. Quantitative detection and analysis of moleculesip
WO2024233363A2 (en) * 2023-05-05 2024-11-14 Foundation Medicine, Inc. Methods and systems for isolating nucleic acids
CN117861624A (zh) * 2023-12-18 2024-04-12 广州奕昕生物科技有限公司 一种dna片段分选纯化磁珠的制备方法及其及应用
WO2026003371A1 (en) 2024-06-29 2026-01-02 Qiagen Gmbh Method for treatment of a biological sample

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3549524A (en) * 1965-11-10 1970-12-22 Wolfgang Haller Material and method for performing steric separations
US3758284A (en) * 1970-12-17 1973-09-11 W Haller Porous material and method of making the same
US4169804A (en) 1976-08-19 1979-10-02 Minnesota Mining And Manufacturing Company Magnetically responsive composite microparticle
US4126437A (en) * 1976-12-02 1978-11-21 Xerox Corporation Magnetic glass carrier materials
US4335094A (en) 1979-01-26 1982-06-15 Mosbach Klaus H Magnetic polymer particles
JPS55147143A (en) * 1979-03-29 1980-11-15 Toyo Eng Corp Agitation method
US4395271A (en) 1979-04-13 1983-07-26 Corning Glass Works Method for making porous magnetic glass and crystal-containing structures
US4233169A (en) * 1979-04-13 1980-11-11 Corning Glass Works Porous magnetic glass structure
US4297337A (en) * 1979-04-13 1981-10-27 Corning Glass Works Solid-phase immunoassays using magnetic glass
FR2461521A1 (fr) * 1979-07-20 1981-02-06 Anvar Fluides magnetiques, notamment ferrofluides, et procede pour leur obtention
EP0030086B2 (de) * 1979-11-13 1990-03-14 TECHNICON INSTRUMENTS CORPORATION (a New York corporation) Vereinigung von Reaktionsbehältern, Teile für ihre Herstellung und manuelles Immunoassayverfahren
JPS5676510A (en) * 1979-11-28 1981-06-24 Tdk Corp Manufacture of magnetic recording material
US4554088A (en) * 1983-05-12 1985-11-19 Advanced Magnetics Inc. Magnetic particles for use in separations
US4628037A (en) * 1983-05-12 1986-12-09 Advanced Magnetics, Inc. Binding assays employing magnetic particles
GB8317228D0 (en) * 1983-06-24 1983-07-27 Exxon Research Engineering Co Magnetizable adsorbents
US4523996A (en) * 1984-02-22 1985-06-18 Westinghouse Electric Corp. Method of separating cationic from anionic beads in mixed resin beds
JPS6139509A (ja) * 1984-07-31 1986-02-25 Japan Synthetic Rubber Co Ltd 超微粒酸化鉄含有物およびその製造方法
EP0180384B1 (de) * 1984-11-01 1991-04-24 TECHNICON INSTRUMENTS CORPORATION(a Delaware corporation) Magnetisch empfindlicher Reagensträger und Verfahren zur Herstellung
US5512332A (en) 1985-10-04 1996-04-30 Immunivest Corporation Process of making resuspendable coated magnetic particles
US4988618A (en) * 1987-11-16 1991-01-29 Gene-Trak Systems Magnetic separation device and methods for use in heterogeneous assays
US4895650A (en) * 1988-02-25 1990-01-23 Gen-Probe Incorporated Magnetic separation rack for diagnostic assays
ES2066851T3 (es) * 1988-05-24 1995-03-16 Anagen Uk Ltd Particulas atraibles magneticamente y metodo de preparacion.
NL8900725A (nl) 1989-03-23 1990-10-16 Az Univ Amsterdam Werkwijze en combinatie van middelen voor het isoleren van nucleinezuur.
GB9003253D0 (en) 1990-02-13 1990-04-11 Amersham Int Plc Precipitating polymers
