ATE421318T1 - Darreichungsform, welche rasche dispersionseigenschaften entfaltet, anwendungsverfahren sowie verfahren zur herstellung derselben - Google Patents
Darreichungsform, welche rasche dispersionseigenschaften entfaltet, anwendungsverfahren sowie verfahren zur herstellung derselbenInfo
- Publication number
- ATE421318T1 ATE421318T1 AT98907531T AT98907531T ATE421318T1 AT E421318 T1 ATE421318 T1 AT E421318T1 AT 98907531 T AT98907531 T AT 98907531T AT 98907531 T AT98907531 T AT 98907531T AT E421318 T1 ATE421318 T1 AT E421318T1
- Authority
- AT
- Austria
- Prior art keywords
- dosage form
- production
- application
- same
- dispersion properties
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3828497P | 1997-02-20 | 1997-02-20 | |
| US3888397P | 1997-02-20 | 1997-02-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE421318T1 true ATE421318T1 (de) | 2009-02-15 |
Family
ID=26715043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98907531T ATE421318T1 (de) | 1997-02-20 | 1998-02-20 | Darreichungsform, welche rasche dispersionseigenschaften entfaltet, anwendungsverfahren sowie verfahren zur herstellung derselben |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6471992B1 (de) |
| EP (1) | EP0973507B1 (de) |
| JP (3) | JP4563516B2 (de) |
| AT (1) | ATE421318T1 (de) |
| AU (1) | AU736912B2 (de) |
| CA (1) | CA2281473C (de) |
| DE (1) | DE69840495D1 (de) |
| ES (1) | ES2318869T3 (de) |
| WO (1) | WO1998036738A1 (de) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU736912B2 (en) * | 1997-02-20 | 2001-08-02 | Therics, Inc. | Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same |
| DK2263660T3 (en) * | 1998-05-18 | 2018-01-02 | Takeda Pharmaceuticals Co | Orally disintegrating tablets. |
| US6284270B1 (en) * | 1999-08-04 | 2001-09-04 | Drugtech Corporation | Means for creating a mass having structural integrity |
| AU2001273687A1 (en) * | 2000-07-10 | 2002-01-21 | Massachusetts Institute Of Technology | Method and materials for controlling migration of binder liquid in a powder |
| DE60232445D1 (de) * | 2001-06-28 | 2009-07-09 | Ucb Farchim Sa | Cetirizin und pseudoephedrin enthaltende tablette |
| IL159715A0 (en) * | 2001-07-10 | 2004-06-20 | Teva Pharma | Drug delivery system for zero order, zero order-biphasic, ascending or descending drug delivery |
| JP2005509001A (ja) * | 2001-10-29 | 2005-04-07 | セリクス, インコーポレイテッド | 投薬形態の三次元懸濁液プリンティング |
| US7931914B2 (en) * | 2001-10-29 | 2011-04-26 | Massachusetts Institute Of Technology | System and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form |
| DE60323482D1 (de) * | 2002-05-06 | 2008-10-23 | Massachusetts Inst Technology | Diffusionskontrollierte arzneiform sowie herstellungsmethode mittels dreidimensionalem drucken |
| MXPA05005528A (es) | 2002-11-26 | 2006-04-05 | Alk Abello As | Producto farmaceutico de alergeno. |
| EP1804804B1 (de) | 2004-09-21 | 2012-01-25 | Hypnion, Inc. | 3-[4-(DIBENZO[b,f][1,4]OXAZEPIN-11-YL)-PIPERAZIN-1-YL]-2,2-DIMETHYL PROPANSÄURE ZUR VERWENDUNG IN DER BEHANDLUNG VON SCHLAFSTÖRUNGEN |
| US7829000B2 (en) * | 2005-02-25 | 2010-11-09 | Hewlett-Packard Development Company, L.P. | Core-shell solid freeform fabrication |
| US8187659B2 (en) | 2006-05-02 | 2012-05-29 | Jerry Robertson Real Estate Llc | Solid medicament dosage form consumption aid |
| WO2008002676A2 (en) | 2006-06-29 | 2008-01-03 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
| EP3777832A1 (de) | 2007-10-20 | 2021-02-17 | Athenex, Inc. | Pharmazeutische zubereitung zur veränderung der kinase kasakade und deren verwendung |
| US12186426B2 (en) | 2009-10-30 | 2025-01-07 | Ix Biopharma Ltd. | Solid dosage form |
| DK3254676T3 (en) | 2009-10-30 | 2019-03-11 | Ix Biopharma Ltd | QUICK-SOLVING SOLID DOSAGE FORM |
| JP2013524275A (ja) * | 2010-04-03 | 2013-06-17 | ドシ,プラフル | 薬剤を含む医療機器、その製造方法とその使用方法 |
| EP2632920A1 (de) | 2010-10-27 | 2013-09-04 | Dynamix Pharmaceuticals Ltd. | Sulfonamide zur modulation von pkm2 |
| WO2012088438A1 (en) | 2010-12-22 | 2012-06-28 | Eutropics Pharmaceuticals, Inc. | Compositions and methods useful for treating diseases |
| WO2012106058A2 (en) | 2011-01-31 | 2012-08-09 | New Market Pharmaceuticals | Animal treatments |
| US9051305B2 (en) | 2011-03-08 | 2015-06-09 | Eutropics Pharmaceuticals, Inc. | Compositions and methods useful for treating diseases |
| ITMI20110792A1 (it) | 2011-05-09 | 2012-11-10 | Probiotical Spa | Ceppi di batteri appartenenti al genere bifidobacterium per uso nel trattamento della ipercolesterolemia. |
| ITMI20110793A1 (it) | 2011-05-09 | 2012-11-10 | Probiotical Spa | Ceppi di batteri probiotici e composizione sinbiotica contenente gli stessi destinata alla alimentazione dei neonati. |
| ITMI20110791A1 (it) | 2011-05-09 | 2012-11-10 | Probiotical Spa | Ceppi di batteri in grado di metabolizzare gli ossalati. |
| WO2012160447A1 (en) | 2011-05-25 | 2012-11-29 | Dynamix Pharmaceuticals Ltd. | 3, 5 -diphenyl- substituted pyrazolines for the treatment of cancer, proliferative, inflammatory or autoimmune diseases |
| ES2585244T3 (es) | 2011-06-07 | 2016-10-04 | Clevexel Pharma | Composiciones y métodos para modular una cinasa |
| ITMI20111718A1 (it) | 2011-09-23 | 2013-03-24 | Probiotical Spa | Un materiale impermeabile alla umidita e allo ossigeno per confezionare prodotti dietetici, cosmetici e specialita medicinali. |
| US9245061B2 (en) * | 2012-04-25 | 2016-01-26 | Shapeways, Inc. | Weight-based identification of three dimensional printed parts |
| WO2013165468A1 (en) | 2012-05-02 | 2013-11-07 | New Market Pharmaceuticals | Pharmaceutical compositions for direct systemic introduction |
| US20150150869A1 (en) | 2012-06-20 | 2015-06-04 | Eutropics Pharmaceuticals, Inc. | Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives |
| US9926273B2 (en) | 2012-08-30 | 2018-03-27 | Athenex, Inc. | Composition and methods for modulating a kinase cascade |
| WO2014116770A1 (en) | 2013-01-23 | 2014-07-31 | Arx, Llc | Production of unit dose constructs |
| ES2761265T3 (es) * | 2013-03-15 | 2020-05-19 | Aprecia Pharmaceuticals LLC | Forma de dosificación de oxcarbazepina rápidamente dispersable |
| JP6466399B2 (ja) | 2013-03-15 | 2019-02-06 | アプレシア・ファーマスーティカルズ・カンパニー | トピラマートの急速分散性の剤形 |
| US9339489B2 (en) | 2013-03-15 | 2016-05-17 | Aprecia Pharmaceuticals Company | Rapid disperse dosage form containing levetiracetam |
| MX365513B (es) | 2013-03-15 | 2019-06-06 | Aprecia Pharmaceuticals LLC | Forma de dosificacion de dispersion rapida que contiene levetiracetam. |
| US10994013B2 (en) | 2013-04-24 | 2021-05-04 | Temple University—Of the Commonwealth System of Higher Education | Solid dosage form containing arabinogalactan |
| ITMI20130793A1 (it) | 2013-05-14 | 2014-11-15 | Probiotical Spa | Composizione comprendente batteri lattici per uso nel trattamento preventivo e/o curativo delle cistiti ricorrenti. |
| KR102171123B1 (ko) | 2013-08-16 | 2020-10-29 | 더 엑스원 컴퍼니 | 3차원 인쇄된 금속 주조용 몰드 및 그를 제조하기 위한 방법 |
| WO2015057761A1 (en) | 2013-10-17 | 2015-04-23 | The Exone Company | Three-dimensional printed hot isostatic pressing containers and processes for making same |
| WO2015100086A1 (en) | 2013-12-23 | 2015-07-02 | The Exone Company | Methods and systems for three-dimensional printing utilizing multiple binder fluids |
| US11001048B2 (en) | 2013-12-23 | 2021-05-11 | The Exone Company | Method of three-dimensional printing using a multi-component build powder |
| WO2015100085A2 (en) * | 2013-12-23 | 2015-07-02 | The Exone Company | Methods and systems for three-dimensional printing utilizing a jetted-particle binder fluid |
| EP3137113A4 (de) * | 2014-04-30 | 2017-03-22 | Blaesi, Aron H. | Schmelzverarbeitete polymere zelluläre darreichungsform |
| US20170120329A1 (en) | 2014-05-29 | 2017-05-04 | The Exone Company | Process for Making Nickel-Based Superalloy Articles by Three-Dimensional Printing |
| US20170203514A1 (en) | 2014-07-17 | 2017-07-20 | The Exone Company | Methods and Apparatuses for Curing Three-Dimensional Printed Articles |
| EA038518B1 (ru) | 2014-11-21 | 2021-09-09 | Биохэйвен Фармасьютикал Холдинг Компани Лтд. | Сублингвальный препарат рилузола |
| US20180001551A1 (en) | 2014-12-03 | 2018-01-04 | The Exone Company | Process for Making Densified Carbon Articles by Three Dimensional Printing |
| CA3254279A1 (en) | 2015-06-03 | 2025-03-18 | Triastek, Inc. | PHARMACEUTICAL FORMS AND RELATED USES |
| EP3108874A1 (de) * | 2015-06-26 | 2016-12-28 | TRB Chemedica AG | Pharmazeutische zubereitung zur anwendung am auge |
| US11129798B2 (en) | 2016-08-19 | 2021-09-28 | Aron H. Blaesi | Fibrous dosage form |
| WO2017075096A1 (en) * | 2015-10-26 | 2017-05-04 | Blaesi Aron H | Solid dosage form immediate drug release and apparatus and method for manufacture thereof |
| JP2019508449A (ja) * | 2016-03-18 | 2019-03-28 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 種々の効能を有する薬物の組み合わせ |
| ITUA20162013A1 (it) | 2016-03-24 | 2017-09-24 | Probiotical Spa | Composizione a base di batteri lattici per il trattamento contemporaneo di infezioni vaginali di origine micotica e batterica. |
| US20190217531A1 (en) * | 2016-04-06 | 2019-07-18 | Astellas Pharma Inc. | Fast-eluting three-dimensionally molded object, filament for fast-eluting three-dimensionally molded object, and material for fast-eluting three-dimensionally molded object |
| CA3023278C (en) | 2016-05-05 | 2019-04-30 | Triastek, Inc. | Controlled release dosage form |
| WO2017201502A1 (en) | 2016-05-20 | 2017-11-23 | Biohaven Pharmaceutical Holding Company Ltd. | Use of glutamate modulating agents with immunotherapies to treat cancer |
| CN118384166A (zh) | 2016-08-12 | 2024-07-26 | 阿西纳斯公司 | 用于调节激酶级联的联芳组合物和方法 |
| EP3529023B1 (de) | 2016-10-19 | 2022-05-25 | Shapeways, Inc. | Systeme und verfahren zur identifizierung dreidimensionaler druckobjekte |
| KR102793584B1 (ko) | 2016-12-31 | 2025-04-09 | 바이오엑셀 테라퓨틱스 인코포레이티드 | 불안의 치료를 위한 설하 덱스메데토미딘의 용도 |
| KR20190107712A (ko) | 2017-01-26 | 2019-09-20 | 트리아스텍 인코포레이티드 | 특정 위장 부위에서의 제어 방출의 투여 형태 |
| WO2018156141A1 (en) * | 2017-02-24 | 2018-08-30 | Hewlett-Packard Development Company, L.P. | Three-dimensional (3d) printing a pharmaceutical tablet |
| EA201992116A1 (ru) | 2017-03-08 | 2020-01-29 | СИНРКС ФАРМА, ЭлЭлСи | Фармацевтические составы флороглюцинола и триметилфлороглюцинола |
| KR102626745B1 (ko) | 2017-05-26 | 2024-01-17 | 인피니트 머티리얼 솔루션즈, 엘엘씨 | 수용성 중합체 조성물 |
| EP3706739B1 (de) | 2017-11-12 | 2024-10-16 | Biohaven Therapeutics Ltd. | Verwendung von riluzolprodrugs zur behandlung von ataxien |
| CN108066302B (zh) * | 2017-12-28 | 2020-09-11 | 无限极(中国)有限公司 | 一种快速分散固体制剂的制备方法及制备的快速分散固体制剂 |
| US10350822B1 (en) | 2018-01-09 | 2019-07-16 | Triastek Inc. | Dosage forms with desired release profiles and methods of designing and making thereof |
| CN116270513A (zh) | 2018-01-09 | 2023-06-23 | 南京三迭纪医药科技有限公司 | 一种包含固定剂量adhd非兴奋剂和adhd兴奋剂的复方口服药物剂型 |
| DE102018107585B3 (de) * | 2018-03-29 | 2019-03-28 | Universität Rostock | Vorrichtung zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen mit Wirkstoffdepots, sowie Verfahren zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen |
| PL3813802T3 (pl) | 2018-06-27 | 2025-04-22 | Bioxcel Therapeutics, Inc. | Formulacje błony zawierające deksmedetomidynę i sposoby ich wytwarzania |
| WO2020081561A1 (en) | 2018-10-15 | 2020-04-23 | Aprecia Pharmaceuticals LLC | Method and system for forming a dosage form within a packaging |
| EP3883546A1 (de) | 2018-11-21 | 2021-09-29 | Rosemont Pharmaceuticals Ltd | Orale topiramat-suspensionsformulierungen mit verlängerter lagerstabilität und verbesserter bioverfügbarkeit |
| US12103229B2 (en) * | 2019-03-15 | 2024-10-01 | Ricoh Company, Ltd. | Jettable temporary binders to create removable support materials |
| JP7287032B2 (ja) | 2019-03-20 | 2023-06-06 | 株式会社リコー | シート、シート積層体、医薬品、シートの製造方法、及びシート積層体の製造方法 |
| BR112021023189A2 (pt) * | 2019-05-21 | 2022-01-04 | Dfe Pharma Gmbh & Co Kg | Uso de partículas de lactose na produção de formulações farmacêuticas por impressão tridimensional, kit, e, processo para preparar uma formulação farmacêutica sólida por impressão tridimensional |
| EP3999058A4 (de) | 2019-07-19 | 2023-05-03 | Bioxcel Therapeutics, Inc. | Behandlungsschemata für nicht-sedierendes dexmedetomidin |
| EP3789015A1 (de) * | 2019-09-05 | 2021-03-10 | Universität Innsbruck | Schnell konsolidierende verbindungen |
| TWI734309B (zh) * | 2019-12-19 | 2021-07-21 | 水星生醫股份有限公司 | 滲透性噴塗製作藥錠裝置 |
| US12371581B2 (en) | 2020-03-25 | 2025-07-29 | Infinite Material Solutions, Llc | High performance water soluble polymer compositions |
| AU2021296908A1 (en) | 2020-06-26 | 2023-02-16 | Aprecia Pharmaceuticals LLC | Rapidly-orodispersible tablets having an interior cavity |
| WO2022089588A1 (zh) | 2020-10-30 | 2022-05-05 | 南京三迭纪医药科技有限公司 | 胃滞留药物剂型 |
| EP4277624B1 (de) | 2021-01-18 | 2026-01-14 | Biohaven Therapeutics Ltd. | Troriluzol zur verwendung bei der behandlung der alzheimer-krankheit leichten grades |
| WO2024108082A1 (en) | 2022-11-18 | 2024-05-23 | Aprecia Pharmaceuticals LLC | Orodispersive dosage forms containing droxidopa |
| US11806334B1 (en) | 2023-01-12 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
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|---|---|---|---|---|
| US4642903A (en) | 1985-03-26 | 1987-02-17 | R. P. Scherer Corporation | Freeze-dried foam dosage form |
| US4855326A (en) | 1987-04-20 | 1989-08-08 | Fuisz Pharmaceutical Ltd. | Rapidly dissoluble medicinal dosage unit and method of manufacture |
| US4990535A (en) * | 1989-05-03 | 1991-02-05 | Schering Corporation | Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine |
| FR2647343B1 (fr) * | 1989-05-24 | 1994-05-06 | Rhone Poulenc Sante | Nouvelle forme pharmaceutique poreuse et sa preparation |
| US5206025A (en) | 1989-05-24 | 1993-04-27 | Rhone-Poulenc Sante | Porous pharmaceutical form and its preparation |
| EP0418596A3 (en) * | 1989-09-21 | 1991-10-23 | American Cyanamid Company | Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form |
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| AU736912B2 (en) * | 1997-02-20 | 2001-08-02 | Therics, Inc. | Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same |
| DE19940944B4 (de) * | 1999-08-31 | 2006-10-12 | Grünenthal GmbH | Retardierte, orale, pharmazeutische Darreichungsformen |
-
1998
- 1998-02-20 AU AU63314/98A patent/AU736912B2/en not_active Ceased
- 1998-02-20 DE DE69840495T patent/DE69840495D1/de not_active Expired - Lifetime
- 1998-02-20 CA CA002281473A patent/CA2281473C/en not_active Expired - Lifetime
- 1998-02-20 EP EP98907531A patent/EP0973507B1/de not_active Expired - Lifetime
- 1998-02-20 AT AT98907531T patent/ATE421318T1/de not_active IP Right Cessation
- 1998-02-20 ES ES98907531T patent/ES2318869T3/es not_active Expired - Lifetime
- 1998-02-20 WO PCT/US1998/003256 patent/WO1998036738A1/en not_active Ceased
- 1998-02-20 JP JP53687898A patent/JP4563516B2/ja not_active Expired - Lifetime
- 1998-02-20 US US09/027,183 patent/US6471992B1/en not_active Expired - Lifetime
-
2002
- 2002-07-19 US US10/200,029 patent/US9463160B2/en not_active Expired - Fee Related
-
2009
- 2009-05-11 JP JP2009114753A patent/JP5091910B2/ja not_active Expired - Lifetime
- 2009-11-09 JP JP2009256374A patent/JP2010120938A/ja not_active Withdrawn
-
2012
- 2012-02-09 US US13/369,473 patent/US9114072B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010120938A (ja) | 2010-06-03 |
| JP5091910B2 (ja) | 2012-12-05 |
| US20120207929A1 (en) | 2012-08-16 |
| AU736912B2 (en) | 2001-08-02 |
| CA2281473A1 (en) | 1998-08-27 |
| AU6331498A (en) | 1998-09-09 |
| JP2009215305A (ja) | 2009-09-24 |
| CA2281473C (en) | 2007-01-16 |
| EP0973507A4 (de) | 2006-08-23 |
| WO1998036738A1 (en) | 1998-08-27 |
| JP4563516B2 (ja) | 2010-10-13 |
| EP0973507B1 (de) | 2009-01-21 |
| US9463160B2 (en) | 2016-10-11 |
| US9114072B2 (en) | 2015-08-25 |
| DE69840495D1 (de) | 2009-03-12 |
| EP0973507A1 (de) | 2000-01-26 |
| US20030133975A1 (en) | 2003-07-17 |
| JP2001512488A (ja) | 2001-08-21 |
| US6471992B1 (en) | 2002-10-29 |
| ES2318869T3 (es) | 2009-05-01 |
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