ATE438452T1 - Verfahren und vorrichtung zur trennung von teilchen - Google Patents

Verfahren und vorrichtung zur trennung von teilchen

Info

Publication number
ATE438452T1
ATE438452T1 AT05786928T AT05786928T ATE438452T1 AT E438452 T1 ATE438452 T1 AT E438452T1 AT 05786928 T AT05786928 T AT 05786928T AT 05786928 T AT05786928 T AT 05786928T AT E438452 T1 ATE438452 T1 AT E438452T1
Authority
AT
Austria
Prior art keywords
particles
standing wave
exposed
order harmonic
fundamental
Prior art date
Application number
AT05786928T
Other languages
English (en)
Inventor
Carl Siversson
Original Assignee
Spectronic Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spectronic Ab filed Critical Spectronic Ab
Application granted granted Critical
Publication of ATE438452T1 publication Critical patent/ATE438452T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/28—Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
    • B01D21/283—Settling tanks provided with vibrators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
AT05786928T 2004-09-24 2005-09-23 Verfahren und vorrichtung zur trennung von teilchen ATE438452T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0402312A SE528313C2 (sv) 2004-09-24 2004-09-24 Metod och apparat för separering av partiklar med hjälp av ultraljudvågor
PCT/EP2005/054794 WO2006032703A1 (en) 2004-09-24 2005-09-23 Method and device for separating particles

Publications (1)

Publication Number Publication Date
ATE438452T1 true ATE438452T1 (de) 2009-08-15

Family

ID=33308821

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05786928T ATE438452T1 (de) 2004-09-24 2005-09-23 Verfahren und vorrichtung zur trennung von teilchen

Country Status (8)

Country Link
US (1) US7674630B2 (de)
EP (1) EP1809399B1 (de)
JP (1) JP4695144B2 (de)
CN (1) CN101060898B (de)
AT (1) ATE438452T1 (de)
DE (1) DE602005015883D1 (de)
SE (1) SE528313C2 (de)
WO (1) WO2006032703A1 (de)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7340957B2 (en) 2004-07-29 2008-03-11 Los Alamos National Security, Llc Ultrasonic analyte concentration and application in flow cytometry
US7835000B2 (en) 2006-11-03 2010-11-16 Los Alamos National Security, Llc System and method for measuring particles in a sample stream of a flow cytometer or the like
JP4984849B2 (ja) 2006-11-27 2012-07-25 パナソニック株式会社 成分分離デバイスと、この成分分離デバイスを用いた化学分析デバイス
US7837040B2 (en) 2007-04-09 2010-11-23 Los Alamos National Security, Llc Acoustic concentration of particles in fluid flow
US8083068B2 (en) 2007-04-09 2011-12-27 Los Alamos National Security, Llc Apparatus for separating particles utilizing engineered acoustic contrast capture particles
JP5040534B2 (ja) * 2007-09-03 2012-10-03 パナソニック株式会社 分注装置
US8263407B2 (en) 2007-10-24 2012-09-11 Los Alamos National Security, Llc Method for non-contact particle manipulation and control of particle spacing along an axis
US8528406B2 (en) 2007-10-24 2013-09-10 Los Alamos National Security, LLP Method for non-contact particle manipulation and control of particle spacing along an axis
ES2326109B1 (es) * 2007-12-05 2010-06-25 Consejo Superior De Investigaciones Cientificas Microdispositivo de separacion y extraccion selectiva y no invasiva de particulas en suspensiones polidispersas, procedimiento de fabricacion y sus aplicaciones.
US8266951B2 (en) 2007-12-19 2012-09-18 Los Alamos National Security, Llc Particle analysis in an acoustic cytometer
US8714014B2 (en) 2008-01-16 2014-05-06 Life Technologies Corporation System and method for acoustic focusing hardware and implementations
US9480935B2 (en) * 2008-02-01 2016-11-01 Lawrence Livermore National Security, Llc Systems and methods for separating particles and/or substances from a sample fluid
US9248318B2 (en) 2008-08-06 2016-02-02 Mirabilis Medica Inc. Optimization and feedback control of HIFU power deposition through the analysis of detected signal characteristics
US8216161B2 (en) * 2008-08-06 2012-07-10 Mirabilis Medica Inc. Optimization and feedback control of HIFU power deposition through the frequency analysis of backscattered HIFU signals
US8865003B2 (en) 2008-09-26 2014-10-21 Abbott Laboratories Apparatus and method for separation of particles suspended in a liquid from the liquid in which they are suspended
US20110154890A1 (en) * 2008-10-08 2011-06-30 Foss Analytical A/S Separation of particles in liquids by use of a standing ultrasonic wave
CA2741723A1 (en) * 2008-10-24 2010-04-29 Mirabilis Medica Inc. Method and apparatus for feedback control of hifu treatments
US8691145B2 (en) 2009-11-16 2014-04-08 Flodesign Sonics, Inc. Ultrasound and acoustophoresis for water purification
FIU20100093U0 (fi) * 2010-02-25 2010-02-25 Pegasor Oy Hiukkasten mittauslaite
EP2582631A4 (de) 2010-06-16 2016-05-25 Flodesign Sonics Inc System zur entsalzung phononischer kristalle und verwendungsverfahren dafür
US8679338B2 (en) 2010-08-23 2014-03-25 Flodesign Sonics, Inc. Combined acoustic micro filtration and phononic crystal membrane particle separation
US9421553B2 (en) 2010-08-23 2016-08-23 Flodesign Sonics, Inc. High-volume fast separation of multi-phase components in fluid suspensions
WO2012148648A2 (en) 2011-04-27 2012-11-01 Becton Dickinson & Co. Devices and methods for separating magnetically labeled moieties in a sample
EP2551337A1 (de) * 2011-07-27 2013-01-30 The Procter & Gamble Company Verfahren zur Herstellung einer rheologiemodifikatorhaltigen Zusammensetzung
US8727129B2 (en) * 2011-08-16 2014-05-20 Lawrence Livermore National Security, Llc. Microfluidic ultrasonic particle separators with engineered node locations and geometries
US9731062B2 (en) 2011-08-29 2017-08-15 The Charles Stark Draper Laboratory, Inc. System and method for blood separation by microfluidic acoustic focusing
FR2979256B1 (fr) * 2011-08-30 2014-09-26 Centre Nat Rech Scient Dispositif de manipulation d'objets par champs de force acoustique
WO2013116696A1 (en) * 2012-02-03 2013-08-08 University Of Cincinnati Microfluidic methods for passive separation of cells and particles
US9752114B2 (en) 2012-03-15 2017-09-05 Flodesign Sonics, Inc Bioreactor using acoustic standing waves
US10689609B2 (en) 2012-03-15 2020-06-23 Flodesign Sonics, Inc. Acoustic bioreactor processes
US9745548B2 (en) 2012-03-15 2017-08-29 Flodesign Sonics, Inc. Acoustic perfusion devices
US9688958B2 (en) 2012-03-15 2017-06-27 Flodesign Sonics, Inc. Acoustic bioreactor processes
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US10967298B2 (en) 2012-03-15 2021-04-06 Flodesign Sonics, Inc. Driver and control for variable impedence load
US9783775B2 (en) 2012-03-15 2017-10-10 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US9340435B2 (en) 2012-03-15 2016-05-17 Flodesign Sonics, Inc. Separation of multi-component fluid through ultrasonic acoustophoresis
US9950282B2 (en) 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
US9272234B2 (en) 2012-03-15 2016-03-01 Flodesign Sonics, Inc. Separation of multi-component fluid through ultrasonic acoustophoresis
US10370635B2 (en) 2012-03-15 2019-08-06 Flodesign Sonics, Inc. Acoustic separation of T cells
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US9416344B2 (en) 2012-03-15 2016-08-16 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US9422328B2 (en) 2012-03-15 2016-08-23 Flodesign Sonics, Inc. Acoustic bioreactor processes
US9796956B2 (en) 2013-11-06 2017-10-24 Flodesign Sonics, Inc. Multi-stage acoustophoresis device
US10953436B2 (en) 2012-03-15 2021-03-23 Flodesign Sonics, Inc. Acoustophoretic device with piezoelectric transducer array
US9752113B2 (en) 2012-03-15 2017-09-05 Flodesign Sonics, Inc. Acoustic perfusion devices
US9822333B2 (en) 2012-03-15 2017-11-21 Flodesign Sonics, Inc. Acoustic perfusion devices
US9567559B2 (en) 2012-03-15 2017-02-14 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US10322949B2 (en) 2012-03-15 2019-06-18 Flodesign Sonics, Inc. Transducer and reflector configurations for an acoustophoretic device
US9623348B2 (en) 2012-03-15 2017-04-18 Flodesign Sonics, Inc. Reflector for an acoustophoretic device
US10040011B2 (en) 2012-03-15 2018-08-07 Flodesign Sonics, Inc. Acoustophoretic multi-component separation technology platform
KR101387662B1 (ko) 2012-04-18 2014-04-22 한국전기연구원 입자 필터링 장치 및 이를 포함하는 바이오칩
US11324873B2 (en) * 2012-04-20 2022-05-10 Flodesign Sonics, Inc. Acoustic blood separation processes and devices
US10737953B2 (en) 2012-04-20 2020-08-11 Flodesign Sonics, Inc. Acoustophoretic method for use in bioreactors
CN104736718A (zh) 2012-10-26 2015-06-24 贝克顿·迪金森公司 用于操纵流体样品中的组分的装置和方法
US9504780B2 (en) 2013-01-30 2016-11-29 The Charles Stark Draper Laboratory, Inc. Extracorporeal clearance of organophosphates from blood on an acoustic separation device
WO2014138739A1 (en) 2013-03-08 2014-09-12 The Charles Stark Draper Laboratory, Inc. System and method for blood separation by microfluidic acoustic focusing
KR101442486B1 (ko) 2013-06-07 2014-09-24 아이에스테크놀로지 주식회사 초음파를 이용한 유체내 불순물 분리장치 및 분리방법
WO2014210046A1 (en) * 2013-06-24 2014-12-31 Flodesign Sonics, Inc. Fluid dynamic sonic separator
US9745569B2 (en) 2013-09-13 2017-08-29 Flodesign Sonics, Inc. System for generating high concentration factors for low cell density suspensions
WO2015105955A1 (en) 2014-01-08 2015-07-16 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
CA2948355A1 (en) 2014-05-08 2015-11-12 Bart Lipkens Acoustophoretic device with piezoelectric transducer array
CA2952299C (en) 2014-07-02 2023-01-03 Bart Lipkens Acoustophoretic device with uniform fluid flow
US9744483B2 (en) 2014-07-02 2017-08-29 Flodesign Sonics, Inc. Large scale acoustic separation device
US10946133B2 (en) 2014-07-31 2021-03-16 The Charles Stark Draper Laboratory, Inc. Systems and methods for parallel channel microfluidic separation
US10099002B2 (en) 2014-07-31 2018-10-16 The Charles Stark Draper Laboratory, Inc. Systems and methods for parallel channel microfluidic separation
CA2961911C (en) 2014-09-30 2022-09-13 Bart Lipkens Acoustophoretic clarification of particle-laden non-flowing fluids
JP6607945B2 (ja) * 2015-01-12 2019-11-20 インストゥルメンテーション ラボラトリー カンパニー 生物医学的な感知及び検出のための粒子を含む溶液中の粒子の空間的な分離
US10106770B2 (en) 2015-03-24 2018-10-23 Flodesign Sonics, Inc. Methods and apparatus for particle aggregation using acoustic standing waves
US11021699B2 (en) 2015-04-29 2021-06-01 FioDesign Sonics, Inc. Separation using angled acoustic waves
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
WO2016176663A1 (en) 2015-04-29 2016-11-03 Flodesign Sonics, Inc. Acoustophoretic device for angled wave particle deflection
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US9550134B2 (en) 2015-05-20 2017-01-24 Flodesign Sonics, Inc. Acoustic manipulation of particles in standing wave fields
WO2016201385A2 (en) * 2015-06-11 2016-12-15 Flodesign Sonics, Inc. Acoustic methods for separation cells and pathogens
US9663756B1 (en) 2016-02-25 2017-05-30 Flodesign Sonics, Inc. Acoustic separation of cellular supporting materials from cultured cells
ES2879238T3 (es) 2015-07-09 2021-11-22 Flodesign Sonics Inc Reflectores y cristales piezoeléctricos no planos y no simétricos
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
JP6554045B2 (ja) 2016-02-25 2019-07-31 東芝メモリ株式会社 集塵装置および基板処理システム
JP2019507681A (ja) 2016-03-06 2019-03-22 ヴィント プルス ゾンネ ゲー・エム・ベー・ハーＷｉｎｄ ｐｌｕｓ Ｓｏｎｎｅ ＧｍｂＨ 音響泳動により、エアロゾルと、ガスからの固形物粒子および繊維と、流体からの固形物粒子および繊維とを分離および／または清浄化するための方法および機器
DE102016002599A1 (de) * 2016-03-06 2017-09-07 WindplusSonne GmbH Vorrichtung und Verfahren zum Aggregieren von Feststoffpartikeln und -fasern eines Flüssigwerkstoffs
US10710006B2 (en) 2016-04-25 2020-07-14 Flodesign Sonics, Inc. Piezoelectric transducer for generation of an acoustic standing wave
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
CN109715124B (zh) 2016-05-03 2022-04-22 弗洛设计声能学公司 利用声泳的治疗细胞洗涤、浓缩和分离
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
WO2018075830A1 (en) 2016-10-19 2018-04-26 Flodesign Sonics, Inc. Affinity cell extraction by acoustics
CN106853381B (zh) * 2016-12-16 2024-02-02 苏州国科昂卓医疗科技有限公司 一种粒子分离装置、系统及粒子分离方法
KR102439221B1 (ko) 2017-12-14 2022-09-01 프로디자인 소닉스, 인크. 음향 트랜스듀서 구동기 및 제어기
US12337319B2 (en) * 2018-03-03 2025-06-24 Applied Cells Inc. Microfluidic chip for acoustic separation of biological objects
US11007502B2 (en) * 2018-05-03 2021-05-18 Chevron Phillips Chemical Company Lp Methods and systems for capturing particulates
CN109201497B (zh) * 2018-08-01 2020-05-12 哈尔滨工业大学 一种混合材料粉末的超声驻波分离装置
DE102018008259A1 (de) * 2018-10-18 2020-04-23 Smart Material Printing B.V. Filteranlagen für Schwebstoffe mit Teilchengrößen von 400 pm bis ≤500 μm und ihre Verwendung
US20210155889A1 (en) * 2019-11-22 2021-05-27 The Charles Stark Draper Laboratory, Inc. End-to-end cell therapy bioprocessing device for continuous-flow enrichment, washing, and electrotransfection of target cells
WO2022027210A1 (zh) * 2020-08-04 2022-02-10 北京航空航天大学 一种分离空气中亚微米颗粒的装置
CN112870854B (zh) * 2021-01-18 2022-04-08 南京航空航天大学 一种驻波切换型声流微操控筛选装置及其工作方法
US20220259555A1 (en) * 2021-02-15 2022-08-18 Applied Cells Inc. Separation of Immune Cells by Multiple Microfluidic Devices
US11291939B1 (en) 2021-07-13 2022-04-05 Smart Material Printing B.V. Ultra-fine particle aggregation, neutralization and filtration
JP7617823B2 (ja) * 2021-08-26 2025-01-20 アークレイ株式会社 粒子回収装置及び粒子回収方法
JP2023032349A (ja) * 2021-08-26 2023-03-09 アークレイ株式会社 粒子回収装置及び粒子回収方法
JP7775719B2 (ja) * 2022-01-20 2025-11-26 セイコーエプソン株式会社 流体デバイスおよび流体デバイスの制御方法
JP7803135B2 (ja) * 2022-01-20 2026-01-21 セイコーエプソン株式会社 流体デバイスおよび流体デバイスの制御方法
US12005388B2 (en) 2022-07-26 2024-06-11 Smart Material Printing B.V. Apparatus and methods for air filtration of HVAC systems
US12584902B2 (en) 2023-12-10 2026-03-24 Instrumentation Laboratory Company Acoustic separation of a test sample

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8417240D0 (en) * 1984-07-06 1984-08-08 Unilever Plc Particle separation
GB8912420D0 (en) * 1989-05-31 1989-07-19 Schram Cornelius J Ultrasonic systems
JP3487699B2 (ja) * 1995-11-08 2004-01-19 株式会社日立製作所 超音波処理方法および装置
GB9708984D0 (en) * 1997-05-03 1997-06-25 Univ Cardiff Particle manipulation
EP1322953A2 (de) 2000-09-30 2003-07-02 Aviva Biosciences Corporation Vorrichtungen und verfahren zur feldflussfraktionierung von teilchen mittels akustischen und anderen kräften
SE522801C2 (sv) * 2001-03-09 2004-03-09 Erysave Ab Anordning för att separera suspenderade partiklar från en fluid med ultraljud samt metod för sådan separering
WO2003102737A2 (en) * 2002-06-04 2003-12-11 Protasis Corporation Method and device for ultrasonically manipulating particles within a fluid

Also Published As

Publication number Publication date
JP4695144B2 (ja) 2011-06-08
CN101060898B (zh) 2013-02-13
SE0402312D0 (sv) 2004-09-24
EP1809399B1 (de) 2009-08-05
SE0402312L (sv) 2006-03-25
SE528313C2 (sv) 2006-10-17
EP1809399A1 (de) 2007-07-25
DE602005015883D1 (de) 2009-09-17
JP2008514397A (ja) 2008-05-08
US7674630B2 (en) 2010-03-09
WO2006032703A1 (en) 2006-03-30
US20080217259A1 (en) 2008-09-11
CN101060898A (zh) 2007-10-24

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