ATE438407T1 - Diagnose, vorbeugung und behandlung von ulcerativer colitis und deren subtypen unter verwendung mikrobieller uc panca antigene - Google Patents
Diagnose, vorbeugung und behandlung von ulcerativer colitis und deren subtypen unter verwendung mikrobieller uc panca antigeneInfo
- Publication number
- ATE438407T1 ATE438407T1 AT99911375T AT99911375T ATE438407T1 AT E438407 T1 ATE438407 T1 AT E438407T1 AT 99911375 T AT99911375 T AT 99911375T AT 99911375 T AT99911375 T AT 99911375T AT E438407 T1 ATE438407 T1 AT E438407T1
- Authority
- AT
- Austria
- Prior art keywords
- panca
- antigens
- microbial
- ulcerative colitis
- methods
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Gram-negative bacteria
- C07K16/1228—Enterobacterales (O), e.g. Citrobacter (G), Serratia (G), Proteus (G), Providencia (G), Morganella (G) or Yersinia (G)
- C07K16/1232—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
- G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/041,889 US6033864A (en) | 1996-04-12 | 1998-03-12 | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens |
| PCT/US1999/005492 WO1999045955A1 (en) | 1998-03-12 | 1999-03-12 | DIAGNOSIS, PREVENTION AND TREATMENT OF ULCERATIVE COLITIS, AND CLINICAL SUBTYPES THEREOF, USING MICROBIAL UC pANCA ANTIGENS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE438407T1 true ATE438407T1 (de) | 2009-08-15 |
Family
ID=21918893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99911375T ATE438407T1 (de) | 1998-03-12 | 1999-03-12 | Diagnose, vorbeugung und behandlung von ulcerativer colitis und deren subtypen unter verwendung mikrobieller uc panca antigene |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US6033864A (de) |
| EP (1) | EP1069907B1 (de) |
| AT (1) | ATE438407T1 (de) |
| AU (1) | AU3002699A (de) |
| CA (1) | CA2322763C (de) |
| DE (1) | DE69941214D1 (de) |
| WO (1) | WO1999045955A1 (de) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9924351D0 (en) | 1999-10-14 | 1999-12-15 | Brennan Frank | Immunomodulation methods and compositions |
| US6348316B1 (en) * | 2000-04-12 | 2002-02-19 | Cedars-Sinai Medical Center | Genetic testing for determining the risk of pouchitis development |
| US7138237B1 (en) * | 2000-05-19 | 2006-11-21 | Cedars-Sinai Medical Center | Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen |
| US6821739B2 (en) * | 2000-10-13 | 2004-11-23 | The Regents Of The University Of California | Methods of diagnosing and treating Crohn's disease using Pseudomonas antigens |
| GB0127916D0 (en) | 2001-11-21 | 2002-01-16 | Rowett Res Inst | Method |
| US20040029786A1 (en) * | 2002-05-08 | 2004-02-12 | Das Kiron M | Treatment of ulcerative colitis by introducing CEP antigen composition |
| US20080193945A1 (en) * | 2002-06-25 | 2008-08-14 | Index Diagnostics Ab | Method and Kit for the Diagnosis of Ulcerative Colitis |
| CA2497883C (en) * | 2002-09-05 | 2010-06-22 | Techlab, Inc. | Method for distinguishing ulcerative colitis from crohn's disease by detecting the presence of fecal anti-neutrophil cytoplasmic antibodies (anca) |
| EP1554580B1 (de) * | 2002-10-25 | 2008-05-14 | Techlab, Inc. | Diagnostisches panel ibd-first chek fur entzundliche darmerkrankung (ibd) und reizkolon |
| WO2004055214A1 (en) * | 2002-12-18 | 2004-07-01 | Department Of Biotechnology | The characterization of hupb gene encoding histone like protein of mycobacterium tuberculosis |
| US20050058663A1 (en) * | 2003-09-17 | 2005-03-17 | Monif Gilles R. G. | Mycobacterium avium subspecies paratuberculosis oral vaccine and methods |
| AU2004294526A1 (en) * | 2003-12-03 | 2005-06-16 | Glycominds, Ltd | Method for diagnosing diseases based on levels of anti-glycan antibodies |
| US20060205022A1 (en) * | 2003-12-03 | 2006-09-14 | Nir Dotan | Method for diagnosing and prognosing inflammatory bowel disease and crohn's disease |
| US7592150B2 (en) * | 2003-12-03 | 2009-09-22 | Glycominds, Ltd | Method for diagnosing diseases based on levels of anti-glycan antibodies |
| US7759079B2 (en) * | 2004-05-13 | 2010-07-20 | Prometheus Laboratories Inc. | Methods of diagnosing inflammatory bowel disease |
| US20060154276A1 (en) | 2004-05-13 | 2006-07-13 | Prometheus Laboratories Inc. | Methods of diagnosing inflammatory bowel disease |
| CN101056979B (zh) | 2004-09-03 | 2013-06-05 | 阿梅特拉斯法玛有限公司 | 抗组蛋白h1单克隆抗体及用于产生其的杂交瘤 |
| US20090197249A1 (en) * | 2004-11-01 | 2009-08-06 | George Mason University | Compositions and methods for diagnosing colon disorders |
| US7873479B2 (en) * | 2005-12-01 | 2011-01-18 | Prometheus Laboratories Inc. | Methods of diagnosing inflammatory bowel disease |
| US8685741B1 (en) | 2007-03-07 | 2014-04-01 | Nestec S.A. | Methods for diagnosing irritable bowel syndrome |
| JP2010524508A (ja) * | 2007-04-27 | 2010-07-22 | ダウ グローバル テクノロジーズ インコーポレイティド | 可溶性組換え二十面体ウイルス様粒子の生産及びインビボ組織化の改善 |
| WO2009069007A2 (en) * | 2007-11-30 | 2009-06-04 | Glycominds, Ltd. | Composition and method for prediction of complicated disease course and surgeries in crohn's disease |
| DK2223121T3 (da) * | 2007-12-20 | 2012-10-22 | Index Diagnostics Ab Publ | Fremgangsmåde og kit til anvendelse ved differentiering mellem ibd og ibs og yderligere skelnen mellem ibd-sygdomstyper |
| CA2794757A1 (en) | 2008-11-11 | 2010-05-20 | Prometheus Laboratories Inc. | Methods for prediction of inflammatory bowel disease (ibd) using serologic markers |
| NZ619527A (en) | 2009-04-14 | 2015-06-26 | Nestec Sa | Inflammatory bowel disease prognostics |
| EP3309556B1 (de) | 2009-06-25 | 2020-04-08 | Prometheus Biosciences, Inc. | Verfahren zur diagnostizierung des reizdarmsyndroms |
| WO2011060098A1 (en) | 2009-11-10 | 2011-05-19 | Prometheus Laboratories Inc. | Methods for predicting post-surgery risk associated with ileal pouch-anal anastomosis |
| US8445215B1 (en) | 2010-07-23 | 2013-05-21 | Nestec S.A. | Assays and methods for the detection of Crohn's disease |
| US9511151B2 (en) | 2010-11-12 | 2016-12-06 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of cancer |
| WO2012154253A1 (en) | 2011-02-17 | 2012-11-15 | Prometheus Laboratories Inc. | ASSAYS FOR DETECTING AUTOANTIBODIES TO ANTI-TNFα DRUGS |
| CN103649336A (zh) | 2011-05-10 | 2014-03-19 | 雀巢产品技术援助有限公司 | 用于个体化治疗管理的疾病活动性表征方法 |
| WO2012158831A1 (en) | 2011-05-16 | 2012-11-22 | Prometheus Laboratories Inc. | Performance of a biomarker panel for irritable bowel syndrome |
| GB201112091D0 (en) | 2011-07-14 | 2011-08-31 | Gt Biolog Ltd | Bacterial strains isolated from pigs |
| GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
| JP2015502740A (ja) | 2011-10-21 | 2015-01-29 | ネステク ソシエテ アノニム | 炎症性腸疾患の診断を改善するための方法 |
| US10988516B2 (en) * | 2012-03-26 | 2021-04-27 | Uti Limited Partnership | Methods and compositions for treating inflammation |
| US9603948B2 (en) | 2012-10-11 | 2017-03-28 | Uti Limited Partnership | Methods and compositions for treating multiple sclerosis and related disorders |
| US9128098B2 (en) | 2012-10-31 | 2015-09-08 | Gilles R. G. Monif | Fuidi herd management and risk stratification methods |
| GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
| PT3065771T (pt) | 2013-11-04 | 2019-06-24 | Uti Lp | Metodos e composicoes para imunoterapia prolongada |
| EP3654037A1 (de) | 2013-12-03 | 2020-05-20 | Prometheus Biosciences, Inc. | Verfahren zur vorhersage des postoperativen wiederauftretens von morbus crohn |
| US10169541B2 (en) | 2014-10-21 | 2019-01-01 | uBiome, Inc. | Method and systems for characterizing skin related conditions |
| US10311973B2 (en) | 2014-10-21 | 2019-06-04 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for autoimmune system conditions |
| US10777320B2 (en) | 2014-10-21 | 2020-09-15 | Psomagen, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for mental health associated conditions |
| US10395777B2 (en) | 2014-10-21 | 2019-08-27 | uBiome, Inc. | Method and system for characterizing microorganism-associated sleep-related conditions |
| US10409955B2 (en) | 2014-10-21 | 2019-09-10 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for locomotor system conditions |
| US10388407B2 (en) | 2014-10-21 | 2019-08-20 | uBiome, Inc. | Method and system for characterizing a headache-related condition |
| US10265009B2 (en) | 2014-10-21 | 2019-04-23 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with microbiome taxonomic features |
| US10789334B2 (en) | 2014-10-21 | 2020-09-29 | Psomagen, Inc. | Method and system for microbial pharmacogenomics |
| US10346592B2 (en) | 2014-10-21 | 2019-07-09 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for neurological health issues |
| US10381112B2 (en) | 2014-10-21 | 2019-08-13 | uBiome, Inc. | Method and system for characterizing allergy-related conditions associated with microorganisms |
| US9754080B2 (en) | 2014-10-21 | 2017-09-05 | uBiome, Inc. | Method and system for microbiome-derived characterization, diagnostics and therapeutics for cardiovascular disease conditions |
| US10793907B2 (en) | 2014-10-21 | 2020-10-06 | Psomagen, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for endocrine system conditions |
| US11783914B2 (en) | 2014-10-21 | 2023-10-10 | Psomagen, Inc. | Method and system for panel characterizations |
| US10366793B2 (en) | 2014-10-21 | 2019-07-30 | uBiome, Inc. | Method and system for characterizing microorganism-related conditions |
| US10073952B2 (en) | 2014-10-21 | 2018-09-11 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for autoimmune system conditions |
| US10325685B2 (en) | 2014-10-21 | 2019-06-18 | uBiome, Inc. | Method and system for characterizing diet-related conditions |
| US9710606B2 (en) | 2014-10-21 | 2017-07-18 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for neurological health issues |
| US9703929B2 (en) | 2014-10-21 | 2017-07-11 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics |
| US10410749B2 (en) | 2014-10-21 | 2019-09-10 | uBiome, Inc. | Method and system for microbiome-derived characterization, diagnostics and therapeutics for cutaneous conditions |
| US9760676B2 (en) | 2014-10-21 | 2017-09-12 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for endocrine system conditions |
| US10357157B2 (en) | 2014-10-21 | 2019-07-23 | uBiome, Inc. | Method and system for microbiome-derived characterization, diagnostics and therapeutics for conditions associated with functional features |
| US9758839B2 (en) | 2014-10-21 | 2017-09-12 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with microbiome functional features |
| PL3193901T3 (pl) | 2014-12-23 | 2018-10-31 | 4D Pharma Research Limited | Polipeptyd pyrynowy i immunomodulacja |
| CN113862175A (zh) | 2014-12-23 | 2021-12-31 | 4D制药研究有限公司 | 免疫调控 |
| US10246753B2 (en) | 2015-04-13 | 2019-04-02 | uBiome, Inc. | Method and system for characterizing mouth-associated conditions |
| AU2016275312B2 (en) | 2015-05-06 | 2021-12-23 | Uti Limited Partnership | Nanoparticle compositions for sustained therapy |
| MD3206700T2 (ro) | 2015-06-15 | 2019-12-31 | 4D Pharma Res Ltd | Compoziții conținând tulpini bacteriene |
| MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| PE20180267A1 (es) | 2015-06-15 | 2018-02-06 | 4D Pharma Res Ltd | Composiciones que comprenden cepas bacterianas |
| RS59446B1 (sr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Blautia stercosis i wexlerae za upotrebu u lečenju inflamatornih i autoimunskih bolesti |
| WO2017079653A2 (en) | 2015-11-06 | 2017-05-11 | Vetica Labs, Inc. | Methods of detecting inflammatory markers and treating inflammatory conditions in companion animals |
| GB201520497D0 (en) | 2015-11-20 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| WO2017085520A1 (en) | 2015-11-20 | 2017-05-26 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| GB201520631D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520638D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| JP6441536B2 (ja) | 2016-03-04 | 2018-12-19 | フォーディー ファーマ ピーエルシー4D Pharma Plc | 細菌株を含む組成物 |
| GB201612191D0 (en) | 2016-07-13 | 2016-08-24 | 4D Pharma Plc | Compositions comprising bacterial strains |
| TW201821093A (zh) | 2016-07-13 | 2018-06-16 | 英商4D製藥有限公司 | 包含細菌菌株之組合物 |
| GB201621123D0 (en) | 2016-12-12 | 2017-01-25 | 4D Pharma Plc | Compositions comprising bacterial strains |
| HUE054164T2 (hu) | 2017-05-22 | 2021-08-30 | 4D Pharma Res Ltd | Baktériumtörzseket tartalmazó készítmények |
| WO2018215782A1 (en) | 2017-05-24 | 2018-11-29 | 4D Pharma Research Limited | Compositions comprising bacterial strain |
| LT3600363T (lt) | 2017-06-14 | 2021-02-10 | 4D Pharma Research Limited | Kompozicijos, apimančios bakterijų kamienus |
| MA49010B1 (fr) | 2017-06-14 | 2020-11-30 | 4D Pharma Res Ltd | Compositions comprenant une souche bactérienne du genre megasphaera et leurs utilisations |
| SMT202000695T1 (it) | 2017-06-14 | 2021-01-05 | 4D Pharma Res Limited | Composizioni comprendenti ceppi batterici |
| AU2018374569B2 (en) | 2017-11-29 | 2024-10-17 | Uti Limited Partnership | Methods of treating autoimmune disease |
| WO2019186084A1 (en) * | 2018-03-26 | 2019-10-03 | The University Of Liverpool | Anti-complement histones |
| WO2019191409A1 (en) * | 2018-03-29 | 2019-10-03 | Kimberly-Clark Worldwide, Inc. | Sensor for indicating a potential forthcoming skin or gastrointestinal issue and methods of using the same |
| CN111187344A (zh) * | 2019-12-19 | 2020-05-22 | 北京安锐鑫生物科技有限公司 | 多肽、包含其的组合物、及其预防或治疗皮肤损伤或抗氧化药物的应用 |
| WO2023076924A1 (en) * | 2021-10-26 | 2023-05-04 | Rensselaer Polytechnic Institute | Systems and methods for increased production of recombinant biopolymers via genome engineering and downregulation of basal expression |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0149468B1 (de) * | 1984-01-12 | 1990-10-31 | SYMBIOTEC Gesellschaft zur Forschung und Entwicklung auf dem Gebiet der Biotechnologie GmbH | Biologisch wirksame Substanz mit hormonellen Eigenschaften, Verfahren zu ihrer Herstellung und Verwendung von Histonen für medizinische Zwecke |
| US5830675A (en) * | 1993-03-10 | 1998-11-03 | Cedars-Sinai Medical Center | Methods for selectively detecting perinuclear anti-neutrophil cytoplasmic antibody of ulcerative colitis, primary sclerosing cholangitis, or type 1 autoimmune hepatitis |
| US6074835A (en) * | 1996-04-12 | 2000-06-13 | Regents Of The Univ. Of California | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using histone H1 |
| WO1997038713A1 (en) * | 1996-04-12 | 1997-10-23 | The Regents Of The University Of California | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using histone h1 |
-
1998
- 1998-03-12 US US09/041,889 patent/US6033864A/en not_active Expired - Lifetime
-
1999
- 1999-03-12 AU AU30026/99A patent/AU3002699A/en not_active Abandoned
- 1999-03-12 EP EP99911375A patent/EP1069907B1/de not_active Expired - Lifetime
- 1999-03-12 DE DE69941214T patent/DE69941214D1/de not_active Expired - Lifetime
- 1999-03-12 CA CA2322763A patent/CA2322763C/en not_active Expired - Lifetime
- 1999-03-12 AT AT99911375T patent/ATE438407T1/de not_active IP Right Cessation
- 1999-03-12 WO PCT/US1999/005492 patent/WO1999045955A1/en not_active Ceased
- 1999-10-12 US US09/417,264 patent/US6537768B1/en not_active Expired - Lifetime
-
2002
- 2002-08-27 US US10/229,567 patent/US7183065B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HK1035662A1 (en) | 2001-12-07 |
| DE69941214D1 (de) | 2009-09-17 |
| US7183065B2 (en) | 2007-02-27 |
| US6537768B1 (en) | 2003-03-25 |
| US6033864A (en) | 2000-03-07 |
| WO1999045955A1 (en) | 1999-09-16 |
| US20030092080A1 (en) | 2003-05-15 |
| EP1069907A1 (de) | 2001-01-24 |
| CA2322763C (en) | 2012-05-01 |
| CA2322763A1 (en) | 1999-09-16 |
| AU3002699A (en) | 1999-09-27 |
| WO1999045955A9 (en) | 2000-02-17 |
| EP1069907B1 (de) | 2009-08-05 |
| EP1069907A4 (de) | 2003-03-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69941214D1 (de) | DIAGNOSE, VORBEUGUNG UND BEHANDLUNG VON ULCERATIVER COLITIS UND DEREN SUBTYPEN UNTER VERWENDUNG MIKROBIELLER UC pANCA ANTIGENE | |
| ATE192339T1 (de) | Verwendung von fulleren-derivaten in diagnostischen und/oder therapeutischen mitteln | |
| CY1109437T1 (el) | ΣΥΝΘΕΣΕΙΣ β-ΓΛΥΚΑΝΩΝ ΚΑΙ ΕΙΔΙΚΩΝ ΑΝΟΣΟΣΦΑΙΡΙΝΩΝ | |
| ATE517125T1 (de) | ANTIKÖRPER GEGEN ßDEATH RECEPTOR 4ß (DR4) UND DEREN VERWENDUNGEN | |
| DE60331941D1 (de) | Mutationen in nod2 sind bei patienten mit morbus crohn mit fibrostenosebildung assoziiert | |
| ATE418565T1 (de) | Antikörper gegen nichtfunktionelle p 2 x 7 rezeptoren, diagnose und behandlung von krebs und anderen leiden | |
| NO973447L (no) | Monoklonale antistoffer som er spesifikke for forskjellige epitoper i human-gp 39, og fremgangsmåter for deres anvendelse i diagnose og terapi | |
| FR2703693B1 (fr) | Procédé rapide de détermination d'une séquence d'ADN et application au séquençage et au diagnostic. | |
| ATE175241T1 (de) | Antikörper gegen alpha v beta 3 integrin | |
| DE69526973D1 (de) | Sequenzen von hepatitis-c-virus genotype 7, und deren verwendung als vorbeugende, therapeutische und diagnostische mittel | |
| ATE244018T1 (de) | Herstellungb und verwendung eines spezifischen gaba-aalpha5 rezeptorligands zur behandlung der erkrankung von alzheimer | |
| RU94045826A (ru) | Моноклональные антитела против рецептора интерферона, с нейтрализующим действием против интерферона типа i | |
| TR200102963T2 (tr) | Yeni tedavi metodu | |
| NO331101B1 (no) | In vitro-fremgangsmate for a uttrykke et antigenmolekyl og antigenmolekyl og et fotosensibiliserende middel for anvendelse ved uttrykking av antigenmolekylet. | |
| RU94046284A (ru) | Способ обнаружения антител, способ с-крекинга компонентов крови, набор для обнаружения антител к hcv | |
| TR199900656T2 (xx) | �ndanonlar ile 262 ve 20S proteazomun engellenmesi. | |
| KR910005862A (ko) | 신규 친수성 유도체, 진단 또는 치료시 그의 응용 그를 함유하는 진단 또는 치료용 키트 및 면역 시약 | |
| BR0113213A (pt) | Método para diagnosticar uma doença auto-imune, anticorpo, composição de diagnóstico, e, uso do anticorpo | |
| EP0674661A4 (de) | Test und behandlung von demyelinierenden krankheiten wie multiple sklerosis. | |
| ATE442439T1 (de) | Melanoma antigene p15 und deren anwendung in diagnostischen und therapeutischen verfahren | |
| ES2032447T3 (es) | Nuevos anticuerpos monoclonales y su produccion y uso. | |
| SE8701905D0 (sv) | A method and a kit for the diagnosis of iga nephropathy | |
| EA200100264A1 (ru) | Ангиоцидин: адгезионный рецептор опухолей клетки, специфический для cys-ser-val-thr-cys-gly | |
| DK0568554T3 (da) | Fremgangsmåde til påvisning af anti-RNA-antistoffer | |
| SE9401960D0 (sv) | Alkalibeständigt proteinadsorbent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |