ATE435295T1 - Herstellung von polyhydroxyalkanoate in pflanzen - Google Patents
Herstellung von polyhydroxyalkanoate in pflanzenInfo
- Publication number
- ATE435295T1 ATE435295T1 AT01203113T AT01203113T ATE435295T1 AT E435295 T1 ATE435295 T1 AT E435295T1 AT 01203113 T AT01203113 T AT 01203113T AT 01203113 T AT01203113 T AT 01203113T AT E435295 T1 ATE435295 T1 AT E435295T1
- Authority
- AT
- Austria
- Prior art keywords
- plant
- polyhydroxyalkanoates
- plants
- production
- polyhydroxyalkanoate
- Prior art date
Links
- 239000005014 poly(hydroxyalkanoate) Substances 0.000 title abstract 3
- 229920000903 polyhydroxyalkanoate Polymers 0.000 title abstract 3
- 241000196324 Embryophyta Species 0.000 abstract 3
- 241000252867 Cupriavidus metallidurans Species 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- C12P7/625—Polyesters of hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polyesters Or Polycarbonates (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Biological Depolymerization Polymers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919108756A GB9108756D0 (en) | 1991-04-24 | 1991-04-24 | Production of polyalkanoate in plants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE435295T1 true ATE435295T1 (de) | 2009-07-15 |
Family
ID=10693835
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01203113T ATE435295T1 (de) | 1991-04-24 | 1992-04-23 | Herstellung von polyhydroxyalkanoate in pflanzen |
| AT92908920T ATE221126T1 (de) | 1991-04-24 | 1992-04-23 | Herstellung von polyhydroxyalkanoate in pflanzen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92908920T ATE221126T1 (de) | 1991-04-24 | 1992-04-23 | Herstellung von polyhydroxyalkanoate in pflanzen |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5502273A (de) |
| EP (2) | EP0589898B1 (de) |
| JP (1) | JPH06510422A (de) |
| AT (2) | ATE435295T1 (de) |
| AU (1) | AU655816B2 (de) |
| CA (1) | CA2109221C (de) |
| DE (2) | DE69233763D1 (de) |
| DK (1) | DK0589898T3 (de) |
| ES (2) | ES2327897T3 (de) |
| GB (1) | GB9108756D0 (de) |
| WO (1) | WO1992019747A1 (de) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5245023A (en) | 1987-06-29 | 1993-09-14 | Massachusetts Institute Of Technology | Method for producing novel polyester biopolymers |
| GB9108756D0 (en) | 1991-04-24 | 1991-06-12 | Ici Plc | Production of polyalkanoate in plants |
| BR9206297A (pt) * | 1991-07-19 | 1995-10-17 | Univ Michigan State | Plantas transgênicas produzindo poli-hidroxialcanoatos |
| US5610041A (en) * | 1991-07-19 | 1997-03-11 | Board Of Trustees Operating Michigan State University | Processes for producing polyhydroxybutyrate and related polyhydroxyalkanoates in the plastids of higher plants |
| AU5676394A (en) * | 1992-11-20 | 1994-06-22 | Agracetus, Inc. | Transgenic cotton plants producing heterologous bioplastic |
| BR9408286A (pt) * | 1993-11-09 | 1997-08-26 | Du Pont | Construção de DNA recombinante planta método de produção de frutose método de produção de dextran método de produção de alternan planta de batata método de aumento de níveis de fructan nas plantas semente e planta de soja |
| RU2144047C1 (ru) * | 1994-01-28 | 2000-01-10 | Дзе Проктер Энд Гэмбл Компани | Биоразлагаемые сополимеры, пластмассовые и впитывающие изделия, содержащие биоразлагаемые сополимеры |
| SG49096A1 (en) * | 1994-01-28 | 1998-05-18 | Procter & Gamble | Biodegradable 3-polyhydtoxybuyrate/3- polyhydroxyhexanoate copolymer films |
| ID23491A (id) * | 1994-01-28 | 1995-09-07 | Procter & Gamble | Kopolimer-kopolimer yang dapat dibiodegradasi dan baha-bahan plastik yang terdiri dari kopolimer-kopolimer yang dapat dibiodegradasi |
| ZA95627B (en) * | 1994-01-28 | 1995-10-05 | Procter & Gamble | Biodegradable copolymers and plastic articles comprising biodegradable copolymers |
| CN1079835C (zh) * | 1994-06-01 | 2002-02-27 | 普罗克特和甘保尔公司 | 利用空气分级作用回收聚羟基链烷酸酯的方法 |
| CN1071379C (zh) * | 1994-06-01 | 2001-09-19 | 普罗克特和甘保尔公司 | 利用离心分级回收聚羟基链烷酸酯的方法 |
| GB9414506D0 (en) * | 1994-07-18 | 1994-09-07 | Zeneca Ltd | Improved production of polyhydroxyalkanoate |
| GB9502456D0 (en) * | 1995-02-08 | 1995-03-29 | Univ Warwick | Control of genes in transgenic plants |
| US6127606A (en) * | 1995-02-08 | 2000-10-03 | University Of Warwick | Method of using transactivation proteins to control expression in transgenic plants |
| US6083729A (en) * | 1995-10-26 | 2000-07-04 | Metabolix, Inc. | Methods for isolating polyhydroxyalkanoates from plants |
| US5849894A (en) * | 1995-11-29 | 1998-12-15 | Monsanto Company | Rhodospirillum rubrum poly-β-hydroxyalkanoate synthase |
| US6600029B1 (en) | 1995-12-19 | 2003-07-29 | Regents Of The University Of Minnesota | Metabolic engineering of polyhydroxyalkanoate monomer synthases |
| US6143947A (en) * | 1996-01-29 | 2000-11-07 | The Procter & Gamble Company | Fibers, nonwoven fabrics and absorbent articles comprising a biodegradable polyhydroxyalkanoate comprising 3-hydroxybutyrate and 3-hydroxyhexanoate |
| US5958745A (en) * | 1996-03-13 | 1999-09-28 | Monsanto Company | Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants |
| US6946588B2 (en) | 1996-03-13 | 2005-09-20 | Monsanto Technology Llc | Nucleic acid encoding a modified threonine deaminase and methods of use |
| US6091002A (en) * | 1996-03-13 | 2000-07-18 | Monsanto Company | Polyhydroxyalkanoates of narrow molecular weight distribution prepared in transgenic plants |
| US5959179A (en) * | 1996-03-13 | 1999-09-28 | Monsanto Company | Method for transforming soybeans |
| US5750848A (en) * | 1996-08-13 | 1998-05-12 | Monsanto Company | DNA sequence useful for the production of polyhydroxyalkanoates |
| US6143561A (en) * | 1997-06-30 | 2000-11-07 | The Curators Of The University Of Missouri | DNA encoding plastid pyruvate dehydrogenase and branched chain oxoacid dehydrogenase components |
| AU8587998A (en) | 1997-07-25 | 1999-02-16 | Monsanto Company | Pha compositions and methods for their use in the production of pha films |
| EP1015565B1 (de) | 1997-09-19 | 2006-04-12 | Metabolix, Inc. | Biologische systeme zur herstellung von polyhydroxyalkanoate polymeren die 4-hydroxysäure enthalten |
| WO1999035278A1 (en) * | 1998-01-05 | 1999-07-15 | Monsanto Company | Biosynthesis of medium chain length polyhydroxyalkanoates |
| AU748733B2 (en) | 1998-01-07 | 2002-06-13 | Metabolix, Inc. | Animal nutrition compositions |
| EP1049784B1 (de) * | 1998-01-19 | 2005-04-20 | Lg Chemical Ltd. | Gene von alcaligenes latus, die mit der biosynthese von polyhydroxyalkanoaten assoziiert sind. |
| US6586658B1 (en) | 1998-03-06 | 2003-07-01 | Metabolix, Inc. | Modification of fatty acid metabolism in plants |
| ES2339725T3 (es) | 1998-04-08 | 2010-05-24 | Metabolix, Inc. | Metodos para la separacion y purificacion de biopolimeros. |
| ATE483023T1 (de) | 1998-05-22 | 2010-10-15 | Metabolix Inc | Polyhydroxyalkanoatbiopolymere |
| ATE317014T1 (de) * | 1998-07-30 | 2006-02-15 | Metabolix Inc | Bifunktionelle enzyme zur biopolymerherstellung |
| US6329183B1 (en) | 1998-08-04 | 2001-12-11 | Metabolix, Inc. | Polyhydroxyalkanoate production from polyols |
| US6077931A (en) * | 1998-12-21 | 2000-06-20 | The Procter & Gamble Company | Biodegradable PHA copolymers |
| US6160199A (en) * | 1998-12-21 | 2000-12-12 | The Procter & Gamble Company | Absorbent articles comprising biodegradable PHA copolymers |
| US6174990B1 (en) | 1998-12-21 | 2001-01-16 | The Procter & Gamble Company | Films comprising biodegradable PHA copolymers |
| EP1141317A1 (de) * | 1999-01-07 | 2001-10-10 | University of Massachusetts | Polyhydroxyalkansäureesterbiosynthese assoziierte proteine und kodierende regionen in i(bacillus megaterium) |
| US6835820B2 (en) | 1999-01-07 | 2004-12-28 | The University Of Massachusetts | Polyhydroxyalkanoate biosynthesis associated proteins and coding region in bacillus megaterium |
| AU3516100A (en) | 1999-03-05 | 2000-09-21 | Monsanto Technology Llc | Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways |
| ES2243235T3 (es) | 1999-03-15 | 2005-12-01 | Universite Laval | Metodo para la produccion de polihidroxialcanoatos en organismos recombinantes. |
| US6451564B1 (en) * | 1999-07-02 | 2002-09-17 | Massachusetts Institute Of Technology | Methods for producing L-isoleucine |
| DE60040125D1 (de) | 1999-08-09 | 2008-10-16 | Riken Wako | Verfahren zur Transformierung von Pflanzen, transformierte Pflanzen und Verfahren zur Herstellung von Polyestern |
| US7407778B2 (en) | 2002-02-07 | 2008-08-05 | Pettegrew Jay W | Compounds, compositions and methods for treating neuropsychiatric disorders |
| US7700074B2 (en) * | 2002-02-07 | 2010-04-20 | Pettegrew Jay W | Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism |
| EP1641806B1 (de) * | 2003-05-29 | 2009-07-29 | Jay W. Pettegrew | Glycerophosphocholin und derivate davon zur medizinischen abbildung von neuropsychiatrischen erkrankungen |
| US20060257842A1 (en) * | 2003-05-29 | 2006-11-16 | Pettegrew Jay W | Cryopreservation media and molecules |
| US7666636B2 (en) * | 2006-03-22 | 2010-02-23 | National Research Council Of Canada | Process for producing poly-β-hydroxybutyrate |
| US8748526B2 (en) | 2006-09-01 | 2014-06-10 | Kaneka Corporation | Thermoplastic elastomer composition |
| BRPI0823327A2 (pt) | 2007-03-16 | 2013-10-22 | Genomatica Inc | Biocatalisadores microbianos que não ocorrem naturalmente e métodos para a biosíntese de ácido 4-hidroxibutanóico e 1,4-butanodiol |
| US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| EP3514242A3 (de) * | 2008-09-10 | 2019-08-28 | Genomatica, Inc. | Mikroorganismen zur herstellung von 1,4-butandiol |
| WO2010141920A2 (en) | 2009-06-04 | 2010-12-09 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol and related methods |
| LT2438036T (lt) * | 2009-06-04 | 2017-06-26 | Genomatica, Inc. | Fermentacijos sultinio komponentų išskyrimo būdas |
| KR20120083908A (ko) * | 2009-10-13 | 2012-07-26 | 게노마티카 인코포레이티드 | 1,4-부탄다이올, 4-하이드록시부탄알, 4-하이드록시부티릴-ｃｏａ, 푸트레신 및 관련 화합물의 제조를 위한 미생물 및 관련 방법 |
| US8530210B2 (en) | 2009-11-25 | 2013-09-10 | Genomatica, Inc. | Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone |
| MX2012009134A (es) | 2010-02-11 | 2012-11-30 | Metabolix Inc | Proceso para producir componente monomerico de biomasa de polihidroxialcanoato geneticamente modificado. |
| US8048661B2 (en) * | 2010-02-23 | 2011-11-01 | Genomatica, Inc. | Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes |
| US8445244B2 (en) * | 2010-02-23 | 2013-05-21 | Genomatica, Inc. | Methods for increasing product yields |
| KR20190094248A (ko) | 2011-02-14 | 2019-08-12 | 질레코 인코포레이티드 | 바이오매스의 가공처리 |
| SI2855687T1 (sl) | 2012-06-04 | 2020-09-30 | Genomatica, Inc. | Mikroorganizmi in metode za proizvodnjo 4-hidroksibutirat, 1,4-butandiola in sorodne spojine |
| JP2021501231A (ja) | 2017-10-27 | 2021-01-14 | キシレコ インコーポレイテッド | バイオマスの加工方法 |
| WO2020251932A1 (en) | 2019-06-10 | 2020-12-17 | Yield10 Bioscience, Inc. | Transgenic land plants that express a polyhydroxyalkanoate synthase seed specifically with cytosolic localization |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4266855A (en) * | 1979-09-24 | 1981-05-12 | Quantor Corporation | Quick change lens system |
| DE3587548T2 (de) * | 1984-12-28 | 1993-12-23 | Bayer Ag | Rekombinante DNA, die in pflanzliche Zellen eingebracht werden kann. |
| US5250430A (en) | 1987-06-29 | 1993-10-05 | Massachusetts Institute Of Technology | Polyhydroxyalkanoate polymerase |
| US5245023A (en) * | 1987-06-29 | 1993-09-14 | Massachusetts Institute Of Technology | Method for producing novel polyester biopolymers |
| US5229279A (en) | 1987-06-29 | 1993-07-20 | Massachusetts Institute Of Technology | Method for producing novel polyester biopolymers |
| ATE172497T1 (de) * | 1989-07-10 | 1998-11-15 | Massachusetts Inst Technology | Verfahren zur herstellung von polyester- biopolymeren |
| GB9108756D0 (en) | 1991-04-24 | 1991-06-12 | Ici Plc | Production of polyalkanoate in plants |
| GB9115245D0 (en) * | 1991-07-16 | 1991-08-28 | Ici Plc | Production of polyalkanoate |
| BR9206297A (pt) | 1991-07-19 | 1995-10-17 | Univ Michigan State | Plantas transgênicas produzindo poli-hidroxialcanoatos |
| GB9223332D0 (en) | 1992-11-06 | 1992-12-23 | Ici Plc | Production of polyhydroxyalkanoate in plants |
-
1991
- 1991-04-24 GB GB919108756A patent/GB9108756D0/en active Pending
-
1992
- 1992-04-23 AT AT01203113T patent/ATE435295T1/de not_active IP Right Cessation
- 1992-04-23 AU AU15797/92A patent/AU655816B2/en not_active Ceased
- 1992-04-23 DE DE69233763T patent/DE69233763D1/de not_active Expired - Lifetime
- 1992-04-23 WO PCT/GB1992/000742 patent/WO1992019747A1/en not_active Ceased
- 1992-04-23 EP EP92908920A patent/EP0589898B1/de not_active Expired - Lifetime
- 1992-04-23 JP JP4508057A patent/JPH06510422A/ja active Pending
- 1992-04-23 DE DE69232694T patent/DE69232694T2/de not_active Expired - Lifetime
- 1992-04-23 AT AT92908920T patent/ATE221126T1/de not_active IP Right Cessation
- 1992-04-23 ES ES01203113T patent/ES2327897T3/es not_active Expired - Lifetime
- 1992-04-23 EP EP01203113A patent/EP1176207B1/de not_active Expired - Lifetime
- 1992-04-23 CA CA002109221A patent/CA2109221C/en not_active Expired - Lifetime
- 1992-04-23 ES ES92908920T patent/ES2182819T3/es not_active Expired - Lifetime
- 1992-04-23 DK DK92908920T patent/DK0589898T3/da active
-
1994
- 1994-09-28 US US08/314,439 patent/US5502273A/en not_active Expired - Lifetime
-
1995
- 1995-09-29 US US08/536,123 patent/US6175061B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU655816B2 (en) | 1995-01-12 |
| DE69232694T2 (de) | 2003-03-06 |
| EP0589898B1 (de) | 2002-07-24 |
| EP1176207B1 (de) | 2009-07-01 |
| ES2327897T3 (es) | 2009-11-05 |
| DE69233763D1 (de) | 2009-08-13 |
| EP1176207A2 (de) | 2002-01-30 |
| ATE221126T1 (de) | 2002-08-15 |
| CA2109221A1 (en) | 1992-10-25 |
| US6175061B1 (en) | 2001-01-16 |
| CA2109221C (en) | 2007-03-06 |
| EP0589898A1 (de) | 1994-04-06 |
| ES2182819T3 (es) | 2003-03-16 |
| GB9108756D0 (en) | 1991-06-12 |
| DE69232694D1 (de) | 2002-08-29 |
| DK0589898T3 (da) | 2002-11-18 |
| JPH06510422A (ja) | 1994-11-24 |
| EP1176207A3 (de) | 2003-01-08 |
| US5502273A (en) | 1996-03-26 |
| WO1992019747A1 (en) | 1992-11-12 |
| AU1579792A (en) | 1992-12-21 |
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