ATE422155T1 - Nanopartikelzusammensetzungen enthaltend fenofibrat - Google Patents
Nanopartikelzusammensetzungen enthaltend fenofibratInfo
- Publication number
- ATE422155T1 ATE422155T1 AT02749130T AT02749130T ATE422155T1 AT E422155 T1 ATE422155 T1 AT E422155T1 AT 02749130 T AT02749130 T AT 02749130T AT 02749130 T AT02749130 T AT 02749130T AT E422155 T1 ATE422155 T1 AT E422155T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions containing
- nanoparticle compositions
- containing fenofibrate
- nanoparticles
- fenofibrate
- Prior art date
Links
- 239000002105 nanoparticle Substances 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 title 1
- 229960002297 fenofibrate Drugs 0.000 title 1
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 abstract 1
- 238000002296 dynamic light scattering Methods 0.000 abstract 1
- 229940125753 fibrate Drugs 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0119480.2A GB0119480D0 (en) | 2001-08-09 | 2001-08-09 | Novel compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE422155T1 true ATE422155T1 (de) | 2009-02-15 |
Family
ID=9920132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02749130T ATE422155T1 (de) | 2001-08-09 | 2002-08-09 | Nanopartikelzusammensetzungen enthaltend fenofibrat |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8663693B2 (de) |
| EP (1) | EP1414410B1 (de) |
| JP (1) | JP4721640B2 (de) |
| AT (1) | ATE422155T1 (de) |
| DE (1) | DE60231082D1 (de) |
| ES (1) | ES2321912T3 (de) |
| GB (1) | GB0119480D0 (de) |
| WO (1) | WO2003013474A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7276249B2 (en) | 2002-05-24 | 2007-10-02 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
| US20080241070A1 (en) * | 2000-09-21 | 2008-10-02 | Elan Pharma International Ltd. | Fenofibrate dosage forms |
| WO2003103640A1 (en) * | 2002-06-10 | 2003-12-18 | Elan Pharma International, Ltd | Nanoparticulate formulations comprising hmg coa reductase inhibitor derivatives (“statins”), novel combinations thereof as well as manufacturing of these pharmaceutical compositions |
| JP2007502331A (ja) * | 2003-05-29 | 2007-02-08 | グリュコン テクノロジーズ グループ エルエルシー | （−）−ヒドロキシクエン酸を安定して制御送達するための方法および組成物 |
| WO2006039268A2 (en) * | 2004-09-30 | 2006-04-13 | Eastman Chemical Company | Pharmaceutical formulations containing vitamin e tpgs molecules that solubilize lipophilic drugs without significant efflux inhibition, and use of such formulations |
| JP5112669B2 (ja) * | 2005-09-30 | 2013-01-09 | 富山化学工業株式会社 | 難溶性薬物のナノ微粒子を含有する水性懸濁液剤 |
| US20070128289A1 (en) * | 2005-12-07 | 2007-06-07 | Zhao Jonathon Z | Nano-and/or micro-particulate formulations for local injection-based treatment of vascular diseases |
| MX2009000035A (es) * | 2006-06-26 | 2009-05-28 | Mutual Pharmaceutical Co | Formulaciones de agente activo, procedimientos de preparacion y procedimientos de uso. |
| US20080161594A1 (en) * | 2006-12-29 | 2008-07-03 | Industrial Technology Research Institute | Method for fabricating nanoparticles containing fenofibrate |
| US20100159010A1 (en) * | 2008-12-24 | 2010-06-24 | Mutual Pharmaceutical Company, Inc. | Active Agent Formulations, Methods of Making, and Methods of Use |
| AR075180A1 (es) * | 2009-01-29 | 2011-03-16 | Novartis Ag | Formulaciones orales solidas de una pirido-pirimidinona |
| WO2010096231A1 (en) * | 2009-02-23 | 2010-08-26 | NanoRx, Inc. | Policosanol nanoparticles |
| US8888736B2 (en) | 2010-04-30 | 2014-11-18 | H R D Corporation | High shear application in medical therapy |
| KR20130080786A (ko) | 2010-04-30 | 2013-07-15 | 에이치 알 디 코포레이션 | 약물 전달에서의 고 전단 응용 |
| WO2012027159A1 (en) | 2010-08-23 | 2012-03-01 | NanoRx, Inc. | Policosanol nanoparticles |
| GB201118181D0 (en) * | 2011-10-21 | 2011-12-07 | Jagotec Ag | Pharmaceutical compositions |
| EP2877159B8 (de) * | 2012-07-27 | 2018-02-14 | Izumi Technology, LLC. | Efflux-inhibitorzusammensetzungen und behandlungsverfahren damit |
| MX2015003700A (es) * | 2012-09-21 | 2015-10-30 | Reoxcyn Discoveries Group Inc | Celda para electrolizar un liquido. |
| US11285115B2 (en) | 2013-02-28 | 2022-03-29 | Ramot At Tel-Aviv University Ltd. | Peptide-based hydrogel particles and uses thereof |
| CN105218370A (zh) * | 2014-06-10 | 2016-01-06 | 无锡康福特药物科技有限公司 | 一种贝特类降脂药物的超微粉体及其制备方法 |
| RS63740B1 (sr) * | 2019-07-31 | 2022-12-30 | Intas Pharmaceuticals Ltd | Farmaceutski sastav koji se sastoji od inhibitora hmg-coa reduktaze i fenofibrata |
| EP3928772B1 (de) | 2020-06-26 | 2024-06-19 | Algiax Pharmaceuticals GmbH | Nanopartikuläre zusammensetzung |
| WO2022094054A1 (en) * | 2020-10-28 | 2022-05-05 | Mydecine Innovations Group Inc. | Novel fungal compound formulations and their therapeutic methods of use |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2627696B1 (fr) | 1988-02-26 | 1991-09-13 | Fournier Innovation Synergie | Nouvelle forme galenique du fenofibrate |
| US5091188A (en) * | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
| US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5567592A (en) * | 1994-02-02 | 1996-10-22 | Regents Of The University Of California | Screening method for the identification of bioenhancers through the inhibition of P-glycoprotein transport in the gut of a mammal |
| GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
| GB9409778D0 (en) * | 1994-05-16 | 1994-07-06 | Dumex Ltd As | Compositions |
| DE4440337A1 (de) | 1994-11-11 | 1996-05-15 | Dds Drug Delivery Services Ges | Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit |
| US5545628A (en) | 1995-01-10 | 1996-08-13 | Galephar P.R. Inc. | Pharmaceutical composition containing fenofibrate |
| FR2730231B1 (fr) * | 1995-02-02 | 1997-04-04 | Fournier Sca Lab | Association de fenofibrate et de vitamine e, utilisation en therapeutique |
| US5716928A (en) * | 1995-06-07 | 1998-02-10 | Avmax, Inc. | Use of essential oils to increase bioavailability of oral pharmaceutical compounds |
| US5891469A (en) | 1997-04-02 | 1999-04-06 | Pharmos Corporation | Solid Coprecipitates for enhanced bioavailability of lipophilic substances |
| US5919776A (en) * | 1996-12-20 | 1999-07-06 | Merck & Co., Inc. | Substituted aminoquinolines as modulators of chemokine receptor activity |
| DE19800250A1 (de) | 1997-01-13 | 1998-08-06 | Winter Cvd Technik Gmbh | Schleifkörper |
| FR2758459B1 (fr) * | 1997-01-17 | 1999-05-07 | Pharma Pass | Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation |
| FR2758461A1 (fr) | 1997-01-17 | 1998-07-24 | Pharma Pass | Composition pharmaceutique presentant une biodisponibilite elevee et son procede de preparation |
| US5891845A (en) * | 1997-11-21 | 1999-04-06 | Fuisz Technologies Ltd. | Drug delivery systems utilizing liquid crystal structures |
| AU1809499A (en) * | 1997-12-10 | 1999-06-28 | Awadhesh K. Mishra | Self-emulsifying fenofibrate formulations |
| FR2774591B1 (fr) | 1998-02-12 | 2000-05-05 | Lipha | Composition pharmaceutique comprenant l'association metformine et fibrate et son utilisation pour la preparation de medicaments destines a reduire l'hyperglycemie |
| FR2776191B1 (fr) * | 1998-03-23 | 2002-05-31 | Theramex | Composition hormonale topique a effet systemique |
| IL140276A0 (en) | 1998-06-19 | 2002-02-10 | Rtp Pharma Inc | Processes to generate submicron particles of water-insoluble compounds |
| FR2783421B1 (fr) | 1998-09-17 | 2000-11-24 | Cll Pharma | Procede de preparation de nouvelles formulations galeniques du fenofibrate, formulations galeniques obtenues par ledit procede et leurs applications |
| US6375986B1 (en) * | 2000-09-21 | 2002-04-23 | Elan Pharma International Ltd. | Solid dose nanoparticulate compositions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate |
| JP5296954B2 (ja) | 1998-11-20 | 2013-09-25 | オバン・エナジー・リミテッド | 不溶性微粒子の安定なサスペンションを製造する方法 |
| US7939105B2 (en) | 1998-11-20 | 2011-05-10 | Jagotec Ag | Process for preparing a rapidly dispersing solid drug dosage form |
| US6180138B1 (en) * | 1999-01-29 | 2001-01-30 | Abbott Laboratories | Process for preparing solid formulations of lipid-regulating agents with enhanced dissolution and absorption |
| US6270806B1 (en) | 1999-03-03 | 2001-08-07 | Elan Pharma International Limited | Use of peg-derivatized lipids as surface stabilizers for nanoparticulate compositions |
| US6372251B2 (en) | 1999-06-11 | 2002-04-16 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
| US6982281B1 (en) | 2000-11-17 | 2006-01-03 | Lipocine Inc | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
| FR2795961B1 (fr) | 1999-07-09 | 2004-05-28 | Ethypharm Lab Prod Ethiques | Composition pharmaceutique contenant du fenofibrate micronise, un tensioactif et un derive cellulosique liant et procede de preparation |
| US6251426B1 (en) * | 1999-09-02 | 2001-06-26 | Banner Pharmacaps, Inc. | Ibuprofen-containing softgels |
| JP2003509453A (ja) * | 1999-09-21 | 2003-03-11 | アールティーピー・ファーマ・インコーポレーテッド | 生物学的に活性な物質の、表面改質された粒状組成物 |
| KR100373152B1 (ko) | 1999-11-17 | 2003-02-25 | 가부시키가이샤 아드반테스트 | Ｉｃ 소켓 및 ｉｃ 시험 장치 |
| FR2803203B1 (fr) * | 1999-12-31 | 2002-05-10 | Fournier Ind & Sante | Nouvelles formulations galeniques du fenofibrate |
-
2001
- 2001-08-09 GB GBGB0119480.2A patent/GB0119480D0/en not_active Ceased
-
2002
- 2002-08-09 EP EP02749130A patent/EP1414410B1/de not_active Expired - Lifetime
- 2002-08-09 DE DE60231082T patent/DE60231082D1/de not_active Expired - Lifetime
- 2002-08-09 WO PCT/GB2002/003687 patent/WO2003013474A1/en not_active Ceased
- 2002-08-09 ES ES02749130T patent/ES2321912T3/es not_active Expired - Lifetime
- 2002-08-09 JP JP2003518484A patent/JP4721640B2/ja not_active Expired - Fee Related
- 2002-08-09 AT AT02749130T patent/ATE422155T1/de not_active IP Right Cessation
- 2002-08-09 US US10/486,299 patent/US8663693B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003013474A1 (en) | 2003-02-20 |
| JP4721640B2 (ja) | 2011-07-13 |
| DE60231082D1 (de) | 2009-03-19 |
| US8663693B2 (en) | 2014-03-04 |
| GB0119480D0 (en) | 2001-10-03 |
| EP1414410B1 (de) | 2009-02-04 |
| JP2005509596A (ja) | 2005-04-14 |
| ES2321912T3 (es) | 2009-06-15 |
| EP1414410A1 (de) | 2004-05-06 |
| US20050095297A1 (en) | 2005-05-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60231082D1 (de) | Nanopartikelzusammensetzungen enthaltend fenofibrat | |
| DE60325718D1 (de) | Nystatin-nanopartikelzusammensetzungen | |
| DE60217367D1 (de) | Nanopartikelzusammensetzungen enthaltend insulin | |
| DE60019693D1 (de) | Pharmazeutische zusammensetzungen, die wirkstoffabsorptionsfördernde verbindungen enthalten | |
| DE602004021107D1 (de) | Meloxican-formulierungen in nanoteilchenform | |
| WO2003032953A1 (en) | Granules containing acid-unstable chemical in large amount | |
| EA200702638A1 (ru) | Стабильная композиция (рецептура) с наночастицами ацетаминофена | |
| BR0214679A (pt) | Composições farmacêuticas compreendendo compostos a base de vitamina d ativa | |
| ATE395042T1 (de) | Darreichungsformen welche mikropartikel und treibgas enthalten | |
| PE84899A1 (es) | Formulaciones farmaceuticas que contienen voriconazol | |
| TW200744677A (en) | Compositions and methods for preparation of poorly water soluble drugs with increased stability | |
| UY27350A1 (es) | Azaindoles | |
| JP2005509596A5 (de) | ||
| DE602005023963D1 (de) | Weitere heteropolycyclische verbindungen und deren verwendung als antagonisten des metabotropen glutamatrezeptors | |
| CY1110505T1 (el) | Ανθρωπινα αντισωματα dr4 και χρησεις αυτων | |
| MXPA05007668A (es) | Colorantes hidrofilicos de cianina, reactivos a tiol y conjugados de los mismos con biomoleculas para diagnostico por fluorescencia. | |
| FR2847812B1 (fr) | Composition cosmetique comprenant des nanoparticules fluorescentes comme pigments | |
| BR0213608A (pt) | Composição oral | |
| WO2004084453A3 (en) | METHODS OF MANUFACTURE OF 2'-DEOXY-β-L-NUCLEOSIDES | |
| DE60108154D1 (de) | Pharmazeutische Zubereitungen enthaltend Clavulansäure | |
| DE50210379D1 (de) | Paramagnetische nanopartikel | |
| DE60229417D1 (de) | Setzungen auf basis von pyrogenisch hergestelltem siliziumdioxid | |
| DE60117835D1 (de) | Amino- substituierte tetracyclische Verbindungen die als entzündungshemmende Mittel nützlich sind, und diese enthaltende Arzneimittel. | |
| DE60229450D1 (de) | Topische nanopartikel-spironolacton-formulierung | |
| BRPI0408848A (pt) | formulações orais de cladribine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |