ATE430754T1 - Phosphororganische indazolderivate und deren verwendung als proteinkinaseinhibitoren - Google Patents
Phosphororganische indazolderivate und deren verwendung als proteinkinaseinhibitorenInfo
- Publication number
- ATE430754T1 ATE430754T1 AT04805706T AT04805706T ATE430754T1 AT E430754 T1 ATE430754 T1 AT E430754T1 AT 04805706 T AT04805706 T AT 04805706T AT 04805706 T AT04805706 T AT 04805706T AT E430754 T1 ATE430754 T1 AT E430754T1
- Authority
- AT
- Austria
- Prior art keywords
- organophoroganic
- protein kinase
- kinase inhibitors
- indazole derivatives
- indazole
- Prior art date
Links
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical class C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 title 1
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
- C07F9/65038—Five-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0314778A FR2864084B1 (fr) | 2003-12-17 | 2003-12-17 | Nouveaux derives organophosphores des indazoles et leur utilisation comme medicaments |
| PCT/FR2004/003225 WO2005058923A1 (fr) | 2003-12-17 | 2004-12-15 | Derives organophosphores des indazoles et leur utilisation comme inhibiteurs des proteines kinase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE430754T1 true ATE430754T1 (de) | 2009-05-15 |
Family
ID=34630228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04805706T ATE430754T1 (de) | 2003-12-17 | 2004-12-15 | Phosphororganische indazolderivate und deren verwendung als proteinkinaseinhibitoren |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7491710B2 (de) |
| EP (1) | EP1732938B1 (de) |
| JP (1) | JP4630285B2 (de) |
| KR (1) | KR20060109942A (de) |
| CN (1) | CN1894264A (de) |
| AR (1) | AR046736A1 (de) |
| AT (1) | ATE430754T1 (de) |
| AU (1) | AU2004299299A1 (de) |
| BR (1) | BRPI0417708A (de) |
| CA (1) | CA2546903A1 (de) |
| DE (1) | DE602004021037D1 (de) |
| FR (1) | FR2864084B1 (de) |
| IL (1) | IL176233A0 (de) |
| MX (1) | MXPA06006832A (de) |
| TW (1) | TW200529828A (de) |
| UY (1) | UY28679A1 (de) |
| WO (1) | WO2005058923A1 (de) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005061519A1 (en) * | 2003-12-19 | 2005-07-07 | Takeda San Diego, Inc. | Kinase inhibitors |
| WO2005105788A1 (en) * | 2004-04-23 | 2005-11-10 | Takeda San Diego, Inc. | Indole derivatives and use thereof as kinase inhibitors |
| EP1778669A2 (de) * | 2004-08-18 | 2007-05-02 | Takeda San Diego, Inc. | Kinase-inhibitoren |
| EP1647549A1 (de) * | 2004-10-14 | 2006-04-19 | Laboratoire Theramex | Indazole, Benzisoxazole und Benzisothiazole mit oestrogenen Eigenschaften |
| ATE479687T1 (de) | 2004-10-15 | 2010-09-15 | Takeda Pharmaceutical | Kinaseinhibitoren |
| DE102004052725B4 (de) * | 2004-10-27 | 2007-07-12 | Technische Universität Chemnitz | Verfahren zur Herstellung substituierter Phosphane und nach dem Verfahren hergestellte substituierte Phosphane |
| WO2006080450A1 (ja) * | 2005-01-27 | 2006-08-03 | Kyowa Hakko Kogyo Co., Ltd. | Igf-1r阻害剤 |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| WO2008001885A1 (en) | 2006-06-30 | 2008-01-03 | Kyowa Hakko Kirin Co., Ltd. | Abl KINASE INHIBITOR |
| WO2008001886A1 (en) | 2006-06-30 | 2008-01-03 | Kyowa Hakko Kirin Co., Ltd. | Aurora inhibitor |
| SG158147A1 (en) | 2006-10-09 | 2010-01-29 | Takeda Pharmaceutical | Kinase inhibitors |
| KR20090115866A (ko) | 2007-03-05 | 2009-11-09 | 교와 핫꼬 기린 가부시키가이샤 | 의약 조성물 |
| CN101440092B (zh) * | 2008-12-25 | 2010-11-17 | 浙江大学 | 2-吲唑-4-氮杂吲哚-5-氨基衍生物及制备和应用 |
| JP2013501792A (ja) * | 2009-08-10 | 2013-01-17 | サミュメッド リミテッド ライアビリティ カンパニー | Ｗｎｔ／ｂ−カテニンシグナル伝達経路阻害剤としてのインダゾールおよびその治療的使用 |
| EP2987487B1 (de) | 2009-08-10 | 2020-10-07 | Samumed, LLC | Indazol-basierte hemmer des wnt-signalpfades und deren therapeutische verwendungen |
| EP2515655B1 (de) | 2009-12-21 | 2015-08-05 | Samumed, LLC | 1h-pyrazolo[3,4-beta]pyridine und therapeutische verwendung davon |
| EP3473099A1 (de) | 2011-09-14 | 2019-04-24 | Samumed, LLC | Indazol-3-carboxamide und deren verwendung als wnt/b-catenin-signalisierungsweghemmer |
| PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| EP2770994B1 (de) | 2012-05-04 | 2019-08-21 | Samumed, LLC | 1h-pyrazolo[3,4-beta]pyridine und therapeutische verwendung davon |
| WO2014110086A2 (en) | 2013-01-08 | 2014-07-17 | Samumed, Llc | 3-(benzoimidazol-2-yl)-indazole inhibitors of the wnt signaling pathway and therapeutic uses thereof |
| WO2016040182A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof |
| WO2016040190A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
| WO2016040188A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040185A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof |
| WO2016040181A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040180A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040193A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
| WO2016040184A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2017024010A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof |
| US10350199B2 (en) | 2015-08-03 | 2019-07-16 | Samumed, Llc | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof |
| WO2017024003A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc | 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| WO2017023996A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof |
| US10329309B2 (en) | 2015-08-03 | 2019-06-25 | Samumed, Llc | 3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| US10604512B2 (en) | 2015-08-03 | 2020-03-31 | Samumed, Llc | 3-(1H-indol-2-yl)-1H-indazoles and therapeutic uses thereof |
| WO2017023989A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| US10226453B2 (en) | 2015-08-03 | 2019-03-12 | Samumed, Llc | 3-(1H-indol-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| US10206908B2 (en) | 2015-08-03 | 2019-02-19 | Samumed, Llc | 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof |
| US10226448B2 (en) | 2015-08-03 | 2019-03-12 | Samumed, Llc | 3-(1H-pyrrolo[3,2-C]pyridin-2-yl)-1H-pyrazolo[3,4-B]pyridines and therapeutic uses thereof |
| US10166218B2 (en) | 2015-08-03 | 2019-01-01 | Samumed, Llc | 3-(1H-indol-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof |
| US10206909B2 (en) | 2015-08-03 | 2019-02-19 | Samumed, Llc | 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| WO2017023975A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof |
| WO2017023972A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| US10519169B2 (en) | 2015-08-03 | 2019-12-31 | Samumed, Llc | 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| US10188634B2 (en) | 2015-08-03 | 2019-01-29 | Samumed, Llc | 3-(3H-imidazo[4,5-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| US10285982B2 (en) | 2015-08-03 | 2019-05-14 | Samumed, Llc | 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof |
| BR112018009252A2 (pt) | 2015-11-06 | 2018-11-06 | Samumed Llc | tratamento da osteoartrite |
| JP6659445B2 (ja) * | 2016-04-28 | 2020-03-04 | 株式会社トクヤマ | 脱ベンジル化方法 |
| LT3464285T (lt) | 2016-06-01 | 2022-12-27 | Biosplice Therapeutics, Inc. | N-(5-(3-(7-(3-fluorfenil)-3h-imidazo[4,5-c]piridin-2-il)-1h-indazol-5-il)piridin-3-il)- 3-metilbutanamido gamybos būdas |
| CN110709082A (zh) | 2016-10-21 | 2020-01-17 | 萨穆梅德有限公司 | 吲唑-3-甲酰胺的使用方法及其作为Wnt/β-连环蛋白信号传导途径抑制剂的用途 |
| US10758523B2 (en) | 2016-11-07 | 2020-09-01 | Samumed, Llc | Single-dose, ready-to-use injectable formulations |
| WO2021088859A1 (zh) * | 2019-11-06 | 2021-05-14 | 暨南大学 | 吲唑类化合物及其药用组合物和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU217661B (hu) * | 1992-03-09 | 2000-03-28 | Zeneca Ltd. | Aril-indazol-származékok, eljárás az előállításukra és herbicidként történő alkalmazásuk |
| JPH09281630A (ja) * | 1996-04-12 | 1997-10-31 | Konica Corp | ハロゲン化銀写真感光材料 |
| US7217722B2 (en) * | 2000-02-01 | 2007-05-15 | Kirin Beer Kabushiki Kaisha | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
| TW200306819A (en) * | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
| FR2836914B1 (fr) * | 2002-03-11 | 2008-03-14 | Aventis Pharma Sa | Indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
-
2003
- 2003-12-17 FR FR0314778A patent/FR2864084B1/fr not_active Expired - Fee Related
-
2004
- 2004-11-30 AR ARP040104454A patent/AR046736A1/es unknown
- 2004-12-15 DE DE602004021037T patent/DE602004021037D1/de not_active Expired - Lifetime
- 2004-12-15 MX MXPA06006832A patent/MXPA06006832A/es active IP Right Grant
- 2004-12-15 EP EP04805706A patent/EP1732938B1/de not_active Expired - Lifetime
- 2004-12-15 BR BRPI0417708-8A patent/BRPI0417708A/pt not_active IP Right Cessation
- 2004-12-15 JP JP2006544494A patent/JP4630285B2/ja not_active Expired - Fee Related
- 2004-12-15 CN CNA2004800376955A patent/CN1894264A/zh active Pending
- 2004-12-15 CA CA002546903A patent/CA2546903A1/fr not_active Abandoned
- 2004-12-15 AU AU2004299299A patent/AU2004299299A1/en not_active Abandoned
- 2004-12-15 AT AT04805706T patent/ATE430754T1/de not_active IP Right Cessation
- 2004-12-15 KR KR1020067012037A patent/KR20060109942A/ko not_active Withdrawn
- 2004-12-15 WO PCT/FR2004/003225 patent/WO2005058923A1/fr not_active Ceased
- 2004-12-16 TW TW093139037A patent/TW200529828A/zh unknown
- 2004-12-17 UY UY28679A patent/UY28679A1/es unknown
- 2004-12-17 US US11/016,595 patent/US7491710B2/en not_active Expired - Fee Related
-
2006
- 2006-06-11 IL IL176233A patent/IL176233A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004299299A1 (en) | 2005-06-30 |
| FR2864084B1 (fr) | 2006-02-10 |
| UY28679A1 (es) | 2005-08-31 |
| DE602004021037D1 (de) | 2009-06-18 |
| WO2005058923A1 (fr) | 2005-06-30 |
| EP1732938B1 (de) | 2009-05-06 |
| FR2864084A1 (fr) | 2005-06-24 |
| TW200529828A (en) | 2005-09-16 |
| MXPA06006832A (es) | 2006-09-04 |
| AR046736A1 (es) | 2005-12-21 |
| IL176233A0 (en) | 2006-10-05 |
| US7491710B2 (en) | 2009-02-17 |
| CA2546903A1 (fr) | 2005-06-30 |
| JP2007514721A (ja) | 2007-06-07 |
| BRPI0417708A (pt) | 2007-03-20 |
| US20050137171A1 (en) | 2005-06-23 |
| JP4630285B2 (ja) | 2011-02-09 |
| KR20060109942A (ko) | 2006-10-23 |
| CN1894264A (zh) | 2007-01-10 |
| EP1732938A1 (de) | 2006-12-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE430754T1 (de) | Phosphororganische indazolderivate und deren verwendung als proteinkinaseinhibitoren | |
| DE60325761D1 (de) | Diaminotriazole derivate und deren verwendung als protein kinase inhibitoren | |
| ATE521598T1 (de) | 5-phenylthiazol-derivate und ihre verwendung als pi3 kinase inhibitoren | |
| DE60133897D1 (de) | Substituierte chinazolin-derivate und deren verwendung als aurora-2-kinase inhibitoren | |
| DE60208661D1 (de) | Diaminothiazole und ihre verwendung als cyclinabhängige kinase inhibitoren | |
| DE60332023D1 (de) | Chinolinderivate und deren verwendung als mycobakterielle inhibitoren | |
| DE602005015699D1 (de) | Prolinderivate und deren verwendung als dipeptidylpeptidase-iv-inhibitoren | |
| ATE472546T1 (de) | 5-heteroarylthiazole und deren verwendung als pi3k-inhibitoren | |
| DE602005022115D1 (de) | Heteroaromatische chinolinverbindungen und deren verwendung als pde10-inhibitoren | |
| PL2305250T3 (pl) | Pochodne benzimidazolu i ich zastosowanie jako inhibitorów kinaz białkowych | |
| ATE404564T1 (de) | Diazepinoindolderivate als kinaseinhibitoren | |
| DE60221233D1 (de) | Neue spirotricyclische derivate und deren verwendung als phosphodiesterase-7-inhibitoren | |
| ATE435859T1 (de) | Gyraseinhibitoren und deren verwendungen | |
| ATE452891T1 (de) | Pyrimidopyrimidone als kinaseinhibitoren | |
| DE602004025258D1 (de) | Aminotriazol-verbindungen als proteinkinase-hemmer | |
| ATE501159T1 (de) | 1-(d-glykopyranosyl)-3-(4- cyclopropylphenylmethyl)-4-halogenindolderivate und deren verwendung als sglt-inhibitoren | |
| ATE395346T1 (de) | Chinazolinderivate als tyrosinkinaseinhibitoren | |
| ATE420861T1 (de) | 2-pyridonderivate als inhibitoren von neutrophilelastase und deren verwendung | |
| ATE312093T1 (de) | 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2- ylmethyliden)-2-indolinon derivate und deren verwendung als protein kinase inhibitoren | |
| DE50311397D1 (de) | Heterocyclisch substituierte indolinone und deren verwendung als rezeptor-tyrosinkinasen inhibitoren | |
| ATE393159T1 (de) | Heterobicyclische pyrazolderivate als kinaseinhibitoren | |
| ATE551329T1 (de) | Chinazolinonderivate und deren verwendung als cb- agonisten | |
| DE60336266D1 (de) | Substituierte 1-piperidin-4-yl-pyrrolidin-3-yl-piperazinderivate und deren verwendung als neurokinin antagonisten | |
| DE60322544D1 (de) | Glycinamid-derivate als raf-kinase-hemmer | |
| ATE308323T1 (de) | Diaminothiazole und ihre anwendung als cdk4 inhibitoren |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |