ATE433485T1 - Chemisch modifizierte mutante serinhydrolasen - Google Patents

Chemisch modifizierte mutante serinhydrolasen

Info

Publication number: ATE433485T1
Authority: AT; Austria
Prior art keywords: cysteine; serine hydrolases; chemically modified; group; modified
Prior art date: 1998-11-10

Application number

AT99964973T

Other languages

English (en)

Inventor

John Jones

Michael Dickman

Original Assignee

Univ Toronto

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-10

Filing date

1999-11-09

Publication date

2009-06-15

1999-11-09 Application filed by Univ Toronto filed Critical Univ Toronto

2009-06-15 Application granted granted Critical

2009-06-15 Publication of ATE433485T1 publication Critical patent/ATE433485T1/de

Links

102000004157 Hydrolases Human genes 0.000 title abstract 3
108090000604 Hydrolases Proteins 0.000 title abstract 3
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 title abstract 2
235000018417 cysteine Nutrition 0.000 abstract 3
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 3
125000003282 alkyl amino group Chemical group 0.000 abstract 2
229930182470 glycoside Natural products 0.000 abstract 2
150000002338 glycosides Chemical class 0.000 abstract 2
150000003573 thiols Chemical class 0.000 abstract 2
IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
238000007056 transamidation reaction Methods 0.000 abstract 1
238000005809 transesterification reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT99964973T 1998-11-10 1999-11-09 Chemisch modifizierte mutante serinhydrolasen ATE433485T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US10775898P	1998-11-10	1998-11-10
US11306198P	1998-12-21	1998-12-21
PCT/US1999/026586 WO2000028007A2 (en)	1998-11-10	1999-11-09	Chemically modified mutant serine hydrolases

Publications (1)

Publication Number	Publication Date
ATE433485T1 true ATE433485T1 (de)	2009-06-15

Family

ID=26805118

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99964973T ATE433485T1 (de)	1998-11-10	1999-11-09	Chemisch modifizierte mutante serinhydrolasen

Country Status (9)

Country	Link
US (4)	US20050282248A1 (de)
EP (1)	EP1129180B1 (de)
JP (1)	JP4932990B2 (de)
AT (1)	ATE433485T1 (de)
AU (1)	AU772427B2 (de)
CA (1)	CA2348014A1 (de)
DE (1)	DE69940978D1 (de)
DK (1)	DK1129180T3 (de)
WO (1)	WO2000028007A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6908757B1 (en)	1998-03-26	2005-06-21	The Procter & Gamble Company	Serine protease variants having amino acid deletions and substitutions
US6495136B1 (en)	1998-03-26	2002-12-17	The Procter & Gamble Company	Proteases having modified amino acid sequences conjugated to addition moieties
US6569663B1 (en)	1998-03-26	2003-05-27	The Procter & Gamble Company	Serine protease variants having amino acid substitutions
WO2000028007A2 (en)	1998-11-10	2000-05-18	Genencor International, Inc.	Chemically modified mutant serine hydrolases
EP1185302B1 (de) *	1999-04-28	2013-07-24	Genencor International, Inc.	Spezifischer zielrichtung von katalytische antagoniste und deren verwendungen
BR0012660A (pt)	1999-07-22	2002-04-09	Procter & Gamble	Variante de protease tipo subtilisina; composição de limpeza; e composição de cuidado pessoal
US6946128B1 (en)	1999-07-22	2005-09-20	The Procter & Gamble Company	Protease conjugates having sterically protected epitope regions
CN1373802A (zh)	1999-07-22	2002-10-09	宝洁公司	在特定表位区域具有氨基酸缺失和取代的枯草杆菌蛋白酶变体
EP1196547A2 (de) *	1999-07-22	2002-04-17	The Procter & Gamble Company	Proteasekonjugate mit sterisch geschützten epitopgebieten
MXPA02000842A (es)	1999-07-22	2002-07-30	Procter & Gamble	Conjugados de proteasa que tienen sitios de corte protegidos estericamente.
US7202070B2 (en) *	2000-10-31	2007-04-10	Biocatalytics, Inc.	Method for reductive amination of a ketone using a mutated enzyme
DE10121463A1 (de) *	2001-05-02	2003-02-27	Henkel Kgaa	Neue Alkalische Protease-Varianten und Wasch- und Reinigungsmittel enthaltend diese neuen Alkalischen Protease-Varianten
EP1354960A1 (de) *	2002-04-08	2003-10-22	Degussa AG	Verfahren zur Bestimmung der Syntheseaktivität von Hydrolasen
EP1359225B1 (de) *	2002-04-08	2006-11-15	Degussa AG	Verfahren zur Bestimmung der Syntheseaktivität von Hydrolasen
EP3307848B1 (de)	2015-06-10	2019-03-06	Merck Patent GmbH	Chirale dotierstoffe mit nortricyclan-einheit

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5155033A (en)	1989-01-06	1992-10-13	Genencor, Inc.	Subtilisins modified at position 225 resulting in a shift in catalytic activity
US5972682A (en)	1984-05-29	1999-10-26	Genencor International, Inc.	Enzymatically active modified subtilisins
US5244791A (en)	1984-05-29	1993-09-14	Genecor International, Inc.	Methods of ester hydrolysis
CN1056187C (zh)	1988-02-11	2000-09-06	金克克国际有限公司	新的蛋白水解酶及其在洗涤剂中的应用
US5116741A (en) *	1988-04-12	1992-05-26	Genex Corporation	Biosynthetic uses of thermostable proteases
DK97190D0 (da)	1990-04-19	1990-04-19	Novo Nordisk As	Oxidationsstabile detergentenzymer
EP0542931B1 (de)	1990-08-09	1999-12-08	Genentech, Inc.	Serinproteasevarianten mit peptidligase aktivität
US5629173A (en) *	1990-08-09	1997-05-13	Genentech, Inc.	Methods of use of serine protease variants having peptide ligase activity
US5316935A (en) *	1992-04-06	1994-05-31	California Institute Of Technology	Subtilisin variants suitable for hydrolysis and synthesis in organic media
US5837516A (en)	1995-03-03	1998-11-17	Genentech, Inc.	Subtilisin variants capable of cleaving substrates containing basic residues
US6946280B1 (en)	1996-03-29	2005-09-20	Genencor International, Inc.	Enzyme multimer and process of producing same
CN1246146A (zh) *	1996-11-26	2000-03-01	金克克国际有限公司	化学修饰的酶
AR015977A1 (es)	1997-10-23	2001-05-30	Genencor Int	Variantes de proteasa multiplemente substituida con carga neta alterada para su empleo en detergentes
EP1064019B1 (de) *	1998-01-23	2010-11-03	The Governing Council Of The University Of Toronto	Chemisch modifizierte enzyme und methoden zu ihrer herstellung und zum screeningder enzyme
US6395532B1 (en) *	1998-01-23	2002-05-28	Genencor International, Inc.	Modified enzymes and their use for peptide synthesis
DE69939538D1 (de) *	1998-07-02	2008-10-23	Univ Toronto	Mit einer kohlenhydratgruppe chemisch modifizierte proteine
WO2000028007A2 (en)	1998-11-10	2000-05-18	Genencor International, Inc.	Chemically modified mutant serine hydrolases
AU2200100A (en) *	1998-12-21	2000-07-12	Genencor International, Inc.	Chemically modified enzymes with multiple charged variants

1999
- 1999-11-09 WO PCT/US1999/026586 patent/WO2000028007A2/en not_active Ceased
- 1999-11-09 AU AU30990/00A patent/AU772427B2/en not_active Ceased
- 1999-11-09 DK DK99964973T patent/DK1129180T3/da active
- 1999-11-09 CA CA002348014A patent/CA2348014A1/en not_active Abandoned
- 1999-11-09 EP EP99964973A patent/EP1129180B1/de not_active Expired - Lifetime
- 1999-11-09 AT AT99964973T patent/ATE433485T1/de not_active IP Right Cessation
- 1999-11-09 DE DE69940978T patent/DE69940978D1/de not_active Expired - Lifetime
- 1999-11-09 JP JP2000581174A patent/JP4932990B2/ja not_active Expired - Fee Related
2004
- 2004-03-01 US US10/791,093 patent/US20050282248A1/en not_active Abandoned
2008
- 2008-09-19 US US12/234,399 patent/US8148128B2/en not_active Expired - Fee Related
2012
- 2012-02-24 US US13/405,083 patent/US20120156721A1/en not_active Abandoned
- 2012-07-30 US US13/561,257 patent/US8357524B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20120156721A1 (en)	2012-06-21
CA2348014A1 (en)	2000-05-18
US8357524B2 (en)	2013-01-22
AU3099000A (en)	2000-05-29
JP2002529078A (ja)	2002-09-10
AU772427B2 (en)	2004-04-29
DE69940978D1 (de)	2009-07-23
JP4932990B2 (ja)	2012-05-16
US20090075329A1 (en)	2009-03-19
US8148128B2 (en)	2012-04-03
EP1129180A2 (de)	2001-09-05
DK1129180T3 (da)	2009-08-24
US20120295329A1 (en)	2012-11-22
US20050282248A1 (en)	2005-12-22
EP1129180B1 (de)	2009-06-10
WO2000028007A3 (en)	2000-07-27
WO2000028007A2 (en)	2000-05-18

Legal Events

Date	Code	Title	Description
2009-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69940978D1 (de)	2009-07-23	Chemisch modifizierte mutante serinhydrolasen
BR9908280A (pt)	2000-10-31	Inibidores de enzimas de fosfolipase
DE60131262D1 (en)	2007-12-20	Ubiquitin-ligase-assay
WO2003103613A3 (en)	2004-04-01	Induction of insulin expression
IL128221A (en)	2003-12-10	Cell adhesion inhibitors
TR200003071T2 (tr)	2001-04-20	Sistein-proteazı önleyici etkiye sahip yeni heterosiklik ikame edilmiş amidler
TR199901191T2 (xx)	1999-12-21	Benzamidoaldehitlerin sistein proteaz� inhibit�r� olarak kullan�m�.
AU7417398A (en)	1998-06-22	Chemically modified enzymes
WO2003006652A3 (en)	2004-05-13	Inhibition of specific histone deacetylase isoforms
TR199902728T2 (xx)	2000-09-21	Kuinolat fosforibosil transferaz ekspresyonunun d�zenlenmesi.
BR0115361A (pt)	2004-02-25	Método de estabilizar hidrogéis de silicone contra a degradação hidrolìtica
BR0011030A (pt)	2002-02-26	Composições de cicloporina substancialmente livre de óleo
DE69433015D1 (de)	2003-09-11	Neue Enzyme und Prodrugs für ADEPT
EP0975353A4 (de)	2001-11-28	Peptidyl-2-amino-1hydroxyalkansulfonsäuren als cystein-protease-inhibitoren
AU2002304335A1 (en)	2002-10-08	Culture medium for enhanced heterologous protein expression
NO975188L (no)	1998-01-14	Anvendelse av mannanaser som slimregulerende midler
AR001732A1 (es)	1997-11-26	Celulasa alcalina novedosa y método para producirla
IL138688A0 (en)	2001-10-31	Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme
DE69820082D1 (de)	2004-01-08	Durch-schnappende dichtung für galvanische zelle
GB0115382D0 (en)	2001-08-15	Mutant
NO20003880D0 (no)	2000-07-28	Transfekterende midler som er sensitive overfor reduserende betingelser, farmasøytiske preparater inneholdende disse samt deres anvendelser
AR030593A1 (es)	2003-08-27	Sistema tensioactivo
AU2003287945A8 (en)	2004-03-19	Mutant protein and refolding method
WO2002086092A3 (en)	2005-03-03	N-methyltransferase
ATE311441T1 (de)	2005-12-15	Acrylamidase-enzyme