ATE426592T1 - Verfahren zur herstellung von substituierten octanoyl-amiden - Google Patents

Verfahren zur herstellung von substituierten octanoyl-amiden

Info

Publication number
ATE426592T1
ATE426592T1 AT01940047T AT01940047T ATE426592T1 AT E426592 T1 ATE426592 T1 AT E426592T1 AT 01940047 T AT01940047 T AT 01940047T AT 01940047 T AT01940047 T AT 01940047T AT E426592 T1 ATE426592 T1 AT E426592T1
Authority
AT
Austria
Prior art keywords
producing substituted
amides
octanoyl amides
substituted octanoyl
producing
Prior art date
Application number
AT01940047T
Other languages
English (en)
Inventor
Peter Herold
Stefan Stutz
Felix Spindler
Original Assignee
Speedel Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Speedel Pharma Ag filed Critical Speedel Pharma Ag
Application granted granted Critical
Publication of ATE426592T1 publication Critical patent/ATE426592T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C247/12—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT01940047T 2000-07-05 2001-06-26 Verfahren zur herstellung von substituierten octanoyl-amiden ATE426592T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH13292000 2000-07-05
CH24502000 2000-12-15

Publications (1)

Publication Number Publication Date
ATE426592T1 true ATE426592T1 (de) 2009-04-15

Family

ID=25738979

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01940047T ATE426592T1 (de) 2000-07-05 2001-06-26 Verfahren zur herstellung von substituierten octanoyl-amiden

Country Status (23)

Country Link
US (1) US6730798B2 (de)
EP (1) EP1296935B1 (de)
JP (1) JP4900755B2 (de)
KR (1) KR100690471B1 (de)
CN (1) CN100482636C (de)
AR (1) AR029564A1 (de)
AT (1) ATE426592T1 (de)
AU (2) AU7376301A (de)
BR (1) BR0112362B1 (de)
CA (1) CA2414847C (de)
CY (1) CY1109110T1 (de)
DE (1) DE60138099D1 (de)
DK (1) DK1296935T3 (de)
ES (1) ES2322547T3 (de)
HU (1) HU228526B1 (de)
IL (4) IL153717A0 (de)
MX (1) MXPA02012628A (de)
NO (1) NO328105B1 (de)
NZ (1) NZ523088A (de)
PL (1) PL212898B1 (de)
PT (1) PT1296935E (de)
TW (1) TWI289551B (de)
WO (1) WO2002002508A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003103653A1 (en) * 2002-06-11 2003-12-18 Elan Pharmaceuticals, Inc. Methods of treating alzheimer's disease using aryl alkanoic acid amides
GB0419361D0 (en) 2004-08-31 2004-10-06 Novartis Ag Organic compounds
GB0511686D0 (en) 2005-06-08 2005-07-13 Novartis Ag Organic compounds
WO2007006532A1 (en) 2005-07-11 2007-01-18 Novartis Ag New pyrocatechin derivatives
GB0519764D0 (en) 2005-09-28 2005-11-09 Novartis Ag Organic compounds
GB2431649A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431645A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
DE102005052195A1 (de) 2005-10-28 2007-05-03 Reuter Chemischer Apparatebau Kg Verfahren zur Herstellung von chiralen Octensäurederivaten
GB0605688D0 (en) * 2006-03-21 2006-05-03 Novartis Ag Organic compounds
PE20081157A1 (es) * 2006-11-07 2008-09-26 Novartis Ag Forma cristalina de hemifumarato de alisquireno
AU2007316878B2 (en) * 2006-11-09 2011-07-14 Novartis Ag Salt of aliskiren with orotic acid
EP1958666A1 (de) 2007-02-13 2008-08-20 Speedel Experimenta AG Heterozyklische substituierte Alkanamide als therapeutische Verbindungen
DE102007049039A1 (de) 2007-10-11 2009-04-16 Reuter Chemischer Apparatebau Kg Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung
BRPI0822652A2 (pt) * 2007-11-13 2015-06-23 Teva Pharmáceutica Ind Ltd Petach Tirva 49131 Fórmulas polimórficas de hemifumarato de alisquireno e processos para a sua preparação
EP2062874B1 (de) 2007-11-20 2014-12-17 KRKA, tovarna zdravil, d.d., Novo mesto Verfahren und Zwischenprodukte für die Herstellung von Aliskiren
EP2280937A1 (de) * 2008-05-23 2011-02-09 Teva Pharmaceutical Industries Ltd. Aliskiren-monofumarat und verfahren zu seiner herstellung
SI2189442T1 (sl) 2008-11-20 2015-03-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Postopek in intermediati za pripravo aliskirena
CN102046162A (zh) 2009-02-05 2011-05-04 特瓦制药工业有限公司 阿利吉仑化合物的固态形式
WO2010089105A2 (en) 2009-02-05 2010-08-12 Krka, Tovarna Zdravil, D.D., Novo Mesto Moisture-activated granulation process
US20120220663A1 (en) 2009-09-03 2012-08-30 Teva Pharmaceuticals Usa, Inc. Solid forms of aliskiren hemifumarate and processes for preparation thereof
US8203005B2 (en) 2009-10-29 2012-06-19 Carbo Design Llc Manufacturing process for enantiomerically pure 8-aryloctanoic acids as Aliskiren
US20110113995A1 (en) * 2009-11-13 2011-05-19 Lindsay Corporation Method and apparatus for planting and irrigation
WO2011148392A1 (en) * 2010-05-28 2011-12-01 Msn Laboratories Limited Process for the preparation of (2s,4s,5s,7s)-n-(2-carbamyl-2- methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3- methoxypropoxy)phenyl]-octanamide hemifumarate and its intermediates thereof
SI2630118T1 (sl) 2010-10-19 2015-03-31 Mylan Laboratories Limited Sinteza aliskirena
ITMI20110893A1 (it) * 2011-05-19 2012-11-20 Chemelectiva S R L Processi ed intermedi per la sintesi di aliskiren
EP2551260A1 (de) 2011-07-28 2013-01-30 Chemo Ibérica, S.A. Chemisches Verfahren zum Öffnen von Ringverbindungen
US8703976B2 (en) 2011-10-02 2014-04-22 Milan Soukup Manufacturing process for 8-aryloctanoic acids such as Aliskiren
WO2013118138A1 (en) 2011-12-13 2013-08-15 Laboratories Ltd Mylan Novel process for the preparation of renin inhibitors
EP2814806B1 (de) 2012-02-17 2016-05-25 Mylan Laboratories Ltd. Verbessertes verfahren zur herstellung von aliskiren
WO2013124868A2 (en) 2012-02-21 2013-08-29 Mylan Laboratories Limited Solid form of aliskiren intermediate
WO2013144979A1 (en) 2012-03-28 2013-10-03 Maylan Laboratories Ltd Process for the preparation of aliskiren
WO2013171767A1 (en) 2012-05-18 2013-11-21 Mylan Laboratories Limited An improved process for the preparation of aliskiren
CN106220528B (zh) * 2014-02-28 2018-05-08 华润双鹤药业股份有限公司 阿利吉仑的4-位差向异构体、其制备方法及用途
CN106146339B (zh) * 2015-04-23 2018-02-23 华润双鹤药业股份有限公司 阿利吉仑的5‑位差向异构体、其制备方法及用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4492799A (en) * 1979-07-02 1985-01-08 Union Carbide Corporation Halo-4-alkenoic acids and their use as pesticidal intermediates
FR2666757B1 (fr) * 1990-09-14 1992-12-18 Usinor Sacilor Virole pour cylindre de coulee continue des metaux, notamment de l'acier, entre cylindres ou sur un cylindre.
US5606078A (en) * 1994-04-18 1997-02-25 Ciba-Geigy Corporation 3,5-Disubstituted tetrahydrofuran-2-ones
US5659065A (en) * 1994-04-18 1997-08-19 Novartis Corporation Alpha-aminoalkanoic acids and reduction products
MY119161A (en) * 1994-04-18 2005-04-30 Novartis Ag Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities
ATE174237T1 (de) * 1994-07-18 1998-12-15 Siemens Ag Giesswalzen-verschleissschutzschicht
AU7418198A (en) * 1997-05-23 1998-12-11 Voest-Alpine Industrieanlagenbau Gmbh Casting cylinder for thin-band continuous casting installation
PT1200390E (pt) * 1999-07-29 2008-12-05 Speedel Pharma Ag Produção de 2,7-dialquil-4-hidroxi-5-amino-8-ariloctanoilamidas n-substituídas

Also Published As

Publication number Publication date
US6730798B2 (en) 2004-05-04
NO20030012L (no) 2003-03-03
JP4900755B2 (ja) 2012-03-21
JP2004502667A (ja) 2004-01-29
IL187795A0 (en) 2008-03-20
KR20030017543A (ko) 2003-03-03
WO2002002508A1 (en) 2002-01-10
HK1093201A1 (zh) 2007-02-23
MXPA02012628A (es) 2004-09-10
US20030149303A1 (en) 2003-08-07
PL358887A1 (en) 2004-08-23
HUP0301463A2 (hu) 2003-09-29
BR0112362B1 (pt) 2013-12-31
IL187796A0 (en) 2008-03-20
AR029564A1 (es) 2003-07-02
PT1296935E (pt) 2009-05-15
IL187796A (en) 2009-05-04
CY1109110T1 (el) 2014-07-02
CN1440381A (zh) 2003-09-03
TWI289551B (en) 2007-11-11
PL212898B1 (pl) 2012-12-31
NO20030012D0 (no) 2003-01-02
IL187795A (en) 2009-05-04
DK1296935T3 (da) 2009-06-22
AU7376301A (en) 2002-01-14
NZ523088A (en) 2004-06-25
CN100482636C (zh) 2009-04-29
EP1296935B1 (de) 2009-03-25
IL153717A0 (en) 2003-07-06
EP1296935A1 (de) 2003-04-02
CA2414847C (en) 2009-06-16
BR0112362A (pt) 2003-05-13
HUP0301463A3 (en) 2008-03-28
NO328105B1 (no) 2009-12-07
ES2322547T3 (es) 2009-06-23
KR100690471B1 (ko) 2007-03-09
CA2414847A1 (en) 2002-01-10
IL153717A (en) 2008-11-03
HU228526B1 (hu) 2013-03-28
AU2001273763B2 (en) 2006-07-13
DE60138099D1 (de) 2009-05-07

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