ATE431423T1 - Verfahren zum screening der leichten kette eines antikörpers - Google Patents

Verfahren zum screening der leichten kette eines antikörpers

Info

Publication number
ATE431423T1
ATE431423T1 AT04703920T AT04703920T ATE431423T1 AT E431423 T1 ATE431423 T1 AT E431423T1 AT 04703920 T AT04703920 T AT 04703920T AT 04703920 T AT04703920 T AT 04703920T AT E431423 T1 ATE431423 T1 AT E431423T1
Authority
AT
Austria
Prior art keywords
antibody
library
desired antigen
screening
heavy chain
Prior art date
Application number
AT04703920T
Other languages
English (en)
Inventor
Tetsuo Kojima
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE431423T1 publication Critical patent/ATE431423T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Pyrane Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
AT04703920T 2003-01-21 2004-01-21 Verfahren zum screening der leichten kette eines antikörpers ATE431423T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003012648 2003-01-21
PCT/JP2004/000496 WO2004065611A1 (ja) 2003-01-21 2004-01-21 抗体の軽鎖スクリーニング方法

Publications (1)

Publication Number Publication Date
ATE431423T1 true ATE431423T1 (de) 2009-05-15

Family

ID=32767339

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04703920T ATE431423T1 (de) 2003-01-21 2004-01-21 Verfahren zum screening der leichten kette eines antikörpers

Country Status (6)

Country Link
US (1) US8337841B2 (de)
EP (1) EP1605058B1 (de)
JP (1) JP4477579B2 (de)
AT (1) ATE431423T1 (de)
DE (1) DE602004021095D1 (de)
WO (1) WO2004065611A1 (de)

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TWI701435B (zh) 2014-09-26 2020-08-11 日商中外製藥股份有限公司 測定ｆｖｉｉｉ的反應性之方法
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WO2017086367A1 (ja) 2015-11-18 2017-05-26 中外製薬株式会社 免疫抑制機能を有する細胞に対するｔ細胞リダイレクト抗原結合分子を用いた併用療法
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WO2017110980A1 (ja) 2015-12-25 2017-06-29 中外製薬株式会社 増強された活性を有する抗体及びその改変方法
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CA3016424A1 (en) 2016-03-14 2017-09-21 Chugai Seiyaku Kabushiki Kaisha Cell injury inducing therapeutic drug for use in cancer therapy
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CN109415444B (zh) 2016-07-29 2024-03-01 中外制药株式会社 显示增加的备选fviii辅因子功能活性的双特异性抗体
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EP3603670A4 (de) 2017-03-31 2021-03-10 Public University Corporation Nara Medical University Medizinische zusammensetzung zur prävention und/oder behandlung von blutgerinnungsfaktor-ix-anomalie mit einer multispezifischen antigenbindenden molekülersatzfunktion des blutgerinnungsfaktors viii
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TW202600611A (zh) 2017-11-01 2026-01-01 日商中外製藥股份有限公司 生物活性降低之抗體變異體與同功型
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EP3561703B1 (de) * 2018-04-25 2021-01-20 Bayer AG Identifizieren der paarung von variablen domänen aus leichten und schweren ketten von antikörpern
CN112513081A (zh) 2018-06-14 2021-03-16 生物蛋白有限公司 多重特异性抗体构建体
JPWO2019244973A1 (ja) 2018-06-20 2021-07-08 中外製薬株式会社 標的細胞に対する免疫反応を活性化する方法およびその組成物
US12463463B2 (en) 2019-01-28 2025-11-04 Ab Therapeutics, Inc. Bispecific antibodies and uses thereof
WO2020205504A1 (en) * 2019-03-29 2020-10-08 Compass Therapeutics Llc Common light chains and methods of use
JPWO2020246563A1 (de) 2019-06-05 2020-12-10
JP2023106635A (ja) 2020-04-17 2023-08-02 中外製薬株式会社 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法
CN116194124A (zh) 2020-07-31 2023-05-30 中外制药株式会社 包含表达嵌合受体的细胞的药物组合物
WO2025154793A1 (ja) * 2024-01-19 2025-07-24 株式会社ペルセウスプロテオミクス 多重特異性抗体の製造に使用するための共通のｌ鎖を同定する方法

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Also Published As

Publication number Publication date
EP1605058A4 (de) 2006-04-19
JP4477579B2 (ja) 2010-06-09
JPWO2004065611A1 (ja) 2006-05-18
US20060159673A1 (en) 2006-07-20
EP1605058A1 (de) 2005-12-14
DE602004021095D1 (de) 2009-06-25
WO2004065611A1 (ja) 2004-08-05
EP1605058B1 (de) 2009-05-13
US8337841B2 (en) 2012-12-25

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