ATE425162T1 - Thiazolderivate als npy-antagonisten - Google Patents

Thiazolderivate als npy-antagonisten

Info

Publication number: ATE425162T1
Authority: AT; Austria
Prior art keywords: thiazole derivatives; npy antagonists; npy; antagonists; compounds
Prior art date: 2003-08-12

Application number

AT04763756T

Other languages

English (en)

Inventor

Werner Neidhart

Matthias Nettekoven

Philippe Pflieger

Sven Taylor

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-08-12

Filing date

2004-08-04

Publication date

2009-03-15

2004-08-04 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2009-03-15 Application granted granted Critical

2009-03-15 Publication of ATE425162T1 publication Critical patent/ATE425162T1/de

Links

239000005557 antagonist Substances 0.000 title abstract 2
150000007979 thiazole derivatives Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
208000008589 Obesity Diseases 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
BPGXUIVWLQTVLZ-OFGSCBOVSA-N neuropeptide y(npy) Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 BPGXUIVWLQTVLZ-OFGSCBOVSA-N 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Photoreceptors In Electrophotography (AREA)
Adhesives Or Adhesive Processes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT04763756T 2003-08-12 2004-08-04 Thiazolderivate als npy-antagonisten ATE425162T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03017633		2003-08-12

Publications (1)

Publication Number	Publication Date
ATE425162T1 true ATE425162T1 (de)	2009-03-15

Family

ID=34130065

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04763756T ATE425162T1 (de)	2003-08-12	2004-08-04	Thiazolderivate als npy-antagonisten

Country Status (14)

Country	Link
US (1)	US7265109B2 (de)
EP (1)	EP1656374B1 (de)
JP (1)	JP2007501824A (de)
KR (1)	KR20060037436A (de)
CN (1)	CN100393718C (de)
AT (1)	ATE425162T1 (de)
AU (1)	AU2004263312A1 (de)
BR (1)	BRPI0413458A (de)
CA (1)	CA2533464A1 (de)
DE (1)	DE602004019939D1 (de)
ES (1)	ES2321299T3 (de)
MX (1)	MXPA06001561A (de)
RU (1)	RU2321586C2 (de)
WO (1)	WO2005014593A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2006034341A2 (en) *	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
AU2006331656B2 (en) *	2005-12-22	2012-08-09	Icagen, Inc.	Calcium channel antagonists
US8889674B2 (en)	2009-03-05	2014-11-18	Shionogi & Co., Ltd.	Piperidine and pyrrolidine derivatives having NPY Y5 receptor antagonism
CA3229226A1 (en)	2021-08-18	2023-02-23	Chemocentryx, Inc.	Aryl sulfonyl compounds as ccr6 inhibitors
JP2024534781A (ja)	2021-08-18	2024-09-26	ケモセントリックス，インコーポレイティド	Ｃｃｒ６阻害剤としてのアリールスルホニル（ヒドロキシ）ピペリジン

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1247547A (en) *	1983-06-22	1988-12-28	Paul Hadvary	Leucine derivatives
US4844839A (en)	1984-09-04	1989-07-04	Manchak Frank	In situ treatment and analysis of wastes
US4776409A (en)	1984-09-04	1988-10-11	Manchak Frank	Insitu waste impoundment treating apparatus and method of using same
US5246960A (en)	1984-12-21	1993-09-21	Hoffmann-La Roche Inc.	Oxetanones
CA1270837A (en)	1984-12-21	1990-06-26	Hoffmann-La Roche Limited	Oxetanones
CA1328881C (en)	1984-12-21	1994-04-26	Pierre Barbier	Process for the manufacture of oxetanones
EP0235249B1 (de)	1985-08-26	1992-12-23	MANCHAK, Frank, Jr.	Vorrichtung zur in-situ-behandlung von gefährlichem abfall und deren verwendung
CA2035972C (en)	1990-02-23	2006-07-11	Martin Karpf	Process for the preparation of oxetanones
US5274143A (en)	1991-07-23	1993-12-28	Hoffmann-La Roche Inc.	Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione
US5245960A (en) *	1992-07-22	1993-09-21	Outboard Marine Corporation	Integral bracket and idler assembly
FR2728901B1 (fr) *	1994-12-28	1997-03-28	Sanofi Sa	Derives de phenyl-4-thiazoles substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
US6004996A (en)	1997-02-05	1999-12-21	Hoffman-La Roche Inc.	Tetrahydrolipstatin containing compositions
US6267952B1 (en)	1998-01-09	2001-07-31	Geltex Pharmaceuticals, Inc.	Lipase inhibiting polymers
DE19824175A1 (de) *	1998-05-29	1999-12-02	Novartis Ag	Amino-azol-Verbindungen
PT1105123E (pt)	1998-08-14	2004-08-31	Hoffmann La Roche	Composicoes farmaceuticas contendo inibidores da lipase e quitosano
CA2340056C (en)	1998-08-14	2007-01-09	F. Hoffmann-La Roche Ag	Pharmaceutical compositions containing lipase inhibitors
US6340683B1 (en) *	1999-04-22	2002-01-22	Synaptic Pharmaceutical Corporation	Selective NPY (Y5) antagonists (triazines)
WO2001064675A1 (en) *	2000-03-03	2001-09-07	Novartis Ag	Condensed thiazolamines and their use as neuropeptide y5 antagonists
EP1417188A1 (de) *	2001-08-03	2004-05-12	Novo Nordisk A/S	Neue 2-4-diaminothiazolderivaten
KR100611854B1 (ko) *	2002-02-28	2006-08-11	에프. 호프만-라 로슈 아게	신경 펩타이드 ｙ(ｎｐｙ) 수용체 길항제로서의 티아졸유도체
EP1597256A1 (de) *	2003-02-21	2005-11-23	Pfizer Inc.	N-heterocyclylsubstituierte aminothiazolderivate als proteinkinaseinhibitoren

2004
- 2004-08-04 WO PCT/EP2004/008699 patent/WO2005014593A1/en not_active Ceased
- 2004-08-04 CN CNB200480022677XA patent/CN100393718C/zh not_active Expired - Fee Related
- 2004-08-04 KR KR1020067002853A patent/KR20060037436A/ko not_active Abandoned
- 2004-08-04 CA CA002533464A patent/CA2533464A1/en not_active Abandoned
- 2004-08-04 RU RU2006107448/04A patent/RU2321586C2/ru not_active IP Right Cessation
- 2004-08-04 JP JP2006522950A patent/JP2007501824A/ja active Pending
- 2004-08-04 AU AU2004263312A patent/AU2004263312A1/en not_active Abandoned
- 2004-08-04 DE DE602004019939T patent/DE602004019939D1/de not_active Expired - Lifetime
- 2004-08-04 EP EP04763756A patent/EP1656374B1/de not_active Expired - Lifetime
- 2004-08-04 AT AT04763756T patent/ATE425162T1/de not_active IP Right Cessation
- 2004-08-04 MX MXPA06001561A patent/MXPA06001561A/es not_active Application Discontinuation
- 2004-08-04 ES ES04763756T patent/ES2321299T3/es not_active Expired - Lifetime
- 2004-08-04 BR BRPI0413458-3A patent/BRPI0413458A/pt not_active IP Right Cessation
- 2004-08-10 US US10/915,190 patent/US7265109B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1656374A1 (de)	2006-05-17
RU2321586C2 (ru)	2008-04-10
MXPA06001561A (es)	2006-05-15
EP1656374B1 (de)	2009-03-11
US20050038073A1 (en)	2005-02-17
CN1832947A (zh)	2006-09-13
WO2005014593A1 (en)	2005-02-17
KR20060037436A (ko)	2006-05-03
DE602004019939D1 (de)	2009-04-23
US7265109B2 (en)	2007-09-04
AU2004263312A1 (en)	2005-02-17
CN100393718C (zh)	2008-06-11
RU2006107448A (ru)	2007-09-20
JP2007501824A (ja)	2007-02-01
ES2321299T3 (es)	2009-06-04
CA2533464A1 (en)	2005-02-17
BRPI0413458A (pt)	2006-10-17

Legal Events

Date	Code	Title	Description
2009-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
NO20060664L (no)	2006-05-16	N-substituerte benzimidazolyl C-kit inhibitorer
NO20060665L (no)	2006-05-16	N-substituerte pyrazolyl-amidyl-benzimidazolyl C-kit inhibitorer
DE602004024375D1 (de)	2010-01-14	Carboxamidderivate
ATE433981T1 (de)	2009-07-15	Heterocyclische verbindungen
NO20082388L (no)	2008-08-26	Heteroaryl substituerte piperidinderivater som L-CPT1 inhibitorer
CY1112886T1 (el)	2016-04-13	Ανοσοκατασταλτικος παραγοντας ο οποιος περιλαμβανει μια ετεροκυκλικη ενωση ως δραστικο συστατικο
TW200738655A (en)	2007-10-16	Novel bicyclic sulfonamide derivatives
ATE478044T1 (de)	2010-09-15	Biphenylderivate und ihre verwendung bei der behandlung von hepatitis c
MX2009004441A (es)	2009-05-22	Derivados de indazol utiles como inhibidores de las isoformas de higado.
NL1027811A1 (nl)	2005-06-21	Heterocyclische aminen als remmers 11- -hydroxy-steroïd-dehydrogenase type 1.
ATE537830T1 (de)	2012-01-15	Nicotinamid derivate und ihre verwendung als therapeutika
CY1116885T1 (el)	2017-04-05	Υποκατεστημενα παραγωγα κυκλοεξυλομεθυλιου
EA200700096A1 (ru)	2007-06-29	Производные 2-карбамид-4-фенилтиазола, способ их получения и их применение в терапии
TW200745032A (en)	2007-12-16	Novel heterobicyclic derivatives
DE602005023015D1 (de)	2010-09-30	Indolderivate als viruzide
ATE384058T1 (de)	2008-02-15	Thiazolderivate
DE602006011752D1 (de)	2010-03-04	Als antikoagulationsmittel geeignete phenylglycinamid- und pyridylglycinamidderivate
ATE553106T1 (de)	2012-04-15	Heteroarylpyrrolopyridinone als kinaseinhibitoren
ATE359791T1 (de)	2007-05-15	Pyrimidin-2,4-dion-derivate als matrix- metalloproteinase-hemmer
EA200800302A1 (ru)	2008-08-29	Применение производных и аналогов тиазола при лечении рака
NO20070089L (no)	2007-01-05	DPP-IV inhibitorer
ATE476431T1 (de)	2010-08-15	Piperidin- und azetidinderivate als glyt1- inhibitoren
DE602004010529D1 (de)	2008-01-17	2-amino-5-benzoylthiazol npy-antagonisten
TW200734313A (en)	2007-09-16	Piperazines and piperidines as mGluR5 potentiators
ATE412636T1 (de)	2008-11-15	Piperazinylpyridinderivate als mittel gegen adipositas