ATE421998T1 - Ermittlung des repertoires von b-lymphozyten populationen - Google Patents
Ermittlung des repertoires von b-lymphozyten populationenInfo
- Publication number
- ATE421998T1 ATE421998T1 AT03293159T AT03293159T ATE421998T1 AT E421998 T1 ATE421998 T1 AT E421998T1 AT 03293159 T AT03293159 T AT 03293159T AT 03293159 T AT03293159 T AT 03293159T AT E421998 T1 ATE421998 T1 AT E421998T1
- Authority
- AT
- Austria
- Prior art keywords
- heavy chain
- repertoire
- given type
- provides
- determination
- Prior art date
Links
- 210000003719 b-lymphocyte Anatomy 0.000 title 1
- 238000000338 in vitro Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 abstract 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03293159A EP1544308B1 (de) | 2003-12-15 | 2003-12-15 | Ermittlung des Repertoires von B-Lymphozyten Populationen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE421998T1 true ATE421998T1 (de) | 2009-02-15 |
Family
ID=34486471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03293159T ATE421998T1 (de) | 2003-12-15 | 2003-12-15 | Ermittlung des repertoires von b-lymphozyten populationen |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP1544308B1 (de) |
| AT (1) | ATE421998T1 (de) |
| DE (1) | DE60326052D1 (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2281065B1 (de) | 2008-04-16 | 2015-09-09 | HudsonAlpha Institute For Biotechnology | Verfahren für die beurteilung und den vergleich von immunrepertoires |
| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| US9394567B2 (en) | 2008-11-07 | 2016-07-19 | Adaptive Biotechnologies Corporation | Detection and quantification of sample contamination in immune repertoire analysis |
| US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
| WO2010053587A2 (en) | 2008-11-07 | 2010-05-14 | Mlc Dx Incorporated | Methods of monitoring conditions by sequence analysis |
| US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
| US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US8691510B2 (en) | 2008-11-07 | 2014-04-08 | Sequenta, Inc. | Sequence analysis of complex amplicons |
| US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| PL2387627T3 (pl) | 2009-01-15 | 2016-10-31 | Profilowanie odporności adaptacyjnej i wytwarzanie przeciwciał monoklonalnych | |
| KR20120044941A (ko) | 2009-06-25 | 2012-05-08 | 프레드 헛친슨 켄서 리서치 센터 | 적응 면역의 측정방법 |
| US9043160B1 (en) | 2009-11-09 | 2015-05-26 | Sequenta, Inc. | Method of determining clonotypes and clonotype profiles |
| ES2740802T3 (es) | 2010-05-06 | 2020-02-06 | Adaptive Biotechnologies Corp | Monitorización del estadio de neoplasia linfoide usando perfiles de clonotipo |
| WO2011140433A2 (en) | 2010-05-07 | 2011-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Measurement and comparison of immune diversity by high-throughput sequencing |
| US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
| CA2853088C (en) | 2011-10-21 | 2018-03-13 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| EP3904536B1 (de) | 2011-12-09 | 2025-10-29 | Adaptive Biotechnologies Corporation | Diagnose von lymphoid-malignität und nachweis minimaler resterkrankungen |
| US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
| US10077478B2 (en) | 2012-03-05 | 2018-09-18 | Adaptive Biotechnologies Corp. | Determining paired immune receptor chains from frequency matched subunits |
| KR101621643B1 (ko) | 2012-05-08 | 2016-05-16 | 어댑티브 바이오테크놀로지스 코포레이션 | 다중 pcr 반응에서 증폭 바이어스를 측정 및 교정하기 위한 조성물 및 방법 |
| EP3640343B1 (de) | 2012-10-01 | 2026-01-07 | Adaptive Biotechnologies Corporation | Immunkompetenzbeurteilung durch adaptive immunrezeptordiversität und klonalitätscharakterisierung |
| WO2015160439A2 (en) | 2014-04-17 | 2015-10-22 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| WO2014121272A2 (en) | 2013-02-04 | 2014-08-07 | Quake Stephen R | Measurement and comparison of immune diversity by high-throughput sequencing |
| EP2959020B1 (de) | 2013-02-22 | 2019-09-18 | Adaptive Biotechnologies Corporation | Verfahren zur auswahl von seltene klonotypen |
| EP3611262B1 (de) | 2013-03-15 | 2020-11-11 | Lineage Biosciences, Inc. | Verfahren zur sequenzierung des immunrepertoirs |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| ES2741740T3 (es) | 2014-03-05 | 2020-02-12 | Adaptive Biotechnologies Corp | Métodos que usan moléculas sintéticas que contienen segmentos de nucleótidos aleatorios |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| US11390921B2 (en) | 2014-04-01 | 2022-07-19 | Adaptive Biotechnologies Corporation | Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs) |
| EP3715455A1 (de) | 2014-10-29 | 2020-09-30 | Adaptive Biotechnologies Corp. | Hochmultiplexierter gleichzeitiger nachweis von für adaptive gepaarte immunrezeptorheterodimere codierenden nukleinsäuren aus einer vielzahl von proben |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| WO2016086029A1 (en) | 2014-11-25 | 2016-06-02 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
| ES3002665T3 (en) | 2015-02-24 | 2025-03-07 | Adaptive Biotechnologies Corp | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
| AU2016242967B2 (en) | 2015-04-01 | 2021-07-01 | Adaptive Biotechnologies Corp. | Method of identifying human compatible T cell receptors specific for an antigenic target |
| GB201612242D0 (en) * | 2016-07-14 | 2016-08-31 | Genome Res Ltd And Cambridge Entpr Ltd | Novel kit |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| US10822662B2 (en) | 2017-03-06 | 2020-11-03 | Karkinos Precision Oncology LLC | Diagnostic methods for identifying T-cell lymphoma and leukemia by high-throughput TCR-β sequencing |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| US20220112557A1 (en) | 2019-01-10 | 2022-04-14 | Iovance Biotherapeutics, Inc. | System and methods for monitoring adoptive cell therapy clonality and persistence |
| AU2024228388A1 (en) | 2023-02-27 | 2025-10-02 | Adaptive Biotechnologies Corp. | Therapeutic t cell receptors targeting kras g12d |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL84285A (en) * | 1986-10-27 | 1993-03-15 | Int Genetic Engineering | Chimeric antibody with specificity to human tumor antigen |
| IT1244983B (it) * | 1991-04-29 | 1994-09-13 | Raggio Italgene Spa | Procedimento per rivelare sequenze di acidi nucleici e kit per la sua utilizzazione. |
| WO1999015696A1 (en) * | 1997-09-19 | 1999-04-01 | Medelys Laboratories Inc. | Method and kit for early diagnosis of autoimmunity and lymphoma in central nervous system |
| GB0008419D0 (en) * | 2000-04-05 | 2000-05-24 | Bioinvent Int Ab | A method for invitro molecular evolution of antibody function |
| DK1309347T3 (da) * | 2000-08-11 | 2013-03-25 | Mmrglobal Inc | Fremgangsmåde og sammensætning til ændring af en B-cellemedieret patologi |
-
2003
- 2003-12-15 AT AT03293159T patent/ATE421998T1/de not_active IP Right Cessation
- 2003-12-15 EP EP03293159A patent/EP1544308B1/de not_active Expired - Lifetime
- 2003-12-15 DE DE60326052T patent/DE60326052D1/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60326052D1 (de) | 2009-03-19 |
| EP1544308A1 (de) | 2005-06-22 |
| EP1544308B1 (de) | 2009-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |