ATE422156T1 - Verfahren zum laden und thermodynamischen aktivieren von arzneimitteln auf polymeren mit superkritischen flüssigkeiten - Google Patents

Verfahren zum laden und thermodynamischen aktivieren von arzneimitteln auf polymeren mit superkritischen flüssigkeiten

Info

Publication number
ATE422156T1
ATE422156T1 AT03711920T AT03711920T ATE422156T1 AT E422156 T1 ATE422156 T1 AT E422156T1 AT 03711920 T AT03711920 T AT 03711920T AT 03711920 T AT03711920 T AT 03711920T AT E422156 T1 ATE422156 T1 AT E422156T1
Authority
AT
Austria
Prior art keywords
drugs
polymers
loading
thermodynamic
supercritical liquids
Prior art date
Application number
AT03711920T
Other languages
English (en)
Inventor
Massimo Bresciani
Luca Dobetti
Stefano Kirchmayer
Original Assignee
Eurand Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurand Pharmaceuticals Ltd filed Critical Eurand Pharmaceuticals Ltd
Application granted granted Critical
Publication of ATE422156T1 publication Critical patent/ATE422156T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
AT03711920T 2002-03-07 2003-03-07 Verfahren zum laden und thermodynamischen aktivieren von arzneimitteln auf polymeren mit superkritischen flüssigkeiten ATE422156T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IE20020184 2002-03-07

Publications (1)

Publication Number Publication Date
ATE422156T1 true ATE422156T1 (de) 2009-02-15

Family

ID=27772935

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03711920T ATE422156T1 (de) 2002-03-07 2003-03-07 Verfahren zum laden und thermodynamischen aktivieren von arzneimitteln auf polymeren mit superkritischen flüssigkeiten

Country Status (10)

Country Link
US (1) US20050163852A1 (de)
EP (1) EP1515699B1 (de)
JP (1) JP5105698B2 (de)
AT (1) ATE422156T1 (de)
AU (1) AU2003218685A1 (de)
CA (1) CA2478519C (de)
DE (1) DE60326071D1 (de)
DK (1) DK1515699T3 (de)
ES (1) ES2321599T3 (de)
WO (1) WO2003074028A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0205868D0 (en) * 2002-03-13 2002-04-24 Univ Nottingham Polymer composite with internally distributed deposition matter
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
GB2417900A (en) * 2004-09-11 2006-03-15 Medway Science Technologies Lt Composition for oral drug delivery
JP5169453B2 (ja) * 2007-05-17 2013-03-27 株式会社リコー 電子写真感光体の製造方法、電子写真感光体、画像形成装置及びプロセスカートリッジ
EP2471516A3 (de) * 2007-09-14 2012-12-26 Wockhardt Limited Rhein- oder Diacereinzusammensetzungen
FR2920991A1 (fr) * 2007-09-14 2009-03-20 Wockhardt Ltd Composition a base de diacerheine pour le traitement de l'arthrose
GB0812742D0 (en) 2008-07-11 2008-08-20 Critical Pharmaceuticals Ltd Process
FR2994850B1 (fr) * 2012-09-04 2015-07-17 Jean-Marie Andre Procede de traitement pour l'elaboration d'implants ou de protheses de polymeres a liberation controlee de principes actifs.
US9204962B2 (en) 2013-03-13 2015-12-08 Acufocus, Inc. In situ adjustable optical mask
CN115531615A (zh) * 2022-09-19 2022-12-30 沈阳百奥医疗器械有限公司 一种浸渍载药方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4598006A (en) * 1985-05-02 1986-07-01 Hercules Incorporated Method for impregnating a thermoplastic polymer
US4695621A (en) * 1985-12-23 1987-09-22 The Dow Chemical Company Method for reducing residual monomers from oversized fat imbibing copolymer beads
GB8928250D0 (en) * 1989-12-14 1990-02-21 Erba Carlo Spa Use of supercritical fluids to obtain porous sponges of biodegradable polymers
US5736371A (en) * 1991-06-04 1998-04-07 A Et S Biovecteurs Biodegradable particulate vector for transporting molecules having biological activity
US5340614A (en) * 1993-02-11 1994-08-23 Minnesota Mining And Manufacturing Company Methods of polymer impregnation
US5977348A (en) * 1997-07-25 1999-11-02 National Starch And Chemical Investment Holding Corporation Polysaccharide modification in densified fluid
IT1296464B1 (it) * 1997-11-19 1999-06-25 Vectorpharma Int Composizioni farmaceutiche in forma di polveri di polimeri reticolati caricati con farmaci e relativo processo di preparazione mediante
US6248797B1 (en) * 1999-05-17 2001-06-19 Shelton A. Dias Supercritical carbon dioxide extraction of contaminants from ion exchange resins
JP2001172524A (ja) * 1999-12-20 2001-06-26 Toray Ind Inc 染料組成物および繊維構造物の染色方法
IT1318404B1 (it) * 2000-03-17 2003-08-25 Eurand Int Processo per la preparazione di formulazioni a rilascio accelerato conimpiego di fluidi compressi.
JP2001295178A (ja) * 2000-04-11 2001-10-26 Toray Ind Inc 繊維用処理剤、それにより処理されてなる繊維構造物およびその製造方法
AU7771901A (en) * 2000-11-30 2002-06-11 Igaki Iryo Sekkei Kk Stent for blood vessel and material for stent for blood vessel
US20030044514A1 (en) * 2001-06-13 2003-03-06 Richard Robert E. Using supercritical fluids to infuse therapeutic on a medical device
TWI230619B (en) * 2001-08-16 2005-04-11 Ind Tech Res Inst Method of crosslinking of porous biodegradable polymers
US8216628B2 (en) * 2001-09-06 2012-07-10 Corn Products Development, Inc. Process for purifying starches

Also Published As

Publication number Publication date
WO2003074028A1 (en) 2003-09-12
JP2006503929A (ja) 2006-02-02
EP1515699A1 (de) 2005-03-23
US20050163852A1 (en) 2005-07-28
AU2003218685A1 (en) 2003-09-16
DE60326071D1 (de) 2009-03-19
CA2478519A1 (en) 2003-09-12
CA2478519C (en) 2011-08-02
DK1515699T3 (da) 2009-05-04
ES2321599T3 (es) 2009-06-09
JP5105698B2 (ja) 2012-12-26
EP1515699B1 (de) 2009-02-04

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