ATE434931T1 - Rattenmodell der diabetes-nephropathie - Google Patents
Rattenmodell der diabetes-nephropathieInfo
- Publication number
- ATE434931T1 ATE434931T1 AT04778887T AT04778887T ATE434931T1 AT E434931 T1 ATE434931 T1 AT E434931T1 AT 04778887 T AT04778887 T AT 04778887T AT 04778887 T AT04778887 T AT 04778887T AT E434931 T1 ATE434931 T1 AT E434931T1
- Authority
- AT
- Austria
- Prior art keywords
- rat
- test compound
- diabetic nephropathy
- rat model
- diabetes nephropathy
- Prior art date
Links
- 238000011552 rat model Methods 0.000 title abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 208000017169 kidney disease Diseases 0.000 title 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 abstract 4
- 208000033679 diabetic kidney disease Diseases 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 230000002508 compound effect Effects 0.000 abstract 1
- 206010061989 glomerulosclerosis Diseases 0.000 abstract 1
- 230000003278 mimic effect Effects 0.000 abstract 1
- 230000000750 progressive effect Effects 0.000 abstract 1
- 201000001474 proteinuria Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0362—Animal model for lipid/glucose metabolism, e.g. obesity, type-2 diabetes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Environmental Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/625,870 US7507871B2 (en) | 2002-07-25 | 2003-07-23 | Rat model of diabetic nephropathy |
| PCT/US2004/023567 WO2005009119A1 (en) | 2003-07-23 | 2004-07-21 | Rat model of diabetic nephropathy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE434931T1 true ATE434931T1 (de) | 2009-07-15 |
Family
ID=34103233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04778887T ATE434931T1 (de) | 2003-07-23 | 2004-07-21 | Rattenmodell der diabetes-nephropathie |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7507871B2 (de) |
| EP (1) | EP1648224B1 (de) |
| JP (1) | JP2006527999A (de) |
| AT (1) | ATE434931T1 (de) |
| CA (1) | CA2533315A1 (de) |
| DE (1) | DE602004021811D1 (de) |
| WO (1) | WO2005009119A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2446484C1 (ru) * | 2010-11-25 | 2012-03-27 | Государственное образовательное учреждение высшего профессионального образования "Северо-Осетинская государственная медицинская академия "Федерального агентства по здравоохранению и социальному развитию" | Способ моделирования кобальтовой нефропатии у экспериментальных животных при хроническом отравлении |
| CN103432572B (zh) * | 2013-06-21 | 2018-09-18 | 四川大学华西医院 | 一种恒河猴糖尿病肾病模型的制备方法 |
| CN106035210B (zh) * | 2016-06-02 | 2020-02-14 | 中国人民解放军海军医学研究所 | 建立急性高原缺氧与焦虑应激反应动物模型的方法 |
| CN111269829A (zh) * | 2018-12-05 | 2020-06-12 | 中国科学院大连化学物理研究所 | 基于器官芯片的二甲双胍对糖尿病肾病保护作用评价方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3025917B2 (ja) * | 1990-12-19 | 2000-03-27 | 大塚製薬株式会社 | インシュリン非依存性糖尿病ラット |
| US6465714B2 (en) | 1999-11-05 | 2002-10-15 | Arexis Ab | Congenic animal models of non-insulin dependent diabetes mellitus |
| US7111755B2 (en) | 2002-07-08 | 2006-09-26 | Canon Kabushiki Kaisha | Liquid discharge method and apparatus and display device panel manufacturing method and apparatus |
-
2003
- 2003-07-23 US US10/625,870 patent/US7507871B2/en not_active Expired - Fee Related
-
2004
- 2004-07-21 EP EP04778887A patent/EP1648224B1/de not_active Expired - Lifetime
- 2004-07-21 AT AT04778887T patent/ATE434931T1/de not_active IP Right Cessation
- 2004-07-21 DE DE602004021811T patent/DE602004021811D1/de not_active Expired - Fee Related
- 2004-07-21 WO PCT/US2004/023567 patent/WO2005009119A1/en not_active Ceased
- 2004-07-21 CA CA002533315A patent/CA2533315A1/en not_active Abandoned
- 2004-07-21 JP JP2006521233A patent/JP2006527999A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US7507871B2 (en) | 2009-03-24 |
| WO2005009119A1 (en) | 2005-02-03 |
| EP1648224A1 (de) | 2006-04-26 |
| JP2006527999A (ja) | 2006-12-14 |
| CA2533315A1 (en) | 2005-02-03 |
| EP1648224B1 (de) | 2009-07-01 |
| US20050166273A1 (en) | 2005-07-28 |
| DE602004021811D1 (de) | 2009-08-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA200970305A1 (ru) | Способ для прогнозирования добычи нефтяного пласта-коллектора с использованием генетического программирования | |
| WO2004099896A3 (en) | Method and system of developing a software with utilizing extented metadata of component under component-based development environment | |
| ATE541260T1 (de) | Verfahren für rechnerunterstütztes testen von softwareanwendungskomponenten | |
| WO2006091425A3 (en) | Security risk analysis system and method | |
| NO20081164L (no) | Maler med ettermaltids testtidsalarm | |
| ATE428141T1 (de) | Ereignis-basierte koordination prozessorientierter zusammengesetzter anwendungen | |
| WO2006099544A3 (en) | Apparatus and method for computer modeling type 1 diabetes | |
| CY1107021T1 (el) | Μεθοδος προσδιορισμου της ποσοτητας εκμαγειου νουκλεϊνικου οξεος που υπαρχει σε ενα δειγμα | |
| NO20091547L (no) | Driftssystem og fremgangsmate for oljefelt | |
| DE60330120D1 (de) | Verfahren zur auswertung der integrität einer struktur | |
| EA200300362A1 (ru) | Способ генерирования молекулярно-функциональной сети | |
| DE602006012292D1 (de) | Verfahren zur datenverarbeitung mit modularer potenzierung und dazugehörige vorrichtung | |
| DE602004021811D1 (de) | Rattenmodell der diabetes-nephropathie | |
| WO2003016906A1 (fr) | Procede de diagnostic ou de controle d'une erreur du metabolisme du saccharose | |
| DE60229303D1 (de) | Bioäquivalenztest für eisenhaltige formulierungen | |
| WO2005073860A3 (fr) | Procede de determination de caracteristiques operationnelles d'un programme | |
| DK1529216T3 (da) | Fremgangsmåde til diagnosticering af dissemineret sklerose | |
| WO2006076114A3 (en) | Model-based pre-assembly testing of multi-component production devices | |
| NO20064446L (no) | Fremgangsmate for stabilisering av oksiderbart fargeutviklingsreagens | |
| TW200701065A (en) | Compact representation of vendor hardware module revisions in an open architecture test system | |
| ATE482398T1 (de) | Verfahren zur stratifizierung von herzinsuffizienz | |
| BR9901329A (pt) | Controle de máquina usando construção de registro. | |
| SE0203661D0 (sv) | Simplified signal processing method for voltammetry | |
| MY149670A (en) | Development framework for mixing semantics-driven and state driven dialog | |
| ATE501434T1 (de) | Elektrochemische sensoren |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |