ATE429908T1 - HORMONE-CONTAINED TRANSDERMAL THERAPEUTIC SYSTEM WITH AN ACTIVE RESERVOIR BASED ON VINYL ACETATE-VINYLPYRROLIDONE COPOLYMER WITH IMPROVED COHESION. - Google Patents

HORMONE-CONTAINED TRANSDERMAL THERAPEUTIC SYSTEM WITH AN ACTIVE RESERVOIR BASED ON VINYL ACETATE-VINYLPYRROLIDONE COPOLYMER WITH IMPROVED COHESION.

Info

Publication number
ATE429908T1
ATE429908T1 AT03744351T AT03744351T ATE429908T1 AT E429908 T1 ATE429908 T1 AT E429908T1 AT 03744351 T AT03744351 T AT 03744351T AT 03744351 T AT03744351 T AT 03744351T AT E429908 T1 ATE429908 T1 AT E429908T1
Authority
AT
Austria
Prior art keywords
therapeutic system
transdermal therapeutic
hormone
vinyl acetate
vinylpyrrolidone copolymer
Prior art date
Application number
AT03744351T
Other languages
German (de)
Inventor
Reinhold Meconi
Robert-Peter Klein
Frank Seibertz
Franz-Josef Becker
Ursula Goette
Original Assignee
Lohmann Therapie Syst Lts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lohmann Therapie Syst Lts filed Critical Lohmann Therapie Syst Lts
Application granted granted Critical
Publication of ATE429908T1 publication Critical patent/ATE429908T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Inorganic Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A transdermal therapeutic system in patch form for the controlled delivery of active substances to the human or animal skin comprises a backing layer, an active substance-containing reservoir attached thereto and a detachable protective layer, is characterized in that the active substance-containing reservoir contains as main components thereof at least one film former as well as at least one polymer which prevents or suppresses the crystallisation of the active substance or active substances.
AT03744351T 2002-03-16 2003-03-12 HORMONE-CONTAINED TRANSDERMAL THERAPEUTIC SYSTEM WITH AN ACTIVE RESERVOIR BASED ON VINYL ACETATE-VINYLPYRROLIDONE COPOLYMER WITH IMPROVED COHESION. ATE429908T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10211832A DE10211832A1 (en) 2002-03-16 2002-03-16 Hormone-containing transdermal therapeutic system with a drug reservoir based on vinyl acetate-vinylpyrrolidone copolymer with improved cohesion
PCT/EP2003/002521 WO2003077890A1 (en) 2002-03-16 2003-03-12 Hormone-containing transdermal therapeutic system with an active substance reservoir based on vinylacetate-vinylpyrrolidone copolymer with improved cohesion.

Publications (1)

Publication Number Publication Date
ATE429908T1 true ATE429908T1 (en) 2009-05-15

Family

ID=27797858

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03744351T ATE429908T1 (en) 2002-03-16 2003-03-12 HORMONE-CONTAINED TRANSDERMAL THERAPEUTIC SYSTEM WITH AN ACTIVE RESERVOIR BASED ON VINYL ACETATE-VINYLPYRROLIDONE COPOLYMER WITH IMPROVED COHESION.

Country Status (8)

Country Link
US (1) US20060088580A1 (en)
EP (1) EP1485072B1 (en)
JP (1) JP2005528356A (en)
AT (1) ATE429908T1 (en)
AU (1) AU2003215657A1 (en)
DE (2) DE10211832A1 (en)
ES (1) ES2326640T3 (en)
WO (1) WO2003077890A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0415725A (en) * 2003-10-23 2006-12-19 Cipla Ltd transdermally sprayable formulation, method for administering a pharmaceutically active agent and method for forming a pharmaceutically active film
US9205062B2 (en) 2004-03-09 2015-12-08 Mylan Pharmaceuticals, Inc. Transdermal systems containing multilayer adhesive matrices to modify drug delivery
US20050202073A1 (en) * 2004-03-09 2005-09-15 Mylan Technologies, Inc. Transdermal systems containing multilayer adhesive matrices to modify drug delivery
DE102004028284A1 (en) * 2004-06-11 2006-01-05 Hexal Ag Matrix-controlled transdermal therapeutic system based on a hotmelt adhesive for the application of norelgestromin
DE102009022915A1 (en) * 2009-05-27 2010-12-09 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system with controlled drug flux
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
RS62297B1 (en) 2011-11-23 2021-09-30 Therapeuticsmd Inc Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
KR101440318B1 (en) * 2012-10-25 2014-09-17 주식회사 제닉 Patch composition for skin and method for preparing patch for skin using the same
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
RU2016143081A (en) 2014-05-22 2018-06-26 Терапьютиксмд, Инк. NATURAL COMBINED HORMONE SUBSTITUTION COMPOSITIONS AND THERAPIES
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
US9931349B2 (en) 2016-04-01 2018-04-03 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
WO2020061071A1 (en) * 2018-09-19 2020-03-26 Isp Investments Llc Peroxide stable polymer composition and process for its preparation and applications thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666441A (en) * 1985-12-17 1987-05-19 Ciba-Geigy Corporation Multicompartmentalized transdermal patches
US5676968A (en) * 1991-10-31 1997-10-14 Schering Aktiengesellschaft Transdermal therapeutic systems with crystallization inhibitors
EP0705097B2 (en) * 1993-06-25 2004-01-14 Alza Corporation Incorporating poly-n-vinyl amide in a transdermal system
DE4405898A1 (en) * 1994-02-18 1995-08-24 Schering Ag Transdermal therapeutic systems containing sex steroids
DE4416927C1 (en) * 1994-05-13 1995-08-31 Lohmann Therapie Syst Lts Device for release of active agents from melt-type adhesive
DE19613698A1 (en) * 1995-07-17 1997-01-23 Schering Ag Agent for transdermal application containing esters of 13-ethyl-17β-hydroxy-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one
FR2739030B1 (en) * 1995-09-27 1997-11-21 Lhd Lab Hygiene Dietetique USE OF A COPOLYMER OF VINYL ACETATE AND N-VINYL-2-PYRROLIDONE IN A TRANSDERMAL MATRIX SYSTEM
FR2739032B1 (en) * 1995-09-27 1997-11-21 Lhd Lab Hygiene Dietetique TRANSDERMAL MATRIX SYSTEM FOR ADMINISTRATION OF AN ESTROGEN AND / OR AN EVA-BASED PROGESTIVE, PROCESS FOR PREPARATION AND THERAPEUTIC USE
FR2739031B1 (en) * 1995-09-27 1997-11-21 Lhd Lab Hygiene Dietetique TRANSDERMAL MATRIX SYSTEM FOR ADMINISTRATION OF AN ESTROGEN AND / OR A PROGESTIVE BASED ON STYRENE-ISOPRENE-STYRENE COPOLYMER, PREPARATION METHOD AND THERAPEUTIC USE
DE19708674C2 (en) * 1996-03-25 2002-02-07 Lohmann Therapie Syst Lts Transdermal therapeutic system with a drug-containing film layer and a soluble release layer, and a method for its preparation
DE19629468A1 (en) * 1996-07-11 1998-01-15 Schering Ag Transdermal therapeutic systems
DE19654468C1 (en) * 1996-12-27 1998-01-22 Lohmann Therapie Syst Lts Flexible dermal or transdermal plaster for drug or cosmetic release
JP4162277B2 (en) * 1997-06-20 2008-10-08 藤森工業株式会社 Adhesive for transdermal and transmucosal absorption preparations
JP3406188B2 (en) * 1997-06-23 2003-05-12 積水化学工業株式会社 Patch
DE19918644A1 (en) * 1999-04-16 2000-10-26 Jenapharm Gmbh Intradermal composition for local treatment of skin aging or wrinkles, comprising matrix containing estrogen and structure former to minimize systemic side-effects
DE10012908B4 (en) * 2000-03-16 2005-03-17 Lts Lohmann Therapie-Systeme Ag Stabilized supersaturated transdermal therapeutic matrix systems and methods for their preparation
DE10025971B4 (en) * 2000-05-25 2004-09-02 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system in plaster form with reduced tendency for drug crystallization and its use
TWI277418B (en) * 2001-06-18 2007-04-01 Noven Pharma Enhanced drug delivery in transdermal systems

Also Published As

Publication number Publication date
JP2005528356A (en) 2005-09-22
AU2003215657A1 (en) 2003-09-29
EP1485072B1 (en) 2009-04-29
DE50311477D1 (en) 2009-06-10
EP1485072A1 (en) 2004-12-15
US20060088580A1 (en) 2006-04-27
WO2003077890A1 (en) 2003-09-25
ES2326640T3 (en) 2009-10-16
DE10211832A1 (en) 2003-10-02

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