ATE430730T1 - Phenyl-substituierte indole als h3 histaminrezeptorantagonisten - Google Patents

Phenyl-substituierte indole als h3 histaminrezeptorantagonisten

Info

Publication number
ATE430730T1
ATE430730T1 AT01920898T AT01920898T ATE430730T1 AT E430730 T1 ATE430730 T1 AT E430730T1 AT 01920898 T AT01920898 T AT 01920898T AT 01920898 T AT01920898 T AT 01920898T AT E430730 T1 ATE430730 T1 AT E430730T1
Authority
AT
Austria
Prior art keywords
phenyl
receptor antagonists
histamine receptor
substituted indoles
substituted
Prior art date
Application number
AT01920898T
Other languages
English (en)
Inventor
J Breitenbucher
Wenying Chai
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Application granted granted Critical
Publication of ATE430730T1 publication Critical patent/ATE430730T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT01920898T 2000-03-31 2001-03-29 Phenyl-substituierte indole als h3 histaminrezeptorantagonisten ATE430730T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19407100P 2000-03-31 2000-03-31
US27228701P 2001-02-28 2001-02-28
PCT/US2001/010320 WO2001074773A2 (en) 2000-03-31 2001-03-29 Phenyl-substituted indoles as histamine h3-receptor antagonists

Publications (1)

Publication Number Publication Date
ATE430730T1 true ATE430730T1 (de) 2009-05-15

Family

ID=26889668

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01920898T ATE430730T1 (de) 2000-03-31 2001-03-29 Phenyl-substituierte indole als h3 histaminrezeptorantagonisten

Country Status (6)

Country Link
EP (1) EP1268421B1 (de)
AT (1) ATE430730T1 (de)
AU (1) AU2001247906A1 (de)
DE (1) DE60138605D1 (de)
ES (1) ES2325477T3 (de)
WO (1) WO2001074773A2 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7208497B2 (en) 2001-07-02 2007-04-24 Novo Nordisk A/S Substituted piperazines and diazepanes
ATE479655T1 (de) 2001-09-14 2010-09-15 High Point Pharmaceuticals Llc Neue aminoazetidin-, aminopyrrolidin- und aminopiperidinderivative
US6673829B2 (en) 2001-09-14 2004-01-06 Novo Nordisk A/S Aminoazetidine,-pyrrolidine and -piperidine derivatives
AU2005212096B2 (en) * 2004-02-18 2010-12-16 Msd K.K. Nitrogenous fused heteroaromatic ring derivative
KR100841838B1 (ko) * 2004-06-21 2008-06-27 에프. 호프만-라 로슈 아게 히스타민 수용체 길항제로서의 인돌 유도체
RU2382778C2 (ru) * 2004-06-21 2010-02-27 Ф.Хоффманн-Ля Рош Аг Производные индола в качестве антагонистов гистаминовых рецепторов
US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
WO2006019831A1 (en) 2004-07-14 2006-02-23 Ptc Therapeutics, Inc. Methods for treating hepatitis c
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
WO2006019832A1 (en) 2004-07-22 2006-02-23 Ptc Therapeutics, Inc. Thienopyridines for treating hepatitis c
MX2007008676A (es) * 2005-01-19 2007-07-25 Hoffmann La Roche Derivados de 5-aminoindol.
EP1717235A3 (de) 2005-04-29 2007-02-28 Bioprojet Phenoxypropylpiperidine und -pyrrolidine und ihre Verwendung als Liganden für den Histamin H3-Rezeptor
MX2007015675A (es) 2005-07-04 2008-02-20 Novo Nordisk As Antagonistas del receptor de histamina h3.
AR056690A1 (es) * 2005-10-14 2007-10-17 Athersys Inc Derivados de indol como inhibidores de indol como inhibidores del receptor 3 de histamina para el tartamiento de trastornos del sueno y cognitivos obesidad y otros trastornos de snc
CN101316835A (zh) * 2005-11-30 2008-12-03 霍夫曼-拉罗奇有限公司 5-取代的吲哚-2-甲酰胺衍生物
EP1994022A2 (de) 2006-03-15 2008-11-26 Wyeth a Corporation of the State of Delaware N-substituierte azacyclylamine als histamin-3-antagonisten
CN101410385B (zh) 2006-03-28 2011-08-24 高点制药有限责任公司 具有组胺h3受体活性的苯并噻唑类
US7432255B2 (en) * 2006-05-16 2008-10-07 Hoffmann-La Roche Inc. 1H-indol-5-yl-piperazin-1-yl-methanone derivatives
CN101432261A (zh) 2006-05-19 2009-05-13 惠氏公司 作为组织胺-3拮抗剂的n-苯甲酰基-吡咯烷-3-基胺和n-苄基-吡咯烷-3-基胺
EP2402324A1 (de) 2006-05-29 2012-01-04 High Point Pharmaceuticals, LLC Benzodioxolylcyclopropylpiperazinylpyridazine
PE20081152A1 (es) 2006-10-06 2008-08-10 Wyeth Corp Azaciclilaminas n-sustituidas como antagonistas de histamina-3
TW200901974A (en) 2007-01-16 2009-01-16 Wyeth Corp Compounds, compositions, and methods of making and using them
US7557108B2 (en) * 2007-02-07 2009-07-07 Hoffmann-La Roche Inc. (Indol-4-yl) or (indol-5-yl)-piperazinylmethanones
EP2014656A3 (de) 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC Neue heterocyclische H3-Antagonisten
CA2693138A1 (en) 2007-07-16 2009-01-22 Wyeth Llc Aminoalkylazole derivatives as histamine-3 antagonists
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US338106A (en) * 1886-03-16 Victor roper
US5385912A (en) * 1991-03-08 1995-01-31 Rhone-Poulenc Rorer Pharmaceuticals Inc. Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
US5681954A (en) * 1993-05-14 1997-10-28 Daiichi Pharmaceutical Co., Ltd. Piperazine derivatives
WO1998006703A1 (en) * 1996-08-14 1998-02-19 Warner-Lambert Company 2-phenyl benzimidazole derivatives as mcp-1 antagonists
EP1011666A4 (de) * 1997-04-30 2004-03-31 Lilly Co Eli Antithrombotische mittel
IL136720A0 (en) * 1997-12-24 2001-06-14 Smithkline Beecham Lab Indole derivatives useful a.o. for the treatment of osteoporosis

Also Published As

Publication number Publication date
AU2001247906A1 (en) 2001-10-15
WO2001074773A2 (en) 2001-10-11
DE60138605D1 (de) 2009-06-18
ES2325477T3 (es) 2009-09-07
EP1268421B1 (de) 2009-05-06
WO2001074773A3 (en) 2002-04-04
EP1268421A2 (de) 2003-01-02

Similar Documents

Publication Publication Date Title
ATE430730T1 (de) Phenyl-substituierte indole als h3 histaminrezeptorantagonisten
DK1773885T3 (da) Humaniserede anti-c-met-antagonister
ATE501118T1 (de) Substituierte indole
DE69929235D1 (de) Spiro-indole als y5-rezeptor antagonisten
ATE340792T1 (de) Substituierte indole als alpha-1 agonisten
UA95768C2 (ru) Антагонисты мускариновых рецепторов ацетилхолина
NO20034930D0 (no) Substituerte cykloheksan-1,4-diaminderivater
TR200202194T2 (tr) Poliglütamik asit-kamptotesin birleşikleri ve hazırlama yöntemleri
DK1265615T3 (da) Ny kombination af ikkesederende antihistaminika med substanser, der påvirker leukotrien-virkningen, til behandling af rhinitis/conjunctivtis
DE60309498D1 (de) 4-piperazinylbenzolsulfonyl-indole mit 5-ht6 rezeptor-affinität
BRPI0415361A (pt) antagonistas do receptor muscarìnico de acetilcolina
MA27382A1 (fr) DERIVES D'INDOLE OU DE BENZIMIDAZOLE POUR MODULER L'IkB KINASE
ATE344798T1 (de) Als histamin-h3-antagonisten geeignete indolderivate
DE50014679D1 (de) Substituierte indol-mannichbasen
NO20052909L (no) Tetracyclic 3-substituted indoles having serotonin receptor affinity.
NO20034130L (no) Benzimidazolderivater som modulerer kjemokinreseptor
DE602004014772D1 (de) Pyrrol-2,5-dithionderivate als modulatoren des liver-x-rezeptors
ATE492535T1 (de) 4-piperidinylalkylamin-derivate, antagonisten von muscarinrezeptoren
HRP20041224A2 (en) Cck-1 receptor modulators
DE60101906D1 (de) Phenyl-substituierte indolizinderivate und deren verwendung als histamin h3 liganden
NO20033223L (no) Histamin-reseptor antagonister
IT1314235B1 (it) Derivati del piperazinone.
DK1068198T3 (da) 5-Heteroarylsubstituerede indoler
DE60205213D1 (de) Substituierte indoline als 5-ht-rezeptor liganden
ATE320254T1 (de) Crf receptor antagonisten

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties