ATE42309T1 - Knockenbildungsfaktoren. - Google Patents

Knockenbildungsfaktoren.

Info

Publication number
ATE42309T1
ATE42309T1 AT85100047T AT85100047T ATE42309T1 AT E42309 T1 ATE42309 T1 AT E42309T1 AT 85100047 T AT85100047 T AT 85100047T AT 85100047 T AT85100047 T AT 85100047T AT E42309 T1 ATE42309 T1 AT E42309T1
Authority
AT
Austria
Prior art keywords
protein
bone
nucking
factors
inducing
Prior art date
Application number
AT85100047T
Other languages
English (en)
Inventor
Arup Sen
Original Assignee
Int Genetic Eng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Int Genetic Eng filed Critical Int Genetic Eng
Application granted granted Critical
Publication of ATE42309T1 publication Critical patent/ATE42309T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Saccharide Compounds (AREA)
  • Magnetic Heads (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT85100047T 1984-01-04 1985-01-02 Knockenbildungsfaktoren. ATE42309T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56816784A 1984-01-04 1984-01-04
EP85100047A EP0148155B1 (de) 1984-01-04 1985-01-02 Knockenbildungsfaktoren

Publications (1)

Publication Number Publication Date
ATE42309T1 true ATE42309T1 (de) 1989-05-15

Family

ID=24270176

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85100047T ATE42309T1 (de) 1984-01-04 1985-01-02 Knockenbildungsfaktoren.

Country Status (11)

Country Link
EP (1) EP0148155B1 (de)
JP (1) JPS60226814A (de)
AT (1) ATE42309T1 (de)
AU (1) AU580975B2 (de)
CA (1) CA1241641A (de)
DE (1) DE3569542D1 (de)
DK (1) DK161524C (de)
GR (1) GR850006B (de)
IE (1) IE57966B1 (de)
NZ (1) NZ210699A (de)
ZA (1) ZA8547B (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
US4627982A (en) * 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
JPH0723322B2 (ja) * 1985-12-07 1995-03-15 克之 藤井 液状骨形成剤からなる注射液
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors
US6432919B1 (en) 1986-07-01 2002-08-13 Genetics Institute, Inc. Bone morphogenetic protein-3 and compositions
US4877864A (en) * 1987-03-26 1989-10-31 Genetics Institute, Inc. Osteoinductive factors
DE3626414C2 (de) * 1986-08-05 1994-11-10 Robapharm Ag Präparat zur Stimulierung von Chondrocyten und Osteoblasten (Ossein-Hydroxyapatit-Komplex), Verfahren zu seiner Herstellung und dieses enthaltende Arzneimittel
EP0271668B1 (de) * 1986-10-22 1991-12-18 Gesellschaft für Biotechnologische Forschung mbH (GBF) Wachstumstimulierendes Material, Herstellungsverfahren und therapeutische Zusammensetzung
PT90216A (pt) * 1988-04-06 1989-11-10 Processo para a preparacao de polipeptidos com actividade osteogenica
US4968590A (en) * 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
US5258494A (en) * 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US5670336A (en) * 1988-04-08 1997-09-23 Stryker Corporation Method for recombinant production of osteogenic protein
US5162114A (en) * 1989-02-23 1992-11-10 Stryker Corporation Bone collagen matrix for xenogenic implants
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
DE68929453T2 (de) * 1988-04-08 2003-11-20 Stryker Corp., Kalamazoo Osteogene Vorrichtungen
US5324819A (en) * 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US5250302A (en) * 1988-04-08 1993-10-05 Stryker Corporation Osteogenic devices
IL90683A0 (en) * 1988-06-27 1990-01-18 Yissum Res Dev Co Osteogenic growth factors derived from regenerating bone marrow
US5106626A (en) * 1988-10-11 1992-04-21 International Genetic Engineering, Inc. Osteogenic factors
PT94241A (pt) * 1989-06-02 1991-02-08 Chiron Corp Processo para a preparacao de factor calcificacao ossea e de composicoes farmaceuticas que os contem
CA2020729A1 (en) * 1989-07-19 1991-01-20 Michael C. Kiefer Bone morphogenetic protein
WO1991005802A1 (en) * 1989-10-17 1991-05-02 Creative Biomolecules, Inc. Osteogenic devices
US5645591A (en) 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US6399569B1 (en) 1991-03-11 2002-06-04 Curis, Inc. Morphogen treatments for limiting proliferation of epithelial cells
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
US5652337A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. OP-3-induced morphogenesis
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5656593A (en) * 1991-03-11 1997-08-12 Creative Biomolecules, Inc. Morphogen induced periodontal tissue regeneration
US6949505B1 (en) 1991-03-11 2005-09-27 Curis, Inc. Morphogen-induced dendritic growth
CA2363965C (en) 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
US5972884A (en) * 1991-03-11 1999-10-26 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US6800603B2 (en) 1991-03-11 2004-10-05 Curis, Inc. Morphogen-induced neural cell adhesion
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
US7056882B2 (en) 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US6090776A (en) * 1991-03-11 2000-07-18 Creative Bio Molecules, Inc. Morphogen treatment of organ implants
US5652118A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. Nucleic acid encoding a novel morphogenic protein, OP-3
US5693615A (en) * 1991-06-05 1997-12-02 The Procter & Gamble Company Therapeutic compositions for osteoinduction
US6022853A (en) * 1991-08-30 2000-02-08 Creative Biomolecules, Inc. Morphogen-enriched dietary composition
KR100259827B1 (ko) 1991-11-04 2000-06-15 브루스 엠. 에이센, 토마스 제이 데스로저 재조합 골형태 형성 단백질 헤테로다이머, 그 조성물 및 사용방법
EP0698094B1 (de) 1993-05-12 2004-02-04 Genetics Institute, LLC Bmp-11 zusammensetzungen
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
EP0733109B9 (de) 1993-12-07 2006-07-05 Genetics Institute, LLC Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen
US5928940A (en) * 1996-09-24 1999-07-27 Creative Biomolecules, Inc. Morphogen-responsive signal transducer and methods of use thereof
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
EP1223990B1 (de) 1999-10-15 2004-07-28 Genetics Institute, LLC Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine
TWI329129B (en) 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
US7728116B2 (en) 2002-06-20 2010-06-01 Altis Biologics (Proprietary) Limited Method of preparing an osteogenic protein fraction
TW200518767A (en) 2003-09-12 2005-06-16 Wyeth Corp Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins
US8734525B2 (en) 2003-12-31 2014-05-27 Warsaw Orthopedic, Inc. Osteoinductive demineralized cancellous bone
EP1701729B1 (de) 2003-12-31 2018-05-02 Warsaw Orthopedic, Inc. Verbesserte knochenmatrixzusammensetzungen und verfahren
JP2008507288A (ja) 2004-07-23 2008-03-13 アクセルロン ファーマ インコーポレーテッド ＡｃｔＲＩＩ受容体ポリペプチド、方法、および組成物
CA2627907C (en) 2005-11-01 2014-06-17 Osteotech, Inc. Osteoinductive composition comprising osteoinductive factors recovered from mineralized bone and a carrier
TW201627320A (zh) 2007-02-02 2016-08-01 艾瑟勒朗法瑪公司 衍生自ＡｃｔＲＩＩＢ的變體與其用途
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
AU2008265850B2 (en) 2007-06-15 2014-06-26 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
CA2945295C (en) 2007-06-15 2020-01-14 Warsaw Orthopedic, Inc. Method of treating tissue
WO2009009688A1 (en) 2007-07-10 2009-01-15 Osteotech, Inc. Delivery system
EP2211921B1 (de) 2007-10-19 2013-12-25 Warsaw Orthopedic, Inc. Demineralisierte knochenmatrix-zusammensetzungen und verfahren
WO2010093950A1 (en) 2009-02-12 2010-08-19 Osteotech, Inc. Delivery system cartridge
ES2658292T3 (es) 2009-11-17 2018-03-09 Acceleron Pharma, Inc. Proteínas ActRIIB y variantes y usos de las mismas con respecto a la inducción de la utrofina para el tratamiento de la distrofia muscular
AU2017338916B2 (en) 2016-10-05 2022-03-24 Acceleron Pharma Inc. Variant ActRIIB proteins and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294753A (en) * 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4608199A (en) * 1984-03-20 1986-08-26 Arnold Caplan Bone protein purification process

