ATE423220T1 - Testverfahren für verbindungen die frühzeitige translations beendigung und nonsense rns decay hemmen - Google Patents

Testverfahren für verbindungen die frühzeitige translations beendigung und nonsense rns decay hemmen

Info

Publication number
ATE423220T1
ATE423220T1 AT00986492T AT00986492T ATE423220T1 AT E423220 T1 ATE423220 T1 AT E423220T1 AT 00986492 T AT00986492 T AT 00986492T AT 00986492 T AT00986492 T AT 00986492T AT E423220 T1 ATE423220 T1 AT E423220T1
Authority
AT
Austria
Prior art keywords
compounds
decay
nonsense
termination
rns
Prior art date
Application number
AT00986492T
Other languages
English (en)
Inventor
Holger Beckmann
Marc Learned
Stuart Peltz
Kevin Czaplinski
Original Assignee
Ptc Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ptc Therapeutics Inc filed Critical Ptc Therapeutics Inc
Application granted granted Critical
Publication of ATE423220T1 publication Critical patent/ATE423220T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Eye Examination Apparatus (AREA)
  • Detection And Correction Of Errors (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00986492T 1999-12-14 2000-12-13 Testverfahren für verbindungen die frühzeitige translations beendigung und nonsense rns decay hemmen ATE423220T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/461,508 US6458538B1 (en) 1999-12-14 1999-12-14 Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay

Publications (1)

Publication Number Publication Date
ATE423220T1 true ATE423220T1 (de) 2009-03-15

Family

ID=23832841

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00986492T ATE423220T1 (de) 1999-12-14 2000-12-13 Testverfahren für verbindungen die frühzeitige translations beendigung und nonsense rns decay hemmen

Country Status (8)

Country Link
US (3) US6458538B1 (de)
EP (2) EP1238110B1 (de)
JP (1) JP4683808B2 (de)
AT (1) ATE423220T1 (de)
AU (1) AU784947B2 (de)
CA (1) CA2394470C (de)
DE (1) DE60041592D1 (de)
WO (1) WO2001044516A2 (de)

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AU2002319180B2 (en) * 2001-05-23 2007-07-05 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Pyruvate-kinase as a novel target molecule
US20030049666A1 (en) * 2001-07-31 2003-03-13 University Of Utah Tissue culture assay for measuring drug induced translational recoding at premature stop codons and frameshift mutations
WO2003014361A1 (en) * 2001-08-02 2003-02-20 Altana Pharma Ag Novel recombinant gene expression method by stop codon suppression
AU2003247610A1 (en) * 2002-06-21 2004-01-06 Ptc Therapeutics, Inc. METHODS FOR IDENTIFYING SMALL MOLECULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY
EP1525185A1 (de) * 2002-07-24 2005-04-27 PTC Therapeutics, Inc. Acetylaminobenzoesäure-verbindungen und deren verwendung zur nonsense-unterdrückung und behandlung von krankheiten
AU2003252136A1 (en) * 2002-07-24 2004-02-09 Ptc Therapeutics, Inc. METHODS FOR IDENTIFYING SMALL MOLEDULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY
WO2004037976A2 (en) * 2002-08-22 2004-05-06 University Of Rochester NONSENSE-MEDIATED mRNA DECAY
HUE047569T2 (hu) 2003-04-11 2020-04-28 Ptc Therapeutics Inc 1,2,4-oxadiazol-benzoesav vegyület és nonszensz szupresszióra történõ alkalmazása
KR100554514B1 (ko) * 2003-12-26 2006-03-03 삼성전자주식회사 반도체 장치에서 패턴 형성 방법 및 이를 이용한 게이트형성방법.
DK1716233T3 (da) * 2004-01-30 2009-10-26 Maxygen Holdings Ltd Reguleret stopkodongennemlæsning
US20080207538A1 (en) * 2004-03-11 2008-08-28 Lawrence David S Enhanced Production of Functional Proteins From Defective Genes
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EP2215074B1 (de) 2007-09-27 2014-02-19 The United States of America, as Represented by the Secretary, Department of Health and Human Services Isoindolinverbindungen zur behandlung von spinaler muskelatrophie und für andere anwendungen
EP2251437B1 (de) * 2009-05-13 2013-12-04 Hannelore Breitenbach-Koller Verfahren zur Identifizierung von Verbindungen, die die translationale Aktivität von ribosomalen Proteinen in differentieller mRNA-Expression steuern
WO2012021707A2 (en) * 2010-08-11 2012-02-16 The Regents Of The University Of California Premature-termination-codons readthrough compounds
US9216180B2 (en) 2012-10-02 2015-12-22 New York University Pharmaceutical compositions and treatment of genetic diseases associated with nonsense mediated RNA decay
KR20150098675A (ko) 2012-12-24 2015-08-28 라모트 앳 텔-아비브 유니버시티 리미티드 넌센스 돌연변이로부터 생긴 유전적 질환을 치료하기 위한 물질 및 이를 확인하는 방법
CA2987980A1 (en) 2015-06-05 2016-12-08 Ptc Therapeutics, Inc. Use of an aminoglycoside for nonsense mutation suppression and the treatment of disease
US11135221B2 (en) 2015-12-23 2021-10-05 Moonshot Pharma Llc Methods for inducing an immune response
CN105928913A (zh) * 2016-04-14 2016-09-07 天津中医药大学 一种基于细胞表型的高内涵多指标肾毒性的检测方法及其应用
JP2020525434A (ja) 2017-06-22 2020-08-27 ムーンショット ファーマ エルエルシー アンレキサノクス及び免疫調節剤を含む組成物で癌を治療する方法
WO2022204471A1 (en) * 2021-03-26 2022-09-29 Ptc Therapeutics Inc. Regulation of transgene expression using a small molecule inducible splicing switch

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Also Published As

Publication number Publication date
EP1238110B1 (de) 2009-02-18
EP1238110A2 (de) 2002-09-11
US20030008317A1 (en) 2003-01-09
CA2394470C (en) 2011-08-09
WO2001044516A3 (en) 2002-06-06
CA2394470A1 (en) 2001-06-21
AU2272001A (en) 2001-06-25
US6458538B1 (en) 2002-10-01
US20060134681A1 (en) 2006-06-22
JP2003516767A (ja) 2003-05-20
US7026122B2 (en) 2006-04-11
AU784947B2 (en) 2006-08-03
JP4683808B2 (ja) 2011-05-18
EP2036991A1 (de) 2009-03-18
WO2001044516A2 (en) 2001-06-21
DE60041592D1 (de) 2009-04-02

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