ATE430758T1 - Lipid-aminoglykosid konjugate zur transfektion - Google Patents
Lipid-aminoglykosid konjugate zur transfektionInfo
- Publication number
- ATE430758T1 ATE430758T1 AT02796324T AT02796324T ATE430758T1 AT E430758 T1 ATE430758 T1 AT E430758T1 AT 02796324 T AT02796324 T AT 02796324T AT 02796324 T AT02796324 T AT 02796324T AT E430758 T1 ATE430758 T1 AT E430758T1
- Authority
- AT
- Austria
- Prior art keywords
- transfection
- lipid
- aminoglycoside
- conjugates
- vivo
- Prior art date
Links
- 229940126575 aminoglycoside Drugs 0.000 title abstract 2
- 238000001890 transfection Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 125000003473 lipid group Chemical group 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0111199A FR2829136B1 (fr) | 2001-08-29 | 2001-08-29 | Derives lipidiques d'aminoglycosides |
| US33145201P | 2001-11-16 | 2001-11-16 | |
| PCT/FR2002/002959 WO2003018603A1 (fr) | 2001-08-29 | 2002-08-29 | Derives lipidiques d'aminoglycosides_pour la transfection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE430758T1 true ATE430758T1 (de) | 2009-05-15 |
Family
ID=26213158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02796324T ATE430758T1 (de) | 2001-08-29 | 2002-08-29 | Lipid-aminoglykosid konjugate zur transfektion |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1430074B1 (de) |
| JP (1) | JP4629333B2 (de) |
| AT (1) | ATE430758T1 (de) |
| AU (1) | AU2002334051B2 (de) |
| CA (1) | CA2458626C (de) |
| DE (1) | DE60232258D1 (de) |
| WO (1) | WO2003018603A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2069500B1 (de) * | 2006-10-04 | 2014-09-24 | Centre National De La Recherche Scientifique (Cnrs) | Zusammensetzungen mit einer sirna und lipidischen 4,5-disubstituierten 2-desoxystreptaminring-aminoglykosid-derivaten und verwendungen davon |
| WO2010026537A1 (en) | 2008-09-05 | 2010-03-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Novel multimodular assembly useful for intracellular delivery |
| CA2944128C (en) | 2014-04-01 | 2022-08-30 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Capped and uncapped rna molecules and block copolymers for intracellular delivery of rna |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4923696A (en) * | 1995-02-10 | 1996-08-27 | Nexstar Pharmaceuticals, Inc. | Lipid constructs for cytoplasmic delivery of agents |
| FR2741066B1 (fr) * | 1995-11-14 | 1997-12-12 | Rhone Poulenc Rorer Sa | Nouveaux agents de transfection et leurs applications pharmaceutiques |
| FR2764304B1 (fr) * | 1997-06-06 | 1999-07-16 | Rhone Poulenc Rorer Sa | Nouvelle classe d'agents transfectants cationiques des acides nucleiques |
| US20020058795A1 (en) * | 1997-09-08 | 2002-05-16 | Russ J. Mumper | Hydrophobic glycosylamine derivatives, compositions, and methods for use |
| AU2600100A (en) * | 1999-01-05 | 2000-07-24 | Valentis, Inc. | Methods and compositions for delivering nucleic acids |
| GB9930533D0 (en) * | 1999-12-23 | 2000-02-16 | Mitsubishi Tokyo Pharm Inc | Nucleic acid delivery |
-
2002
- 2002-08-29 AT AT02796324T patent/ATE430758T1/de not_active IP Right Cessation
- 2002-08-29 AU AU2002334051A patent/AU2002334051B2/en not_active Expired
- 2002-08-29 WO PCT/FR2002/002959 patent/WO2003018603A1/fr not_active Ceased
- 2002-08-29 JP JP2003523262A patent/JP4629333B2/ja not_active Expired - Lifetime
- 2002-08-29 DE DE60232258T patent/DE60232258D1/de not_active Expired - Lifetime
- 2002-08-29 EP EP02796324A patent/EP1430074B1/de not_active Expired - Lifetime
- 2002-08-29 CA CA2458626A patent/CA2458626C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002334051B2 (en) | 2008-05-15 |
| JP2005504061A (ja) | 2005-02-10 |
| JP4629333B2 (ja) | 2011-02-09 |
| CA2458626C (en) | 2011-05-03 |
| EP1430074B1 (de) | 2009-05-06 |
| CA2458626A1 (en) | 2003-03-06 |
| WO2003018603A1 (fr) | 2003-03-06 |
| EP1430074A1 (de) | 2004-06-23 |
| DE60232258D1 (de) | 2009-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |