ATE432715T1 - Iniezierbare hyaluronat-sulphatierte polysaccharid konjugate - Google Patents
Iniezierbare hyaluronat-sulphatierte polysaccharid konjugateInfo
- Publication number
- ATE432715T1 ATE432715T1 AT00944722T AT00944722T ATE432715T1 AT E432715 T1 ATE432715 T1 AT E432715T1 AT 00944722 T AT00944722 T AT 00944722T AT 00944722 T AT00944722 T AT 00944722T AT E432715 T1 ATE432715 T1 AT E432715T1
- Authority
- AT
- Austria
- Prior art keywords
- injectable
- hyaluronate
- polysaccharide conjugates
- sulphated polysaccharide
- linking groups
- Prior art date
Links
- 150000004676 glycans Chemical class 0.000 title abstract 3
- 229920001282 polysaccharide Polymers 0.000 title abstract 3
- 239000005017 polysaccharide Substances 0.000 title abstract 3
- 125000005647 linker group Chemical group 0.000 abstract 2
- 230000001737 promoting effect Effects 0.000 abstract 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 125000004427 diamine group Chemical group 0.000 abstract 1
- 230000012010 growth Effects 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 229920002674 hyaluronan Polymers 0.000 abstract 1
- 229960003160 hyaluronic acid Drugs 0.000 abstract 1
- 239000007972 injectable composition Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920001515 polyalkylene glycol Polymers 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000008467 tissue growth Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/336,005 US6288043B1 (en) | 1999-06-18 | 1999-06-18 | Injectable hyaluronate-sulfated polysaccharide conjugates |
| PCT/US2000/016793 WO2000078356A1 (en) | 1999-06-18 | 2000-06-16 | Injectable hyaluronate-sulfated polysaccharide conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE432715T1 true ATE432715T1 (de) | 2009-06-15 |
Family
ID=23314176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00944722T ATE432715T1 (de) | 1999-06-18 | 2000-06-16 | Iniezierbare hyaluronat-sulphatierte polysaccharid konjugate |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6288043B1 (de) |
| EP (1) | EP1187636B1 (de) |
| JP (1) | JP2003502389A (de) |
| AT (1) | ATE432715T1 (de) |
| AU (1) | AU771500B2 (de) |
| CA (1) | CA2377529C (de) |
| DE (1) | DE60042325D1 (de) |
| ES (1) | ES2327709T3 (de) |
| WO (1) | WO2000078356A1 (de) |
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| US20050043234A1 (en) | 1996-10-16 | 2005-02-24 | Deisher Theresa A. | Novel FGF homologs |
| US6383519B1 (en) * | 1999-01-26 | 2002-05-07 | Vita Special Purpose Corporation | Inorganic shaped bodies and methods for their production and use |
| US6458162B1 (en) | 1999-08-13 | 2002-10-01 | Vita Special Purpose Corporation | Composite shaped bodies and methods for their production and use |
| US8366787B2 (en) | 2000-08-04 | 2013-02-05 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
| US6638312B2 (en) | 2000-08-04 | 2003-10-28 | Depuy Orthopaedics, Inc. | Reinforced small intestinal submucosa (SIS) |
| US7186419B2 (en) | 2000-08-25 | 2007-03-06 | Contura Sa | Polyacrylamide hydrogel for arthritis |
| MY130475A (en) | 2000-08-25 | 2007-06-29 | Contura As | Polyacrylamide hydrogel and its use as an endoprosthesis |
| EP1287048B2 (de) | 2000-08-25 | 2008-04-30 | Contura S.A. | Polyacrylamid hydrogel und seine verwendung als endoprothese |
| CA2430130A1 (en) * | 2000-11-28 | 2002-06-06 | Focal, Inc. | Polyalkylene glycol viscosity-enhancing polymeric formulations |
| AU2002316694B2 (en) | 2001-07-16 | 2007-09-06 | Depuy Products, Inc. | Hybrid biologic/synthetic porous extracellular matrix scaffolds |
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| JP4302515B2 (ja) | 2001-07-16 | 2009-07-29 | デピュイ・プロダクツ・インコーポレイテッド | 単体型外科装置および方法 |
| US20030032961A1 (en) | 2001-07-16 | 2003-02-13 | Pelo Mark Joseph | Devices from naturally occurring biologically derived materials |
| US7819918B2 (en) | 2001-07-16 | 2010-10-26 | Depuy Products, Inc. | Implantable tissue repair device |
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| US7569233B2 (en) | 2004-05-04 | 2009-08-04 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
| US9220595B2 (en) | 2004-06-23 | 2015-12-29 | Orthovita, Inc. | Shapeable bone graft substitute and instruments for delivery thereof |
| US20090319045A1 (en) * | 2004-10-12 | 2009-12-24 | Truncale Katherine G | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
| US7837740B2 (en) * | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
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| US7354627B2 (en) | 2004-12-22 | 2008-04-08 | Depuy Products, Inc. | Method for organizing the assembly of collagen fibers and compositions formed therefrom |
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| CA2623106C (en) | 2005-09-19 | 2013-12-24 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
| WO2007070547A2 (en) | 2005-12-14 | 2007-06-21 | Anika Therapeutics, Inc. | Treatment of arthritis and other musculoskeletal disorders with crosslinked hyaluronic acid |
| US20070202084A1 (en) | 2005-12-14 | 2007-08-30 | Anika Therapeutics, Inc. | Bioabsorbable implant of hyaluronic acid derivative for treatment of osteochondral and chondral defects |
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| ITPD20060219A1 (it) | 2006-05-31 | 2007-12-01 | Fidia Farmaceutici | Composizioni farmaceutiche contenenti acido ialuronico solfatato nel trattamento dell'osteoartrosi |
| EP2040765A2 (de) | 2006-06-29 | 2009-04-01 | Orthovita, INC. | Bioaktiver knochentransplantatersatz |
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| AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
| US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
| US20080255041A1 (en) * | 2007-04-11 | 2008-10-16 | Ebi, L.P. | Treatment of annulus fibrosis defects |
| US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
| CN101801405A (zh) | 2007-08-07 | 2010-08-11 | 先进科技及再生医学有限责任公司 | 包含于酸性水溶液中的gdf-5的蛋白质配方 |
| EP2254944B1 (de) * | 2008-02-29 | 2018-12-19 | PVAC Medical Technologies Ltd. | Zusammensetzung zur bildung von gelen |
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| US8343942B2 (en) | 2008-04-04 | 2013-01-01 | University Of Utah Research Foundation | Methods for treating interstitial cystitis |
| JP5599778B2 (ja) * | 2008-04-14 | 2014-10-01 | デピュイ・シンセス・プロダクツ・エルエルシー | 液体緩衝ｇｄｆ−５製剤 |
| GB2463474B (en) | 2008-09-11 | 2012-05-02 | Agency Science Tech & Res | Therapeutic bone growth and regeneration |
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| US20120294868A1 (en) | 2009-04-24 | 2012-11-22 | Edwards James R | Anti-tgf-beta induction of bone cell function and bone growth |
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| US8398611B2 (en) | 2010-12-28 | 2013-03-19 | Depuy Mitek, Inc. | Compositions and methods for treating joints |
| US8455436B2 (en) | 2010-12-28 | 2013-06-04 | Depuy Mitek, Llc | Compositions and methods for treating joints |
| US8524662B2 (en) | 2010-12-28 | 2013-09-03 | Depuy Mitek, Llc | Compositions and methods for treating joints |
| CA2830933A1 (en) | 2011-03-23 | 2012-09-27 | University Of Utah Research Foundation | Methods for treating or preventing urological inflammation |
| WO2012140650A2 (en) | 2011-04-12 | 2012-10-18 | Hepacore Ltd. | Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof |
| US8623839B2 (en) | 2011-06-30 | 2014-01-07 | Depuy Mitek, Llc | Compositions and methods for stabilized polysaccharide formulations |
| TW201322988A (zh) * | 2011-09-08 | 2013-06-16 | Shin Poong Pharmaceutical Co | 關節炎之治療注射劑 |
| CZ303879B6 (cs) | 2012-02-28 | 2013-06-05 | Contipro Biotech S.R.O. | Deriváty na bázi kyseliny hyaluronové schopné tvorit hydrogely, zpusob jejich prípravy, hydrogely na bázi techto derivátu, zpusob jejich prípravy a pouzití |
| CZ304512B6 (cs) | 2012-08-08 | 2014-06-11 | Contipro Biotech S.R.O. | Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití |
| CZ304654B6 (cs) | 2012-11-27 | 2014-08-20 | Contipro Biotech S.R.O. | Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití |
| WO2014165513A2 (en) * | 2013-04-02 | 2014-10-09 | The Regents Of The University Of California | Ethylsulfonated hyaluronic acid biopolymers and methods of use thereof |
| WO2015100343A1 (en) | 2013-12-23 | 2015-07-02 | Massachusetts Institute Of Technology | Controllably degradable compositions and methods |
| EP3101064B1 (de) * | 2014-01-31 | 2020-07-15 | Seikagaku Corporation | Diaminvernetzungsmittel, saurer polysaccharid-vernetzter körper und medizinisches material |
| CZ2014150A3 (cs) | 2014-03-11 | 2015-05-20 | Contipro Biotech S.R.O. | Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití |
| CZ2014451A3 (cs) | 2014-06-30 | 2016-01-13 | Contipro Pharma A.S. | Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| US9682099B2 (en) | 2015-01-20 | 2017-06-20 | DePuy Synthes Products, Inc. | Compositions and methods for treating joints |
| CZ309295B6 (cs) | 2015-03-09 | 2022-08-10 | Contipro A.S. | Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití |
| US10195305B2 (en) | 2015-03-24 | 2019-02-05 | Orthovita, Inc. | Bioactive flowable wash-out resistant bone graft material and method for production thereof |
| WO2016172026A1 (en) | 2015-04-20 | 2016-10-27 | The Board Of Regents Of The University Of Texas System | Clec11a is a bone growth agent |
| CZ2015398A3 (cs) | 2015-06-15 | 2017-02-08 | Contipro A.S. | Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin |
| CZ306662B6 (cs) | 2015-06-26 | 2017-04-26 | Contipro A.S. | Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití |
| CZ308106B6 (cs) | 2016-06-27 | 2020-01-08 | Contipro A.S. | Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití |
| WO2018053111A1 (en) | 2016-09-15 | 2018-03-22 | University Of Utah Research Foundation | In situ gelling compositions for the treatment or prevention of inflammation and tissue damage |
| CN111228653A (zh) | 2018-11-13 | 2020-06-05 | 格莱科米拉治疗公司 | 用电离辐射加强癌症治疗的方法 |
| WO2021087378A1 (en) * | 2019-11-01 | 2021-05-06 | Icahn School Of Medicine At Mount Sinai | Improved approach to repair tissue defects by bonding injectable gels to native soft tissues |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3706633A (en) * | 1970-04-10 | 1972-12-19 | Monsanto Co | Preparation of water-insoluble enzyme derivatives |
| US4582865A (en) * | 1984-12-06 | 1986-04-15 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
| US5128326A (en) * | 1984-12-06 | 1992-07-07 | Biomatrix, Inc. | Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same |
| US5011918A (en) * | 1987-10-26 | 1991-04-30 | National Starch And Chemical Investment Holding Corporation | Polysaccharides containing aromatic aldehydes and their derivatization via amine-aldehyde interactions |
| JP3404557B2 (ja) * | 1993-09-30 | 2003-05-12 | グンゼ株式会社 | 架橋ヒアルロン酸及びこれらの複合材料 |
| CA2140053C (en) * | 1994-02-09 | 2000-04-04 | Joel S. Rosenblatt | Collagen-based injectable drug delivery system and its use |
| JP3107726B2 (ja) * | 1994-05-13 | 2000-11-13 | 株式会社クラレ | 水膨潤性高分子ゲル |
| US5942499A (en) * | 1996-03-05 | 1999-08-24 | Orquest, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
| FR2752843B1 (fr) * | 1996-08-30 | 1998-10-16 | Sod Conseils Rech Applic | Copolymeres reticules a base de polymeres polycarboxyliques et leur utilisation comme support de composition pharmaceutique |
| JP4335316B2 (ja) * | 1996-09-19 | 2009-09-30 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン | アルギネートまたは修飾アルギネートのようなポリサッカライドを含むポリマー |
| US6303585B1 (en) | 1997-07-03 | 2001-10-16 | Orquest, Inc. | Cross-linked polysaccharide drug carrier |
| DE60024059T2 (de) | 1999-01-26 | 2006-07-20 | Newton Laboratories, Inc., Woburn | Vorrichtung zur autofluoreszensbildgebung für ein endoskop |
| GB9902412D0 (en) * | 1999-02-03 | 1999-03-24 | Fermentech Med Ltd | Process |
-
1999
- 1999-06-18 US US09/336,005 patent/US6288043B1/en not_active Expired - Lifetime
-
2000
- 2000-06-16 JP JP2001504418A patent/JP2003502389A/ja active Pending
- 2000-06-16 CA CA2377529A patent/CA2377529C/en not_active Expired - Fee Related
- 2000-06-16 AU AU58778/00A patent/AU771500B2/en not_active Ceased
- 2000-06-16 ES ES00944722T patent/ES2327709T3/es not_active Expired - Lifetime
- 2000-06-16 DE DE60042325T patent/DE60042325D1/de not_active Expired - Lifetime
- 2000-06-16 AT AT00944722T patent/ATE432715T1/de active
- 2000-06-16 WO PCT/US2000/016793 patent/WO2000078356A1/en not_active Ceased
- 2000-06-16 EP EP00944722A patent/EP1187636B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1187636B1 (de) | 2009-06-03 |
| DE60042325D1 (de) | 2009-07-16 |
| AU771500B2 (en) | 2004-03-25 |
| US6288043B1 (en) | 2001-09-11 |
| CA2377529A1 (en) | 2000-12-28 |
| JP2003502389A (ja) | 2003-01-21 |
| CA2377529C (en) | 2011-04-26 |
| EP1187636A1 (de) | 2002-03-20 |
| WO2000078356A1 (en) | 2000-12-28 |
| AU5877800A (en) | 2001-01-09 |
| ES2327709T3 (es) | 2009-11-03 |
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