ATE432276T1 - Herstellung eines atorvastatin-zwischenprodukts - Google Patents

Herstellung eines atorvastatin-zwischenprodukts

Info

Publication number: ATE432276T1
Authority: AT; Austria
Prior art keywords: diol; ester; atorvastatin; acid; acetonide
Prior art date: 2005-09-09

Application number

AT05777481T

Other languages

English (en)

Inventor

Susan O'sullivan

John O'neill

Original Assignee

Pfizer Science & Tech Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-09

Filing date

2005-09-09

Publication date

2009-06-15

2005-09-09 Application filed by Pfizer Science & Tech Ltd filed Critical Pfizer Science & Tech Ltd

2009-06-15 Application granted granted Critical

2009-06-15 Publication of ATE432276T1 publication Critical patent/ATE432276T1/de

Links

XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 title abstract 2
XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 title abstract 2
229960005370 atorvastatin Drugs 0.000 title abstract 2
-1 tert-butyl isopropylidene nitrile Chemical class 0.000 abstract 7
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
OUCSEDFVYPBLLF-KAYWLYCHSA-N 5-(4-fluorophenyl)-1-[2-[(2r,4r)-4-hydroxy-6-oxooxan-2-yl]ethyl]-n,4-diphenyl-2-propan-2-ylpyrrole-3-carboxamide Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@H]2OC(=O)C[C@H](O)C2)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 OUCSEDFVYPBLLF-KAYWLYCHSA-N 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 3
150000002009 diols Chemical class 0.000 abstract 3
159000000000 sodium salts Chemical class 0.000 abstract 2
150000001412 amines Chemical class 0.000 abstract 1
125000005594 diketone group Chemical group 0.000 abstract 1
238000004821 distillation Methods 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

AT05777481T 2005-09-09 2005-09-09 Herstellung eines atorvastatin-zwischenprodukts ATE432276T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/IE2005/000094 WO2007029216A1 (en)	2005-09-09	2005-09-09	Preparation of an atorvastatin intermediate

Publications (1)

Publication Number	Publication Date
ATE432276T1 true ATE432276T1 (de)	2009-06-15

Family

ID=36283782

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05777481T ATE432276T1 (de)	2005-09-09	2005-09-09	Herstellung eines atorvastatin-zwischenprodukts

Country Status (7)

Country	Link
US (1)	US20090221839A1 (de)
EP (1)	EP1922315B1 (de)
JP (1)	JP2009507821A (de)
AT (1)	ATE432276T1 (de)
CA (1)	CA2621506A1 (de)
DE (1)	DE602005014686D1 (de)
WO (1)	WO2007029216A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA03012045A (es)	2001-07-06	2004-03-29	Teva Pharma	Proceso para preparar derivados del acido 7-amino sin 3,5-dihidroxi heptanoico a traves de derivados del acido 6-ciano sin 3,5-dihidroxi hexanoico.
US20090081801A1 (en) *	2007-08-15	2009-03-26	Vinod Kumar Kansal	Process for synthesis of pyrrole derivative, an intermediate for atorvastatin
KR100850558B1 (ko)	2008-01-02	2008-08-06	조동옥	아토르바스타틴의 효율적인 제조방법
KR100850850B1 (ko)	2008-01-25	2008-08-06	주식회사종근당	아토르바스타틴의 제조방법 및 이에 사용되는 중간체
JP5705580B2 (ja) *	2011-02-21	2015-04-22	公益財団法人微生物化学研究会	チオアミド化合物、チオアミド化合物の製造方法、［（４ｒ，６ｒ）−６−アミノエチル−１，３−ジオキサン−４−イル］アセテート誘導体の製造方法、及びアトルバスタチンの製造方法
CN111362856B (zh) *	2020-04-29	2023-08-18	福建海西新药创制股份有限公司	一种利用微反应装置生产阿托伐他汀钙的方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4681893A (en) *	1986-05-30	1987-07-21	Warner-Lambert Company	Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US5097045A (en) *	1989-02-01	1992-03-17	Warner-Lambert Company	Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5124482A (en) *	1988-02-22	1992-06-23	Warner-Lambert Company	Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis
US5149837A (en) *	1988-02-22	1992-09-22	Warner-Lambert Company	Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5245047A (en) *	1988-02-22	1993-09-14	Warner-Lambert Company	Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5003080A (en) *	1988-02-22	1991-03-26	Warner-Lambert Company	Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
US5216174A (en) *	1988-02-22	1993-06-01	Warner-Lambert Co.	Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
FI94339C (fi) *	1989-07-21	1995-08-25	Warner Lambert Co	Menetelmä farmaseuttisesti käyttökelpoisen /R-(R,R)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5103024A (en) *	1990-10-17	1992-04-07	Warner-Lambert Company	Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5248793A (en) *	1990-10-17	1993-09-28	Warner-Lambert Company	Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5155251A (en) *	1991-10-11	1992-10-13	Warner-Lambert Company	Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
US5298627A (en) *	1993-03-03	1994-03-29	Warner-Lambert Company	Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US6087511A (en) *	1996-07-16	2000-07-11	Warner-Lambert Company	Process for the production of amorphous [R-(R,R)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1)
DE19635598A1 (de) *	1996-09-02	1998-03-05	Focke & Co	Anlage zum Handhaben von insbesondere Zigaretten
EP1054860B1 (de) *	1997-12-19	2007-04-25	Pfizer Ireland Pharmaceuticals	Verfahren zur herstellung von 1,3-diolen
PL362981A1 (en) *	2000-11-16	2004-11-02	Teva Pharmaceutical Industries Ltd.	Hydrolysis of [r(r,r)]-2-(4-fluorophenyl)-beta,delta -dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid esters with calcium hydroxide

2005
- 2005-09-09 AT AT05777481T patent/ATE432276T1/de not_active IP Right Cessation
- 2005-09-09 EP EP05777481A patent/EP1922315B1/de not_active Expired - Lifetime
- 2005-09-09 WO PCT/IE2005/000094 patent/WO2007029216A1/en not_active Ceased
- 2005-09-09 DE DE602005014686T patent/DE602005014686D1/de not_active Expired - Fee Related
- 2005-09-09 US US12/065,555 patent/US20090221839A1/en not_active Abandoned
- 2005-09-09 JP JP2008529773A patent/JP2009507821A/ja active Pending
- 2005-09-09 CA CA002621506A patent/CA2621506A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20090221839A1 (en)	2009-09-03
EP1922315A1 (de)	2008-05-21
EP1922315B1 (de)	2009-05-27
WO2007029216A1 (en)	2007-03-15
JP2009507821A (ja)	2009-02-26
DE602005014686D1 (de)	2009-07-09
CA2621506A1 (en)	2007-03-15

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Legal Events

Date	Code	Title	Description
2009-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties