ATE430160T1 - Lipopeptid-stereoisomere, verfahren zu ihrer herstellung und nützliche zwischenprodukte - Google Patents

Lipopeptid-stereoisomere, verfahren zu ihrer herstellung und nützliche zwischenprodukte

Info

Publication number: ATE430160T1
Authority: AT; Austria
Prior art keywords: lipopeptide; stereoisomers; production; compounds; intermediate products
Prior art date: 2001-08-06

Application number

AT02789158T

Other languages

English (en)

Inventor

Michael Morytko

Yanzhi Zhang

Michael Jung

John Finn

Mario Bouchard

Original Assignee

Cubist Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-06

Filing date

2002-08-06

Publication date

2009-05-15

2002-08-06 Application filed by Cubist Pharm Inc filed Critical Cubist Pharm Inc

2009-05-15 Application granted granted Critical

2009-05-15 Publication of ATE430160T1 publication Critical patent/ATE430160T1/de

Links

108010028921 Lipopeptides Proteins 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical class O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 abstract 2
230000000844 anti-bacterial effect Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT02789158T 2001-08-06 2002-08-06 Lipopeptid-stereoisomere, verfahren zu ihrer herstellung und nützliche zwischenprodukte ATE430160T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US31031301P	2001-08-06	2001-08-06
PCT/US2002/025106 WO2003017924A2 (en)	2001-08-06	2002-08-06	Lipopeptide stereoisomers, methods for preparing same, and useful intermediates

Publications (1)

Publication Number	Publication Date
ATE430160T1 true ATE430160T1 (de)	2009-05-15

Family

ID=23201948

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02789158T ATE430160T1 (de)	2001-08-06	2002-08-06	Lipopeptid-stereoisomere, verfahren zu ihrer herstellung und nützliche zwischenprodukte

Country Status (15)

Country	Link
US (5)	US20030083240A1 (de)
EP (2)	EP1423414A4 (de)
JP (1)	JP2005531486A (de)
KR (1)	KR20040022233A (de)
CN (1)	CN100352836C (de)
AT (1)	ATE430160T1 (de)
AU (1)	AU2002353775A1 (de)
BR (1)	BR0211761A (de)
CA (2)	CA2456761A1 (de)
DE (1)	DE60232158D1 (de)
IL (1)	IL160171A0 (de)
NZ (1)	NZ531493A (de)
RU (1)	RU2348647C2 (de)
WO (2)	WO2003014147A1 (de)
ZA (1)	ZA200400928B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1423414A4 (de) *	2001-08-06	2005-11-30	Cubist Pharm Inc	Neue depsipeptide und verfahren zu deren herstellung
US6767718B2 (en) *	2002-05-10	2004-07-27	Biosource Pharm, Inc.	Lipodepsipeptide antibiotics and methods of preparation
EP1633380A4 (de) *	2003-06-19	2010-08-11	Yeda Res & Dev	Antimikrobielle und anti-krebs-lipopeptide
US20060004185A1 (en)	2004-07-01	2006-01-05	Leese Richard A	Peptide antibiotics and peptide intermediates for their prepartion
RU2007121705A (ru) *	2004-11-12	2008-12-20	Кьюбист Фармасьютикалз	Антиинфекционные липопептиды
KR20070089996A (ko) *	2004-12-06	2007-09-04	더 리전트 오브 더 유니버시티 오브 캘리포니아	세동맥의 구조 및 기능의 개선 방법
EP2974718A1 (de) *	2005-04-29	2016-01-20	Cubist Pharmaceuticals, Inc.	Therapeutische zusammensetzungen
AU2009239430B2 (en) *	2008-04-21	2015-01-22	Signum Biosciences, Inc.	Compounds, compositions and methods for making the same
CN102325787B (zh)	2008-12-22	2014-05-28	丘比斯特药物股份有限公司	治疗革兰氏阳性感染的新的抗菌剂
US8343912B2 (en)	2008-12-23	2013-01-01	Biosource Pharm, Inc.	Antibiotic compositions for the treatment of gram negative infections
CN101899094B (zh) *	2009-06-01	2012-11-21	安徽丰原发酵技术工程研究有限公司	一种高纯达托霉素的制备方法
KR101013755B1 (ko) *	2010-02-02	2011-02-14	주식회사 삼광산전	정출력용 엘이디모듈 전원공급 컨버터
US8415307B1 (en)	2010-06-23	2013-04-09	Biosource Pharm, Inc.	Antibiotic compositions for the treatment of gram negative infections
CN102351775B (zh) *	2011-09-14	2013-10-09	佛山普正医药科技有限公司	一种左旋5-羟基色氨酸的制备方法
WO2013059610A1 (en)	2011-10-20	2013-04-25	Trius Therapeutics, Inc.	Therapeutic combination of daptomycin and protein synthesis inhibitor antibiotic, and methods of use
EP3301109B1 (de) *	2012-12-03	2021-05-26	Novobiotic Pharmaceuticals, LLC	Neuartige depsipeptide und verwendungen davon
JP6634197B2 (ja) *	2013-05-08	2020-01-22	株式会社ゲノム創薬研究所	固相レジンを用いた環状ペプチド化合物の製造方法
WO2015172047A1 (en) *	2014-05-08	2015-11-12	Merck Sharp & Dohme Corp.	Cyclic peptide compounds and related methods, salts and compositions
KR101671325B1 (ko) *	2015-01-09	2016-11-02	한국생명공학연구원	신규한 고리형 뎁시펩타이드계 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 항균용 약학적 조성물
US11667674B2 (en) *	2016-04-08	2023-06-06	Versitech Limited	Antibacterial cyclic lipopeptides
US10072045B1 (en)	2017-06-26	2018-09-11	Ramapo Pharmaceuticals, Inc.	Antibacterial lipopeptides and methods for their preparation and use
WO2020018888A1 (en)	2018-07-20	2020-01-23	The Board Of Regents Of The University Of Oklahoma	Antimicrobial peptides and methods of use

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
USRE32333E (en)	1978-10-16	1987-01-20	Eli Lilly And Company	A-21978 Antibiotics and process for their production
USRE32455E (en)	1978-10-16	1987-07-07	Eli Lilly And Company	A-21978 antibiotics and process for their production
US4537717A (en) *	1982-05-21	1985-08-27	Eli Lilly And Company	Derivatives of A-21978C cyclic peptides
USRE32311E (en)	1982-05-21	1986-12-16	Eli Lilly And Company	Derivatives of A-21978C cyclic peptides
USRE32310E (en) *	1982-05-21	1986-12-16	Eli Lilly And Company	Derivatives of A-21978C cyclic peptides
US4482487A (en) *	1982-05-21	1984-11-13	Eli Lilly And Company	A-21978C cyclic peptides
US4399067A (en) *	1982-05-21	1983-08-16	Eli Lilly And Company	Derivatives of A-21978C cyclic peptides
US4524135A (en)	1982-05-21	1985-06-18	Eli Lilly And Company	A-21978C cyclic peptides
US4885243A (en)	1984-10-09	1989-12-05	Eli Lilly And Company	Process for producing A-21978C derivatives
US4800157A (en)	1985-09-09	1989-01-24	Eli Lilly And Company	Process for producing the A-21978C antibiotics
ZA883887B (en) *	1987-06-10	1990-02-28	Lilly Co Eli	Chromatographic purification process
US4874843A (en) *	1987-12-03	1989-10-17	Eli Lilly And Company	Chromatographic purification process
US4977083A (en) *	1988-04-11	1990-12-11	Eli Lilly And Company	Processes for preparing A54145 compounds
US5028590A (en) *	1988-04-11	1991-07-02	Eli Lilly And Company	Derivatives of A54145 cyclic peptides
US4994270A (en) *	1988-04-11	1991-02-19	Eli Lilly And Company	A54145 antibiotics and process for their production
US5039789A (en) *	1988-04-11	1991-08-13	Eli Lilly And Company	A54145 cyclic peptides
DK0460882T3 (da) *	1990-06-07	1996-08-26	Lilly Co Eli	Lipopeptiddeacylase
WO1993018141A1 (en) *	1992-03-02	1993-09-16	Biogen, Inc.	Thrombin receptor antagonists
US5378804A (en) *	1993-03-16	1995-01-03	Merck & Co., Inc.	Aza cyclohexapeptide compounds
DE4411025A1 (de) *	1994-03-30	1995-10-05	Hoechst Ag	Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
US6010861A (en) *	1994-08-03	2000-01-04	Dgi Biotechnologies, Llc	Target specific screens and their use for discovering small organic molecular pharmacophores
DE69739532D1 (de)	1996-03-08	2009-09-24	Astellas Pharma Inc	Prozess für die deacylierung von zyklischen lipopeptiden.
US5958728A (en) *	1996-11-18	1999-09-28	Novo Nordiskbiotech, Inc.	Methods for producing polypeptides in mutants of bacillus cells
US20010041346A1 (en)	1999-07-14	2001-11-15	Michael E. Mendelsohn	Method for assaying compounds affecting smooth muscle contractile state
JP2003517480A (ja)	1999-12-15	2003-05-27	キュービストファーマシューティカルズ，インコーポレイテッド	抗菌剤としてのリポペプチド
US6911525B2 (en)	1999-12-15	2005-06-28	Cubist Pharmaceuticals, Inc.	Lipopeptides as antibacterial agents
AU784942B2 (en)	1999-12-15	2006-08-03	Cubist Pharmaceuticals, Inc.	Daptomycin analogs and their use as antibacterial agents
US6696412B1 (en)	2000-01-20	2004-02-24	Cubist Pharmaceuticals, Inc.	High purity lipopeptides, Lipopeptide micelles and processes for preparing same
US6750199B2 (en) *	2000-07-17	2004-06-15	Micrologix Biotech Inc.	Antimicrobial sulfonamide derivatives of lipopeptide antibiotics
EP1423414A4 (de)	2001-08-06	2005-11-30	Cubist Pharm Inc	Neue depsipeptide und verfahren zu deren herstellung

2002
- 2002-08-06 EP EP02761255A patent/EP1423414A4/de not_active Withdrawn
- 2002-08-06 CA CA002456761A patent/CA2456761A1/en not_active Abandoned
- 2002-08-06 CA CA002456323A patent/CA2456323A1/en not_active Abandoned
- 2002-08-06 IL IL16017102A patent/IL160171A0/xx unknown
- 2002-08-06 KR KR10-2004-7001758A patent/KR20040022233A/ko not_active Ceased
- 2002-08-06 EP EP02789158A patent/EP1423137B1/de not_active Expired - Lifetime
- 2002-08-06 NZ NZ531493A patent/NZ531493A/xx not_active IP Right Cessation
- 2002-08-06 JP JP2003519096A patent/JP2005531486A/ja active Pending
- 2002-08-06 CN CNB028174658A patent/CN100352836C/zh not_active Expired - Fee Related
- 2002-08-06 DE DE60232158T patent/DE60232158D1/de not_active Expired - Fee Related
- 2002-08-06 AT AT02789158T patent/ATE430160T1/de not_active IP Right Cessation
- 2002-08-06 US US10/213,389 patent/US20030083240A1/en not_active Abandoned
- 2002-08-06 AU AU2002353775A patent/AU2002353775A1/en not_active Abandoned
- 2002-08-06 WO PCT/US2002/024896 patent/WO2003014147A1/en not_active Ceased
- 2002-08-06 RU RU2004106630/04A patent/RU2348647C2/ru not_active IP Right Cessation
- 2002-08-06 US US10/213,218 patent/US7262268B2/en not_active Expired - Fee Related
- 2002-08-06 WO PCT/US2002/025106 patent/WO2003017924A2/en not_active Ceased
- 2002-08-06 BR BRPI0211761-4A patent/BR0211761A/pt not_active IP Right Cessation
2004
- 2004-02-04 ZA ZA200400928A patent/ZA200400928B/en unknown
2006
- 2006-04-28 US US11/414,762 patent/US20060194714A1/en not_active Abandoned
- 2006-06-06 US US11/448,066 patent/US7335726B2/en not_active Expired - Fee Related
2008
- 2008-01-30 US US12/022,470 patent/US20080119395A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20030083240A1 (en)	2003-05-01
WO2003017924A2 (en)	2003-03-06
CA2456323A1 (en)	2003-03-06
RU2004106630A (ru)	2005-06-27
CN100352836C (zh)	2007-12-05
EP1423137B1 (de)	2009-04-29
EP1423137A2 (de)	2004-06-02
BR0211761A (pt)	2007-01-09
US7335726B2 (en)	2008-02-26
KR20040022233A (ko)	2004-03-11
JP2005531486A (ja)	2005-10-20
EP1423414A1 (de)	2004-06-02
CN1551887A (zh)	2004-12-01
ZA200400928B (en)	2005-05-04
CA2456761A1 (en)	2003-02-20
WO2003017924A3 (en)	2004-03-04
US20060223983A1 (en)	2006-10-05
US20080119395A1 (en)	2008-05-22
NZ531493A (en)	2006-03-31
US20060194714A1 (en)	2006-08-31
RU2348647C2 (ru)	2009-03-10
IL160171A0 (en)	2004-07-25
EP1423414A4 (de)	2005-11-30
US7262268B2 (en)	2007-08-28
EP1423137A4 (de)	2005-11-30
DE60232158D1 (de)	2009-06-10
US20030096948A1 (en)	2003-05-22
AU2002353775A1 (en)	2003-03-10
WO2003014147A1 (en)	2003-02-20

Legal Events

Date	Code	Title	Description
2009-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE430160T1 (de)	2009-05-15	Lipopeptid-stereoisomere, verfahren zu ihrer herstellung und nützliche zwischenprodukte
WO2001044271A3 (en)	2002-03-07	Daptomycin analogs and their use as antibacterial agents
WO2001044272A3 (en)	2001-11-29	Daptomycin analogs as antibacterial agents
TW200505837A (en)	2005-02-16	Novel compounds
TW200519075A (en)	2005-06-16	Novel compounds
MXPA02006030A (es)	2004-08-23	Lipopeptidos como agentes antibacterianos.
DE602004021472D1 (en)	2009-07-23	Pyrimiidinverbindungen
SG131109A1 (en)	2007-04-26	Muteins of tear lipocalin
TW200612892A (en)	2006-05-01	Novel compounds
MXPA05012362A (es)	2006-02-02	Yodopirazolilcarboxanilidas.
ATE529409T1 (de)	2011-11-15	Verfahren zur herstellung von kristallinen aripiprazolformen
DE60202958D1 (de)	2005-03-17	Stabiles polymorph von flibanserin, industrielles verfahren zu dessen herstellung und dessen verwendung zur herstellung von medikamenten
GB0216001D0 (en)	2002-08-21	Process and composition
WO2004106322A3 (en)	2005-04-21	Polymorphs of aripiprazole
MXPA04002282A (es)	2005-03-07	Nuevos compuestos y preparaciones como inhibidores de la catepsina.
DE60128112D1 (de)	2007-06-06	Aminoalkoxybenzoyl-benzofurane oder benzothiophene, verfahren zu ihrer herstellung und die enthaltenden zusammensetzungen
TR200503401T1 (tr)	2008-03-21	Kuetiapin (Quetiapine) Fumarat'ın yeni polimorfları
ATE461934T1 (de)	2010-04-15	Verfahren zur herstellung von 17-hydroxy-6 beta, 7 beta, 15 beta,16 beta-bismethylen-17alpha-pregn-4-en-3-on-21-car onsäure -lacton und schlüsselzwischenprodukte für dieses verfahren
DE60309847D1 (de)	2007-01-04	Zwischenprodukte und verfahren zur herstellung von heptapeptid-oxytocinanaloga
WO2001081298A3 (en)	2002-05-02	Cyclic carboxylic acids as integrin antagonists
ATE496038T1 (de)	2011-02-15	Verfahren zur herstellung von quetiapin
ATE299851T1 (de)	2005-08-15	Verfahren zur herstellung von zwischenprodukten
DE602004031727D1 (de)	2011-04-21	Neues verfahren und zwischenprodukte zur herstellung von 19-nor-steroiden
WO2006110185A3 (en)	2007-10-25	Antiinfective lipopeptides
DE60102084D1 (de)	2004-03-25	Propanolaminotetraline, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende pharmazeutische zusammensetzungen