ATE437845T1 - Verfahren zur herstellung einer verbindungsbibliothek und identifizierung von lead chemischen templaten und liganden von zielmolekülen - Google Patents
Verfahren zur herstellung einer verbindungsbibliothek und identifizierung von lead chemischen templaten und liganden von zielmolekülenInfo
- Publication number
- ATE437845T1 ATE437845T1 AT00977289T AT00977289T ATE437845T1 AT E437845 T1 ATE437845 T1 AT E437845T1 AT 00977289 T AT00977289 T AT 00977289T AT 00977289 T AT00977289 T AT 00977289T AT E437845 T1 ATE437845 T1 AT E437845T1
- Authority
- AT
- Austria
- Prior art keywords
- ligands
- target molecules
- producing
- compound library
- identifying lead
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000003446 ligand Substances 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 4
- 238000005481 NMR spectroscopy Methods 0.000 abstract 1
- 238000009510 drug design Methods 0.000 abstract 1
- 238000007876 drug discovery Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/30—Sample handling arrangements, e.g. sample cells, spinning mechanisms
- G01R33/307—Sample handling arrangements, e.g. sample cells, spinning mechanisms specially adapted for moving the sample relative to the MR system, e.g. spinning mechanisms, flow cells or means for positioning the sample inside a spectrometer
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
Landscapes
- Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15681899P | 1999-09-29 | 1999-09-29 | |
| US16168299P | 1999-10-26 | 1999-10-26 | |
| US19268500P | 2000-03-28 | 2000-03-28 | |
| PCT/US2000/041034 WO2001023330A2 (en) | 1999-09-29 | 2000-09-29 | Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE437845T1 true ATE437845T1 (de) | 2009-08-15 |
Family
ID=27387923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00977289T ATE437845T1 (de) | 1999-09-29 | 2000-09-29 | Verfahren zur herstellung einer verbindungsbibliothek und identifizierung von lead chemischen templaten und liganden von zielmolekülen |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1242339B1 (de) |
| AT (1) | ATE437845T1 (de) |
| AU (1) | AU1494401A (de) |
| CA (1) | CA2400094A1 (de) |
| DE (1) | DE60042658D1 (de) |
| ES (1) | ES2331050T3 (de) |
| WO (1) | WO2001023330A2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7329489B2 (en) | 2000-04-14 | 2008-02-12 | Matabolon, Inc. | Methods for drug discovery, disease treatment, and diagnosis using metabolomics |
| JP2003530130A (ja) | 2000-04-14 | 2003-10-14 | メタボロン インコーポレイテッド | メタボロミクスを使用した薬物発見、疾患の処置、及び診断のための方法 |
| US7470543B2 (en) | 2002-06-05 | 2008-12-30 | Nerviano Medical Sciences S.R.L. | Methods for identifying ligands using competitive binding 1H NMR experiments |
| WO2003104824A2 (en) * | 2002-06-05 | 2003-12-18 | Pharmacia & Upjohn Company | Methods for identifying ligands using waterlogsy nmr |
| WO2008033575A2 (en) | 2006-09-15 | 2008-03-20 | Metabolon, Inc. | Methods of identifying biochemical pathways |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60107554A (ja) * | 1983-11-16 | 1985-06-13 | Ube Ind Ltd | 未知物質の化学構造を決定する方法および装置 |
| DE4234544C2 (de) * | 1992-10-14 | 1996-09-05 | Bruker Analytische Messtechnik | Direkt-gekoppeltes Probenwechselsystem für Flüssigkeits-NMR-Spektroskopie und Verfahren zu dessen Betrieb |
| US5668734A (en) * | 1995-04-10 | 1997-09-16 | The Uab Research Foundation | Method for analyzing 2D transferred noesy spectra of molecules undergoing multistate conformational exchange |
| AU6386196A (en) * | 1995-06-19 | 1997-01-15 | Eli Lilly And Company | Process for parallel synthesis of a non-peptide library |
| US5698401A (en) * | 1995-11-14 | 1997-12-16 | Abbott Laboratories | Use of nuclear magnetic resonance to identify ligands to target biomolecules |
| GB9610811D0 (en) * | 1996-05-23 | 1996-07-31 | Pharmacia Spa | Combinatorial solid phase synthesis of a library of indole derivatives |
| GB2316941A (en) * | 1996-07-02 | 1998-03-11 | Merck & Co Inc | Combinatorial sythesis on soluble polyvalent supports |
| DE19649359C1 (de) * | 1996-11-28 | 1998-02-12 | Thomas Prof Dr Peters | Verfahren zum Nachweis biologisch aktiver Substanzen in Substanzbibliotheken |
| GB9707744D0 (en) * | 1997-04-17 | 1997-06-04 | Zeneca Ltd | Method |
| JP2002505004A (ja) | 1997-06-13 | 2002-02-12 | バーテックス ファマシューティカルズ インコーポレイテッド | 薬剤核を同定する方法 |
| AR016817A1 (es) * | 1997-08-14 | 2001-08-01 | Smithkline Beecham Plc | Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento |
| JP2002509149A (ja) * | 1998-01-14 | 2002-03-26 | ザ ユーエイビー リサーチ ファウンデイション | 細菌ｎａｄシンテターゼ酵素の阻害剤の合成およびスクリーニング方法、その化合物、ならびに細菌ｎａｄシンテターゼ酵素の阻害剤を用いる細菌および微生物感染の治療方法 |
| EP1058678B1 (de) * | 1998-02-26 | 2002-12-11 | Massachusetts Institute of Technology | Metallkatalysierte arylierungen und vinylierungen von hydrazinen, hydrazonen, hydroxylaminen und oximen |
-
2000
- 2000-09-29 AU AU14944/01A patent/AU1494401A/en not_active Abandoned
- 2000-09-29 CA CA002400094A patent/CA2400094A1/en not_active Abandoned
- 2000-09-29 EP EP00977289A patent/EP1242339B1/de not_active Expired - Lifetime
- 2000-09-29 ES ES00977289T patent/ES2331050T3/es not_active Expired - Lifetime
- 2000-09-29 AT AT00977289T patent/ATE437845T1/de not_active IP Right Cessation
- 2000-09-29 DE DE60042658T patent/DE60042658D1/de not_active Expired - Fee Related
- 2000-09-29 WO PCT/US2000/041034 patent/WO2001023330A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1242339A2 (de) | 2002-09-25 |
| WO2001023330A2 (en) | 2001-04-05 |
| ES2331050T3 (es) | 2009-12-21 |
| EP1242339B1 (de) | 2009-07-29 |
| DE60042658D1 (de) | 2009-09-10 |
| CA2400094A1 (en) | 2001-04-05 |
| AU1494401A (en) | 2001-04-30 |
| WO2001023330A3 (en) | 2002-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |