ATE437229T1 - Ricin-ähnliche toxine zur therapie von kreb, viraler oder parasitärer infektionen - Google Patents

Ricin-ähnliche toxine zur therapie von kreb, viraler oder parasitärer infektionen

Info

Publication number
ATE437229T1
ATE437229T1 AT98916743T AT98916743T ATE437229T1 AT E437229 T1 ATE437229 T1 AT E437229T1 AT 98916743 T AT98916743 T AT 98916743T AT 98916743 T AT98916743 T AT 98916743T AT E437229 T1 ATE437229 T1 AT E437229T1
Authority
AT
Austria
Prior art keywords
ricin
cancer
viral
nucleic acid
infection
Prior art date
Application number
AT98916743T
Other languages
English (en)
Inventor
Thor Borgford
Original Assignee
Twinstrand Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Twinstrand Therapeutics Inc filed Critical Twinstrand Therapeutics Inc
Application granted granted Critical
Publication of ATE437229T1 publication Critical patent/ATE437229T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98916743T 1997-04-30 1998-04-30 Ricin-ähnliche toxine zur therapie von kreb, viraler oder parasitärer infektionen ATE437229T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4514897P 1997-04-30 1997-04-30
US6371597P 1997-10-29 1997-10-29
PCT/CA1998/000394 WO1998049311A2 (en) 1997-04-30 1998-04-30 Ricin-like toxin variants for treatment of cancer, viral or parasitic infections

Publications (1)

Publication Number Publication Date
ATE437229T1 true ATE437229T1 (de) 2009-08-15

Family

ID=26722431

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98916743T ATE437229T1 (de) 1997-04-30 1998-04-30 Ricin-ähnliche toxine zur therapie von kreb, viraler oder parasitärer infektionen

Country Status (8)

Country Link
US (3) US6593132B1 (de)
EP (1) EP0977862B8 (de)
JP (1) JP4566290B2 (de)
AT (1) ATE437229T1 (de)
AU (1) AU7023798A (de)
CA (1) CA2288943C (de)
DE (1) DE69840998D1 (de)
WO (1) WO1998049311A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6361946B1 (en) 1997-02-05 2002-03-26 Licentia Ltd Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof
WO2001025267A2 (en) 1999-10-04 2001-04-12 Twinstrand Therapeutics Inc. Improved ricin-like toxins for treatment of cancer
US7247715B2 (en) * 1997-04-30 2007-07-24 Twinstrand Therapeutics Inc. Ricin-like toxin variants for treatment of cancer, viral or parasitic infections
US6942853B2 (en) * 2001-01-09 2005-09-13 Queen Mary And Westfield College Latent fusion protein
CA2475177A1 (en) 2002-02-11 2003-08-21 Zymogenetics, Inc. Materials and methods for preparing dimeric growth factors
KR20060034698A (ko) * 2003-07-10 2006-04-24 와이어쓰 홀딩스 코포레이션 화농성 연쇄상구균 시스테인 프로테아제의 재조합 발현 및이의 면역원성 조성물
US20090304817A1 (en) * 2004-03-24 2009-12-10 Thor Borgford Glycosylation Variants of Ricin-Like Proteins
EP1727827B1 (de) * 2004-03-26 2010-05-12 Molecular Templates, Inc. Bibliothek von toxin mutanten und deren verwendung
JP2008514900A (ja) * 2004-07-30 2008-05-08 アデザ・バイオメデイカル・コーポレイシヨン 疾病および他の状態のマーカーとしての癌胎児性フィブロネクチンならびに癌胎児性フィブロネクチンの検出のための方法
DE102005002978B4 (de) * 2005-01-21 2013-04-25 Merz Pharma Gmbh & Co. Kgaa Rekombinante Expression von Proteinen in einer disulfidverbrückten, zweikettigen Form
EP1945660B1 (de) 2005-09-26 2014-05-07 Molecular Templates, Inc. Bibliothek aus toxinmutanten und verfahren zu deren anwendung
ATE458000T1 (de) * 2005-11-18 2010-03-15 Dabur Pharma Ltd Zielgerichtete fusionsproteine für die krebstherapie
US20100240597A1 (en) * 2007-06-15 2010-09-23 Arkansas State University Methods of delivery of molecules to cells using a ricin subunit and compositions relating to same
WO2010084488A1 (en) 2009-01-20 2010-07-29 Ramot At Tel-Aviv University Ltd. Mir-21 promoter driven targeted cancer therapy
WO2012038950A1 (en) * 2010-09-20 2012-03-29 Ramot At Tel-Aviv University Ltd. Activatable toxin complexes comprising a cleavable inhibitory peptide
US10363323B2 (en) 2011-02-10 2019-07-30 Ruprecht-Karls-Universitat Heidelberg Hydrophobic modified peptides for liver specific diagnosis
ES2663368T3 (es) 2011-02-10 2018-04-12 Ruprecht-Karls-Universität Heidelberg Péptidos modificados hidrófobos y uso de los mismos para su direccionamiento específico al hígado
CN103561771B (zh) 2011-03-17 2019-01-04 伯明翰大学 重新定向的免疫治疗
JP7134461B2 (ja) * 2018-03-23 2022-09-12 国立大学法人金沢大学 マラリア治療剤、マラリア予防剤及び抗マラリア自然免疫賦活剤
EP4271651B1 (de) 2020-12-30 2024-10-23 Hawkeye Bio, Limited Biosensor auf basis von reinem graphen zum nachweis von biomarkern und zugehörige kernpartikel, materialzusammensetzungen, methoden und systeme
EP4402157B1 (de) * 2021-09-14 2025-12-17 Xilio Development, Inc. Spaltbare linker

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2442A (en) 1842-02-01 Floating dry-dock
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
EP0145111B1 (de) * 1983-07-15 1990-05-09 The University Of Warwick Für ein Pflanzentoxin des Ricin-Typs kodierende DNA-Sequenz oder ein Teil davon
US4736866B1 (en) 1984-06-22 1988-04-12 Transgenic non-human mammals
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (de) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimäre Rezeptoren durch Verbindung und Expression von DNS
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US4869903A (en) 1987-05-29 1989-09-26 Genelabs Incorporated Method of selectively inhibiting HIV
WO1990010457A1 (en) 1989-03-14 1990-09-20 New York University Method of treating hiv infections using immunotoxins
US5101025A (en) 1989-04-04 1992-03-31 Genelabs Incorporated Recombinant trichosanthin and coding sequence
US5128460A (en) 1989-04-04 1992-07-07 Genelabs Incorporated Recombinant trichosanthin and coding sequence
US5248606A (en) 1990-06-11 1993-09-28 Dowelanco Dna encoding inactive precursor and active forms of maize ribosome inactivating protein
GB9021679D0 (en) 1990-10-05 1990-11-21 Gorman Scott David Antibody preparation
US5677274A (en) 1993-02-12 1997-10-14 The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services Anthrax toxin fusion proteins and related methods
EP0909322B1 (de) * 1996-04-30 2005-11-16 Twinstrand Therapeutics Inc. Antivirale variante von ricin-proteinen

Also Published As

Publication number Publication date
US20040009551A1 (en) 2004-01-15
EP0977862B8 (de) 2009-09-16
CA2288943A1 (en) 1998-11-05
AU7023798A (en) 1998-11-24
JP2001523961A (ja) 2001-11-27
US7375186B2 (en) 2008-05-20
DE69840998D1 (de) 2009-09-03
CA2288943C (en) 2011-02-01
WO1998049311A2 (en) 1998-11-05
US20110144004A1 (en) 2011-06-16
JP4566290B2 (ja) 2010-10-20
WO1998049311A3 (en) 1999-02-11
EP0977862A2 (de) 2000-02-09
US6593132B1 (en) 2003-07-15
EP0977862B1 (de) 2009-07-22

Similar Documents

Publication Publication Date Title
ATE437229T1 (de) Ricin-ähnliche toxine zur therapie von kreb, viraler oder parasitärer infektionen
Utkin Animal venom studies: Current benefits and future developments
RU95115239A (ru) Аналог эритропоэтина
BR7908410A (pt) Meio para deteccao de anticorpos de vhb no soro do sangue,e processo para deteccao da presenca da infeccao por virus da hepatite b em seres humanos
DE69934967D1 (de) Verfahren zur verminderung der immunogenität von proteinen
CY1107628T1 (el) Ανθρωπινα ctla-4 αντισωματα και χρησεις αυτων
BR0213786A (pt) Peptìdeos efetivos no tratamento de tumores e outras condições que requerem a remoção ou destruição de células
CY1106926T1 (el) Γονιδιο που κωδικοποιει την ηλιομυκινη και η χρηση της
CY1111120T1 (el) Πεπτιδια που παραγονται απο πρωτεϊνες νευρικων ινων και η ιατρικη τους χρηση
SE8703225L (sv) Monoklonala antikroppar och peptider anvendbara vid behandling och diagnostisering av hiv-infektioner
ATE196475T1 (de) Auf histatin basierende, gegen pilze und bakterien gerichtete peptide
BR0012919A (pt) Vacina para uso na profilaxia e/ou no tratamento da sìndrome de ponto branco (white spot syndrome) em crustáceos, proteìna estrutural derivada do vìrus da sìndrome de ponto branco, sequência de ácido nucléico, uso de uma proteìna estrutural, composição farmacêutica, anticorpos, vacina ou formulação farmacêutica, e, kit diagnóstico para detecção de wssv
DK0750672T3 (da) DNA-sekvenser for matrix-metalproteaser, deres tilvejebringelse og anvendelse
Korir et al. Proteomic studies of Plasmodium knowlesi SICA variant antigens demonstrate their relationship with P. falciparum EMP1
ATE163676T1 (de) Molekulare klone von hiv-1 und deren verwendung
RU94045907A (ru) Вич-антитела человека или их фрагменты, экспрессионные кассеты, клетки-хозяева, фармацевтические композиции, способ защиты
TR200400049T2 (tr) Eimeria maxima gametositinden rekombinant 56 ve 82 kda antijenleri kodlayan nükleik asitler
EA200100700A1 (ru) Гены и белки и их применение
UY26763A1 (es) Inmunización del ganado lacteo con proteína gapc quimérica contra infección por estreptococo.
WO2001025267A3 (en) Improved ricin-like toxins for treatment of cancer
EP1572721A4 (de) Prävention und behandlung von hcv-infektionen unter anwendung von gegen konformationelle und lineare epitope gerichteten antikörpern
CA2252799A1 (en) Antiviral ricin-like proteins
WO2022150654A3 (en) Antigen-binding polypeptides specific for coronaviruses and uses thereof
CY1105947T1 (el) Νουκλεϊνικα οξεα και πρωτεϊνες του γονιδιου mhp3 του mycoplasma hyopneumoniae και χρησεις αυτων
DE60035485D1 (de) IDENTIFIZIERUNG VON SPEZIFISCHEN DIFFERENZIELL EXPRIMIERTEN ANTIGENEN AUS MYCOBACTERIUM UND MEDIZINISCHE VERWENDUNG DER MYCOBAKTERIUMPROTEINE Rv0068 UND Rv3407

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties