ATE425258T1 - Verfahren zur herstellung von (r)- und (s)-4-(1- aminomethyl)benzoesäuremethylester-sulfat aus racemischem 4-(1- amin0ethyl)benzoesäuremethylester - Google Patents
Verfahren zur herstellung von (r)- und (s)-4-(1- aminomethyl)benzoesäuremethylester-sulfat aus racemischem 4-(1- amin0ethyl)benzoesäuremethylesterInfo
- Publication number
- ATE425258T1 ATE425258T1 AT06830713T AT06830713T ATE425258T1 AT E425258 T1 ATE425258 T1 AT E425258T1 AT 06830713 T AT06830713 T AT 06830713T AT 06830713 T AT06830713 T AT 06830713T AT E425258 T1 ATE425258 T1 AT E425258T1
- Authority
- AT
- Austria
- Prior art keywords
- benzoic acid
- methyl ester
- acid methyl
- aminoethyl
- racemic
- Prior art date
Links
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 title abstract 3
- XSYGLHLLQZGWPT-UHFFFAOYSA-N methyl 4-(1-aminoethyl)benzoate Chemical compound COC(=O)C1=CC=C(C(C)N)C=C1 XSYGLHLLQZGWPT-UHFFFAOYSA-N 0.000 title abstract 3
- QPJVMBTYPHYUOC-UHFFFAOYSA-N methyl benzoate Chemical compound COC(=O)C1=CC=CC=C1 QPJVMBTYPHYUOC-UHFFFAOYSA-N 0.000 title 2
- 238000004519 manufacturing process Methods 0.000 title 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 102000004882 Lipase Human genes 0.000 abstract 1
- 108090001060 Lipase Proteins 0.000 abstract 1
- 239000004367 Lipase Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 235000019421 lipase Nutrition 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/34—Preparation of optical isomers by separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
- C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE200510062966 DE102005062966A1 (de) | 2005-12-28 | 2005-12-28 | Verfahren zur Herstellung von (R)- und (S)-4-(Ammoniumethyl)benzoesäuremethylester-sulfat |
| DE200610001160 DE102006001160A1 (de) | 2006-01-06 | 2006-01-06 | Verfahren zur Herstellung von (R) und (S)-4-(1-Aminoethyl)benzoesäure-methylester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE425258T1 true ATE425258T1 (de) | 2009-03-15 |
Family
ID=37983555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06830713T ATE425258T1 (de) | 2005-12-28 | 2006-12-19 | Verfahren zur herstellung von (r)- und (s)-4-(1- aminomethyl)benzoesäuremethylester-sulfat aus racemischem 4-(1- amin0ethyl)benzoesäuremethylester |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8008062B2 (fr) |
| EP (1) | EP1969129B1 (fr) |
| JP (1) | JP5329973B2 (fr) |
| AT (1) | ATE425258T1 (fr) |
| DE (1) | DE502006003145D1 (fr) |
| WO (1) | WO2007077120A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH709629B1 (de) | 2000-10-06 | 2015-11-30 | Chemspeed Technologies Ag | Vorrichtung mit einem Werkzeughalter, einem Werkzeug und einer Waage. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991019002A1 (fr) | 1990-06-01 | 1991-12-12 | Carlbiotech Ltd. A/S | Procede d'enrichissement chiral d'amines primaires asymetriques |
| DE4332738A1 (de) | 1993-09-25 | 1995-03-30 | Basf Ag | Racematspaltung primärer und sekundärer Amine durch Enzym-katalysierte Acylierung |
| WO1997020946A1 (fr) * | 1995-12-06 | 1997-06-12 | Bayer Aktiengesellschaft | Procede de production d'amines optiquement actives |
| ATE293603T1 (de) | 1997-10-14 | 2005-05-15 | Mitsubishi Pharma Corp | Piperazin-verbindungen und ihre medizinische verwendung |
| MXPA06011555A (es) * | 2004-05-04 | 2006-12-15 | Pfizer | Compuestos de metil-aril o heteroaril-amida sustituida. |
-
2006
- 2006-12-19 JP JP2008547944A patent/JP5329973B2/ja not_active Expired - Fee Related
- 2006-12-19 EP EP06830713A patent/EP1969129B1/fr not_active Not-in-force
- 2006-12-19 US US12/159,283 patent/US8008062B2/en not_active Expired - Fee Related
- 2006-12-19 AT AT06830713T patent/ATE425258T1/de not_active IP Right Cessation
- 2006-12-19 DE DE502006003145T patent/DE502006003145D1/de active Active
- 2006-12-19 WO PCT/EP2006/069890 patent/WO2007077120A1/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1969129A1 (fr) | 2008-09-17 |
| JP2009522230A (ja) | 2009-06-11 |
| DE502006003145D1 (de) | 2009-04-23 |
| EP1969129B1 (fr) | 2009-03-11 |
| JP5329973B2 (ja) | 2013-10-30 |
| US8008062B2 (en) | 2011-08-30 |
| US20080305530A1 (en) | 2008-12-11 |
| WO2007077120A1 (fr) | 2007-07-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |