ATE429433T1 - Herstellungsverfahren für moxifloxacin und moxifloxacinhydrochlorid - Google Patents
Herstellungsverfahren für moxifloxacin und moxifloxacinhydrochloridInfo
- Publication number
- ATE429433T1 ATE429433T1 AT07103405T AT07103405T ATE429433T1 AT E429433 T1 ATE429433 T1 AT E429433T1 AT 07103405 T AT07103405 T AT 07103405T AT 07103405 T AT07103405 T AT 07103405T AT E429433 T1 ATE429433 T1 AT E429433T1
- Authority
- AT
- Austria
- Prior art keywords
- moxifloxacin
- pot
- production process
- hydrochloride
- avoids
- Prior art date
Links
- FABPRXSRWADJSP-MEDUHNTESA-N moxifloxacin Chemical compound COC1=C(N2C[C@H]3NCCC[C@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2C1CC1 FABPRXSRWADJSP-MEDUHNTESA-N 0.000 title abstract 3
- 229960003702 moxifloxacin Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 229960005112 moxifloxacin hydrochloride Drugs 0.000 title 1
- IDIIJJHBXUESQI-DFIJPDEKSA-N moxifloxacin hydrochloride Chemical compound Cl.COC1=C(N2C[C@H]3NCCC[C@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2C1CC1 IDIIJJHBXUESQI-DFIJPDEKSA-N 0.000 title 1
- 238000000034 method Methods 0.000 abstract 4
- 239000000543 intermediate Substances 0.000 abstract 2
- 238000005580 one pot reaction Methods 0.000 abstract 2
- -1 bicyclic amine Chemical class 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000017858 demethylation Effects 0.000 abstract 1
- 238000010520 demethylation reaction Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200600608A ES2284380B1 (es) | 2006-03-10 | 2006-03-10 | Procedimiento para la preparacion de moxifloxacino y moxifloxacino clorhidrato. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE429433T1 true ATE429433T1 (de) | 2009-05-15 |
Family
ID=38042667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07103405T ATE429433T1 (de) | 2006-03-10 | 2007-03-02 | Herstellungsverfahren für moxifloxacin und moxifloxacinhydrochlorid |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1832587B1 (de) |
| AT (1) | ATE429433T1 (de) |
| DE (1) | DE602007000930D1 (de) |
| DK (1) | DK1832587T3 (de) |
| ES (2) | ES2284380B1 (de) |
| PL (1) | PL1832587T3 (de) |
| PT (1) | PT1832587E (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0612422D0 (en) * | 2006-06-23 | 2006-08-02 | Generics Uk Ltd | Novel hydrate form |
| NZ576929A (en) | 2006-11-13 | 2012-07-27 | Cipla Ltd | Crystalline anhydrous form C of moxifloxacin hydrochloride |
| ES2311391B1 (es) * | 2007-02-07 | 2009-12-22 | Quimica Sintetica, S.A. | Forma cristalina de moxifloxacino base. |
| IT1393337B1 (it) | 2009-03-06 | 2012-04-20 | Italiana Sint Spa | Sintesi di (4as, 7as)-ottaidro-1h-pirrolo[3,4-b]piridina |
| CN102617622B (zh) * | 2011-01-31 | 2016-06-15 | 深圳信立泰药业股份有限公司 | 一种制备莫西沙星或其可药用盐及其中间体的方法 |
| ITTO20110705A1 (it) | 2011-07-29 | 2013-01-30 | Italiana Sint Spa | Procedimento di preparazione della moxifloxacina cloridrato e relativi intermedi |
| CN102603738B (zh) * | 2012-02-24 | 2013-12-11 | 天津市汉康医药生物技术有限公司 | 一种稳定的盐酸莫西沙星化合物 |
| CN102924449B (zh) * | 2012-10-30 | 2015-08-12 | 重庆福安药业集团庆余堂制药有限公司 | 盐酸莫西沙星h晶型及其制备方法和药物组合物 |
| CA2893534A1 (en) * | 2012-12-04 | 2014-06-12 | Mankind Research Centre | An improved process for the preparation of moxifloxacin hydrochloride |
| CN104098561B (zh) * | 2013-04-10 | 2016-01-20 | 山东省生物医药科学院 | 一种适合工业化生产的制备高光学纯度盐酸莫西沙星的方法 |
| CN103965189B (zh) * | 2013-12-30 | 2015-09-09 | 西安万隆制药股份有限公司 | 一种新的盐酸莫西沙星化合物 |
| CN112759590B (zh) * | 2020-11-19 | 2021-12-31 | 内蒙古源宏精细化工有限公司 | 一种莫西沙星的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI95130C (fi) * | 1988-07-20 | 1995-12-27 | Sankyo Co | Menetelmä lääkeaineena käyttökelpoisten 4-oksokinoliini-3-karboksyylihapon johdannaisten valmistamiseksi |
| ES2017864A6 (es) * | 1989-11-29 | 1991-03-01 | Marga Investigacion | Procedimiento para la preparacion de n-ciclopropilquinolonas. |
| TW209865B (de) * | 1992-01-10 | 1993-07-21 | Bayer Ag | |
| ES2077490B1 (es) * | 1992-11-18 | 1996-10-16 | Marga Investigacion | Esteres trimetilsililicos y solvatos de quelatos de acidos quinolin-3-carboxilicos. preparacion y aplicacion al proceso de quinolonas. |
| CA2521398C (en) * | 2003-04-09 | 2011-03-22 | Dr. Reddy's Laboratories Limited | A crystalline form iii of anhydrous moxifloxacin hydrochloride and a process for preparation thereof |
| WO2005012285A1 (en) * | 2003-08-05 | 2005-02-10 | Matrix Laboratories Ltd | An improved process for the preparation of moxifloxacin hydrochloride |
| ES2232309B1 (es) * | 2003-11-13 | 2006-08-01 | Quimica Sintetica, S.A. | Procedimiento simplificado para la obtencion de gatifloxacino. |
-
2006
- 2006-03-10 ES ES200600608A patent/ES2284380B1/es not_active Expired - Fee Related
-
2007
- 2007-03-02 DK DK07103405T patent/DK1832587T3/da active
- 2007-03-02 AT AT07103405T patent/ATE429433T1/de active
- 2007-03-02 PL PL07103405T patent/PL1832587T3/pl unknown
- 2007-03-02 PT PT07103405T patent/PT1832587E/pt unknown
- 2007-03-02 ES ES07103405T patent/ES2324923T3/es active Active
- 2007-03-02 DE DE602007000930T patent/DE602007000930D1/de active Active
- 2007-03-02 EP EP07103405A patent/EP1832587B1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2284380A1 (es) | 2007-11-01 |
| PT1832587E (pt) | 2009-07-10 |
| ES2324923T3 (es) | 2009-08-19 |
| EP1832587B1 (de) | 2009-04-22 |
| ES2284380B1 (es) | 2008-11-01 |
| EP1832587A1 (de) | 2007-09-12 |
| PL1832587T3 (pl) | 2010-01-29 |
| DK1832587T3 (da) | 2009-08-10 |
| DE602007000930D1 (de) | 2009-06-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEIH | Change in the person of patent owner | ||
| UEP | Publication of translation of european patent specification |
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