ATE435035T1 - Verbesserte linker für radiopharmazeutische verbindungen - Google Patents
Verbesserte linker für radiopharmazeutische verbindungenInfo
- Publication number
- ATE435035T1 ATE435035T1 AT03808615T AT03808615T ATE435035T1 AT E435035 T1 ATE435035 T1 AT E435035T1 AT 03808615 T AT03808615 T AT 03808615T AT 03808615 T AT03808615 T AT 03808615T AT E435035 T1 ATE435035 T1 AT E435035T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- diagnostic
- methods
- therapeutic moiety
- linker
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 8
- 229940121896 radiopharmaceutical Drugs 0.000 title 1
- 239000012217 radiopharmaceutical Substances 0.000 title 1
- 230000002799 radiopharmaceutical effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 abstract 5
- 230000001225 therapeutic effect Effects 0.000 abstract 4
- 238000002059 diagnostic imaging Methods 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 230000008685 targeting Effects 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000012216 imaging agent Substances 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 230000003439 radiotherapeutic effect Effects 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0493—Steroids, e.g. cholesterol, testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43972203P | 2003-01-13 | 2003-01-13 | |
| PCT/US2003/041656 WO2004062574A2 (en) | 2003-01-13 | 2003-12-24 | Improved linkers for radiopharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE435035T1 true ATE435035T1 (de) | 2009-07-15 |
Family
ID=32713508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03808615T ATE435035T1 (de) | 2003-01-13 | 2003-12-24 | Verbesserte linker für radiopharmazeutische verbindungen |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7989417B2 (de) |
| EP (1) | EP1583564B1 (de) |
| JP (1) | JP4610345B2 (de) |
| CN (1) | CN100534535C (de) |
| AT (1) | ATE435035T1 (de) |
| AU (1) | AU2003303714B2 (de) |
| CA (1) | CA2512310C (de) |
| DE (1) | DE60328226D1 (de) |
| WO (1) | WO2004062574A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7611692B2 (en) | 2003-01-13 | 2009-11-03 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US7922998B2 (en) | 2003-01-13 | 2011-04-12 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US8420050B2 (en) | 2003-01-13 | 2013-04-16 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US7226577B2 (en) * | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| ATE435035T1 (de) * | 2003-01-13 | 2009-07-15 | Bracco Imaging Spa | Verbesserte linker für radiopharmazeutische verbindungen |
| US7850947B2 (en) | 2003-01-13 | 2010-12-14 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| AU2004314112A1 (en) * | 2003-12-24 | 2005-07-28 | Bracco Imaging S.P.A. | Improved gastrin releasing peptide compounds |
| EP2438847A3 (de) * | 2004-06-18 | 2012-11-07 | David R. Elmaleh | Kontrastmittel und dessen Verwendung in einer Intravaskuläre Bildgebungsvorrichtung |
| US8758723B2 (en) * | 2006-04-19 | 2014-06-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for cellular imaging and therapy |
| DK2013221T3 (en) * | 2006-04-19 | 2015-09-28 | Univ Texas | Compositions and methods for cellular imaging and therapy |
| US10925977B2 (en) | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
| EP2606911A1 (de) * | 2007-02-16 | 2013-06-26 | KTB Tumorforschungsgesellschaft mbH | Rezeptor- und antigengerichtete Prodrug |
| WO2008144728A1 (en) * | 2007-05-21 | 2008-11-27 | Bracco Imaging S.P.A. | Conjugates which bind a blood protein such as human serum albumin and methods of using the same in diagnostic and therapeutic applications |
| WO2014040192A1 (en) | 2012-09-13 | 2014-03-20 | British Columbia Cancer Agency Branch | Compositions targeting bradykinin receptor b1 for medical imaging of cancer and other disorders |
| CN104744568B (zh) * | 2013-12-25 | 2018-02-23 | 华东理工大学 | 对神经激肽‑1受体蛋白特异性识别的p物质多肽探针及其制备与应用 |
| GB201417067D0 (en) | 2014-09-26 | 2014-11-12 | South African Nuclear Energy | Radiopharmaceutical conjugate |
| WO2017132642A1 (en) * | 2016-01-29 | 2017-08-03 | The Regents Of The University Of California | A wearable sensor, and method, to monitor anti-coagulation therapy |
| CN109970834A (zh) * | 2019-02-27 | 2019-07-05 | 郑州明泽医药科技有限公司 | 一种氢化可的松琥珀酸钠的制备方法 |
| CN112067556B (zh) * | 2020-09-29 | 2021-08-17 | 湖北鑫英泰系统技术股份有限公司 | 一种油浸式设备油气检测方法及装置 |
| JP2024115570A (ja) * | 2023-02-15 | 2024-08-27 | Ｊｆｅエンジニアリング株式会社 | 放射性核種標識薬剤 |
| CN121627612A (zh) * | 2025-11-28 | 2026-03-10 | 拓及鼎(嘉兴)医药科技有限公司 | 一种偶联药物用自带双连接子的螯合剂及其制备方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4885363A (en) * | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| US5534497A (en) * | 1986-05-28 | 1996-07-09 | Mallinckrodt Medical, Inc. | Technetium chelates to be used for determining the renal function |
| AU618029B2 (en) * | 1987-11-02 | 1991-12-12 | Imperial Chemical Industries Plc | Polypeptide compounds |
| US4988496A (en) * | 1988-05-31 | 1991-01-29 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
| ATE120374T1 (de) | 1989-07-20 | 1995-04-15 | Sandoz Ag | Markierte polypeptidderivate. |
| US5686410A (en) * | 1989-07-20 | 1997-11-11 | Novartis Ag | Polypeptide derivatives |
| DE3930696A1 (de) * | 1989-09-14 | 1991-03-28 | Hoechst Ag | Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel |
| US5217955A (en) * | 1989-09-15 | 1993-06-08 | Biomeasure, Inc. | Treatment of cancer with peptide analog of bombesin, grp, litorin or neuromedin |
| US5811387A (en) * | 1990-05-15 | 1998-09-22 | Chiron Corporation | Peptoid mixtures |
| US5834433A (en) * | 1990-07-26 | 1998-11-10 | Merrell Pharmaceuticals Inc. | Compounds and pharmaceutical uses of peptides of bombesin and GRP |
| US5620959A (en) * | 1990-07-31 | 1997-04-15 | Glaxo Wellcome Inc. | Bombesin antagonists |
| US5244883A (en) * | 1990-11-29 | 1993-09-14 | The Administrators Of The Tulane Educational Fund | Nonapeptide bombesin antagonists |
| US5369094A (en) * | 1990-11-29 | 1994-11-29 | The Administrators Of The Tulane Educational Fund | Polypeptide bombesin antagonists |
| DK0585397T3 (da) * | 1991-05-23 | 1997-08-25 | Merrell Pharma Inc | Bombesinanaloger |
| HUT71585A (en) * | 1992-02-07 | 1995-12-28 | Merrell Dow Pharma | Process for producing bombesin phenylalanine analogue peptides |
| US5620955A (en) * | 1993-06-18 | 1997-04-15 | Peptide Technologies Corporation | Bombesin receptor antagonists and uses thereof |
| US5410018A (en) * | 1994-02-25 | 1995-04-25 | Oregon Regional Primate Research Center | Bombesin-related peptides |
| US5662885A (en) | 1994-07-22 | 1997-09-02 | Resolution Pharmaceuticals Inc. | Peptide derived radionuclide chelators |
| US5753206A (en) * | 1995-06-07 | 1998-05-19 | Immunomedics, Inc. | Radiometal-binding analogues of luteinizing hormone releasing hormone |
| ATE380038T1 (de) * | 1996-07-12 | 2007-12-15 | Immunomedics Inc | Radiometall-bindende peptide analoge |
| WO1998047524A1 (en) * | 1997-04-22 | 1998-10-29 | Curators Of The University Of Missouri | Gastrin receptor-avid peptide conjugates |
| AU8157198A (en) * | 1997-06-20 | 1999-01-04 | Massachusetts Institute Of Technology | Nuclear matrix targeting peptides and uses therefor |
| PT1075282E (pt) | 1998-04-28 | 2005-09-30 | Applied Research Systems | Conjugados analogos de peg-lhrh |
| US6656922B2 (en) * | 1998-05-28 | 2003-12-02 | Mediplex Corporation, Korea | Oral delivery of macromolecules |
| US6866837B2 (en) * | 1998-06-05 | 2005-03-15 | Mallinckrodt Inc. | Radiolabeled peptides for the diagnosis and treatment of breast and prostate tumors and metastases of such tumors |
| IT1304501B1 (it) * | 1998-12-23 | 2001-03-19 | Bracco Spa | Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza |
| GB2355009A (en) * | 1999-07-30 | 2001-04-11 | Univ Glasgow | Peptides conjugated to bile acids/salts |
| IT1317862B1 (it) * | 2000-02-29 | 2003-07-15 | Bracco Spa | Coniugati di acidi biliari con chelati complessi di ioni metallici eloro uso. |
| WO2001076531A2 (en) * | 2000-04-07 | 2001-10-18 | University Of Maryland, Baltimore | Bile acid containing prodrugs with enhanced bioavailability |
| ATE435035T1 (de) * | 2003-01-13 | 2009-07-15 | Bracco Imaging Spa | Verbesserte linker für radiopharmazeutische verbindungen |
-
2003
- 2003-12-24 AT AT03808615T patent/ATE435035T1/de not_active IP Right Cessation
- 2003-12-24 CN CNB2003801087500A patent/CN100534535C/zh not_active Expired - Fee Related
- 2003-12-24 JP JP2004566646A patent/JP4610345B2/ja not_active Expired - Fee Related
- 2003-12-24 EP EP03808615A patent/EP1583564B1/de not_active Expired - Lifetime
- 2003-12-24 US US10/542,396 patent/US7989417B2/en not_active Expired - Fee Related
- 2003-12-24 DE DE60328226T patent/DE60328226D1/de not_active Expired - Lifetime
- 2003-12-24 AU AU2003303714A patent/AU2003303714B2/en not_active Ceased
- 2003-12-24 CA CA2512310A patent/CA2512310C/en not_active Expired - Fee Related
- 2003-12-24 WO PCT/US2003/041656 patent/WO2004062574A2/en not_active Ceased
-
2011
- 2011-07-08 US US13/179,035 patent/US20110280802A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004062574A9 (en) | 2005-05-26 |
| US20060241018A1 (en) | 2006-10-26 |
| JP4610345B2 (ja) | 2011-01-12 |
| AU2003303714A1 (en) | 2004-08-10 |
| CA2512310C (en) | 2012-09-25 |
| AU2003303714B2 (en) | 2009-02-19 |
| JP2006513247A (ja) | 2006-04-20 |
| CN1738652A (zh) | 2006-02-22 |
| WO2004062574A3 (en) | 2005-04-14 |
| DE60328226D1 (de) | 2009-08-13 |
| US20110280802A1 (en) | 2011-11-17 |
| CA2512310A1 (en) | 2004-07-29 |
| WO2004062574A2 (en) | 2004-07-29 |
| EP1583564A2 (de) | 2005-10-12 |
| EP1583564B1 (de) | 2009-07-01 |
| CN100534535C (zh) | 2009-09-02 |
| US7989417B2 (en) | 2011-08-02 |
| EP1583564A4 (de) | 2007-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |