ATE434131T1 - System zur handhabung einer fluidmenge - Google Patents

System zur handhabung einer fluidmenge

Info

Publication number
ATE434131T1
ATE434131T1 AT04799095T AT04799095T ATE434131T1 AT E434131 T1 ATE434131 T1 AT E434131T1 AT 04799095 T AT04799095 T AT 04799095T AT 04799095 T AT04799095 T AT 04799095T AT E434131 T1 ATE434131 T1 AT E434131T1
Authority
AT
Austria
Prior art keywords
fluid
droplet
control electrodes
counter electrode
fluid droplet
Prior art date
Application number
AT04799095T
Other languages
English (en)
Inventor
Michel Decre
Thomas Duriez
Stein Kuiper
Original Assignee
Koninkl Philips Electronics Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninkl Philips Electronics Nv filed Critical Koninkl Philips Electronics Nv
Application granted granted Critical
Publication of ATE434131T1 publication Critical patent/ATE434131T1/de

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B17/00—Methods preventing fouling
    • B08B17/02—Preventing deposition of fouling or of dust
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0493—Specific techniques used
    • B01L2400/0496—Travelling waves, e.g. in combination with electrical or acoustic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
    • B41J—TYPEWRITERS; SELECTIVE PRINTING MECHANISMS, i.e. MECHANISMS PRINTING OTHERWISE THAN FROM A FORME; CORRECTION OF TYPOGRAPHICAL ERRORS
    • B41J2/00—Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed
    • B41J2/005—Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed characterised by bringing liquid or particles selectively into contact with a printing material
    • B41J2/01—Ink jet
    • B41J2/135—Nozzles
    • B41J2/14—Structure thereof only for on-demand ink jet heads
    • B41J2002/14395—Electrowetting

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Coating Apparatus (AREA)
  • Fats And Perfumes (AREA)
  • Control Of Non-Electrical Variables (AREA)
AT04799095T 2003-11-17 2004-11-09 System zur handhabung einer fluidmenge ATE434131T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03104229 2003-11-17
PCT/IB2004/052355 WO2005047696A1 (en) 2003-11-17 2004-11-09 System for manipulation of a body of fluid

Publications (1)

Publication Number Publication Date
ATE434131T1 true ATE434131T1 (de) 2009-07-15

Family

ID=34585907

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04799095T ATE434131T1 (de) 2003-11-17 2004-11-09 System zur handhabung einer fluidmenge

Country Status (7)

Country Link
US (1) US7328979B2 (de)
EP (1) EP1687531B1 (de)
JP (1) JP4773360B2 (de)
CN (1) CN100478075C (de)
AT (1) ATE434131T1 (de)
DE (1) DE602004021624D1 (de)
WO (1) WO2005047696A1 (de)

Families Citing this family (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080135411A1 (en) * 2004-06-16 2008-06-12 Whitehead Lorne A Microfluidic Transport By Electrostatic Deformation of Fluidic Interfaces
JP4539213B2 (ja) * 2004-07-27 2010-09-08 ブラザー工業株式会社 液体移送装置
DK1859330T3 (da) 2005-01-28 2012-10-15 Univ Duke Apparater og fremgangsmåder til håndtering af små dråber på et trykt kredsløbskort
EP1877334A4 (de) * 2005-04-25 2011-05-04 Agency Science Tech & Res Systeme und verfahren zum pumpen von kontinuierlichen flüssigkeitssäulen unter verwendung von hydrophobizitätssteuermerkmalen in einem mikrokanal
EP1885885A4 (de) 2005-05-11 2008-08-27 Nanolytics Inc Verfahren und vorrichtung zur ausführung biochemischer oder chemischer reaktionen bei mehreren temperaturen
FR2887705B1 (fr) * 2005-06-27 2007-08-10 Commissariat Energie Atomique Dispositif de pompage ou de centrifugation des gouttes deplacees par electromouillage
KR100781739B1 (ko) * 2005-09-28 2007-12-03 삼성전자주식회사 전기습윤에서 액적의 접촉각 변위 및 변화속도 증가방법 및상기 방법에 의해 형성된 액적을 적용한 액적제어장치
US20140193807A1 (en) 2006-04-18 2014-07-10 Advanced Liquid Logic, Inc. Bead manipulation techniques
US9476856B2 (en) 2006-04-13 2016-10-25 Advanced Liquid Logic, Inc. Droplet-based affinity assays
WO2007123908A2 (en) 2006-04-18 2007-11-01 Advanced Liquid Logic, Inc. Droplet-based multiwell operations
US7901947B2 (en) 2006-04-18 2011-03-08 Advanced Liquid Logic, Inc. Droplet-based particle sorting
US8389297B2 (en) 2006-04-18 2013-03-05 Duke University Droplet-based affinity assay device and system
US7439014B2 (en) * 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
US8658111B2 (en) 2006-04-18 2014-02-25 Advanced Liquid Logic, Inc. Droplet actuators, modified fluids and methods
US8637324B2 (en) 2006-04-18 2014-01-28 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US10078078B2 (en) 2006-04-18 2018-09-18 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US8716015B2 (en) 2006-04-18 2014-05-06 Advanced Liquid Logic, Inc. Manipulation of cells on a droplet actuator
US8980198B2 (en) 2006-04-18 2015-03-17 Advanced Liquid Logic, Inc. Filler fluids for droplet operations
US8809068B2 (en) * 2006-04-18 2014-08-19 Advanced Liquid Logic, Inc. Manipulation of beads in droplets and methods for manipulating droplets
WO2009111769A2 (en) 2008-03-07 2009-09-11 Advanced Liquid Logic, Inc. Reagent and sample preparation and loading on a fluidic device
US8172159B2 (en) * 2006-11-07 2012-05-08 Wch Technologies, Inc. Surface to move a fluid via fringe electric fields
US20100024908A1 (en) * 2006-11-27 2010-02-04 Takashi Yasuda Microvolume liquid dispensing device
FR2909293B1 (fr) * 2006-12-05 2011-04-22 Commissariat Energie Atomique Micro-dispositif de traitement d'echantillons liquides
WO2008091848A2 (en) 2007-01-22 2008-07-31 Advanced Liquid Logic, Inc. Surface assisted fluid loading and droplet dispensing
KR101503510B1 (ko) 2007-02-09 2015-03-18 어드밴스드 리퀴드 로직, 아이엔씨. 자성 비즈를 이용하는 액적 작동기 장치 및 방법
WO2008101194A2 (en) 2007-02-15 2008-08-21 Advanced Liquid Logic, Inc. Capacitance detection in a droplet actuator
WO2011084703A2 (en) 2009-12-21 2011-07-14 Advanced Liquid Logic, Inc. Enzyme assays on a droplet actuator
EP2126038B1 (de) 2007-03-22 2015-01-07 Advanced Liquid Logic, Inc. Enzymassays für einen tropfenaktuator
EP2132296A4 (de) * 2007-04-10 2015-04-08 Advanced Liquid Logic Inc Tropfenausgabevorrichtung und verfahren
WO2009002920A1 (en) 2007-06-22 2008-12-31 Advanced Liquid Logic, Inc. Droplet-based nucleic acid amplification in a temperature gradient
EP2188059B1 (de) * 2007-08-24 2016-05-04 Advanced Liquid Logic, Inc. Kügelchenmanipulation bei einem tröpfchenbetätiger
WO2009032863A2 (en) 2007-09-04 2009-03-12 Advanced Liquid Logic, Inc. Droplet actuator with improved top substrate
US8460528B2 (en) * 2007-10-17 2013-06-11 Advanced Liquid Logic Inc. Reagent storage and reconstitution for a droplet actuator
US20100236928A1 (en) * 2007-10-17 2010-09-23 Advanced Liquid Logic, Inc. Multiplexed Detection Schemes for a Droplet Actuator
US20100236929A1 (en) * 2007-10-18 2010-09-23 Advanced Liquid Logic, Inc. Droplet Actuators, Systems and Methods
US8562807B2 (en) * 2007-12-10 2013-10-22 Advanced Liquid Logic Inc. Droplet actuator configurations and methods
CA2709928A1 (en) * 2007-12-23 2009-07-09 Advanced Liquid Logic, Inc. Droplet actuator configurations and methods of conducting droplet operations
US8367370B2 (en) * 2008-02-11 2013-02-05 Wheeler Aaron R Droplet-based cell culture and cell assays using digital microfluidics
US8852952B2 (en) 2008-05-03 2014-10-07 Advanced Liquid Logic, Inc. Method of loading a droplet actuator
US20110097763A1 (en) * 2008-05-13 2011-04-28 Advanced Liquid Logic, Inc. Thermal Cycling Method
EP2286228B1 (de) * 2008-05-16 2019-04-03 Advanced Liquid Logic, Inc. Tröpfchenaktuatorvorrichtungen und verfahren zur manipulation von kügelchen
US8187864B2 (en) 2008-10-01 2012-05-29 The Governing Council Of The University Of Toronto Exchangeable sheets pre-loaded with reagent depots for digital microfluidics
US8053239B2 (en) 2008-10-08 2011-11-08 The Governing Council Of The University Of Toronto Digital microfluidic method for protein extraction by precipitation from heterogeneous mixtures
EP2346777A4 (de) 2008-10-10 2014-10-01 Univ Toronto Hybride digitale mikrofluidische kanalvorrichtungen und herstellungsverfahren dafür
US8877512B2 (en) * 2009-01-23 2014-11-04 Advanced Liquid Logic, Inc. Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator
US9851365B2 (en) 2009-02-26 2017-12-26 The Governing Council Of The University Of Toronto Digital microfluidic liquid-liquid extraction device and method of use thereof
US8202736B2 (en) * 2009-02-26 2012-06-19 The Governing Council Of The University Of Toronto Method of hormone extraction using digital microfluidics
US8926065B2 (en) 2009-08-14 2015-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
US8846414B2 (en) 2009-09-29 2014-09-30 Advanced Liquid Logic, Inc. Detection of cardiac markers on a droplet actuator
US9091649B2 (en) 2009-11-06 2015-07-28 Advanced Liquid Logic, Inc. Integrated droplet actuator for gel; electrophoresis and molecular analysis
WO2011106314A2 (en) 2010-02-25 2011-09-01 Advanced Liquid Logic, Inc. Method of making nucleic acid libraries
EP2553473A4 (de) 2010-03-30 2016-08-10 Advanced Liquid Logic Inc Tröpfchenoperationsplattform
DK2556171T3 (en) 2010-04-05 2015-12-14 Prognosys Biosciences Inc Spatially CODED BIOLOGICAL ASSAYS
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US10232374B2 (en) 2010-05-05 2019-03-19 Miroculus Inc. Method of processing dried samples using digital microfluidic device
EP2588322B1 (de) 2010-06-30 2015-06-17 Advanced Liquid Logic, Inc. Tropfen-stellgliedbaugruppen und verfahren zur herstellung davon
WO2012040861A1 (en) 2010-10-01 2012-04-05 The Governing Council Of The University Of Toronto Digital microfluidic devices and methods incorporating a solid phase
WO2012068055A2 (en) 2010-11-17 2012-05-24 Advanced Liquid Logic, Inc. Capacitance detection in a droplet actuator
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
EP2705374A4 (de) 2011-05-02 2014-11-12 Advanced Liquid Logic Inc Molekulare diagnoseplattform
US9188615B2 (en) 2011-05-09 2015-11-17 Advanced Liquid Logic, Inc. Microfluidic feedback using impedance detection
CN103597356A (zh) 2011-05-10 2014-02-19 先进流体逻辑公司 酶浓缩与分析
US8901043B2 (en) 2011-07-06 2014-12-02 Advanced Liquid Logic, Inc. Systems for and methods of hybrid pyrosequencing
AU2012279420A1 (en) 2011-07-06 2014-01-30 Advanced Liquid Logic Inc Reagent storage on a droplet actuator
US9513253B2 (en) 2011-07-11 2016-12-06 Advanced Liquid Logic, Inc. Droplet actuators and techniques for droplet-based enzymatic assays
WO2013016413A2 (en) 2011-07-25 2013-01-31 Advanced Liquid Logic Inc Droplet actuator apparatus and system
EP2776165A2 (de) 2011-11-07 2014-09-17 Illumina, Inc. Integrierte sequenzierungsvorrichtungen und verwendungsverfahren
US10731199B2 (en) 2011-11-21 2020-08-04 Advanced Liquid Logic, Inc. Glucose-6-phosphate dehydrogenase assays
US9223317B2 (en) 2012-06-14 2015-12-29 Advanced Liquid Logic, Inc. Droplet actuators that include molecular barrier coatings
AU2013284425B2 (en) 2012-06-27 2017-07-27 Advanced Liquid Logic Inc. Techniques and droplet actuator designs for reducing bubble formation
WO2014062551A1 (en) 2012-10-15 2014-04-24 Advanced Liquid Logic, Inc. Digital microfluidics cartridge and system for operating a flow cell
WO2014060483A1 (en) 2012-10-17 2014-04-24 Spatial Transcriptomics Ab Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
US9868979B2 (en) 2013-06-25 2018-01-16 Prognosys Biosciences, Inc. Spatially encoded biological assays using a microfluidic device
EP3033599A4 (de) 2013-08-13 2017-03-22 Advanced Liquid Logic, Inc. Verfahren zur verbesserung der genauigkeit und präzision der tröpfchendosierung unter verwendung eines behälters auf einem aktuator als flüssigkeitseingabe
US20160199832A1 (en) 2013-08-30 2016-07-14 Advanced Liquid Logic France Sas Manipulation of droplets on hydrophilic or variegated-hydrophilic surfaces
CN106459967A (zh) 2014-04-29 2017-02-22 Illumina公司 使用模板转换和标签化的多重单细胞基因表达分析
KR102241309B1 (ko) * 2014-08-12 2021-04-16 광주과학기술원 전기습윤 구동 방식의 광자극기
BR112017005038B1 (pt) 2014-10-09 2022-01-25 Illumina, Inc Método e dispositivo para separar líquidos imiscíveis para isolar efetivamente pelo menos um dos líquidos
EP3210010B1 (de) * 2014-10-21 2019-04-24 The Governing Council of the University of Toronto Digitale mikrofluidische vorrichtungen mit integrierten elektrochemischen sensoren
EP3227025B1 (de) 2014-12-05 2019-03-27 The Regents of The University of California Einseitige lichtaktivierte mikrofluidische vorrichtung mit integriertem gitterboden
SG11201706504RA (en) 2015-02-10 2017-09-28 Illumina Inc Methods and compositions for analyzing cellular components
EP3271073B1 (de) 2015-03-20 2019-06-12 Illumina, Inc. Fluidikkassette zur verwendung in vertikaler oder weitgehend vertikaler position
EP4282977B1 (de) 2015-04-10 2024-06-05 10x Genomics Sweden AB Räumlich getrennte multiplex-nukleinsäureanalyse von biologischen proben
CA3176115A1 (en) 2015-04-22 2016-10-27 Berkeley Lights, Inc. Microfluidic device for culturing biological cells and methods of use thereof
EP4190912A1 (de) 2015-05-11 2023-06-07 Illumina, Inc. Plattform zur entdeckung und analyse von therapeutika
WO2016197106A1 (en) 2015-06-05 2016-12-08 Miroculus Inc. Evaporation management in digital microfluidic devices
WO2016197103A1 (en) 2015-06-05 2016-12-08 Miroculus Inc. Air-matrix digital microfluidics apparatuses and methods for limiting evaporation and surface fouling
WO2017007757A1 (en) 2015-07-06 2017-01-12 Illumina, Inc. Balanced ac modulation for driving droplet operations electrodes
DK3334839T3 (da) 2015-08-14 2021-04-26 Illumina Inc Systemer og fremgangsmåder under anvendelse af magnetisk reagerende sensorer til bestemmelse af en genetisk egenskab
JP6743150B2 (ja) 2015-08-28 2020-08-19 イルミナ インコーポレイテッド 単一細胞の核酸配列分析
US10906044B2 (en) 2015-09-02 2021-02-02 Illumina Cambridge Limited Methods of improving droplet operations in fluidic systems with a filler fluid including a surface regenerative silane
US10450598B2 (en) 2015-09-11 2019-10-22 Illumina, Inc. Systems and methods for obtaining a droplet having a designated concentration of a substance-of-interest
AU2016341948A1 (en) 2015-10-22 2018-05-10 Illumina Cambridge Limited Filler fluid for fluidic devices
US10799865B2 (en) 2015-10-27 2020-10-13 Berkeley Lights, Inc. Microfluidic apparatus having an optimized electrowetting surface and related systems and methods
AU2016344171B2 (en) * 2015-10-27 2021-09-23 Berkeley Lights, Inc. Microfluidic electrowetting device apparatus having a covalently bound hydrophobic surface
WO2017095845A1 (en) 2015-12-01 2017-06-08 Illumina, Inc. Liquid storage and delivery mechanisms and methods
US11203016B2 (en) 2015-12-01 2021-12-21 Illumina, Inc. Digital microfluidic system for single-cell isolation and characterization of analytes
CN109312396A (zh) 2016-04-07 2019-02-05 伊鲁米那股份有限公司 用于构建标准化核酸文库的方法和系统
WO2017205830A1 (en) 2016-05-26 2017-11-30 Berkeley Lights, Inc. Covalently modified surfaces, kits, and methods of preparation and use
CN109715781A (zh) 2016-08-22 2019-05-03 米罗库鲁斯公司 用于数字微流控设备中的并行液滴控制的反馈系统
EP3563151A4 (de) 2016-12-28 2020-08-19 Miroculus Inc. Digitale mikrofluidische vorrichtung und verfahren
US11623219B2 (en) 2017-04-04 2023-04-11 Miroculus Inc. Digital microfluidics apparatuses and methods for manipulating and processing encapsulated droplets
US11413617B2 (en) 2017-07-24 2022-08-16 Miroculus Inc. Digital microfluidics systems and methods with integrated plasma collection device
JP7341124B2 (ja) 2017-09-01 2023-09-08 ミロキュラス インコーポレイテッド デジタルマイクロ流体デバイスおよびその使用方法
ES2983417T3 (es) 2018-01-29 2024-10-23 St Jude Childrens Res Hospital Inc Método para la amplificación de ácidos nucleicos
CA3096855A1 (en) 2018-05-23 2019-11-28 Miroculus Inc. Control of evaporation in digital microfluidics
WO2020160520A1 (en) 2019-01-31 2020-08-06 Miroculus Inc. Non fouling compositions and methods for manipulating and processing encapsulated droplets
WO2020210292A1 (en) 2019-04-08 2020-10-15 Miroculus Inc. Multi-cartridge digital microfluidics apparatuses and methods of use
WO2021016614A1 (en) 2019-07-25 2021-01-28 Miroculus Inc. Digital microfluidics devices and methods of use thereof
WO2021022085A2 (en) 2019-07-31 2021-02-04 Bioskryb, Inc. Single cell analysis
US12157124B2 (en) 2019-11-06 2024-12-03 10X Genomics, Inc. Imaging system hardware
WO2021102134A1 (en) 2019-11-20 2021-05-27 E Ink Corporation Spatially variable hydrophobic layers for digital microfluidics
CN114945426A (zh) 2020-01-17 2022-08-26 核酸有限公司 用于数字微流体的空间可变介电层
US12405264B2 (en) 2020-01-17 2025-09-02 10X Genomics, Inc. Electrophoretic system and method for analyte capture
US11946901B2 (en) 2020-01-27 2024-04-02 Nuclera Ltd Method for degassing liquid droplets by electrical actuation at higher temperatures
US11410620B2 (en) 2020-02-18 2022-08-09 Nuclera Nucleics Ltd. Adaptive gate driving for high frequency AC driving of EWoD arrays
CN115135413A (zh) 2020-02-19 2022-09-30 核酸有限公司 用于EWoD阵列的高频AC驱动的锁存晶体管驱动
CN115461152A (zh) 2020-04-27 2022-12-09 核酸有限公司 用于数字微流体的可变驱动和短路保护的分段顶板
US12416603B2 (en) 2020-05-19 2025-09-16 10X Genomics, Inc. Electrophoresis cassettes and instrumentation
EP4414459B1 (de) 2020-05-22 2025-09-03 10X Genomics, Inc. Simultane räumlich-zeitliche messung der genexpression und der zellaktivität
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
WO2021252747A1 (en) 2020-06-10 2021-12-16 1Ox Genomics, Inc. Fluid delivery methods
JP2023540754A (ja) 2020-09-04 2023-09-26 バービーズ インコーポレイテッド 非結合型ビリルビンのためのマイクロ流体に基づく検定評価
EP4214678B1 (de) 2020-09-18 2024-11-06 10X Genomics, Inc. Probenhandhabungsvorrichtung und bildregistrierungsverfahren
TW202228845A (zh) 2020-10-08 2022-08-01 英商核酸有限公司 微流體系統中試劑特異驅動ewod（介電質上電潤濕）陣列的方法
EP4240528A1 (de) 2020-11-04 2023-09-13 Nuclera Ltd Dielektrische schichten für digitale mikrofluidische vorrichtungen
WO2022178267A2 (en) 2021-02-19 2022-08-25 10X Genomics, Inc. Modular assay support devices
KR20240033223A (ko) 2021-06-02 2024-03-12 배비스 인코포레이티드 디지털 미세유체의 미세 영역 열 제어(micro-regional thermal control for digital microfluidics)
US12553805B2 (en) 2021-08-02 2026-02-17 10X Genomics, Inc. Methods of preserving a biological sample
USD1064308S1 (en) 2021-09-17 2025-02-25 10X Genomics, Inc. Sample handling device
EP4441711A1 (de) 2021-12-20 2024-10-09 10X Genomics, Inc. Selbsttest für eine pathologie-/histologie-objektträgerbildgebungsvorrichtung
US11772093B2 (en) 2022-01-12 2023-10-03 Miroculus Inc. Methods of mechanical microfluidic manipulation
US20250060333A1 (en) 2023-08-16 2025-02-20 E Ink Corporation Devices, methods, and systems for visualizing electrowetting pathing using electrophoretic materials

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0267782A3 (de) * 1986-11-10 1989-09-27 Kabushiki Kaisha Toshiba Tintenstrahlsystem
US6315953B1 (en) * 1993-11-01 2001-11-13 Nanogen, Inc. Devices for molecular biological analysis and diagnostics including waveguides
US6071394A (en) * 1996-09-06 2000-06-06 Nanogen, Inc. Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
JP3791999B2 (ja) * 1997-03-24 2006-06-28 株式会社アドバンス 液体微粒子ハンドリング装置
FR2769375B1 (fr) * 1997-10-08 2001-01-19 Univ Joseph Fourier Lentille a focale variable
FI980874A7 (fi) * 1998-04-20 1999-10-21 Wallac Oy Menetelmä ja laite pienten nestemäärien kemiallisen analyysin suorittamiseksi
US6565727B1 (en) * 1999-01-25 2003-05-20 Nanolytics, Inc. Actuators for microfluidics without moving parts
US6939451B2 (en) 2000-09-19 2005-09-06 Aclara Biosciences, Inc. Microfluidic chip having integrated electrodes
DE10124988A1 (de) * 2001-05-22 2002-12-12 Infineon Technologies Ag Dispensier-Anordnung und Verfahren zum Dispensieren einer zu dispensierenden Lösung unter Verwendung der Dispensier-Anordnung
US6538823B2 (en) * 2001-06-19 2003-03-25 Lucent Technologies Inc. Tunable liquid microlens
CA2472649A1 (en) * 2002-01-08 2003-07-17 Japan Science And Technology Agency Pcr and hybridization methods utilizing electrostatic transportation and devices therefor
US6887362B2 (en) * 2002-02-06 2005-05-03 Nanogen, Inc. Dielectrophoretic separation and immunoassay methods on active electronic matrix devices
JP4031322B2 (ja) * 2002-08-26 2008-01-09 独立行政法人科学技術振興機構 液滴操作装置
JP4438044B2 (ja) * 2002-10-15 2010-03-24 キヤノン株式会社 電気泳動表示用粒子分散液およびそれを用いた電気泳動表示装置

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EP1687531A1 (de) 2006-08-09
JP2007512121A (ja) 2007-05-17
US20070139486A1 (en) 2007-06-21
DE602004021624D1 (de) 2009-07-30
CN100478075C (zh) 2009-04-15
WO2005047696A1 (en) 2005-05-26
JP4773360B2 (ja) 2011-09-14
EP1687531B1 (de) 2009-06-17
CN1882778A (zh) 2006-12-20

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