ATE439139T1 - Bakteriophage zur behandlung von bakteriellen biofilmen - Google Patents

Bakteriophage zur behandlung von bakteriellen biofilmen

Info

Publication number
ATE439139T1
ATE439139T1 AT04701383T AT04701383T ATE439139T1 AT E439139 T1 ATE439139 T1 AT E439139T1 AT 04701383 T AT04701383 T AT 04701383T AT 04701383 T AT04701383 T AT 04701383T AT E439139 T1 ATE439139 T1 AT E439139T1
Authority
AT
Austria
Prior art keywords
bacteriophage
biofilm
treatment
bacterial biofilm
bacteriophages
Prior art date
Application number
AT04701383T
Other languages
English (en)
Inventor
Richard Sharp
Gavin Hughes
A Hart
James Taggart Walker
Original Assignee
Health Prot Agency
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Health Prot Agency filed Critical Health Prot Agency
Application granted granted Critical
Publication of ATE439139T1 publication Critical patent/ATE439139T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
    • C12Y402/02003—Poly(beta-D-mannuronate) lyase (4.2.2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2795/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT04701383T 2003-01-10 2004-01-12 Bakteriophage zur behandlung von bakteriellen biofilmen ATE439139T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0300597.2A GB0300597D0 (en) 2003-01-10 2003-01-10 Phage biofilms
PCT/GB2004/000073 WO2004062677A1 (en) 2003-01-10 2004-01-12 Bacteriophage for the treatment of bacterial biofilms

Publications (1)

Publication Number Publication Date
ATE439139T1 true ATE439139T1 (de) 2009-08-15

Family

ID=9950965

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04701383T ATE439139T1 (de) 2003-01-10 2004-01-12 Bakteriophage zur behandlung von bakteriellen biofilmen

Country Status (6)

Country Link
US (1) US7758856B2 (de)
EP (1) EP1587520B1 (de)
AT (1) ATE439139T1 (de)
DE (1) DE602004022506D1 (de)
GB (1) GB0300597D0 (de)
WO (1) WO2004062677A1 (de)

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EP1663265B1 (de) * 2003-07-23 2015-09-23 Biocontrol Limited Bakteriophagen-enthaltende medikamente
EP1791566A4 (de) * 2004-08-06 2008-07-16 Nat Jewish Med & Res Center Produkt und verfahren zur hemmung der biofilm-entwicklung
WO2006137847A2 (en) * 2004-09-13 2006-12-28 Trustees Of Boston University Engineered enzymatically active bacteriophages and methods of uses thereof
WO2006095345A2 (en) 2005-03-08 2006-09-14 Ramot At Tel-Aviv University Ltd. Targeted drug-carrying bacteriophages
US7932029B1 (en) * 2006-01-04 2011-04-26 Si Lok Methods for nucleic acid mapping and identification of fine-structural-variations in nucleic acids and utilities
EP2004800B1 (de) * 2006-04-04 2014-01-15 Henry Morris Krisch Verfahren zur herstellung von bakteriophagenzusammensetzungen sowie verfahren auf dem gebiet der phagentherapie
KR100781669B1 (ko) 2006-06-20 2007-12-03 주식회사 인트론바이오테크놀로지 황색포도상구균 특이적 사멸능을 갖는 박테리오파지
KR100759988B1 (ko) 2006-08-04 2007-09-19 주식회사 인트론바이오테크놀로지 황색포도상구균에 특이적인 항균 단백질
GB0704553D0 (en) * 2007-03-09 2007-04-18 Harper David R Beneficial effects of bacteriophage treatments
US7622293B2 (en) * 2007-06-18 2009-11-24 Intralytix, Inc. Pseudomonas aeruginosa: bacteriophage and uses thereof
US8366652B2 (en) * 2007-08-17 2013-02-05 The Invention Science Fund I, Llc Systems, devices, and methods including infection-fighting and monitoring shunts
US8734718B2 (en) 2007-08-17 2014-05-27 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having an actively controllable therapeutic agent delivery component
KR100910961B1 (ko) 2007-09-13 2009-08-05 주식회사 인트론바이오테크놀로지 황색포도상구균의 균막 처치에 효과적인 박테리오파지 또는그것 유래의 용균단백질
RU2527894C2 (ru) 2007-11-27 2014-09-10 Альгифарма ИПР АС Использование альгинатных олигомеров в борьбе с биопленками
US8153119B2 (en) * 2007-12-18 2012-04-10 Trustees Of Boston University Engineered enzymatically active bacteriophage and methods for dispersing biofilms
US8329889B2 (en) 2008-02-15 2012-12-11 Trustees Of Boston University In vivo gene sensors
US8889105B2 (en) * 2008-11-28 2014-11-18 Warren H. Finlay Bacteriophage compositions for treatment of bacterial infections
US20110208021A1 (en) * 2008-12-04 2011-08-25 Goodall Eleanor V Systems, devices, and methods including implantable devices with anti-microbial properties
US9474831B2 (en) 2008-12-04 2016-10-25 Gearbox, Llc Systems, devices, and methods including implantable devices with anti-microbial properties
US20110160681A1 (en) * 2008-12-04 2011-06-30 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems, devices, and methods including catheters having light removable coatings based on a sensed condition
US20110208026A1 (en) * 2008-12-04 2011-08-25 Goodall Eleanor V Systems, devices, and methods including implantable devices with anti-microbial properties
EP2384168B1 (de) 2008-12-04 2014-10-08 Searete LLC Aktiv kontrollierbare sterilisierende erregungsabgabe-implantate
US8377866B2 (en) 2009-02-12 2013-02-19 Intron Biotechnology, Inc. Antimicrobial protein derived from Podoviridae bacteriophage specific to Staphylococcus aureus
US8043613B2 (en) 2009-02-12 2011-10-25 Intron Biotechnology, Inc. Podoviriedae bacteriophage having killing activity specific to Staphylococcus aureus
WO2010141135A2 (en) 2009-03-05 2010-12-09 Trustees Of Boston University Bacteriophages expressing antimicrobial peptides and uses thereof
CA2764197C (en) 2009-06-03 2017-09-12 Algipharma As Alginate oligomers for use in overcoming multidrug resistance in bacteria
EP2473042B1 (de) 2009-09-02 2017-08-02 Synedgen, Inc. Verfahren und zusammensetzungen zur zersetzung eines biofilms mithilfe von chitosanderivat-komponenten
EP3443970B1 (de) * 2010-09-17 2020-09-09 Tecnifar-Indústria Técnica Farmacêutica, S.A. Antibakterielle phage, phagenpeptide und verfahren zu ihrer verwendung
EP2465926A1 (de) * 2010-12-20 2012-06-20 University College Cork Pseudomonas aeruginosa-Bakteriophage und Verwendungen davon
WO2013006458A1 (en) * 2011-07-01 2013-01-10 Synedgen, Inc. Methods and compositions of reducing and preventing bacterial growth and the formation of biofilm on a surface utilizing chitosan-derivative compounds
US8669226B2 (en) 2011-10-07 2014-03-11 Morehouse School Of Medicine Antimicrobial compositions and methods of use thereof
US12083158B2 (en) 2011-10-07 2024-09-10 Morehouse School Of Medicine Antibacterial compositions, methods of making and use thereof
US9546361B2 (en) 2012-10-12 2017-01-17 Lehigh University Thermally stable enzymes, compositions thereof and methods of using same
DE102013106455A1 (de) 2013-06-20 2014-12-24 Airbus Defence and Space GmbH Verfahren zur Dekontamination von bakteriologischen Verunreinigungen
JP2017524344A (ja) 2014-06-06 2017-08-31 ザ・ホスピタル・フォー・シック・チルドレンＴｈｅ Ｈｏｓｐｉｔａｌ Ｆｏｒ Ｓｉｃｋ Ｃｈｉｌｄｒｅｎ バイオフィルムの阻害及び分散における可溶性細菌及び真菌タンパク質並びに方法並びにそれらの使用
WO2016040899A1 (en) 2014-09-11 2016-03-17 Synedgen, Inc. Compositions and methods of use thereof
US11185555B2 (en) 2016-04-11 2021-11-30 Noah James Harrison Method to kill pathogenic microbes in a patient
WO2017211737A1 (fr) 2016-06-08 2017-12-14 Onelife S.A. Composition comprenant au moins une enzyme et au moins une molécule microbicide pour la prévention ou le traitement des infections post-implantatoires
CN112543595B (zh) 2018-05-30 2022-11-01 莫尔豪斯医学院 抗微生物组合物，其制备方法和用途
US12577538B2 (en) 2019-06-27 2026-03-17 Baylor College Of Medicine Systems and methods for generating bacteriophages adapted to infect a target bacterial strain
WO2021221656A1 (en) 2020-04-30 2021-11-04 Synedgen, Inc. Compositions and methods of use thereof
JP2024530170A (ja) * 2021-08-02 2024-08-16 アルマタ・ファーマシューティカルズ・インコーポレーテッド 改善された抗微生物活性を有するバクテリオファージ

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Also Published As

Publication number Publication date
DE602004022506D1 (de) 2009-09-24
EP1587520B1 (de) 2009-08-12
US7758856B2 (en) 2010-07-20
US20060140911A1 (en) 2006-06-29
GB0300597D0 (en) 2003-02-12
EP1587520A1 (de) 2005-10-26
WO2004062677A1 (en) 2004-07-29
WO2004062677A9 (en) 2004-10-07

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