US5523231A (en) 1990-02-13 1996-06-04 Amersham International Plc Method to isolate macromolecules using magnetically attractable beads which do not specifically bind the macromolecules
US5610274A (en) * 1991-11-20 1997-03-11 Cpg, Inc. Production and use of magnetic porous inorganic materials
US5734020A (en) * 1991-11-20 1998-03-31 Cpg, Inc. Production and use of magnetic porous inorganic materials
GB9223334D0 (en) 1992-11-06 1992-12-23 Hybaid Ltd Magnetic solid phase supports
DE4307262A1 (de) 1993-03-02 1994-09-08 Christian Bergemann Magnetisches polymeres Siliciumdioxid
DE4321904B4 (de) 1993-07-01 2013-05-16 Qiagen Gmbh Verfahren zur chromatographischen Reinigung und Trennung von Nucleinsäuregemischen
JPH07235407A (ja) * 1994-02-22 1995-09-05 Hitachi Ltd 磁気粒子
GB9411572D0 (en) 1994-06-09 1994-08-03 Amersham Int Plc Magnetic bead precipitation method
DE19520398B4 (de) 1995-06-08 2009-04-16 Roche Diagnostics Gmbh Magnetisches Pigment
JP2965131B2 (ja) * 1995-07-07 1999-10-18 東洋紡績株式会社 核酸結合用磁性担体およびそれを用いる核酸単離方法
US5904848A (en) * 1996-02-21 1999-05-18 Cpg, Inc. Controlled pore glass-synthetic resin membrane
JPH1081507A (ja) * 1996-09-05 1998-03-31 Mizusawa Ind Chem Ltd 磁性体非晶質シリカ複合粒子及びその製造方法
DE19638591A1 (de) 1996-09-20 1998-04-02 Merck Patent Gmbh Kugelförmige magnetische Partikel
US6027945A (en) * 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
CZ297990B6 (cs) * 1997-01-21 2007-05-16 W. R. Grace & Co.-Conn. Cásticový adsorbent a zpusob jeho výroby
JP3735990B2 (ja) * 1997-01-28 2006-01-18 東ソー株式会社 磁性シリカゲルの製造方法
AU7685498A (en) 1997-05-14 1998-12-08 Weixin Tang Fully-coated, uniform-sized metallic particles
JPH11262387A (ja) * 1998-03-16 1999-09-28 Toyobo Co Ltd 核酸結合性磁性担体およびそれを用いた核酸単離方法
US20020104801A1 (en) * 1998-04-06 2002-08-08 Nicolas Voute Small dense microporous solid support materials, their preparation,and use for purification of large macromolecules and bioparticles
GB9812800D0 (en) * 1998-06-12 1998-08-12 Rolic Ag Optically active compounds
JP2000256388A (ja) * 1999-03-10 2000-09-19 Jsr Corp 核酸結合用磁性シリカ粒子および核酸単離方法
US6296934B1 (en) * 1999-03-12 2001-10-02 E.I. Du Pont De Nemours And Company Glitter containing filaments for use in brushes
AU6380001A (en) * 2000-03-24 2001-10-03 Qiagen Gmbh Porous ferro- or ferrimagnetic glass particles for isolating molecules
US6607667B2 (en) * 2000-11-28 2003-08-19 W. R. Grace & Co.-Conn. Method for adsorbing substances using silica adsorbent on magnetic substrate

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JP2003528455A (ja) 2003-09-24
EP1266385B1 (de) 2008-12-31
EP1266385A2 (de) 2002-12-18
WO2001071732A2 (de) 2001-09-27
US7183002B2 (en) 2007-02-27
WO2001071732B1 (de) 2002-02-28
AU6380001A (en) 2001-10-03
DE60137203D1 (de) 2009-02-12
CA2400724C (en) 2009-11-24
AU2001263800B2 (en) 2006-03-09
US20030148101A1 (en) 2003-08-07
US20110186524A1 (en) 2011-08-04
JP4907030B2 (ja) 2012-03-28
JP2012106241A (ja) 2012-06-07
US7922917B2 (en) 2011-04-12
CA2400724A1 (en) 2001-09-27
WO2001071732A3 (de) 2002-01-03
US20070080316A1 (en) 2007-04-12
US8202427B2 (en) 2012-06-19

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