Also Published As

Publication number Publication date
ZA8547B (en) 1986-09-24
EP0148155A3 (en) 1986-08-13
DK161524B (da) 1991-07-15
IE850010L (en) 1985-07-04
JPS60226814A (ja) 1985-11-12
AU580975B2 (en) 1989-02-09
NZ210699A (en) 1989-06-28
AU3722184A (en) 1985-07-11
DK2285D0 (da) 1985-01-02
EP0148155B1 (de) 1989-04-19
IE57966B1 (en) 1993-06-02
EP0148155A2 (de) 1985-07-10
DK2285A (da) 1985-07-05
DE3569542D1 (en) 1989-05-24
CA1241641A (en) 1988-09-06
DK161524C (da) 1991-12-23
GR850006B (de) 1985-05-03

Similar Documents

Publication Publication Date Title
AU580975B2 (en) Osteogenic factors
PT87492A (pt) Process for the preparation of benzo ]b" pyrrans and pyranopyridines and pharmaceutical compositions containing them
FI861673L (fi) Menetelmä uusien ihmisen kudosplasminogeeniaktivaattorimutanttien valmistamiseksi
PL275089A1 (en) Method of obtaining novel pharmaceutical compositions
HUT47090A (en) Process for producing new thiazol derivatives and pharmaceutical compositions of leukotrinen-antagonistic activity containing them as active components
IT8547835A1 (it) Procedimento di purificazione di proteine ossee
HUT47274A (en) Process for producing terciary hydroxy-alkyl-xantines and pharmaceutical compositions containing them as active components
IT1164626B (it) Procedimento per il ricupero di ifn-b umano da microorganismi produttori trasformati
HUT45695A (en) Compositions for determining growth of plants and process for producing 5-acylamino-pyrazol derivatives as active components
HUT45252A (en) Process for producing imidazo-pyridine derivatives and pharmaceutical compositions containing them as active components
NZ208831A (en) Imidazolium derivatives and pharmaceutical compositions
HUT48609A (en) Process for producing kumaran derivatives and pharmaceutical compositions comprising same as active ingredient
IT8747583A0 (it) Derivati di diidrobenzofurano - e cromano - carbossammidi, procedimento per prepararli e loro impiegocome neurolettici
GB8729542D0 (en) Upper part of two-part piston for i c engines & process for production thereof
PT80191A (en) Process for preparing substituted benzopyrans useful as medicaments
HUT46837A (en) Compositions of insectifuge and acarifuge activity containing alpha, omega-amino-alkohol derivatives as active components and process for producing the active components
FI891986A7 (fi) Farmaseuttiset koostumukset psoriasiksen hoitoon
HUT46930A (en) Process for producing aminoglycoside-steroides and pharmaceutical compositions containing them as active components
HUT39437A (en) Process for producing new morpholinol derivatives and pharmaceutical compositions containing them as active agents
HUT50157A (en) Process for production of 1,3-dioxane and medical compositions containing them as active substance
FI873701L (fi) Menetelmä kylmäkuivattujen farmaseuttisten fenyylikinoliinikarboksyylihappokoostumusten valmistamiseksi
PT85278A (fr) Procede de preparation d:une fraction immunogene active a liegard des bilharzioses et de compositions immunisantes la contenant
PT87332A (pt) Method of purification of product of expression of recombinant ferment
IT1206247B (it) Metodo e composizione per migliorare il regime di crescita di animali
FI871479A0 (fi) Menetelmä lääkeaineina käyttökelpoisten perhydrotiatsepiini- ja perhydroatsepiinijohdannaisten valmistamiseksi

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee