ATE423974T1 - Verfahren zum nachweis geringer konzentrationen eines fusionsproteins - Google Patents

Verfahren zum nachweis geringer konzentrationen eines fusionsproteins

Info

Publication number
ATE423974T1
ATE423974T1 AT04774869T AT04774869T ATE423974T1 AT E423974 T1 ATE423974 T1 AT E423974T1 AT 04774869 T AT04774869 T AT 04774869T AT 04774869 T AT04774869 T AT 04774869T AT E423974 T1 ATE423974 T1 AT E423974T1
Authority
AT
Austria
Prior art keywords
fusion protein
sample
protein
binding molecule
low concentrations
Prior art date
Application number
AT04774869T
Other languages
English (en)
Inventor
Frank Staal
Dongen Jacobus Van
Original Assignee
Univ Erasmus Medical Ct
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Erasmus Medical Ct filed Critical Univ Erasmus Medical Ct
Application granted granted Critical
Publication of ATE423974T1 publication Critical patent/ATE423974T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57505—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the blood, e.g. leukaemia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT04774869T 2003-08-12 2004-08-11 Verfahren zum nachweis geringer konzentrationen eines fusionsproteins ATE423974T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03077529A EP1507147A1 (de) 2003-08-12 2003-08-12 Verfahren zum Nachweiss von niedrigem Gehalt an Fusionsprotein

Publications (1)

Publication Number Publication Date
ATE423974T1 true ATE423974T1 (de) 2009-03-15

Family

ID=33560826

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04774869T ATE423974T1 (de) 2003-08-12 2004-08-11 Verfahren zum nachweis geringer konzentrationen eines fusionsproteins

Country Status (11)

Country Link
US (1) US20060172345A1 (de)
EP (2) EP1507147A1 (de)
JP (1) JP2007502404A (de)
CN (1) CN1836165B (de)
AT (1) ATE423974T1 (de)
AU (1) AU2004264178A1 (de)
CA (1) CA2535073A1 (de)
DE (1) DE602004019659D1 (de)
DK (1) DK1660888T3 (de)
ES (1) ES2323067T3 (de)
WO (1) WO2005015235A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4594733B2 (ja) 2002-11-07 2010-12-08 エラスムス ユニフェルシテイト ロッテルダム 腫瘍特異的融合蛋白質の検出のための方法およびプローブ
EP2108956A1 (de) 2008-04-07 2009-10-14 Erasmus University Medical Center Rotterdam Verbesserte Verfahren und Kits zum Erkennen von tumorspezifischen Fusionsproteinen
WO2011050069A1 (en) * 2009-10-20 2011-04-28 Prometheus Laboratories Inc. Proximity-mediated assays for detecting oncogenic fusion proteins
KR102682118B1 (ko) 2016-04-29 2024-07-08 주식회사유한양행 Ccl3 변이체를 포함하는 융합 단백질 및 이의 용도

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091206A (en) * 1987-10-26 1992-02-25 Baxter Diagnostics Inc. Process for producing magnetically responsive polymer particles and application thereof
WO1992021032A1 (en) * 1991-05-24 1992-11-26 The Regents Of The University Of California Methods for the detection of bcr-abl and abnormal abl proteins in leukemia patients
JP3331398B2 (ja) * 1993-05-28 2002-10-07 バクスター、インターナショナル、インコーポレイテッド 不均質な細胞混合物から特定の細胞集団を分離するための方法、装置およびシステム
US5514340A (en) * 1994-01-24 1996-05-07 Magnetix Biotechnology, Inc. Device for separating magnetically labelled cells
US6107457A (en) * 1995-02-16 2000-08-22 Board Of Regents, The University Of Texas System Bcr-Abl directed compositions and uses for inhibiting Philadelphia chromosome stimulated cell growth
US6159748A (en) * 1995-03-13 2000-12-12 Affinitech, Ltd Evaluation of autoimmune diseases using a multiple parameter latex bead suspension and flow cytometry
IL121659A (en) * 1996-10-25 2000-07-16 Bayer Ag Method for determining CPSA in a blood sample
US6686165B2 (en) * 1997-05-20 2004-02-03 Erasmus Universiteit Rotterdam Recognition of tumor-specific gene products in cancer
ATE261125T1 (de) * 1997-05-20 2004-03-15 Univ Erasmus Erkennung von tmorspezifische genprodukte
DE19856261C1 (de) * 1998-12-07 2000-03-30 Hoechst Marion Roussel De Gmbh Aß-Peptid Screening Assay
CA2411392C (en) * 2001-11-07 2012-10-16 Stemcell Technologies Inc. Tetrameric antibody complexes for blocking non-specific binding of antigens

Also Published As

Publication number Publication date
EP1507147A1 (de) 2005-02-16
ES2323067T3 (es) 2009-07-06
EP1660888B1 (de) 2009-02-25
JP2007502404A (ja) 2007-02-08
WO2005015235A1 (en) 2005-02-17
US20060172345A1 (en) 2006-08-03
CN1836165B (zh) 2010-10-06
CN1836165A (zh) 2006-09-20
EP1660888A1 (de) 2006-05-31
DK1660888T3 (da) 2009-06-15
CA2535073A1 (en) 2005-02-17
DE602004019659D1 (de) 2009-04-09
AU2004264178A1 (en) 2005-02-17

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