ATE430728T1 - Substituierte tetraline und indane und ihre verwendung - Google Patents

Substituierte tetraline und indane und ihre verwendung

Info

Publication number: ATE430728T1
Authority: AT; Austria
Prior art keywords: indanes; substituted tetralines; tetralines; substituted; tetralin
Prior art date: 2002-10-21

Application number

AT03773302T

Other languages

English (en)

Inventor

Xiaoli Chen

Keith Demarest

Jung Lee

Jay Matthews

Philip Rybczynski

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-21

Filing date

2003-10-17

Publication date

2009-05-15

2003-10-17 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2009-05-15 Application granted granted Critical

2009-05-15 Publication of ATE430728T1 publication Critical patent/ATE430728T1/de

Links

150000002468 indanes Chemical class 0.000 title 1
CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 abstract 3
102000023984 PPAR alpha Human genes 0.000 abstract 1
108010028924 PPAR alpha Proteins 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
125000003392 indanyl group Chemical class C1(CCC2=CC=CC=C12)* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
- C07C323/44—X or Y being nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/61—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Obesity (AREA)
Endocrinology (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

AT03773302T 2002-10-21 2003-10-17 Substituierte tetraline und indane und ihre verwendung ATE430728T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US42002602P	2002-10-21	2002-10-21
US49578803P	2003-08-15	2003-08-15
PCT/US2003/033371 WO2004037779A1 (en)	2002-10-21	2003-10-17	Substituted tetralins and indanes and their use

Publications (1)

Publication Number	Publication Date
ATE430728T1 true ATE430728T1 (de)	2009-05-15

Family

ID=32179777

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03773302T ATE430728T1 (de)	2002-10-21	2003-10-17	Substituierte tetraline und indane und ihre verwendung

Country Status (28)

Country	Link
US (2)	US20040167211A1 (de)
EP (1)	EP1554240B1 (de)
JP (1)	JP4411275B2 (de)
KR (1)	KR100989394B1 (de)
CN (1)	CN100354259C (de)
AT (1)	ATE430728T1 (de)
AU (1)	AU2003279996B2 (de)
BR (1)	BR0315623A (de)
CA (1)	CA2502665A1 (de)
CY (1)	CY1110326T1 (de)
DE (1)	DE60327543D1 (de)
DK (1)	DK1554240T3 (de)
EA (1)	EA009554B1 (de)
ES (1)	ES2325783T3 (de)
HR (1)	HRP20050336B1 (de)
IL (1)	IL168147A (de)
ME (1)	MEP53108A (de)
MX (1)	MXPA05004192A (de)
NO (1)	NO332352B1 (de)
NZ (1)	NZ539451A (de)
PL (1)	PL376326A1 (de)
PT (1)	PT1554240E (de)
RS (1)	RS52079B (de)
SI (1)	SI1554240T1 (de)
TW (1)	TWI308563B (de)
UA (1)	UA80561C2 (de)
WO (1)	WO2004037779A1 (de)
ZA (1)	ZA200504064B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20060094786A1 (en) *	2002-10-21	2006-05-04	Xiaoli Chen	Treating syndrome X with substituted tetralins and indanes
KR20050055773A (ko) *	2002-10-21	2005-06-13	얀센 파마슈티카 엔.브이.	치환된 테트라린 및 인단
US20060247314A1 (en) *	2002-10-21	2006-11-02	Xiaoli Chen	Substituted tetralins and indanes
CA2503405A1 (en) *	2002-10-21	2004-05-06	Janssen Pharmaceutica, N.V.	Treating syndrome x with substituted tetralins and indanes
AR048931A1 (es) *	2004-04-21	2006-06-14	Janssen Pharmaceutica Nv	Proceso para la preparacion de derivados de tetralina sustituida e indano sustituido y preparacion de intermediarios de sintesis
JP4619413B2 (ja) *	2004-10-12	2011-01-26	ファーマコペイアドラッグディスカバリー，インコーポレイテッド	肥満および関連障害の処置のための選択的メラニン濃縮ホルモンレセプターアンタゴニストとしての二環式化合物
AR095570A1 (es) *	2013-03-20	2015-10-28	Hoffmann La Roche	Derivados de urea

Family Cites Families (23)

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AU632809B2 (en) *	1989-05-25	1993-01-14	Takeda Chemical Industries Ltd.	Benzocycloalkane benzopyran and benzothiopyran urea derivatives and production thereof
GB9027023D0 (en)	1990-12-12	1991-01-30	Wellcome Found	Anti-atherosclerotic aryl compounds
JP3342491B2 (ja)	1993-08-06	2002-11-11	ファルマシア・アンド・アップジョン・カンパニー	選択的ドーパミンｄ３リガンドとしての２−アミノインダン類
GB9606805D0 (en)	1996-03-30	1996-06-05	Glaxo Wellcome Inc	Medicaments
EP1666587A1 (de)	1996-06-13	2006-06-07	Astellas Pharma Inc.	Zyclische lipopeptid acylase
GB9822473D0 (en) *	1998-10-16	1998-12-09	Glaxo Group Ltd	Chemical compounds
US6300339B1 (en)	1998-10-21	2001-10-09	Novo Nordisk A/S	Compounds, their preparation and use
TWI234557B (en)	1999-05-26	2005-06-21	Telik Inc	Novel naphthalene ureas as glucose uptake enhancers
JP2003523336A (ja) *	2000-02-18	2003-08-05	メルクエンドカムパニーインコーポレーテッド	糖尿病及び脂質障害のためのアリールオキシ酢酸
HUP0302306A3 (en) *	2000-10-05	2005-02-28	Bayer Ag	Propionic acid derivatives with ppar-alpha activating properties
WO2002044129A1 (fr) *	2000-11-29	2002-06-06	Kyorin Pharmaceutical Co., Ltd.	Dérivés d'acide carboxylique substitués
WO2002046146A1 (fr) *	2000-12-05	2002-06-13	Kyorin Pharmaceutical Co., Ltd.	Derives d'acide carboxylique substitues
AU2002233271A1 (en) *	2000-12-20	2002-07-01	Glaxo Group Limited	Substitued oxazoles and thiazoles as hppar alpha agonists
TWI241190B (en)	2001-02-13	2005-10-11	Aventis Pharma Gmbh	4-Fluoro-N-indan-2-yl benzamide and its use as pharmaceutical
BR0207285A (pt)	2001-02-15	2004-02-10	Pfizer Producs Inc	Agonistas de ppar
JP2004520397A (ja)	2001-02-15	2004-07-08	ファイザー・プロダクツ・インク	増殖性アクチベータ受容体（ｐｐａｒ）化合物
US6548538B2 (en)	2001-05-22	2003-04-15	Bayer Aktiengesellschaft	Propionic acid derivatives
UA82835C2 (en) *	2001-12-03	2008-05-26	Reddys Lab Ltd Dr	?-aryl-?-oxysubstituted propionuc acid derivatives and pharmaceutical composition based thereon
US20060094786A1 (en) *	2002-10-21	2006-05-04	Xiaoli Chen	Treating syndrome X with substituted tetralins and indanes
CA2503405A1 (en) *	2002-10-21	2004-05-06	Janssen Pharmaceutica, N.V.	Treating syndrome x with substituted tetralins and indanes
US20060247314A1 (en) *	2002-10-21	2006-11-02	Xiaoli Chen	Substituted tetralins and indanes
KR20050055773A (ko) *	2002-10-21	2005-06-13	얀센 파마슈티카 엔.브이.	치환된 테트라린 및 인단
AR048931A1 (es) *	2004-04-21	2006-06-14	Janssen Pharmaceutica Nv	Proceso para la preparacion de derivados de tetralina sustituida e indano sustituido y preparacion de intermediarios de sintesis

2003
- 2003-10-17 AU AU2003279996A patent/AU2003279996B2/en not_active Ceased
- 2003-10-17 EP EP03773302A patent/EP1554240B1/de not_active Expired - Lifetime
- 2003-10-17 HR HRP20050336AA patent/HRP20050336B1/hr not_active IP Right Cessation
- 2003-10-17 BR BR0315623-0A patent/BR0315623A/pt not_active IP Right Cessation
- 2003-10-17 KR KR1020057006805A patent/KR100989394B1/ko not_active Expired - Fee Related
- 2003-10-17 EA EA200500516A patent/EA009554B1/ru not_active IP Right Cessation
- 2003-10-17 DE DE60327543T patent/DE60327543D1/de not_active Expired - Lifetime
- 2003-10-17 RS YU20050320A patent/RS52079B/sr unknown
- 2003-10-17 SI SI200331635T patent/SI1554240T1/sl unknown
- 2003-10-17 ES ES03773302T patent/ES2325783T3/es not_active Expired - Lifetime
- 2003-10-17 PL PL03376326A patent/PL376326A1/xx not_active Application Discontinuation
- 2003-10-17 NZ NZ539451A patent/NZ539451A/en not_active IP Right Cessation
- 2003-10-17 US US10/688,379 patent/US20040167211A1/en not_active Abandoned
- 2003-10-17 ME MEP-531/08A patent/MEP53108A/xx unknown
- 2003-10-17 DK DK03773302T patent/DK1554240T3/da active
- 2003-10-17 JP JP2005501641A patent/JP4411275B2/ja not_active Expired - Fee Related
- 2003-10-17 AT AT03773302T patent/ATE430728T1/de active
- 2003-10-17 WO PCT/US2003/033371 patent/WO2004037779A1/en not_active Ceased
- 2003-10-17 CA CA002502665A patent/CA2502665A1/en not_active Abandoned
- 2003-10-17 CN CNB2003801060885A patent/CN100354259C/zh not_active Expired - Fee Related
- 2003-10-17 MX MXPA05004192A patent/MXPA05004192A/es active IP Right Grant
- 2003-10-17 UA UAA200503454A patent/UA80561C2/uk unknown
- 2003-10-17 PT PT03773302T patent/PT1554240E/pt unknown
- 2003-10-21 TW TW092129193A patent/TWI308563B/zh not_active IP Right Cessation
2005
- 2005-04-19 IL IL168147A patent/IL168147A/en unknown
- 2005-05-10 NO NO20052280A patent/NO332352B1/no not_active IP Right Cessation
- 2005-05-19 ZA ZA200504064A patent/ZA200504064B/en unknown
- 2005-06-03 US US11/145,119 patent/US7351857B2/en not_active Expired - Lifetime
2009
- 2009-08-04 CY CY20091100820T patent/CY1110326T1/el unknown

Also Published As

Publication number	Publication date
NO332352B1 (no)	2012-09-03
HRP20050336B1 (hr)	2013-06-30
CA2502665A1 (en)	2004-05-06
ZA200504064B (en)	2006-09-27
MEP53108A (en)	2011-05-10
PT1554240E (pt)	2009-06-17
IL168147A (en)	2010-11-30
CN100354259C (zh)	2007-12-12
WO2004037779A1 (en)	2004-05-06
HRP20050336A2 (en)	2006-11-30
ES2325783T3 (es)	2009-09-17
TW200418774A (en)	2004-10-01
SI1554240T1 (sl)	2009-10-31
EP1554240B1 (de)	2009-05-06
AU2003279996A1 (en)	2004-05-13
US7351857B2 (en)	2008-04-01
UA80561C2 (en)	2007-10-10
PL376326A1 (en)	2005-12-27
US20060074130A1 (en)	2006-04-06
KR20050071597A (ko)	2005-07-07
NZ539451A (en)	2008-03-28
DE60327543D1 (de)	2009-06-18
MXPA05004192A (es)	2005-09-20
EA009554B1 (ru)	2008-02-28
CN1726187A (zh)	2006-01-25
EP1554240A1 (de)	2005-07-20
AU2003279996B2 (en)	2009-07-09
US20040167211A1 (en)	2004-08-26
DK1554240T3 (da)	2009-08-17
EA200500516A1 (ru)	2005-10-27
RS20050320A (sr)	2007-11-15
NO20052280L (no)	2005-06-24
TWI308563B (en)	2009-04-11
JP4411275B2 (ja)	2010-02-10
KR100989394B1 (ko)	2010-10-25
BR0315623A (pt)	2005-08-23
CY1110326T1 (el)	2015-01-14
RS52079B (sr)	2012-06-30
JP2006503917A (ja)	2006-02-02

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