ATE4383T1 - Antisekretorisch wirksame heterozyklische guanidinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen. - Google Patents

Antisekretorisch wirksame heterozyklische guanidinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.

Info

Publication number: ATE4383T1
Authority: AT; Austria
Prior art keywords: antisecretory; heterocyclic; derivatives; guaranide; preparation
Prior art date: 1978-10-16

Application number

AT79302212T

Other languages

English (en)

Inventor

Tobias Oregon Yellin

Derrick Fleet Jones

Original Assignee

Imperial Chemical Industries Plc

Ici Americas Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-10-16

Filing date

1979-10-15

Publication date

1983-08-15

1979-10-15 Application filed by Imperial Chemical Industries Plc, Ici Americas Inc filed Critical Imperial Chemical Industries Plc

1983-08-15 Application granted granted Critical

1983-08-15 Publication of ATE4383T1 publication Critical patent/ATE4383T1/de

Links

230000001262 anti-secretory effect Effects 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
-1 2-phenethyl Chemical group 0.000 abstract 6
229910052760 oxygen Inorganic materials 0.000 abstract 5
229910052717 sulfur Inorganic materials 0.000 abstract 5
229910052799 carbon Inorganic materials 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
ZSWPBLVQIZTETP-UHFFFAOYSA-N 2-[4-[2-[[5-[(4-chlorophenyl)methyl]-6-oxo-1h-pyrimidin-2-yl]amino]ethylsulfanylmethyl]-1,3-thiazol-2-yl]guanidine Chemical compound S1C(NC(=N)N)=NC(CSCCNC=2NC(=O)C(CC=3C=CC(Cl)=CC=3)=CN=2)=C1 ZSWPBLVQIZTETP-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000004923 naphthylmethyl group Chemical group C1(=CC=CC2=CC=CC=C12)C* 0.000 abstract 1
125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000005302 thiazolylmethyl group Chemical group [H]C1=C([H])N=C(S1)C([H])([H])* 0.000 abstract 1
125000005301 thienylmethyl group Chemical group [H]C1=C([H])C([H])=C(S1)C([H])([H])* 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)

AT79302212T 1978-10-16 1979-10-15 Antisekretorisch wirksame heterozyklische guanidinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen. ATE4383T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB7840706		1978-10-16
EP79302212A EP0010894B1 (de)	1978-10-16	1979-10-15	Antisekretorisch wirksame heterozyklische Guanidinderivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen

Publications (1)

Publication Number	Publication Date
ATE4383T1 true ATE4383T1 (de)	1983-08-15

Family

ID=10500371

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT79302212T ATE4383T1 (de)	1978-10-16	1979-10-15	Antisekretorisch wirksame heterozyklische guanidinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.

Country Status (6)

Country	Link
US (1)	US4374836A (de)
EP (1)	EP0010894B1 (de)
JP (1)	JPS5553288A (de)
AT (1)	ATE4383T1 (de)
CA (1)	CA1218066A (de)
DE (1)	DE2966030D1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4578459A (en) *	1973-05-03	1986-03-25	Smithkline & French Laboratories Limited	Heterocyclic alkylaminoheterocycles
US4467087A (en) *	1973-05-03	1984-08-21	Smith Kline & French Laboratories Limited	1,2,4-Triazines
US4521418A (en) *	1979-02-21	1985-06-04	Smith Kline & French Laboratories Limited	Guanidinothiazolyl derivatives
NL189197C (nl) *	1979-09-04	1993-02-01	Bristol Myers Squibb Co	3,4-digesubstitueerde-1,2,5-thiadiazool-1-oxiden en 1,1-dioxiden, bereiding daarvan alsmede farmaceutische preparaten.
IL61234A (en) *	1979-10-24	1984-03-30	Smith Kline French Lab	Guanidino thiazolyl alkylamino(alkylthioalkylamino)nitrotetrahydropyridines,process for preparing them and pharmaceutical compositions containing them
GR71929B (de) *	1979-11-13	1983-08-19	Ici Ltd
US4352933A (en) *	1981-02-06	1982-10-05	Smithkline Beckman Corporation	Chemical methods and intermediates for preparing substituted pyrimidinones
EP0065823A1 (de) *	1981-05-13	1982-12-01	Imperial Chemical Industries Plc	Heterozyklische Guanidinderivate als Histamin-H-2-Antagonisten
IE53068B1 (en) *	1981-06-15	1988-05-25	Merck & Co Inc	Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors
US5171860A (en) *	1981-06-15	1992-12-15	Merck & Co., Inc.	Diamino isothiazole-1-oxides and 1,1 dioxides as gastric secretion inhibitors
EP0102026A3 (de) *	1982-08-20	1984-05-16	Hoechst Uk Limited	Thiazolderivate
GB8318638D0 (en) *	1983-07-09	1983-08-10	Smith Kline French Lab	Chemical compounds
US4552899A (en) *	1984-04-09	1985-11-12	Analgesic Associates	Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
GB8421427D0 (en) *	1984-08-23	1984-09-26	Smith Kline French Lab	Chemical compounds
US6025355A (en)	1997-05-19	2000-02-15	Cambridge Neuroscience, Inc.	Pharmaceutically active compounds and methods of use
US6242198B1 (en)	1996-07-25	2001-06-05	Cambridge Neuroscience, Inc.	Methods of treatment of eye trauma and disorders
US6756389B2 (en)	1996-08-09	2004-06-29	Cambridge Neuroscience, Inc.	Pharmaceutically active compounds and methods of use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1338169A (en) *	1971-03-09	1973-11-21	Smith Kline French Lab	Ureas thioureas and guanidines
GB1419994A (en) *	1973-05-03	1976-01-07	Smith Kline French Lab	Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them
US4104381A (en) *	1973-05-03	1978-08-01	Smith Kline & French Laboratories Limited	Pharmacologically active compounds
US4005205A (en) *	1974-04-24	1977-01-25	Smith Kline & French Laboratories Limited	Compositions and methods for inhibiting H2 histamine receptors
US4218452A (en) *	1975-10-02	1980-08-19	Smith Kline & French Laboratories Limited	Substituted 4-pyrimidone compounds, compositions and methods of use
IN146736B (de)	1975-10-02	1979-08-25	Smith Kline French Lab
US4216318A (en) *	1975-12-29	1980-08-05	Smith Kline & French Laboratories Limited	Heterocyclic alkyl 4-pyrimidones
US4154834A (en) *	1975-12-29	1979-05-15	Smith Kline & French Laboratories Limited	Substituted isocytosines having histamine H2 -antagonist activity
MW5076A1 (en)	1975-12-29	1978-02-08	Smith Kline French Lab	Pharmacologicalle active compounds
NZ186511A (en) *	1977-03-19	1980-11-14	Smith Kline French Lab	3-substituted alkylamino-6-substituted alkyl-1,2,4-triazin-5-ones and pharmaceutical compositions 3-substituted thio-1,2,4-triazin-5-ones
GB2001624B (en) *	1977-04-20	1982-03-03	Ici Ltd	Guanidine derivatives processes for their manufacture and pharmaceutical compositions containing them
JPS54132566A (en) *	1978-01-18	1979-10-15	Ici Ltd	Guanidine derivative*its manufacture and secretion controlling pharmaceutical composition containing it

1979
- 1979-10-10 US US06/083,479 patent/US4374836A/en not_active Expired - Lifetime
- 1979-10-15 AT AT79302212T patent/ATE4383T1/de not_active IP Right Cessation
- 1979-10-15 CA CA000337642A patent/CA1218066A/en not_active Expired
- 1979-10-15 EP EP79302212A patent/EP0010894B1/de not_active Expired
- 1979-10-15 DE DE7979302212T patent/DE2966030D1/de not_active Expired
- 1979-10-16 JP JP13249079A patent/JPS5553288A/ja active Pending

Also Published As

Publication number	Publication date
EP0010894A1 (de)	1980-05-14
JPS5553288A (en)	1980-04-18
EP0010894B1 (de)	1983-08-03
DE2966030D1 (en)	1983-09-08
US4374836A (en)	1983-02-22
CA1218066A (en)	1987-02-17

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Legal Events

Date	Code	Title	Description
1984-02-15	UEP	Publication of translation of european patent specification
1989-07-15	REN	Ceased due to non-payment of the annual fee