ATE435423T1 - Kompositmatrix - Google Patents

Kompositmatrix

Info

Publication number
ATE435423T1
ATE435423T1 AT05010428T AT05010428T ATE435423T1 AT E435423 T1 ATE435423 T1 AT E435423T1 AT 05010428 T AT05010428 T AT 05010428T AT 05010428 T AT05010428 T AT 05010428T AT E435423 T1 ATE435423 T1 AT E435423T1
Authority
AT
Austria
Prior art keywords
composite matrix
composite
arrays
samples
allow
Prior art date
Application number
AT05010428T
Other languages
English (en)
Inventor
Mark S Chee
Steven R Auger
John R Steulpnagel
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26811698&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE435423(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Illumina Inc filed Critical Illumina Inc
Application granted granted Critical
Publication of ATE435423T1 publication Critical patent/ATE435423T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00382—Stamping
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/00648—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Manufacture Of Alloys Or Alloy Compounds (AREA)
  • Glass Compositions (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
AT05010428T 1998-12-28 1999-12-28 Kompositmatrix ATE435423T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11396898P 1998-12-28 1998-12-28
US09/256,943 US6429027B1 (en) 1998-12-28 1999-02-24 Composite arrays utilizing microspheres

Publications (1)

Publication Number Publication Date
ATE435423T1 true ATE435423T1 (de) 2009-07-15

Family

ID=26811698

Family Applications (2)

Application Number Title Priority Date Filing Date
AT99967670T ATE300047T1 (de) 1998-12-28 1999-12-28 Kompositmatrix mit mikrokugeln
AT05010428T ATE435423T1 (de) 1998-12-28 1999-12-28 Kompositmatrix

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT99967670T ATE300047T1 (de) 1998-12-28 1999-12-28 Kompositmatrix mit mikrokugeln

Country Status (8)

Country Link
US (3) US6429027B1 (de)
EP (3) EP2083271A3 (de)
JP (2) JP3566653B2 (de)
AT (2) ATE300047T1 (de)
AU (1) AU775056B2 (de)
CA (2) CA2729739C (de)
DE (3) DE29925020U1 (de)
WO (1) WO2000039587A1 (de)

Families Citing this family (421)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
WO1998053300A2 (en) 1997-05-23 1998-11-26 Lynx Therapeutics, Inc. System and apparaus for sequential processing of analytes
KR19990008052A (ko) * 1995-04-25 1999-01-25 마이클 피 노바 기억 장치를 갖는 원격적으로 프로그램 가능한 매트릭스 및 이의 용도
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
US6958245B2 (en) 1996-04-25 2005-10-25 Bioarray Solutions Ltd. Array cytometry
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
US7144119B2 (en) * 1996-04-25 2006-12-05 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US7041510B2 (en) 1996-04-25 2006-05-09 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US6387707B1 (en) * 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
US6327410B1 (en) * 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
US7348181B2 (en) * 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US8236500B2 (en) 1997-10-23 2012-08-07 The United States Of America, As Represented By The Department Of Veterans Affairs Promoter variants of the alpha-7 nicotinic acetylcholine receptor
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
DE69940430D1 (de) 1998-06-24 2009-04-02 Illumina Inc Dekodierung von matrixartig-angeordneten Sensoren durch Mikropartikel
US7510841B2 (en) * 1998-12-28 2009-03-31 Illumina, Inc. Methods of making and using composite arrays for the detection of a plurality of target analytes
US7595189B2 (en) 1999-01-08 2009-09-29 Applied Biosystems, Llc Integrated optics fiber array
US6635470B1 (en) 1999-01-08 2003-10-21 Applera Corporation Fiber array and methods for using and making same
US6908737B2 (en) 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US7253435B2 (en) 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
DK1923471T3 (da) 1999-04-20 2013-04-02 Illumina Inc Detektion af nukleinsyrereaktioner på bead-arrays
CA2374390A1 (en) 1999-05-20 2000-12-14 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
CA2382157C (en) 1999-08-18 2012-04-03 Illumina, Inc. Compositions and methods for preparing oligonucleotide solutions
EP1212599A2 (de) 1999-08-30 2002-06-12 Illumina, Inc. Verfahren zur verbesserung des signals einer sensorarray
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6642046B1 (en) 1999-12-09 2003-11-04 Motorola, Inc. Method and apparatus for performing biological reactions on a substrate surface
AU3436601A (en) * 1999-12-23 2001-07-03 Illumina, Inc. Decoding of array sensors with microspheres
US7361488B2 (en) 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
US6913884B2 (en) 2001-08-16 2005-07-05 Illumina, Inc. Compositions and methods for repetitive use of genomic DNA
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
ATE411397T1 (de) 2000-02-07 2008-10-15 Illumina Inc Nukleinsäure-nachweisverfahren mit universellem priming
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
CA2399908A1 (en) * 2000-02-10 2001-08-16 Todd Dickinson Array of individual arrays as substrate for bead-based simultaneous processing of samples and manufacturing method therefor
AU3838901A (en) * 2000-02-16 2001-08-27 Illumina Inc Parallel genotyping of multiple patient samples
EP1274983B1 (de) * 2000-03-21 2012-02-01 The Board Of Trustees Of The University Of Illinois Kolorimetrische künstliche nase mit einem array von farbstoffen und verfahren zur künstlichen geruchswahrnehmung
US6734420B2 (en) * 2000-04-06 2004-05-11 Quantum Dot Corporation Differentiable spectral bar code methods and systems
US7338773B2 (en) * 2000-04-14 2008-03-04 Millipore Corporation Multiplexed assays of cell migration
US20030104494A1 (en) * 2001-10-26 2003-06-05 Ilya Ravkin Assay systems with adjustable fluid communication
ATE418733T1 (de) * 2000-05-04 2009-01-15 Blood Res Center Kolloidzusammensetzungen für festphasen- biomolekulare analytische systeme
DE10065632A1 (de) * 2000-05-12 2001-11-15 Smtech Biovision Holding Ag Ec Verfahren zum Nachweis von Polynukleotiden
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
AU2001272993B2 (en) 2000-06-21 2005-03-10 Bioarray Solutions, Ltd. Multianalyte molecular analysis
CA2414618C (en) * 2000-06-28 2009-11-03 Illumina, Inc. Composite arrays utilizing microspheres with a hybridization chamber
DE60125596T2 (de) 2000-07-11 2007-10-04 Kirk Madison Hogan Verfahren und zusammensetzungen zur bestimmung von perioperativen genomprofile
US7057704B2 (en) * 2000-09-17 2006-06-06 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
AU2002213080A1 (en) * 2000-10-06 2002-04-15 Trustees Of Tufts College Self-encoding sensor arrays with microspheres
US20030045005A1 (en) * 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
JP2004537712A (ja) 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド 多重細胞分析システム
US7060442B2 (en) 2000-10-30 2006-06-13 Regents Of The University Of Michigan Modulators on Nod2 signaling
WO2002040634A2 (en) * 2000-11-14 2002-05-23 Genetag Technology, Inc. Expression miniarrays and uses thereof
US6905816B2 (en) * 2000-11-27 2005-06-14 Intelligent Medical Devices, Inc. Clinically intelligent diagnostic devices and methods
EP1397679B1 (de) * 2000-11-27 2010-01-20 Intelligent Medical Devices LLC Klinische intelligente diagnostische vorrichtungen und verfahren
JP3525142B2 (ja) * 2001-01-12 2004-05-10 独立行政法人 科学技術振興機構 金属ナノウェルを用いた蛍光分析用素子及びその製造方法
WO2002057743A2 (en) * 2001-01-17 2002-07-25 Streamline Proteomics, Llc. Methods of analyzing and sorting one or more analytes
CA2441086A1 (en) * 2001-03-19 2002-09-26 Wisconsin Alumni Research Foundation Identification of gene expression alterations underlying the aging process in mammals
CN1500140A (zh) * 2001-03-28 2004-05-26 上海晶泰生物技术有限公司 用于测试多种待分析物的装置及方法
WO2002084283A2 (en) * 2001-04-10 2002-10-24 Nmi Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen In Reutlingen Stiftung Bürgerlichen Rechts Method for determining analyte molecules in a sample
DE10119468A1 (de) * 2001-04-12 2002-10-24 Epigenomics Ag Mikroarray-Verfahren zur Anreicherung von DNA-Fragmenten aus komplexen Mischungen
US7572642B2 (en) 2001-04-18 2009-08-11 Ambrigen, Llc Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
NL1017989C2 (nl) * 2001-05-03 2002-11-05 Univ Delft Tech Werkwijze voor het uitvoeren van een assay, inrichting daarvoor, alsmede een werkwijze voor het vervaardigen van een inrichting.
GB0113358D0 (en) * 2001-06-01 2001-07-25 Scient Generics Ltd Enhanced target capture
US20040048241A1 (en) * 2001-06-11 2004-03-11 Freeman Beverly Annette Methods for attaching molecules
US6824974B2 (en) * 2001-06-11 2004-11-30 Genorx, Inc. Electronic detection of biological molecules using thin layers
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
WO2003022421A2 (en) * 2001-09-07 2003-03-20 Corning Incorporated Microcolumn-platform based array for high-throughput analysis
ATE295155T1 (de) 2001-10-05 2005-05-15 Surmodics Inc Beschichtungen mit immobilisierten partikeln sowie verwendungen derselben
US7195913B2 (en) * 2001-10-05 2007-03-27 Surmodics, Inc. Randomly ordered arrays and methods of making and using
KR20040068122A (ko) 2001-10-15 2004-07-30 바이오어레이 솔루션스 리미티드 공동 검색과 효소-매개된 탐지에 의한 다형성 좌위의 다중분석
US7381375B2 (en) * 2001-10-26 2008-06-03 Millipore Corporation Assay systems with adjustable fluid communication
US20080187949A1 (en) * 2001-10-26 2008-08-07 Millipore Corporation Multiplexed assays of cell migration
US6956114B2 (en) 2001-10-30 2005-10-18 '454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
EP1444338A4 (de) * 2001-11-15 2007-07-04 Arryx Inc Probenchip
US7335153B2 (en) * 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
US7255986B2 (en) 2002-01-31 2007-08-14 The Board Of Trustees Operating Michigan State University Compositions for the diagnosis and treatment of epizootic catarrhal enteritis in ferrets
WO2005062866A2 (en) * 2003-12-22 2005-07-14 The Regents Of The University Of California Optically encoded particles, system and high-throughput screening
AU2003208935A1 (en) * 2002-02-07 2003-09-02 The Regents Of The University Of California Optically encoded particles
AU2003215240A1 (en) 2002-02-14 2003-09-04 Illumina, Inc. Automated information processing in randomly ordered arrays
CA2478985A1 (en) 2002-03-13 2003-09-25 Syngenta Participations Ag Nucleic acid detection method
US20030208936A1 (en) * 2002-05-09 2003-11-13 Lee Charles Hee Method for manufacturing embroidery decorated cards and envelopes
US6730515B2 (en) * 2002-06-11 2004-05-04 Eastman Kodak Company Micro-array calibration means
US20040096622A1 (en) * 2002-06-19 2004-05-20 Ali Razavi Multi well plate with self sealing advantages
EP1552010B1 (de) * 2002-07-19 2010-06-09 Althea Technologies, Inc. Strategien zur genexpressionsanalyse
AU2003254298A1 (en) 2002-08-02 2004-02-23 Stratatech Corporation Species specific dna detection
US7473535B2 (en) * 2002-08-20 2009-01-06 The Institute For Systems Biology Chemical reagents and methods for detection and quantification of proteins in complex mixtures
US20040132173A1 (en) * 2002-08-28 2004-07-08 Kimon Angelides Optical fiber array device capable of simultaneously performing multiple functional assays
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
JP4087200B2 (ja) * 2002-09-17 2008-05-21 ユニバーサル・バイオ・リサーチ株式会社 粒子複合体及び該粒子複合体の作製方法
US7364846B2 (en) * 2002-10-11 2008-04-29 Molecular Devices Corporation Gene expression profiling from FFPE samples
US20080207465A1 (en) * 2002-10-28 2008-08-28 Millipore Corporation Assay systems with adjustable fluid communication
AU2003298655A1 (en) 2002-11-15 2004-06-15 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
JP2004184312A (ja) * 2002-12-05 2004-07-02 Yokogawa Electric Corp 生体高分子検出方法およびバイオチップ
US8206904B2 (en) 2002-12-18 2012-06-26 Third Wave Technologies, Inc. Detection of nucleic acids
WO2004057017A2 (en) 2002-12-18 2004-07-08 Third Wave Technologies, Inc. Detection of small nucleic acids
US7297780B2 (en) 2003-01-06 2007-11-20 Third Wave Technologies, Inc. Reactive functional groups for preparation of modified nucleic acid
US7887752B2 (en) 2003-01-21 2011-02-15 Illumina, Inc. Chemical reaction monitor
US7575865B2 (en) 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
AU2004209001B2 (en) 2003-01-29 2007-10-11 454 Life Sciences Corporation Bead emulsion nucleic acid amplification
US6943768B2 (en) 2003-02-21 2005-09-13 Xtellus Inc. Thermal control system for liquid crystal cell
TWI220766B (en) * 2003-04-17 2004-09-01 Au Optronics Corp Method for fabricating liquid crystal display panel array
US8150626B2 (en) * 2003-05-15 2012-04-03 Illumina, Inc. Methods and compositions for diagnosing lung cancer with specific DNA methylation patterns
US8150627B2 (en) 2003-05-15 2012-04-03 Illumina, Inc. Methods and compositions for diagnosing lung cancer with specific DNA methylation patterns
US20040259100A1 (en) * 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20050181394A1 (en) * 2003-06-20 2005-08-18 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
CA2528577C (en) 2003-06-20 2012-08-07 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20050019954A1 (en) * 2003-07-23 2005-01-27 Eastman Kodak Company Photochromic dyes for microsphere based sensor
US20050019944A1 (en) * 2003-07-23 2005-01-27 Eastman Kodak Company Colorable microspheres for DNA and protein microarray
US8022013B2 (en) 2003-08-29 2011-09-20 Illumina, Inc. Method of forming and using solid-phase support
JP2005077284A (ja) * 2003-09-01 2005-03-24 Seiko Epson Corp 粒子アレイの製造装置及び製造方法と標的物質の検出方法
US7488451B2 (en) 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
US9492820B2 (en) 2003-09-19 2016-11-15 Applied Biosystems, Llc High density plate filler
US7407630B2 (en) 2003-09-19 2008-08-05 Applera Corporation High density plate filler
US7695688B2 (en) * 2003-09-19 2010-04-13 Applied Biosystems, Llc High density plate filler
US8277760B2 (en) 2003-09-19 2012-10-02 Applied Biosystems, Llc High density plate filler
US7998435B2 (en) 2003-09-19 2011-08-16 Life Technologies Corporation High density plate filler
US7595279B2 (en) 2003-09-22 2009-09-29 Bioarray Solutions Ltd. Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
EP1692298A4 (de) 2003-10-28 2008-08-13 Bioarray Solutions Ltd Optimierung der genexpressionsanalyse unter verwendung immobilisierter fängersonden
NZ547495A (en) 2003-10-29 2008-05-30 Bioarray Solutions Ltd Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
US7259258B2 (en) 2003-12-17 2007-08-21 Illumina, Inc. Methods of attaching biological compounds to solid supports using triazine
CN1918582A (zh) * 2003-12-22 2007-02-21 加利福尼亚大学董事会 具有灰度光谱的光学编码粒子
US20050136414A1 (en) * 2003-12-23 2005-06-23 Kevin Gunderson Methods and compositions for making locus-specific arrays
US7432057B2 (en) 2004-01-30 2008-10-07 Michigan State University Genetic test for PSE-susceptible turkeys
US20050266432A1 (en) * 2004-02-26 2005-12-01 Illumina, Inc. Haplotype markers for diagnosing susceptibility to immunological conditions
DE102004021351A1 (de) * 2004-04-23 2005-11-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Funktionalisierter poröser Träger für Mikroarrays
US7462451B2 (en) 2004-04-26 2008-12-09 Third Wave Technologies, Inc. Compositions for modifying nucleic acids
NZ551782A (en) 2004-06-03 2010-03-26 Athlomics Pty Ltd Agents and methods for diagnosing stress
EP1774033A4 (de) * 2004-06-10 2008-04-23 Perkinelmer Las Inc Multiplex-assays zum nachweisen von analyten
US7692219B1 (en) 2004-06-25 2010-04-06 University Of Hawaii Ultrasensitive biosensors
US7702466B1 (en) 2004-06-29 2010-04-20 Illumina, Inc. Systems and methods for selection of nucleic acid sequence probes
US7440930B1 (en) 2004-07-22 2008-10-21 Adobe Systems Incorporated Training an attentional cascade
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US7785785B2 (en) 2004-11-12 2010-08-31 The Board Of Trustees Of The Leland Stanford Junior University Charge perturbation detection system for DNA and other molecules
WO2006062745A2 (en) * 2004-11-23 2006-06-15 454 Life Sciences Corporation Method for isolation of independent, parallel chemical micro-reactions using a porous filter
US7647186B2 (en) * 2004-12-07 2010-01-12 Illumina, Inc. Oligonucleotide ordering system
JP2008524600A (ja) * 2004-12-16 2008-07-10 インヴィトロジェン コーポレーション 多重化アッセイの較正及び定量化用の量子ドットコード化ビーズセット、及びその使用方法
US7634142B1 (en) 2005-01-24 2009-12-15 Adobe Systems Incorporated Detecting objects in images using a soft cascade
EP2230315A1 (de) 2005-02-01 2010-09-22 AB Advanced Genetic Analysis Corporation Nukleinsäuresequenzierung durch schrittweise Duplexverlängerung
EP2241637A1 (de) 2005-02-01 2010-10-20 AB Advanced Genetic Analysis Corporation Nukleinsäuresequenzierung durch schrittweise Duplexverlängerung
US9695472B2 (en) 2005-03-04 2017-07-04 Intel Corporation Sensor arrays and nucleic acid sequencing applications
US9040237B2 (en) * 2005-03-04 2015-05-26 Intel Corporation Sensor arrays and nucleic acid sequencing applications
US20070108465A1 (en) * 2005-03-10 2007-05-17 The Regents Of The University Of California Porous microstructure multi layer spectroscopy and biosensing
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
EP1715344A1 (de) * 2005-04-22 2006-10-25 Universiteit Utrecht Holding B.V. Immobilisierung der Antigenkohlenhydrate, zum der pathogenen Mikroorganismen zu ermitteln
US7939257B2 (en) 2005-05-12 2011-05-10 Third Wave Technologies, Inc. Polymorphic GHSR nucleic acids and uses thereof
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
CN101501215A (zh) 2005-07-07 2009-08-05 阿什洛米克斯控股有限公司 用于诊断内毒素血症的多核苷酸标记基因及它们的表达
US7595473B2 (en) * 2005-08-22 2009-09-29 Tufts University Method and system of array imaging
US8168447B2 (en) 2005-10-07 2012-05-01 University Of Florida Research Foundation, Inc. Multiple component nanoparticles for multiplexed signaling and optical encoding
US7803751B2 (en) * 2005-12-09 2010-09-28 Illumina, Inc. Compositions and methods for detecting phosphomonoester
JP5537034B2 (ja) 2005-12-23 2014-07-02 ナノストリング テクノロジーズ，インコーポレーテッド ナノレポーターならびにその作製方法および使用方法
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
JP2009538123A (ja) * 2006-04-19 2009-11-05 アプライド バイオシステムズ， エルエルシー ゲル非含有ビーズベースの配列決定のための試薬、方法およびライブラリー
US8933209B2 (en) 2006-04-26 2015-01-13 Abbvie Inc. Dep2 and its uses in major depressive disorder and other related disorders
KR100772897B1 (ko) * 2006-05-02 2007-11-05 삼성전자주식회사 향상된 잡음률을 나타내는 올리고머 프로브 어레이 및 그제조 방법
US7702468B2 (en) 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
US10522240B2 (en) 2006-05-03 2019-12-31 Population Bio, Inc. Evaluating genetic disorders
US20080003667A1 (en) * 2006-05-19 2008-01-03 Affymetrix, Inc. Consumable elements for use with fluid processing and detection systems
US7674924B2 (en) 2006-05-22 2010-03-09 Third Wave Technologies, Inc. Compositions, probes, and conjugates and uses thereof
JP5260503B2 (ja) 2006-06-01 2013-08-14 サード ウェーブ テクノロジーズ，インコーポレーテッド 核酸の検出
US7759062B2 (en) 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
EP2024512A4 (de) 2006-06-14 2009-12-09 Artemis Health Inc Verfahren zur diagnose fötaler anomalitäten
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
EP3424598B1 (de) 2006-06-14 2022-06-08 Verinata Health, Inc. Analyse seltener zellen mittels probentrennung und dna-etiketten
US20110312907A1 (en) 2006-11-15 2011-12-22 Michael Hayden Polymorphisms predictive of anthracycline- induced cardiotoxicity
US7813013B2 (en) * 2006-11-21 2010-10-12 Illumina, Inc. Hexagonal site line scanning method and system
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
EP2639578B1 (de) 2006-12-14 2016-09-14 Life Technologies Corporation Vorrichtung zur Messung von Analyten mithilfe großer FET-Arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
WO2008085857A2 (en) 2007-01-04 2008-07-17 Children's Hospital Medical Center Processing text with domain-specific spreading activation methods
CA2677994A1 (en) 2007-02-07 2008-08-14 Decode Genetics Ehf. Genetic variants contributing to risk of prostate cancer
US20080243865A1 (en) * 2007-03-28 2008-10-02 Oracle International Corporation Maintaining global state of distributed transaction managed by an external transaction manager for clustered database systems
EA018444B1 (ru) 2007-05-25 2013-08-30 Декоуд Дженетикс Ехф. ГЕНЕТИЧЕСКИЕ ВАРИАНТЫ В Chr 5p12 И 10q26 В КАЧЕСТВЕ МАРКЕРОВ ДЛЯ ПРИМЕНЕНИЯ ПРИ ОЦЕНКЕ РИСКА, ДИАГНОСТИРОВАНИИ, ПРОГНОЗИРОВАНИИ И ЛЕЧЕНИИ РАКА ГРУДИ
CN101320404B (zh) * 2007-06-06 2010-05-26 中国科学院半导体研究所 一种生物病毒的计算机自动分类方法
WO2009012340A2 (en) 2007-07-16 2009-01-22 California Institute Of Technology Microfluidic devices, methods and systems for detecting target molecules
ES2556627T3 (es) 2007-08-30 2016-01-19 Trustees Of Tufts College Métodos para determinar la concentración de un analito en solución
US8877141B2 (en) * 2007-09-06 2014-11-04 Qiagen Sciences Llc System for preparing arrays of biomolecules
FR2921002B1 (fr) * 2007-09-13 2010-11-12 Innopsys Procede de depot simultane d'un ensemble de motifs sur un substrat par un macro timbre
EP2212434A1 (de) * 2007-10-01 2010-08-04 Applied Biosystems Inc. Chase-ligation-sequenzierung
WO2009047809A2 (en) * 2007-10-12 2009-04-16 Decode Genetics Ehf Sequence variants for inferring human pigmentation patterns
US7811810B2 (en) 2007-10-25 2010-10-12 Industrial Technology Research Institute Bioassay system including optical detection apparatuses, and method for detecting biomolecules
US7767441B2 (en) * 2007-10-25 2010-08-03 Industrial Technology Research Institute Bioassay system including optical detection apparatuses, and method for detecting biomolecules
US8697360B2 (en) 2007-11-30 2014-04-15 Decode Genetics Ehf. Genetic variants on CHR 11Q and 6Q as markers for prostate and colorectal cancer predisposition
US20090181390A1 (en) * 2008-01-11 2009-07-16 Signosis, Inc. A California Corporation High throughput detection of micrornas and use for disease diagnosis
US8202691B2 (en) 2008-01-25 2012-06-19 Illumina, Inc. Uniform fragmentation of DNA using binding proteins
CA2714521A1 (en) * 2008-02-14 2009-08-20 Decode Genetics Ehf Susceptibility variants for lung cancer
CA2717918C (en) * 2008-03-12 2016-12-13 Universite De Rouen Method for a highly sensitive detection and quantification of biomolecules using secondary ion mass spectrometry (sims) and related technologies
CN102301000B (zh) 2008-03-15 2015-04-29 豪洛捷公司 核酸分子扩增反应的分析组分及方法
EP2274450A2 (de) 2008-04-01 2011-01-19 Decode Genetics EHF Suszeptibilitätsvarianten bei peripherer arterienkrankheit und bauchschlagader-aneurysma
US20110105356A1 (en) * 2008-05-07 2011-05-05 Derosier Chad F Compositions and methods for providing substances to and from an array
EP2982437B1 (de) 2008-06-25 2017-12-06 Life Technologies Corporation Verfahren und vorrichtung zur messung von analyten mithilfe grossskaliger fet-arrays
EP2313520B1 (de) * 2008-07-04 2014-08-27 Decode Genetics EHF Kopienzahlvariationen als vorhersage des schizophrenierisikos
WO2010005550A1 (en) * 2008-07-07 2010-01-14 The Regents Of The University Of California Caged quantum dots
CA2729934A1 (en) 2008-07-07 2010-01-14 Decode Genetics Ehf Genetic variants for breast cancer risk assessment
JP2011530306A (ja) * 2008-08-12 2011-12-22 ディコーデ ジェネテクス イーエイチエフ 甲状腺癌のリスクアセスメントに有用な遺伝的変異
US8519115B2 (en) 2008-08-14 2013-08-27 Nanostring Technologies, Inc. Stable nanoreporters
WO2010018601A2 (en) * 2008-08-15 2010-02-18 Decode Genetics Ehf Genetic variants predictive of cancer risk
US8583380B2 (en) 2008-09-05 2013-11-12 Aueon, Inc. Methods for stratifying and annotating cancer drug treatment options
US20100075439A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of molecules by capture-and-release using reducing agents followed by quantification
US20100075862A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US20100301398A1 (en) * 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
EP2191893B1 (de) * 2008-11-19 2019-03-06 Euroimmun Medizinische Labordiagnostika AG Analyseverfahren und Vorrichtungen für biologische Reaktionen zwischen einer flüssigen und einer festen Phase
US20100151473A1 (en) * 2008-12-10 2010-06-17 Yeakley Joanne M Methods and compositions for hybridizing nucleic acids
CN102625850B (zh) * 2009-04-03 2014-11-26 蒂莫西·Z·刘 多重核酸检测方法和系统
NZ595918A (en) 2009-04-03 2013-07-26 Decode Genetics Ehf Genetic markers for risk management of atrial fibrillation and stroke
EP2451975A4 (de) * 2009-05-08 2013-08-14 Decode Genetics Ehf Genetische varianten als risikofaktoren für prostatakrebs
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8574835B2 (en) 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
US8796182B2 (en) 2009-07-10 2014-08-05 Decode Genetics Ehf. Genetic markers associated with risk of diabetes mellitus
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
AU2010277239A1 (en) 2009-07-31 2012-02-02 Centre Hospitalier Universitaire Vaudois Methods for diagnosing or predicting hepatitis C outcome in HCV infected patients
WO2011047087A2 (en) 2009-10-13 2011-04-21 Nanostring Technologies, Inc. Protein detection via nanoreporters
CA2684636A1 (en) * 2009-10-30 2011-04-30 Sqi Diagnostics Systems Inc Multiplex microarrays and methods for the quantification of analytes
GB2475226A (en) 2009-11-03 2011-05-18 Genetic Analysis As Universal Prokaryote 16S ribosome PCR primer pair
CA2779750C (en) 2009-11-06 2019-03-19 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive diagnosis of graft rejection in organ transplant patients
US8500979B2 (en) * 2009-12-31 2013-08-06 Intel Corporation Nanogap chemical and biochemical sensors
EP2525905B1 (de) 2010-01-19 2020-11-04 Illumina, Inc. Verfahren und zusammensetzungen zur verarbeitung chemischer reaktionen
WO2011100541A2 (en) 2010-02-11 2011-08-18 Nanostring Technologies, Inc. Compositions and methods for the detection of small rnas
US9678068B2 (en) * 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
EP2542890B1 (de) 2010-03-01 2015-05-06 Quanterix Corporation Verfahren zur erweiterung des dynamischen bereichs bei tests für den nachweis von molekülen oder partikeln
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
CN106932456B (zh) 2010-06-30 2020-02-21 生命科技公司 用于测试isfet阵列的方法和装置
WO2012003363A1 (en) 2010-06-30 2012-01-05 Life Technologies Corporation Ion-sensing charge-accumulation circuits and methods
CN119165030A (zh) 2010-06-30 2024-12-20 生命科技公司 阵列列积分器
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
US8653567B2 (en) 2010-07-03 2014-02-18 Life Technologies Corporation Chemically sensitive sensor with lightly doped drains
WO2012018387A2 (en) 2010-08-02 2012-02-09 Population Diagnotics, Inc. Compositions and methods for discovery of causative mutations in genetic disorders
US8715932B2 (en) 2010-08-20 2014-05-06 Intel Corporation Nucleic acid sequencing
US8444835B2 (en) 2010-09-09 2013-05-21 Intel Corporation Electronic and fluidic interface
EP2617061B1 (de) 2010-09-15 2021-06-30 Life Technologies Corporation Verfahren und vorrichtung zur analytmessung
CN103228798B (zh) 2010-09-24 2015-12-09 斯坦福大学托管董事会 使用固定的引物直接捕获、扩增及测序靶标dna
CN103299182A (zh) 2010-09-24 2013-09-11 生命科技公司 匹配的晶体管对电路
WO2012050920A1 (en) 2010-09-29 2012-04-19 Illumina, Inc. Compositions and methods for sequencing nucleic acids
EP2633069B1 (de) 2010-10-26 2015-07-01 Illumina, Inc. Sequenzierungsverfahren
GB201021399D0 (en) 2010-12-16 2011-01-26 Genetic Analysis As Oligonucleotide probe set and methods of microbiota profiling
GB201021397D0 (en) 2010-12-16 2011-01-26 Genetic Analysis As Diagnosis of Crohn's disease
EP2663656B1 (de) 2011-01-13 2016-08-24 Decode Genetics EHF Genetische varianten als marker zur verwendung bei der bestimmung eines harnblasenkrebsrisikos
FR2970568B1 (fr) * 2011-01-14 2016-05-06 Centre Nat Rech Scient Nouvelles surfaces adhesives pour l'immobilisation de ligands
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
EP2670864B1 (de) 2011-01-31 2017-03-08 Illumina, Inc. Verfahren zur reduzierung von nukleinsäureschäden
GB201102693D0 (en) 2011-02-16 2011-03-30 Genetic Analysis As Method for identifying neonates at risk for necrotizing enterocolitis
US9758834B2 (en) 2011-03-28 2017-09-12 Nanostring Technologies, Inc. Compositions and methods for diagnosing cancer
US20120258871A1 (en) 2011-04-08 2012-10-11 Prognosys Biosciences, Inc. Peptide constructs and assay systems
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
EP2699903B1 (de) 2011-04-20 2018-07-18 Life Technologies Corporation Verfahren, zusammensetzungen und systeme zur probenablagerung
WO2013001504A1 (en) 2011-06-30 2013-01-03 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) Polymorphisms associated with non-response to a hepatitis c treatment or susceptibility to non-spontaneous hepatitis c clearance
WO2013033073A1 (en) 2011-08-31 2013-03-07 Ventana Medical Systems, Inc. Expression of ets related gene (erg) and phosphatase and tensin homolog (pten) correlates with prostate cancer capsular penetration
WO2013030786A1 (en) 2011-08-31 2013-03-07 Centre Hospitalier Universitaire Vaudois Method for diagnosing or predicting hepatocellular carcinoma outcome
CA3069089A1 (en) 2011-09-22 2013-03-28 Lineage Biosciences, Inc. Compositions and methods for analyzing heterogeneous samples
US20140271542A1 (en) 2011-10-05 2014-09-18 The United States Of America As Represented By The Secretary, Department Of Health And Human Service Genetic marker for predicting prognosis in patients infected with hepatitis c virus
WO2013054200A2 (en) 2011-10-10 2013-04-18 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
EP2773779B1 (de) 2011-11-04 2020-10-14 Population Bio, Inc. Verfahren und zusammensetzungen zur diagnose, prognose und behandlung neurologischer erkrankungen
EP3483288B1 (de) 2011-11-30 2022-03-16 Children's Hospital Medical Center Personalisiertes schmerzmanagement und anästhesie: präventive risikoidentifizierung
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
WO2013096661A1 (en) 2011-12-22 2013-06-27 Illumina, Inc. Methylation biomarkers for ovarian cancer
US8747748B2 (en) 2012-01-19 2014-06-10 Life Technologies Corporation Chemical sensor with conductive cup-shaped sensor surface
US8821798B2 (en) 2012-01-19 2014-09-02 Life Technologies Corporation Titanium nitride as sensing layer for microwell structure
DK2812452T3 (da) 2012-02-09 2020-06-29 Population Bio Inc Fremgangsmåder og sammensætninger til screening og behandling af udviklingsforstyrrelser
NO2694769T3 (de) 2012-03-06 2018-03-03
CN104379563B (zh) 2012-04-10 2018-12-21 加利福尼亚大学董事会 用于治疗癌症的组合物和方法
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
EP2888349B1 (de) 2012-08-24 2022-02-09 Yale University System, vorrichtung und verfahren für multiplex-erkennung mit hohem durchsatz
EP2895621B1 (de) 2012-09-14 2020-10-21 Population Bio, Inc. Verfahren und zusammensetzungen zur diagnose, prognose und behandlung neurologischer erkrankungen
US10233495B2 (en) 2012-09-27 2019-03-19 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
WO2014074942A1 (en) 2012-11-08 2014-05-15 Illumina, Inc. Risk variants of alzheimer's disease
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
US8962366B2 (en) 2013-01-28 2015-02-24 Life Technologies Corporation Self-aligned well structures for low-noise chemical sensors
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
US8841217B1 (en) 2013-03-13 2014-09-23 Life Technologies Corporation Chemical sensor with protruded sensor surface
US9116117B2 (en) 2013-03-15 2015-08-25 Life Technologies Corporation Chemical sensor with sidewall sensor surface
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
WO2014144822A2 (en) 2013-03-15 2014-09-18 Immumetrix, Inc. Methods and compositions for tagging and analyzing samples
US20140264471A1 (en) 2013-03-15 2014-09-18 Life Technologies Corporation Chemical device with thin conductive element
US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
WO2014149778A1 (en) 2013-03-15 2014-09-25 Life Technologies Corporation Chemical sensors with consistent sensor surface areas
US20140274749A1 (en) 2013-03-15 2014-09-18 Affymetrix, Inc. Systems and Methods for SNP Characterization and Identifying off Target Variants
EP2972280B1 (de) 2013-03-15 2021-09-29 Life Technologies Corporation Chemischer sensor mit stetigen sensoroberflächen
US9618520B2 (en) 2013-04-25 2017-04-11 Vladislav B. Bergo Microarray compositions and methods of their use
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
WO2014195236A1 (en) 2013-06-06 2014-12-11 Koninklijke Philips N.V. Correction for osmotic pressure variations in chemo-optical sensor spots
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
JO3805B1 (ar) 2013-10-10 2021-01-31 Araxes Pharma Llc مثبطات كراس جي12سي
US10144015B2 (en) 2013-11-11 2018-12-04 Life Technologies Corporation Rotor plate and bucket assembly and method for using same
DK3511422T3 (da) 2013-11-12 2023-02-06 Population Bio Inc Fremgangsmåder og sammensætninger til diagnosticering, prognose og behandling af endometriose
CA2940422A1 (en) 2014-02-24 2015-08-27 Children's Hospital Medical Center Methods and compositions for personalized pain management
CA2957549C (en) 2014-08-08 2022-07-26 Children's Hospital Medical Center Diagnostic method for distinguishing forms of esophageal eosinophilia
GB2558326B (en) 2014-09-05 2021-01-20 Population Bio Inc Methods and compositions for inhibiting and treating neurological conditions
JO3556B1 (ar) 2014-09-18 2020-07-05 Araxes Pharma Llc علاجات مدمجة لمعالجة السرطان
WO2016049568A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Methods and compositions for inhibition of ras
JP2017528498A (ja) 2014-09-25 2017-09-28 アラクセス ファーマ エルエルシー Ｋｒａｓ ｇ１２ｃ変異体タンパク質のインヒビター
DE112015004899B4 (de) * 2014-11-27 2022-10-20 Hitachi High-Tech Corporation Spot-array-substrat, verfahren zum herstellen eines solchen und nukleinsäurepolymer-analyseverfahren und -vorrichtung
DK3227684T3 (da) 2014-12-03 2019-11-11 Isoplexis Corp Analyse af og screening for cellesekretionsprofiler
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
KR102593647B1 (ko) 2014-12-18 2023-10-26 라이프 테크놀로지스 코포레이션 트랜스미터 구성을 갖춘 높은 데이터율 집적 회로
TW202024628A (zh) 2014-12-18 2020-07-01 美商生命技術公司 用於使用大規模fet陣列量測分析物之方法及設備
AU2016200047A1 (en) * 2015-01-07 2016-07-21 Personal Genomics, Inc. Oriented Loading Systems And Method For Orienting A Particle Loaded In A Well
EP3247384B1 (de) 2015-01-14 2023-10-04 The Regents of the University of Colorado, a body corporate In vitro verfahren zur diagnose von typ-1-diabetes mit insulinmimotopen
US11353448B2 (en) 2015-02-13 2022-06-07 California Institute Of Technology Methods and compositions for quantifying metabolites and proteins from single cells
RS64567B1 (sr) * 2015-02-24 2023-10-31 Hope City Platforme za skrining hemijski kodiranih prostorno adresiranih biblioteka
ES2898765T3 (es) 2015-04-10 2022-03-08 Araxes Pharma Llc Compuestos de quinazolina sustituidos y métodos de uso de los mismos
ES2856880T3 (es) 2015-04-15 2021-09-28 Araxes Pharma Llc Inhibidores tricíclicos condensados de KRAS y métodos de uso de los mismos
AU2016297513B2 (en) 2015-07-17 2021-02-25 Board Of Regents, The University Of Texas System Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue
EP3325650B1 (de) 2015-07-17 2024-01-03 Nanostring Technologies, Inc. Simultane quantifizierung der genexpression in einer benutzerdefinierten region eines gewebequerschnitts
US10144724B2 (en) 2015-07-22 2018-12-04 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
JP6701338B2 (ja) 2015-08-10 2020-05-27 エッセンリックス コーポレーション ステップが簡略化され、試料が少なく、スピードアップし、使いやすい、生化学的／化学的なアッセイ装置及び方法
US10132794B2 (en) 2015-09-14 2018-11-20 Essenlix Corporation Device and system for collecting and analyzing vapor condensate, particularly exhaled breath condensate, as well as method of using the same
AU2016323062A1 (en) 2015-09-14 2018-04-12 Essenlix Corp. Device and system for analyzing a sample, particularly blood, as well as methods of using the same
US10975071B2 (en) 2015-09-28 2021-04-13 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017058792A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
US10647703B2 (en) 2015-09-28 2020-05-12 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
US10689356B2 (en) 2015-09-28 2020-06-23 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
EP3356353A1 (de) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitoren von kras-g12c-mutanten proteinen
EP3356347A1 (de) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitoren von kras-g12c-mutanten proteinen
US10730867B2 (en) 2015-09-28 2020-08-04 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017070256A2 (en) 2015-10-19 2017-04-27 Araxes Pharma Llc Method for screening inhibitors of ras
US10414757B2 (en) 2015-11-16 2019-09-17 Araxes Pharma Llc 2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof
US9988357B2 (en) 2015-12-09 2018-06-05 Araxes Pharma Llc Methods for preparation of quinazoline derivatives
EP3798321B1 (de) 2015-12-17 2025-08-27 Illumina, Inc. Unterscheidung von methylierungsspiegeln in komplexen biologischen proben
EP4059570A1 (de) 2016-01-13 2022-09-21 Children's Hospital Medical Center Zusammensetzungen und verfahren zur behandlung von allergischen entzündungserkrankungen
EP3432877B1 (de) 2016-03-24 2023-01-11 ImmunoMolecular Therapeutics, Inc. D-alpha-methyldopa zur behandlung von autoimmunerkrankungen
WO2017172979A1 (en) 2016-03-30 2017-10-05 Araxes Pharma Llc Substituted quinazoline compounds and methods of use
WO2018009547A1 (en) 2016-07-05 2018-01-11 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Diagnosing col6-related disorders and methods for treating same
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
EP3510398B1 (de) 2016-09-12 2026-02-25 Isoplexis Corporation System und verfahren zur multiplex-analyse von zellularen und anderen immunotherapeutika
WO2018064510A1 (en) 2016-09-29 2018-04-05 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
US10377743B2 (en) 2016-10-07 2019-08-13 Araxes Pharma Llc Inhibitors of RAS and methods of use thereof
EP3538891B1 (de) 2016-11-11 2022-01-05 Isoplexis Corporation Zusammensetzungen und verfahren zur gleichzeitigen genomischen, transkriptomischen und proteomischen analyse von einzelzellen
KR102476709B1 (ko) 2016-11-21 2022-12-09 나노스트링 테크놀로지스, 인크. 화학적 조성물 및 이것을 사용하는 방법
CN110226084A (zh) 2016-11-22 2019-09-10 伊索普莱克西斯公司 用于细胞捕获的系统、装置和方法，以及其制造方法
WO2018112420A1 (en) 2016-12-15 2018-06-21 The Regents Of The University Of California Compositions and methods for treating cancer
JP6667052B1 (ja) 2016-12-21 2020-03-18 エッセンリックス コーポレーション 試料を認証するためのデバイスおよび方法ならびにその使用
US11618924B2 (en) 2017-01-20 2023-04-04 Children's Hospital Medical Center Methods and compositions relating to OPRM1 DNA methylation for personalized pain management
EP3573971A1 (de) 2017-01-26 2019-12-04 Araxes Pharma LLC 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-on-derivate und ähnliche verbindungen als kras-g12c-modulatoren zur behandlung von krebs
US11136308B2 (en) 2017-01-26 2021-10-05 Araxes Pharma Llc Substituted quinazoline and quinazolinone compounds and methods of use thereof
WO2018140599A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc Benzothiophene and benzothiazole compounds and methods of use thereof
WO2018140600A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc Fused hetero-hetero bicyclic compounds and methods of use thereof
EP3573954A1 (de) 2017-01-26 2019-12-04 Araxes Pharma LLC Fusionierte bicyclische benzoheteroaromatische verbindungen und verfahren zur verwendung davon
US10240205B2 (en) 2017-02-03 2019-03-26 Population Bio, Inc. Methods for assessing risk of developing a viral disease using a genetic test
WO2018148342A1 (en) 2017-02-07 2018-08-16 Essenlix Corporation Compressed open flow assay and use
CA3053005A1 (en) 2017-02-08 2018-08-16 Essenlix Corporation Sample collection and handling for delayed analysis
WO2018148764A1 (en) 2017-02-08 2018-08-16 Essenlix Corporation Molecular manipulation and assay with controlled temperature
US12066434B2 (en) * 2017-02-08 2024-08-20 Essenlix Corporation QMAX assays and applications
CA3052962A1 (en) 2017-02-08 2018-08-16 Essenlix Corp. Digital assay
US11927560B2 (en) 2017-02-08 2024-03-12 Essenlix Corporation Bio/chemical material extraction and assay
JP2020507770A (ja) 2017-02-09 2020-03-12 エッセンリックス コーポレーション 比色アッセイ法
EP3580565B1 (de) 2017-02-09 2024-05-29 Essenlix Corporation Assay mit verschiedenen abstandshöhen
WO2018148461A1 (en) 2017-02-09 2018-08-16 Essenlix Corp. Assay with amplification
US12350680B2 (en) 2017-02-15 2025-07-08 Essenlix Corporation Assay with rapid temperature change
CN120195095A (zh) 2017-02-16 2025-06-24 上海宜晟生物科技有限公司 采用纹理化表面的测定方法及装置
US11639925B2 (en) * 2017-04-06 2023-05-02 Agilent Technologies, Inc. Method and apparatus for measuring physiological properties of biological samples
KR20200010306A (ko) 2017-05-25 2020-01-30 아락세스 파마 엘엘씨 Kras의 공유적 억제제
WO2018218069A1 (en) 2017-05-25 2018-11-29 Araxes Pharma Llc Quinazoline derivatives as modulators of mutant kras, hras or nras
CN110869357A (zh) 2017-05-25 2020-03-06 亚瑞克西斯制药公司 化合物及其用于治疗癌症的使用方法
EP3638421A4 (de) 2017-06-12 2021-04-07 Essenlix Corporation Homogener assay
WO2019028123A1 (en) 2017-08-01 2019-02-07 Essenlix Corporation COLLECTION, MAINTENANCE AND DETERMINATION OF SAMPLES
US11280706B2 (en) 2017-08-01 2022-03-22 Essenlix Corporation Dilution calibration
CN120668916A (zh) 2017-08-01 2025-09-19 上海宜晟生物科技有限公司 检查药物对微生物影响的装置和方法
US12403465B2 (en) 2017-10-11 2025-09-02 Essenlix Corporation Containing a liquid sample
US11393561B2 (en) 2017-10-13 2022-07-19 Essenlix Corporation Devices and methods for authenticating a medical test and use of the same
US10807095B2 (en) 2017-10-26 2020-10-20 Essenlix Corporation Making and tracking assay card
US11609224B2 (en) 2017-10-26 2023-03-21 Essenlix Corporation Devices and methods for white blood cell analyses
US11237113B2 (en) 2017-10-26 2022-02-01 Essenlix Corporation Rapid pH measurement
US11648551B2 (en) 2017-12-12 2023-05-16 Essenlix Corporation Sample manipulation and assay with rapid temperature change
US11510608B2 (en) 2017-12-14 2022-11-29 Essenlix Corporation Devices, systems, and methods for monitoring hair
WO2019140334A1 (en) 2018-01-11 2019-07-18 Essenlix Corporation Homogeneous assay (ii)
WO2019157445A1 (en) 2018-02-12 2019-08-15 Nanostring Technologies, Inc. Biomolecular probes and methods of detecting gene and protein expression
US11052060B2 (en) 2018-02-12 2021-07-06 The Regents Of The University Of Colorado, A Body Corporate Compounds and methods for treating autoimmunity
US11859250B1 (en) 2018-02-23 2024-01-02 Children's Hospital Medical Center Methods for treating eosinophilic esophagitis
US11013707B2 (en) 2018-03-23 2021-05-25 The Regents Of The University Of Colorado, A Body Corporate Administration of oral methyldopa
WO2019204580A1 (en) 2018-04-20 2019-10-24 Children's Hospital Medical Center Blood biomarker for eosinophilic gastrointestinal disorders
EP3794146B1 (de) 2018-05-14 2025-12-10 Bruker Spatial Biology, Inc. Verfahren zur erkennung einer zuvor bestimmten nukleotidesequenz
EP3802886A1 (de) 2018-05-25 2021-04-14 Philip Morris Products S.A. Verfahren zur klassifizierung von pflanzenmaterial
JP7437161B2 (ja) 2018-06-29 2024-02-22 イラミーナ インコーポレーテッド フローセル
US11885952B2 (en) 2018-07-30 2024-01-30 Essenlix Corporation Optics, device, and system for assaying and imaging
CA3107168A1 (en) 2018-08-01 2020-02-06 Araxes Pharma Llc Heterocyclic spiro compounds and methods of use thereof for the treatment of cancer
EP4177356B1 (de) 2018-08-08 2024-05-08 PML Screening, LLC Verfahren zur beurteilung des risikos der entwicklung einer viruserkrankung unter verwendung eines genetischen tests
WO2020085104A1 (ja) * 2018-10-24 2020-04-30 凸版印刷株式会社 免疫測定用カップ及びその製造方法、並びに免疫測定方法
CN112639126A (zh) 2018-12-14 2021-04-09 伊卢米纳剑桥有限公司 降低测序期间用未标记的核苷酸的定相
ES3032918T3 (en) 2018-12-17 2025-07-28 Illumina Cambridge Ltd Method of polynucleotide sequencing
CN112654714B (zh) 2018-12-17 2024-10-11 伊卢米纳剑桥有限公司 用于测序的引物寡核苷酸
US12297501B2 (en) 2019-02-25 2025-05-13 Children's Hospital Medical Center Methods for diagnosing and treating eosinophilic gastritis
CA3145322A1 (en) 2019-12-20 2021-06-24 Illumina, Inc. Flow cells
JP7532867B2 (ja) * 2020-04-23 2024-08-14 Ｔｏｐｐａｎホールディングス株式会社 免疫測定用デバイス
CN113008764B (zh) * 2020-06-17 2022-12-02 山东大学 一种单细胞功能评估试剂盒及评估方法
US11939300B2 (en) 2020-08-21 2024-03-26 Immunomolecular Therapeutics, Inc. Compounds and methods for treating autoimmune disorders by targeting HLA-DQ2
EP4229175A4 (de) 2020-10-13 2024-10-16 Bio-Rad Europe GmbH System und verfahren zur zielerkennung mit anwendungen bei der charakterisierung der lebensmittelqualität und verbesserung der lebensmittelsicherheit
AU2021364598A1 (en) 2020-10-19 2023-06-08 Bio-Rad Laboratories, Inc. System and method for rapid multiplexed sample processing with applications for nucleic acid amplification assays
US12480157B2 (en) 2021-09-30 2025-11-25 Illumina, Inc. Polynucleotide sequencing
CN120153089A (zh) 2022-09-01 2025-06-13 赢创运营有限公司 检测dna-甲基化的多物种芯片
CA3266144A1 (en) 2022-09-01 2024-03-07 Evonik Operations Gmbh DNA METHYLATION DETECTION IN ANIMAL DERIVATIVES
EP4581163A1 (de) 2022-09-01 2025-07-09 Evonik Operations GmbH Verfahren zur beurteilung der proteinproduktion in cho-zellen
AU2024216648A1 (en) 2023-02-07 2025-09-18 Evonik Operations Gmbh Dna-methylation based evaluation of animal feed
EP4673564A1 (de) 2023-03-02 2026-01-07 Evonik Operations GmbH Entwicklung von zellmedium und futter auf säugetierzellen
AU2024227981A1 (en) 2023-03-02 2025-10-09 Evonik Operations Gmbh Detection of viral presence in cells
WO2025087779A1 (en) 2023-10-27 2025-05-01 Evonik Operations Gmbh A measure of ageing based on epigenetics
WO2025108794A1 (en) 2023-11-24 2025-05-30 Evonik Operations Gmbh Predicting the fitness of a cho cell
WO2025108795A1 (en) 2023-11-24 2025-05-30 Evonik Operations Gmbh A method of classifying cho cells
US20250215491A1 (en) 2023-12-28 2025-07-03 Illumina, Inc. Sequencing with single-stranded binding proteins
WO2026017441A1 (en) 2024-07-15 2026-01-22 Evonik Operations Gmbh Prediction of quality of recombinant protein from cho cells
WO2026037761A1 (en) 2024-08-16 2026-02-19 Evonik Operations Gmbh An epigenetic clock for cho cells

Family Cites Families (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200110A (en) 1977-11-28 1980-04-29 United States Of America Fiber optic pH probe
US4349510A (en) 1979-07-24 1982-09-14 Seppo Kolehmainen Method and apparatus for measurement of samples by luminescence
US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4707454A (en) 1981-08-10 1987-11-17 Bio-Diagnostics, Inc. Fluorescent chlorophyll labeled assay reagents
US4499052A (en) 1982-08-30 1985-02-12 Becton, Dickinson And Company Apparatus for distinguishing multiple subpopulations of cells
EP0207532B1 (de) 1982-11-20 1990-05-16 The University Of Birmingham Vorrichtung zum Registrieren von Reaktionen
NZ207394A (en) * 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US4672040A (en) 1983-05-12 1987-06-09 Advanced Magnetics, Inc. Magnetic particles for use in separations
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US4682895A (en) 1985-08-06 1987-07-28 Texas A&M University Fiber optic probe for quantification of colorimetric reactions
US4824789B1 (en) 1986-10-10 1996-08-13 Minnesota Mining & Mfg Gas sensor
US4798738A (en) 1986-10-10 1989-01-17 Cardiovascular Devices, Inc. Micro sensor
US5254477A (en) 1986-06-25 1993-10-19 Trustees Of Tufts College Flourescence intramolecular energy transfer conjugate compositions and detection methods
US4822746A (en) 1986-06-25 1989-04-18 Trustees Of Tufts College Radiative and non-radiative energy transfer and absorbance modulated fluorescence detection methods and sensors
US5143853A (en) 1986-06-25 1992-09-01 Trustees Of Tufts College Absorbance modulated fluorescence detection methods and sensors
US5252494A (en) 1986-06-25 1993-10-12 Trustees Of Tufts College Fiber optic sensors, apparatus, and detection methods using controlled release polymers and reagent formulations held within a polymeric reaction matrix
US5114864A (en) 1986-06-25 1992-05-19 Trustees Of Tufts College Fiber optic sensors, apparatus, and detection methods using fluid erodible controlled release polymers for delivery of reagent formulations
DE3681176D1 (de) 1986-12-01 1991-10-02 Molecular Biosystems Inc Verfahren zur erhoehung der empfindlichkeit von nukleinsaeure-hybridisierungstesten.
SE458968B (sv) 1987-06-16 1989-05-22 Wallac Oy Biospecifikt analysfoerfarande foer flera analyter i vilket ingaar partikelraekning och maerkning med fluorescerande maerksubstanser
US5132242A (en) 1987-07-15 1992-07-21 Cheung Sau W Fluorescent microspheres and methods of using them
US5194300A (en) 1987-07-15 1993-03-16 Cheung Sau W Methods of making fluorescent microspheres
US4785814A (en) 1987-08-11 1988-11-22 Cordis Corporation Optical probe for measuring pH and oxygen in blood and employing a composite membrane
US5002867A (en) 1988-04-25 1991-03-26 Macevicz Stephen C Nucleic acid sequence determination by multiple mixed oligonucleotide probes
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
NO164622C (no) 1988-05-11 1990-10-24 Tore Lindmo Binaer immunometrisk partikkelbasert metode for maaling av spesifikke serum-antigener ved hjelp av vaeskestroemsmikrofotometri og et ferdigpreparert maaloppsett derav.
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
US5575849A (en) 1988-11-25 1996-11-19 Canon Kabushiki Kaisha Apparatus for producing a substrate having a surface with a plurality of spherical dimples for photoconductive members
JPH02299598A (ja) 1989-04-14 1990-12-11 Ro Inst For Molecular Genetics & Geneteic Res 微視的サイズの別個の粒子と結合している核酸試料中のごく短い配列の全部または一部のオリゴヌクレチドプローブとのハイブリダイゼーションによる決定法
US5087820A (en) 1989-05-31 1992-02-11 Digital Diagnostic Corp. Radiometric analysis system for solid support samples
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5176881A (en) * 1989-08-11 1993-01-05 The University Of Tennessee Research Corporation Fiber optic-based regenerable biosensor
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
EP0416148A1 (de) 1989-09-07 1991-03-13 RSM ANALYTISCHE INSTRUMENTE GmbH Einrichtung zum gleichzeitigen Messen von Mehrfachproben-Partikel-oder Quanten-Strahlungen
US5326692B1 (en) 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
CA2084987C (en) 1990-06-11 2007-02-13 Gilead Sciences, Inc. Nucleic acid ligands
US5637459A (en) 1990-06-11 1997-06-10 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chimeric selex
US5683867A (en) 1990-06-11 1997-11-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: blended SELEX
US5496938A (en) 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5705337A (en) 1990-06-11 1998-01-06 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5386023A (en) 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
US5602240A (en) 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
DE69125441T2 (de) 1990-09-28 1997-11-06 Toshiba Kawasaki Kk Verfahren zum Gennachweis
US5105305A (en) 1991-01-10 1992-04-14 At&T Bell Laboratories Near-field scanning optical microscope using a fluorescent probe
US5320814A (en) 1991-01-25 1994-06-14 Trustees Of Tufts College Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample
US5250264A (en) 1991-01-25 1993-10-05 Trustees Of Tufts College Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample
US5244636A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample
US5244813A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample
US5380489A (en) 1992-02-18 1995-01-10 Eastman Kodak Company Element and method for nucleic acid amplification and detection using adhered probes
WO1993002360A1 (en) 1991-07-16 1993-02-04 Transmed Biotech Incorporated Methods and compositions for simultaneous analysis of multiple analytes
US5770358A (en) * 1991-09-18 1998-06-23 Affymax Technologies N.V. Tagged synthetic oligomer libraries
US5639603A (en) * 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
ATE161964T1 (de) 1991-10-15 1998-01-15 Multilyte Ltd Bindungstest unter benutzung eines markierten reagens
US5644048A (en) 1992-01-10 1997-07-01 Isis Pharmaceuticals, Inc. Process for preparing phosphorothioate oligonucleotides
US5888723A (en) 1992-02-18 1999-03-30 Johnson & Johnson Clinical Diagnostics, Inc. Method for nucleic acid amplification and detection using adhered probes
US5445970A (en) 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
EP0565999A2 (de) 1992-04-16 1993-10-20 Siemens Aktiengesellschaft Anordnung zur optischen Kopplung von zwei Gruppen von Wellenleitern
WO1994001774A1 (en) 1992-07-02 1994-01-20 Erkki Soini Biospecific multiparameter assay method
DK0723146T3 (da) 1992-09-14 2004-08-30 Stanford Res Inst Int Opkonverterende reportermolekyler til biologiske og andre assays ved anvendelse af laser-excitationsteknikker
US5674698A (en) * 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5565324A (en) 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5298741A (en) 1993-01-13 1994-03-29 Trustees Of Tufts College Thin film fiber optic sensor array and apparatus for concurrent viewing and chemical sensing of a sample
CA2102884A1 (en) 1993-03-04 1994-09-05 James J. Wynne Dental procedures and apparatus using ultraviolet radiation
JP3302458B2 (ja) 1993-08-31 2002-07-15 富士通株式会社 集積化光装置及び製造方法
JP3488465B2 (ja) 1993-10-28 2004-01-19 ヒューストン・アドバンスド・リサーチ・センター 結合反応を別々に検出する微細加工フロースルー多孔性装置
US5494798A (en) 1993-12-09 1996-02-27 Gerdt; David W. Fiber optic evanscent wave sensor for immunoassay
US5496997A (en) 1994-01-03 1996-03-05 Pope; Edward J. A. Sensor incorporating an optical fiber and a solid porous inorganic microsphere
US5637684A (en) 1994-02-23 1997-06-10 Isis Pharmaceuticals, Inc. Phosphoramidate and phosphorothioamidate oligomeric compounds
US6015880A (en) 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
AU2990595A (en) 1994-07-26 1996-02-22 Sydney Brenner Multidimensional conduit combinatorial library synthesis device
US5512490A (en) 1994-08-11 1996-04-30 Trustees Of Tufts College Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns
US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
WO1998053300A2 (en) 1997-05-23 1998-11-26 Lynx Therapeutics, Inc. System and apparaus for sequential processing of analytes
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5609826A (en) * 1995-04-17 1997-03-11 Ontogen Corporation Methods and apparatus for the generation of chemical libraries
US5690894A (en) 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US6074614A (en) 1995-06-07 2000-06-13 Molecular Devices Corporation Multi-assay plate cover for elimination of meniscus
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5656241A (en) 1995-09-07 1997-08-12 Optical Sensors Incorporated Method for manufacturing fiber optic sensors
AU7398996A (en) 1995-10-11 1997-04-30 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US5981180A (en) 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
GB9521159D0 (en) 1995-10-16 1995-12-20 Brint Norman T A weapon
US5633972A (en) 1995-11-29 1997-05-27 Trustees Of Tufts College Superresolution imaging fiber for subwavelength light energy generation and near-field optical microscopy
US5814524A (en) 1995-12-14 1998-09-29 Trustees Of Tufts College Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations
US6660233B1 (en) * 1996-01-16 2003-12-09 Beckman Coulter, Inc. Analytical biochemistry system with robotically carried bioarray
US5837196A (en) 1996-01-26 1998-11-17 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5649576A (en) * 1996-02-26 1997-07-22 Pharmacopeia, Inc. Partitioning device
DE69707853T2 (de) 1996-03-15 2002-06-27 President And Fellows Of Harvard College, Cambridge Verfahren zum formen von gegenständen und zum mikrostrukturieren von oberflächen durch giessformen mit kapillarwirkung
US5840256A (en) 1996-04-09 1998-11-24 David Sarnoff Research Center Inc. Plate for reaction system
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
WO1998008092A1 (en) 1996-08-21 1998-02-26 Smithkline Beecham Corporation Rapid process for arraying and synthesizing bead-based combinatorial libraries
US5854684A (en) 1996-09-26 1998-12-29 Sarnoff Corporation Massively parallel detection
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
DE19782097T1 (de) * 1996-11-06 1999-10-14 Sequenom Inc Zusammensetzungen und Verfahren zur Immobilisierung von Nucleinsäuren an feste Träger
CA2389358C (en) 1996-12-31 2008-07-15 Genometrix Incorporated Multiplexed molecular analysis apparatus and method
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US6406845B1 (en) 1997-05-05 2002-06-18 Trustees Of Tuft College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
WO1998053093A1 (en) 1997-05-23 1998-11-26 Bioarray Solutions Llc Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
US6037186A (en) * 1997-07-16 2000-03-14 Stimpson; Don Parallel production of high density arrays
US6071748A (en) * 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
NZ501775A (en) 1997-07-22 2001-08-31 Qiagen Genomics Inc Hybridization analysis using low density nucleic acid arrays
US7115884B1 (en) * 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
US5922617A (en) * 1997-11-12 1999-07-13 Functional Genetics, Inc. Rapid screening assay methods and devices
WO1999060170A1 (en) 1998-05-21 1999-11-25 Hyseq, Inc. Linear arrays of immobilized compounds and methods of using same
EP1090138A4 (de) 1998-06-24 2003-01-02 Glaxo Group Ltd Nachweisverfahren für nukleotide
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
WO2000013004A2 (en) 1998-08-26 2000-03-09 Trustees Of Tufts College Combinatorial polymer synthesis of sensors for polymer-based sensor arrays
AU770146B2 (en) 1999-02-09 2004-02-12 Illumina, Inc. Intrabead screening methods and compositions
US9217559B2 (en) 2012-03-20 2015-12-22 Martin Professional A/S Moving head light fixture with yoke and head position encoding means
US9821193B2 (en) 2012-11-01 2017-11-21 Acushnet Company Golf balls having multi-layered core with metal-containing center and thermoplastic outer layers
US9809163B2 (en) 2015-04-14 2017-11-07 Harman International Industries, Incorporation Techniques for transmitting an alert towards a target area
CA2932173C (en) 2015-06-05 2023-09-26 Snap-Loc Cargo Control Systems, LLC Cargo control cinch strap system
US9805025B2 (en) 2015-07-13 2017-10-31 Seal Software Limited Standard exact clause detection
US9904473B2 (en) 2015-11-20 2018-02-27 International Business Machines Corporation Memory and processor affinity in a deduplicated environment

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DE69941068D1 (de) 2009-08-13
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US6429027B1 (en) 2002-08-06
CA2729739A1 (en) 2000-07-06
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AU2391600A (en) 2000-07-31
JP2002533727A (ja) 2002-10-08
CA2353868A1 (en) 2000-07-06
CA2353868C (en) 2011-03-29
US6858394B1 (en) 2005-02-22
DE69926260D1 (de) 2005-08-25
DE69926260T2 (de) 2006-04-27
ATE300047T1 (de) 2005-08-15
EP1593967A2 (de) 2005-11-09
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EP1593967B1 (de) 2009-07-01
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DE29925020U1 (de) 2009-09-10
EP2083271A2 (de) 2009-07-29
EP1141712B1 (de) 2005-07-20
AU775056B2 (en) 2004-07-15
US6998274B2 (en) 2006-02-14
US20020187515A1 (en) 2002-12-12
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