ATE422155T1 - Nanopartikelzusammensetzungen enthaltend fenofibrat - Google Patents
Nanopartikelzusammensetzungen enthaltend fenofibratInfo
- Publication number
- ATE422155T1 ATE422155T1 AT02749130T AT02749130T ATE422155T1 AT E422155 T1 ATE422155 T1 AT E422155T1 AT 02749130 T AT02749130 T AT 02749130T AT 02749130 T AT02749130 T AT 02749130T AT E422155 T1 ATE422155 T1 AT E422155T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions containing
- nanoparticle compositions
- containing fenofibrate
- nanoparticles
- fenofibrate
- Prior art date
Links
- 239000002105 nanoparticle Substances 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 title 1
- 229960002297 fenofibrate Drugs 0.000 title 1
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 abstract 1
- 238000002296 dynamic light scattering Methods 0.000 abstract 1
- 229940125753 fibrate Drugs 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0119480.2A GB0119480D0 (en) | 2001-08-09 | 2001-08-09 | Novel compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE422155T1 true ATE422155T1 (de) | 2009-02-15 |
Family
ID=9920132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02749130T ATE422155T1 (de) | 2001-08-09 | 2002-08-09 | Nanopartikelzusammensetzungen enthaltend fenofibrat |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8663693B2 (de) |
| EP (1) | EP1414410B1 (de) |
| JP (1) | JP4721640B2 (de) |
| AT (1) | ATE422155T1 (de) |
| DE (1) | DE60231082D1 (de) |
| ES (1) | ES2321912T3 (de) |
| GB (1) | GB0119480D0 (de) |
| WO (1) | WO2003013474A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080241070A1 (en) * | 2000-09-21 | 2008-10-02 | Elan Pharma International Ltd. | Fenofibrate dosage forms |
| US7276249B2 (en) | 2002-05-24 | 2007-10-02 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
| EP1531799A1 (de) * | 2002-06-10 | 2005-05-25 | Elan Pharma International Limited | Pharmazeutische nanopartikel-formulierungen mit hmg-coa-reduktase-inhibitoren ("statine"), neue kombinationen davon sowie herstellung dieser pharmazeutischen zusammensetzungen |
| CN1829499A (zh) * | 2003-05-29 | 2006-09-06 | 格利康科技集团有限责任公司 | 稳定并控制传递(－)－羟基柠檬酸的方法和组合物 |
| CN101031284A (zh) * | 2004-09-30 | 2007-09-05 | 伊斯曼化学公司 | 使亲脂性药物增溶而无显著外排抑制作用的含有维生素e tpgs分子的药物制剂和该制剂的用途 |
| JP5112669B2 (ja) * | 2005-09-30 | 2013-01-09 | 富山化学工業株式会社 | 難溶性薬物のナノ微粒子を含有する水性懸濁液剤 |
| US20070128289A1 (en) * | 2005-12-07 | 2007-06-07 | Zhao Jonathon Z | Nano-and/or micro-particulate formulations for local injection-based treatment of vascular diseases |
| CA2656277A1 (en) * | 2006-06-26 | 2008-01-03 | Mutual Pharmaceutical Company, Inc. | Active agent formulations, methods of making, and methods of use |
| US20080161594A1 (en) * | 2006-12-29 | 2008-07-03 | Industrial Technology Research Institute | Method for fabricating nanoparticles containing fenofibrate |
| US20100159010A1 (en) * | 2008-12-24 | 2010-06-24 | Mutual Pharmaceutical Company, Inc. | Active Agent Formulations, Methods of Making, and Methods of Use |
| AR075180A1 (es) * | 2009-01-29 | 2011-03-16 | Novartis Ag | Formulaciones orales solidas de una pirido-pirimidinona |
| JP5711671B2 (ja) * | 2009-02-23 | 2015-05-07 | ナノルクス、インコーポレイテッドＮａｎｏｒｘ，Ｉｎｃ． | ポリコサノールナノ粒子 |
| CN102869348A (zh) | 2010-04-30 | 2013-01-09 | Hrd有限公司 | 药物递送中的高剪切力应用 |
| US8888736B2 (en) | 2010-04-30 | 2014-11-18 | H R D Corporation | High shear application in medical therapy |
| US9034383B2 (en) | 2010-08-23 | 2015-05-19 | NanoRx, Inc. | Policosanol nanoparticles |
| GB201118181D0 (en) * | 2011-10-21 | 2011-12-07 | Jagotec Ag | Pharmaceutical compositions |
| CN104736144B (zh) * | 2012-07-27 | 2019-02-01 | 艾祖米科技有限公司 | 外排抑制剂组合物和使用此组合物治疗的方法 |
| WO2014046697A1 (en) * | 2012-09-21 | 2014-03-27 | Reoxcyn Discoveries Group, Inc. | Cell for electrolyzing a liquid |
| US11285115B2 (en) | 2013-02-28 | 2022-03-29 | Ramot At Tel-Aviv University Ltd. | Peptide-based hydrogel particles and uses thereof |
| CN105218370A (zh) * | 2014-06-10 | 2016-01-06 | 无锡康福特药物科技有限公司 | 一种贝特类降脂药物的超微粉体及其制备方法 |
| HRP20251674T1 (hr) * | 2019-07-31 | 2026-02-13 | Intas Pharmaceuticals Ltd. | Farmaceutski pripravak koji sadrži inhibitore hmg coa reduktaze i fenofibrat |
| EP3928772B1 (de) | 2020-06-26 | 2024-06-19 | Algiax Pharmaceuticals GmbH | Nanopartikuläre zusammensetzung |
| WO2022094054A1 (en) * | 2020-10-28 | 2022-05-05 | Mydecine Innovations Group Inc. | Novel fungal compound formulations and their therapeutic methods of use |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2627696B1 (fr) | 1988-02-26 | 1991-09-13 | Fournier Innovation Synergie | Nouvelle forme galenique du fenofibrate |
| US5091188A (en) * | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
| US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5567592A (en) * | 1994-02-02 | 1996-10-22 | Regents Of The University Of California | Screening method for the identification of bioenhancers through the inhibition of P-glycoprotein transport in the gut of a mammal |
| GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
| GB9409778D0 (en) * | 1994-05-16 | 1994-07-06 | Dumex Ltd As | Compositions |
| DE4440337A1 (de) | 1994-11-11 | 1996-05-15 | Dds Drug Delivery Services Ges | Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit |
| US5545628A (en) | 1995-01-10 | 1996-08-13 | Galephar P.R. Inc. | Pharmaceutical composition containing fenofibrate |
| FR2730231B1 (fr) * | 1995-02-02 | 1997-04-04 | Fournier Sca Lab | Association de fenofibrate et de vitamine e, utilisation en therapeutique |
| US5716928A (en) * | 1995-06-07 | 1998-02-10 | Avmax, Inc. | Use of essential oils to increase bioavailability of oral pharmaceutical compounds |
| US5891469A (en) | 1997-04-02 | 1999-04-06 | Pharmos Corporation | Solid Coprecipitates for enhanced bioavailability of lipophilic substances |
| US5919776A (en) * | 1996-12-20 | 1999-07-06 | Merck & Co., Inc. | Substituted aminoquinolines as modulators of chemokine receptor activity |
| DE19800250A1 (de) | 1997-01-13 | 1998-08-06 | Winter Cvd Technik Gmbh | Schleifkörper |
| FR2758459B1 (fr) * | 1997-01-17 | 1999-05-07 | Pharma Pass | Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation |
| FR2758461A1 (fr) | 1997-01-17 | 1998-07-24 | Pharma Pass | Composition pharmaceutique presentant une biodisponibilite elevee et son procede de preparation |
| US5891845A (en) * | 1997-11-21 | 1999-04-06 | Fuisz Technologies Ltd. | Drug delivery systems utilizing liquid crystal structures |
| AU1809499A (en) * | 1997-12-10 | 1999-06-28 | Awadhesh K. Mishra | Self-emulsifying fenofibrate formulations |
| FR2774591B1 (fr) | 1998-02-12 | 2000-05-05 | Lipha | Composition pharmaceutique comprenant l'association metformine et fibrate et son utilisation pour la preparation de medicaments destines a reduire l'hyperglycemie |
| FR2776191B1 (fr) * | 1998-03-23 | 2002-05-31 | Theramex | Composition hormonale topique a effet systemique |
| ATE233549T1 (de) | 1998-06-19 | 2003-03-15 | Skyepharma Canada Inc | Neues verfahren zur herstellung von partikeln wasserunlöslicher komponenten im grössenbereich bis 2000 nm |
| FR2783421B1 (fr) | 1998-09-17 | 2000-11-24 | Cll Pharma | Procede de preparation de nouvelles formulations galeniques du fenofibrate, formulations galeniques obtenues par ledit procede et leurs applications |
| US6375986B1 (en) * | 2000-09-21 | 2002-04-23 | Elan Pharma International Ltd. | Solid dose nanoparticulate compositions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate |
| WO2000030616A1 (en) | 1998-11-20 | 2000-06-02 | Rtp Pharma Inc. | Dispersible phospholipid stabilized microparticles |
| EP1133280A1 (de) | 1998-11-20 | 2001-09-19 | RTP Pharma Inc. | Verfahren zur herstellung stabiler suspensionen von unlöslichen mikropartikeln |
| US6180138B1 (en) * | 1999-01-29 | 2001-01-30 | Abbott Laboratories | Process for preparing solid formulations of lipid-regulating agents with enhanced dissolution and absorption |
| US6270806B1 (en) | 1999-03-03 | 2001-08-07 | Elan Pharma International Limited | Use of peg-derivatized lipids as surface stabilizers for nanoparticulate compositions |
| US6372251B2 (en) * | 1999-06-11 | 2002-04-16 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
| US6982281B1 (en) * | 2000-11-17 | 2006-01-03 | Lipocine Inc | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
| FR2795961B1 (fr) | 1999-07-09 | 2004-05-28 | Ethypharm Lab Prod Ethiques | Composition pharmaceutique contenant du fenofibrate micronise, un tensioactif et un derive cellulosique liant et procede de preparation |
| US6251426B1 (en) | 1999-09-02 | 2001-06-26 | Banner Pharmacaps, Inc. | Ibuprofen-containing softgels |
| AU7984200A (en) | 1999-09-21 | 2001-04-24 | Skyepharma Canada Inc. | Surface modified particulate compositions of biologically active substances |
| US6464511B1 (en) | 1999-11-17 | 2002-10-15 | Advantest Corporation | IC socket and IC tester |
| FR2803203B1 (fr) * | 1999-12-31 | 2002-05-10 | Fournier Ind & Sante | Nouvelles formulations galeniques du fenofibrate |
-
2001
- 2001-08-09 GB GBGB0119480.2A patent/GB0119480D0/en not_active Ceased
-
2002
- 2002-08-09 WO PCT/GB2002/003687 patent/WO2003013474A1/en not_active Ceased
- 2002-08-09 ES ES02749130T patent/ES2321912T3/es not_active Expired - Lifetime
- 2002-08-09 EP EP02749130A patent/EP1414410B1/de not_active Expired - Lifetime
- 2002-08-09 AT AT02749130T patent/ATE422155T1/de not_active IP Right Cessation
- 2002-08-09 US US10/486,299 patent/US8663693B2/en not_active Expired - Fee Related
- 2002-08-09 JP JP2003518484A patent/JP4721640B2/ja not_active Expired - Fee Related
- 2002-08-09 DE DE60231082T patent/DE60231082D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005509596A (ja) | 2005-04-14 |
| EP1414410B1 (de) | 2009-02-04 |
| ES2321912T3 (es) | 2009-06-15 |
| EP1414410A1 (de) | 2004-05-06 |
| GB0119480D0 (en) | 2001-10-03 |
| JP4721640B2 (ja) | 2011-07-13 |
| US8663693B2 (en) | 2014-03-04 |
| US20050095297A1 (en) | 2005-05-05 |
| WO2003013474A1 (en) | 2003-02-20 |
| DE60231082D1 (de) | 2009-03-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60231082D1 (de) | Nanopartikelzusammensetzungen enthaltend fenofibrat | |
| ATE419835T1 (de) | Nystatin-nanopartikelzusammensetzungen | |
| DE602004021107D1 (de) | Meloxican-formulierungen in nanoteilchenform | |
| BRPI0410767A (pt) | formulações farmacêuticas de partìcula pequena de agentes antiataque e antidemência e agentes imunossupressores | |
| WO2003032953A1 (en) | Granules containing acid-unstable chemical in large amount | |
| ATE293995T1 (de) | Pharmazeutische zusammensetzungen, die wirkstoffabsorptionsfördernde verbindungen enthalten | |
| CY1113036T1 (el) | Φαρμακοτεχνικες μορφες νανοσωματιδιων μεγεστρολης | |
| EA200702638A1 (ru) | Стабильная композиция (рецептура) с наночастицами ацетаминофена | |
| BR0214679A (pt) | Composições farmacêuticas compreendendo compostos a base de vitamina d ativa | |
| ECSP034914A (es) | "azaindoles" | |
| BR0014087A (pt) | Composições com pérolas de caroteno - xantofila estáveis e métodos de uso | |
| ATE395042T1 (de) | Darreichungsformen welche mikropartikel und treibgas enthalten | |
| PE84899A1 (es) | Formulaciones farmaceuticas que contienen voriconazol | |
| TW200744677A (en) | Compositions and methods for preparation of poorly water soluble drugs with increased stability | |
| ATE478840T1 (de) | 3-aminoazetidinderivate enthaltende pharmazeutische zusammensetzungen, diese derivate und deren herstellung | |
| ATE225341T1 (de) | In 6-position durch thio substituierte paclitaxele | |
| JP2005509596A5 (de) | ||
| BR0213608A (pt) | Composição oral | |
| DE50210379D1 (de) | Paramagnetische nanopartikel | |
| DE60220771D1 (de) | Hemmer von cyclinabhängigen kinasen als mittel gegen krebs | |
| TNSN04034A1 (en) | Combined preparations, containing 1,4-benzothiepine-1,1-dioxide derivatives and other active substances, and the use thereof | |
| MA29723B1 (fr) | Composes | |
| DE60229450D1 (de) | Topische nanopartikel-spironolacton-formulierung | |
| BRPI0408848A (pt) | formulações orais de cladribine | |
| ATE308969T1 (de) | Kosmetische formulierung enthaltend dihydroxyaceton |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |