ATE424821T1 - Pyrrolopyridin-2-karbonsäureamide - Google Patents

Pyrrolopyridin-2-karbonsäureamide

Info

Publication number
ATE424821T1
ATE424821T1 AT05821654T AT05821654T ATE424821T1 AT E424821 T1 ATE424821 T1 AT E424821T1 AT 05821654 T AT05821654 T AT 05821654T AT 05821654 T AT05821654 T AT 05821654T AT E424821 T1 ATE424821 T1 AT E424821T1
Authority
AT
Austria
Prior art keywords
pyrrolopyridine
carbonic acid
acid amides
ischemia
cardioprotectants
Prior art date
Application number
AT05821654T
Other languages
English (en)
Inventor
Thomas Martin Krulle
Robert John Rowley
Gerard Hugh Thomas
Original Assignee
Prosidion Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prosidion Ltd filed Critical Prosidion Ltd
Application granted granted Critical
Publication of ATE424821T1 publication Critical patent/ATE424821T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT05821654T 2004-12-02 2005-12-02 Pyrrolopyridin-2-karbonsäureamide ATE424821T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63246104P 2004-12-02 2004-12-02

Publications (1)

Publication Number Publication Date
ATE424821T1 true ATE424821T1 (de) 2009-03-15

Family

ID=36201419

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05821654T ATE424821T1 (de) 2004-12-02 2005-12-02 Pyrrolopyridin-2-karbonsäureamide

Country Status (7)

Country Link
US (1) US20090099176A1 (de)
EP (1) EP1819332B1 (de)
JP (1) JP2008521873A (de)
AT (1) ATE424821T1 (de)
DE (1) DE602005013275D1 (de)
ES (1) ES2324173T3 (de)
WO (1) WO2006059164A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006137485A1 (ja) 2005-06-24 2006-12-28 Toyama Chemical Co., Ltd. 新規な含窒素複素環化合物およびその塩
EP1829867A1 (de) * 2006-03-03 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Gegenüber dem Sigmarezeptor pharmazeutisch aktive Imidazolverbindungen
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
CN103497181B (zh) 2013-09-30 2016-03-30 承德医学院 作为糖原磷酸化酶抑制剂的苯并氮杂卓酮类化合物、其制备方法及医药用途
CN104744353B (zh) * 2015-03-31 2017-11-24 山东友帮生化科技有限公司 2‑氨基‑3‑碘‑5‑氯吡啶的合成方法
SG10201913587WA (en) 2016-02-05 2020-02-27 Denali Therapeutics Inc Inhibitors of receptor-interacting protein kinase 1
DK3552017T3 (da) 2016-12-09 2022-05-16 Denali Therapeutics Inc Forbindelser, der er anvendelige som ripk1-inhibitorer
CN113906293A (zh) * 2019-05-31 2022-01-07 株式会社新日本科学 使用色谱质谱分析装置的质谱分析方法
CN112442022B (zh) * 2019-09-02 2022-05-20 承德医学院 苯并嗪-4-酮类化合物、其制备方法及医药用途
CN114057716B (zh) * 2020-08-04 2023-06-09 承德医学院 苯并氮杂卓酮类化合物及其盐、其制备方法及医药用途
EP4222143A1 (de) 2020-09-30 2023-08-09 Katholieke Universiteit Leuven 1,2,3,4-tetrahydrochinolinderivate als inhibitoren der yap/taz-tead-aktivierung zur behandlung von krebs
WO2022160138A1 (zh) * 2021-01-27 2022-08-04 承德医学院 苯并嗪-4-酮类化合物、其制备方法及医药用途
WO2023137035A1 (en) 2022-01-12 2023-07-20 Denali Therapeutics Inc. Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8618188D0 (en) 1986-07-25 1986-09-03 Ici Plc Diamine compounds
US5346907A (en) 1988-04-05 1994-09-13 Abbott Laboratories Amino acid analog CCK antagonists
GB8813356D0 (en) 1988-06-06 1988-07-13 Ici Plc Polypeptide compounds
US5672582A (en) 1993-04-30 1997-09-30 Merck & Co., Inc. Thrombin inhibitors
US5821241A (en) 1994-02-22 1998-10-13 Merck & Co., Inc. Fibrinogen receptor antagonists
US5885967A (en) 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
ES2199247T3 (es) 1994-03-11 2004-02-16 Pharmacopeia Drug Discovery, Inc. Derivados de sulfonamida y su uso.
GB2292149A (en) 1994-08-09 1996-02-14 Ferring Res Ltd Peptide inhibitors of pro-interleukin-1beta converting enzyme
US6001811A (en) 1994-11-21 1999-12-14 Cortech Inc. Serine protease inhibitors--N-substituted derivatives
US5618792A (en) 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
TW394764B (en) 1995-02-14 2000-06-21 Mitsubishi Chemcal Corp Oxygen-containing heterocyclic derivatives
DE19516483A1 (de) 1995-05-05 1996-11-07 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
AU5772296A (en) 1995-05-19 1996-11-29 Chiroscience Limited 3,4-disubstituted-phenylsulphonamides and their therapeutic use
JP3314938B2 (ja) 1995-06-06 2002-08-19 ファイザー・インコーポレーテッド グリコーゲンホスホリラーゼ抑制剤としての置換されたｎ−（インドール−２−カルボニル）−グリシンアミド類および誘導体
CA2502764A1 (en) 1995-08-22 1997-03-06 Japan Tobacco Inc. Amide compounds
EP0761680A3 (de) 1995-09-12 1999-05-06 Ono Pharmaceutical Co., Ltd. Tetrazolverbindungen mit Interleukin-1beta-konvertierendes Enzym inhibierende Aktivität
IL119466A (en) 1995-11-03 2001-08-26 Akzo Nobel Nv Thrombin inhibitors, their preparation and pharmaceutical compositions containing them
US6107309A (en) 1995-11-13 2000-08-22 Smithkline Beecham Corporation Hemoregulatory compounds
EP0874638A4 (de) 1995-11-13 1999-07-21 Smithkline Beecham Corp Hämoregulatorische verbindungen
FR2744361B1 (fr) 1996-02-07 1998-02-27 Rhone Poulenc Rorer Sa Application de derives de pyrrolidine a la preparation de medicaments destines au traitement de l'abus de drogues ou de substances donnant lieu a des pharmacomanies ou a un usage excessif
AU719216B2 (en) 1996-02-13 2000-05-04 Akzo Nobel N.V. Serine protease inhibitors
WO1997031016A2 (en) 1996-02-23 1997-08-28 Ariad Pharmaceuticals, Inc. New inhibitors of sh2-mediated processes
IL120310A (en) 1996-03-01 2002-02-10 Akzo Nobel Nv Serine protease inhibitors and pharmaceuticals containing them
US5952322A (en) 1996-12-05 1999-09-14 Pfizer Inc. Method of reducing tissue damage associated with non-cardiac ischemia using glycogen phosphorylase inhibitors
WO1998025617A1 (en) 1996-12-13 1998-06-18 Merck & Co., Inc. Substituted aryl piperazines as modulators of chemokine receptor activity
WO2000077027A2 (en) 1999-06-14 2000-12-21 Tularik Limited Serine protease inhibitors
EP1101759A4 (de) 1998-07-31 2001-12-12 Nippon Soda Co Phenylazol-derivate, verfahren zu ihrer herstellung und medikamente für hyperlipemie
UA73492C2 (en) 1999-01-19 2005-08-15 Aromatic heterocyclic compounds as antiinflammatory agents
WO2000069815A1 (en) 1999-05-13 2000-11-23 Teijin Limited Ureido-substituted cyclic amine derivatives and their use as drug
ES2250132T3 (es) 1999-05-18 2006-04-16 Teijin Limited Remedios preventivos para enfermedades asociadas a quimioquinas.
WO2001002601A2 (en) 1999-07-07 2001-01-11 Du Pont Pharmaceuticals Company Cell-based assay systems for examining hcv ns3 protease activity
CN1192773C (zh) 1999-08-04 2005-03-16 帝人株式会社 环胺ccr3拮抗剂
SE9903998D0 (sv) 1999-11-03 1999-11-03 Astra Ab New compounds
US6797504B1 (en) 2000-09-08 2004-09-28 Dendreon San Diego Llc Inhibitors of serine protease activity of matriptase or MTSP1
EP1136071A3 (de) 2000-03-22 2003-03-26 Pfizer Products Inc. Verwendung von Glykogen-Phosphorylase-Hemmern
AU2001269769A1 (en) 2000-06-07 2001-12-17 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Methods for making bis-heterocyclic alkaloids
CA2411813A1 (en) 2000-06-14 2001-12-20 Eli Lilly And Company Tricyclic compounds as mrp1-inhibitors
WO2002016314A1 (en) 2000-08-18 2002-02-28 H. Lundbeck A/S Substituted polyamine compounds
CA2321348A1 (en) 2000-09-27 2002-03-27 Blaise Magloire N'zemba Aromatic derivatives with hiv integrase inhibitory properties
GB2369117A (en) 2000-11-17 2002-05-22 Warner Lambert Co Bombesin receptor antagonists
PL362320A1 (en) 2000-12-06 2004-10-18 Aventis Pharma Deutschland Gmbh Guanidine and amidine derivatives as factor xa inhibitors
FR2830012B1 (fr) * 2001-09-21 2003-10-31 Servier Lab Nouveaux derives heterocycliques, leur procede de preparation et les compositions pharamaceutiques qui les contiennent
GB0205162D0 (en) * 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
JPWO2003091213A1 (ja) * 2002-04-25 2005-09-02 アステラス製薬株式会社 新規なアミド誘導体又はその塩
US7057046B2 (en) * 2002-05-20 2006-06-06 Bristol-Myers Squibb Company Lactam glycogen phosphorylase inhibitors and method of use
JP2006528702A (ja) * 2003-05-21 2006-12-21 プロシディオン・リミテッド グリコーゲンホスホリラーゼのピロロピリジン−２−カルボン酸アミドインヒビター

Also Published As

Publication number Publication date
WO2006059164A3 (en) 2006-08-17
US20090099176A1 (en) 2009-04-16
ES2324173T3 (es) 2009-07-31
EP1819332A2 (de) 2007-08-22
DE602005013275D1 (de) 2009-04-23
JP2008521873A (ja) 2008-06-26
WO2006059164A2 (en) 2006-06-08
EP1819332B1 (de) 2009-03-11

Similar Documents

Publication Publication Date Title
NO20055305D0 (no) Pyrrolopyridin-2-karboksylsyreamid-inhibitorer av glykogenfosforylase
EA200501095A1 (ru) Фенилацетамиды и их применение в качестве модуляторов глюкокиназы
NO20081315L (no) Benzokinazolinderivater og deres anvendelse ved behandling av benlidelser
JO2282B1 (en) Oxazole derivatives
TW200718424A (en) Novel compounds of amino sulfonyl derivatives
ATE384058T1 (de) Thiazolderivate
EA201000050A1 (ru) Замещенные бициклолактамные соединения
NO20081846L (no) Bifenylderivater og deres anvendelse ved behandling av hepatitt C
NO20074275L (no) 2- (4-okso-4H-kinazolin-3-yl) acetamider og deres anvendelse som Vasopressin-V3-antagonister
SE0401971D0 (sv) Piperidne derivatives
GB0413087D0 (en) Therapeutic compounds
NO20070224L (no) 2-karbamid-4-fenyltiazolderivater, fremstilling og terapeutisk anvendelse derav
NO20082496L (no) Pyrazinderivater
NO20082445L (no) Neuropeptid-2 reseptor-agonister
NO20082096L (no) Azaindol-2-karboksamidderivativer
DE602005013275D1 (de) Pyrrolopyridin-2-karbonsäureamide
NO20080394L (no) N-(arylalkyl)-1H-pyrrolopyridin-2-karboksamidderivater, fremstilling og anvendelse derav
ATE483708T1 (de) Pyrrolopyridin-2-carbonsäurehydrazide als inhibitoren von glykogenphosphorylase
NO20062021L (no) Omleirede pentanoler, fremgangsmpte for fremstilling av dette, og deres anvendelse som antiflogistika
EA201000439A1 (ru) Бензотиазолы в качестве модуляторов рецептора грелина
NO20063576L (no) 1,3-dioksanederivativer og analoge forbindelser for behandling av fedme og diabetes
NO20073941L (no) Dihydroimidazotiazolderivater
ATE478856T1 (de) Spirobenzodioxole und deren verwendung als cb1- antagonisten
ATE467632T1 (de) Pyrroloä2,3-büpyridinderivate als modulatoren des h3-rezeptors
ATE449776T1 (de) Pyrroloä2,3-cüpyridinderivate

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties