ATE427489T1 - Diagnostische marker fur ischamie und mortalitatsrisiken - Google Patents

Diagnostische marker fur ischamie und mortalitatsrisiken

Info

Publication number
ATE427489T1
ATE427489T1 AT02768861T AT02768861T ATE427489T1 AT E427489 T1 ATE427489 T1 AT E427489T1 AT 02768861 T AT02768861 T AT 02768861T AT 02768861 T AT02768861 T AT 02768861T AT E427489 T1 ATE427489 T1 AT E427489T1
Authority
AT
Austria
Prior art keywords
ischemia
diagnostic markers
mortality risk
concentration
ischemic
Prior art date
Application number
AT02768861T
Other languages
English (en)
Inventor
Alan Kleinfeld
Original Assignee
Torrey Pines Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torrey Pines Inst filed Critical Torrey Pines Inst
Application granted granted Critical
Publication of ATE427489T1 publication Critical patent/ATE427489T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2871—Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT02768861T 2001-09-14 2002-09-16 Diagnostische marker fur ischamie und mortalitatsrisiken ATE427489T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32252301P 2001-09-14 2001-09-14
US10/243,566 US7262017B2 (en) 2001-09-14 2002-09-13 Diagnostic markers for ischemia

Publications (1)

Publication Number Publication Date
ATE427489T1 true ATE427489T1 (de) 2009-04-15

Family

ID=26935946

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02768861T ATE427489T1 (de) 2001-09-14 2002-09-16 Diagnostische marker fur ischamie und mortalitatsrisiken

Country Status (10)

Country Link
US (2) US7262017B2 (de)
EP (1) EP1425582B1 (de)
JP (2) JP4579537B2 (de)
KR (1) KR20040039177A (de)
CN (1) CN100554963C (de)
AT (1) ATE427489T1 (de)
AU (1) AU2002331867B2 (de)
CA (1) CA2425784A1 (de)
DE (1) DE60231814D1 (de)
WO (1) WO2003025571A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050154407A1 (en) * 2000-12-20 2005-07-14 Fox Hollow Technologies, Inc. Method of evaluating drug efficacy for treating atherosclerosis
US20100121360A9 (en) * 2000-12-20 2010-05-13 Fox Hollow Technologies, Inc Testing a patient population having a cardiovascular condition for drug efficacy
US7699790B2 (en) * 2000-12-20 2010-04-20 Ev3, Inc. Debulking catheters and methods
US7202089B2 (en) * 2001-09-14 2007-04-10 Alan Kleinfeld Early diagnosis of stroke
US7063782B2 (en) 2001-11-26 2006-06-20 Ischemia Technologies, Inc. Electrochemical detection of ischemia
US7074194B2 (en) 2003-05-19 2006-07-11 Ischemia Technologies, Inc. Apparatus and method for risk stratification of patients with chest pain of suspected cardiac origin
US7634360B2 (en) * 2003-09-23 2009-12-15 Prediction Sciences, LL Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof
US7274772B2 (en) * 2004-05-27 2007-09-25 Cabot Microelectronics Corporation X-ray source with nonparallel geometry
WO2006036476A2 (en) * 2004-09-07 2006-04-06 The General Hospital Corporation Methods of detecting myocardial ischemia and myocardial infarction
US7794413B2 (en) * 2005-04-19 2010-09-14 Ev3, Inc. Libraries and data structures of materials removed by debulking catheters
WO2008052221A2 (en) * 2006-10-27 2008-05-02 Aretais, Inc. Use of coherent raman techniques for medical diagnostic and therapeutic purposes, and calibration techniques for same
WO2008060841A2 (en) * 2006-10-27 2008-05-22 Ffa Sciences, Llc Use of probes for unbound metabolites
US20100179066A1 (en) * 2007-06-07 2010-07-15 Inserm (Institut National De La Santé Et De La Rec Method for Assessing the Risk of a Cardiovascular Disease and for Diagnosing Dyslipidemia
US20110045520A1 (en) * 2007-09-13 2011-02-24 Bhagavan Nadhipuram V Fatty acid markers for the diagnosis, prognosis and management of cardiovascular disease
JP5481023B2 (ja) * 2007-10-25 2014-04-23 株式会社小松製作所 作業車両および作業車両の制御方法
WO2010077741A1 (en) * 2008-12-09 2010-07-08 The Trustees Of Columbia University In The City Of New York Diagnosis and therapy of organ dysfunction using sphinganine-1-phosphate
US20100228101A1 (en) * 2009-03-04 2010-09-09 Michael Maschke Workflow for stroke diagnosis combining in-vitro diagnosis (ivd) with an imaging modality
CN103154742B (zh) 2010-06-20 2017-11-21 佐拉生物科学公司 用于鉴定高风险冠状动脉疾病患者的脂质组学标志
EP3088900B1 (de) 2011-10-17 2020-08-12 Roche Diagniostics GmbH Troponin als marker für intermittierendes vorhofflimmern
GB201304460D0 (en) * 2013-03-13 2013-04-24 Univ Leeds Biomarker
WO2015084894A1 (en) 2013-12-03 2015-06-11 Alan Kleinfeld Determination of the unbound free fatty acid profiles in biological and industrial specimens
GB201509974D0 (en) * 2015-06-09 2015-07-22 Sarissa Biomedical Ltd Methods and device to detect the presence of ischaemia in a subject

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5217085A (en) 1975-07-30 1977-02-08 Ono Pharmaceut Co Ltd Method of quantitative determination of free fatty acids in serum usin g fatty acid activating enzymes
CA1215903A (en) 1981-06-25 1986-12-30 Hideo Misaki Assay method for component relating to lipids, composition for assay and process for production of enzyme used therefor
US4369250A (en) 1981-07-31 1983-01-18 Sherwood Medical Industries Inc. Fatty acid determination
SU1270706A1 (ru) 1981-09-30 1986-11-15 Украинский научно-исследовательский институт кардиологии им.акад.Н.Д.Стражеско Способ определени фосфолипидов в инфарктной зоне сердечной мышцы
AT390840B (de) 1983-06-08 1990-07-10 Avl Verbrennungskraft Messtech Verfahren zur fluorimetrischen bestimmung der konzentration von in einer substanz enthaltenen stoffen und anordnung zur durchfuehrung dieses verfahrens
JP2657225B2 (ja) * 1987-03-31 1997-09-24 株式会社 日本抗体研究所 脂質代謝異常の検出方法
US4833332A (en) 1987-06-12 1989-05-23 E. I. Du Pont De Nemours And Company Scanning fluorescent detection system
US5512429A (en) 1989-09-19 1996-04-30 British Technology Group Limited Assay for enzyme activity
AU7162991A (en) 1989-12-12 1991-07-18 Lidak Pharmaceuticals Free fatty acid determination
US5470714A (en) 1989-12-12 1995-11-28 Lidak Pharmaceuticals One-step free fatty acid determination method
US5604105B1 (en) 1990-10-12 1999-08-24 Spectral Diagnostics Inc Method and device for diagnosingand distinguishing chest pain in early onset thereof
GB9105707D0 (en) 1991-03-18 1991-05-01 Wilton David C Assay
US5227307A (en) * 1991-07-26 1993-07-13 Diagnostic Markers, Inc. Test for the rapid evaluation of ischemic state
US5225329A (en) 1991-10-18 1993-07-06 Yale University Method for early detection of intestinal ischemia
WO1994006014A1 (en) 1992-09-02 1994-03-17 Kleinfeld Alan M Diagnostic aid for early detection of cancer and diabetes
US5362649A (en) 1993-02-16 1994-11-08 The United States Of America As Represented By The Secretary Of The Air Force Method for concentration based analysis of lipid fatty acids and its use in determining the likelihood that a patient is at risk for coronary artery disease
US5914112A (en) 1996-01-23 1999-06-22 Genentech, Inc. Anti-CD18 antibodies in stroke
CN1223587A (zh) * 1996-05-02 1999-07-21 先灵公司 治疗或预防局部缺血－再灌注损伤的方法
US6210976B1 (en) * 1997-06-10 2001-04-03 Medlyte Diagnostics, Inc. Methods for early detection of heart disease
US6444432B1 (en) 1997-06-13 2002-09-03 Alan M. Kleinfeld Method of detection of cardiac ischemia using fatty acid binding protein
WO1998057171A1 (en) 1997-06-13 1998-12-17 Medical Biology Institute Method of detection of cardiac ischemia using fatty acid binding protein
US6727258B2 (en) 1997-10-29 2004-04-27 King Pharmaceutical Research & Development, Inc. Allosteric adenosine receptor modulators
US5977174A (en) 1997-11-26 1999-11-02 Neuromedica, Inc. Cholinergic compositions and uses thereof
TW562926B (en) 1997-11-26 2003-11-21 Tanabe Seiyaku Co Method for testing renal diseases
DE19836617C2 (de) * 1998-08-12 2001-02-08 Ulrich Frei In vitro Verfahren zur Erkennung und Diagnostik akuter koronarer Syndrome
WO2000020840A1 (en) 1998-10-02 2000-04-13 Ischemia Technologies, Inc. Tests for the rapid evaluation of ischemic states and kits
US6475743B1 (en) * 1998-10-02 2002-11-05 Ischemia Technologies, Inc. Marker useful for detection and measurement of free radical damage and method
US6492179B1 (en) * 1998-10-02 2002-12-10 Ischemia Techologies, Inc. Test for rapid evaluation of ischemic states and kit
US6461875B1 (en) * 1998-10-02 2002-10-08 Ischemia Technologies, Inc. Test for rapid evaluation of ischemic states and kit
US6264960B1 (en) 1998-11-10 2001-07-24 Sander J. Robins Treatment of vascular events using lipid-modifying compositions
JP2002536459A (ja) 1999-02-12 2002-10-29 プレジデント アンド フェローズ オブ ハーヴァード カレッジ アテローム性動脈硬化症性病変の形成の阻害
US6663862B1 (en) 1999-06-04 2003-12-16 Duke University Reagents for detection and purification of antibody fragments
GB9923146D0 (en) 1999-09-30 1999-12-01 Imperial College Detector array
US6563585B1 (en) 1999-11-24 2003-05-13 University Of Maryland Biotechnology Institute Ratiometric fluorometer
US20040077017A1 (en) 2001-01-12 2004-04-22 Amelie Karlstrom Detection methods
AU2002255756A1 (en) 2001-03-14 2002-09-24 Clf Medical Technology Acceleration Program, Inc. System for screening fatty acid transport inhibitors, methods of use and modulators identified thereby
JP2004529351A (ja) 2001-05-04 2004-09-24 イスケミア・テクノロジーズ・インコーポレーテッド 急性心筋梗塞および他の臨床的状態の診断への改良
US7202089B2 (en) 2001-09-14 2007-04-10 Alan Kleinfeld Early diagnosis of stroke
US20050239155A1 (en) 2002-01-04 2005-10-27 Javier Alarcon Entrapped binding protein as biosensors
CA2484187A1 (en) 2002-05-01 2003-11-13 Adipogenix, Inc. Human adipocyte cell populations and methods for identifying modulators of same
US7335481B2 (en) 2002-07-24 2008-02-26 Christer Owman Methods of identifying compounds that affect a fatty acid cell-surface receptor
AU2005227312B2 (en) 2004-03-22 2011-04-07 Ffa Sciences, Llp Development and use of fluorescent probes of unbound analytes
US20060257938A1 (en) 2005-05-10 2006-11-16 Kleinfeld Alan M Method of screening for drugs that block ligand binding to a lipid binding protein

Also Published As

Publication number Publication date
JP5244156B2 (ja) 2013-07-24
EP1425582A4 (de) 2005-02-16
JP2010223972A (ja) 2010-10-07
JP4579537B2 (ja) 2010-11-10
AU2002331867B2 (en) 2007-08-02
CN100554963C (zh) 2009-10-28
US7262017B2 (en) 2007-08-28
WO2003025571A1 (en) 2003-03-27
CA2425784A1 (en) 2003-03-27
JP2005504277A (ja) 2005-02-10
US7879558B2 (en) 2011-02-01
KR20040039177A (ko) 2004-05-10
CN1630818A (zh) 2005-06-22
US20080004210A1 (en) 2008-01-03
EP1425582B1 (de) 2009-04-01
US20030064522A1 (en) 2003-04-03
DE60231814D1 (de) 2009-05-14
EP1425582A1 (de) 2004-06-09

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