ATE440821T1 - Isochinolinderivate als mao-b inhibitoren - Google Patents

Isochinolinderivate als mao-b inhibitoren

Info

Publication number
ATE440821T1
ATE440821T1 AT03725018T AT03725018T ATE440821T1 AT E440821 T1 ATE440821 T1 AT E440821T1 AT 03725018 T AT03725018 T AT 03725018T AT 03725018 T AT03725018 T AT 03725018T AT E440821 T1 ATE440821 T1 AT E440821T1
Authority
AT
Austria
Prior art keywords
mao
inhibitors
isoquinoline derivatives
isoquinoline
derivatives
Prior art date
Application number
AT03725018T
Other languages
English (en)
Inventor
Andrea Cesura
Sarmiento Rosa Maria Rodriguez
Michelangelo Scalone
Andrew Thomas
Rene Wyler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE440821T1 publication Critical patent/ATE440821T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT03725018T 2002-04-26 2003-04-14 Isochinolinderivate als mao-b inhibitoren ATE440821T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02009253 2002-04-26
PCT/EP2003/003845 WO2003091219A1 (en) 2002-04-26 2003-04-14 Isoquinoline derivatives

Publications (1)

Publication Number Publication Date
ATE440821T1 true ATE440821T1 (de) 2009-09-15

Family

ID=29265896

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03725018T ATE440821T1 (de) 2002-04-26 2003-04-14 Isochinolinderivate als mao-b inhibitoren

Country Status (30)

Country Link
US (1) US6818774B2 (de)
EP (1) EP1501804B1 (de)
JP (1) JP4322685B2 (de)
KR (1) KR100681585B1 (de)
CN (1) CN1310890C (de)
AR (1) AR039651A1 (de)
AT (1) ATE440821T1 (de)
AU (1) AU2003227614B2 (de)
BR (1) BR0309562A (de)
CA (1) CA2483461C (de)
DE (1) DE60328978D1 (de)
DK (1) DK1501804T3 (de)
ES (1) ES2329354T3 (de)
GT (1) GT200300095A (de)
HR (1) HRP20040952A2 (de)
IL (1) IL164677A0 (de)
MX (1) MXPA04010537A (de)
MY (1) MY133527A (de)
NO (1) NO20044571L (de)
NZ (1) NZ535885A (de)
PA (1) PA8572001A1 (de)
PE (1) PE20040594A1 (de)
PL (1) PL373697A1 (de)
PT (1) PT1501804E (de)
RU (1) RU2318812C2 (de)
SI (1) SI1501804T1 (de)
TW (1) TWI278451B (de)
UY (1) UY27786A1 (de)
WO (1) WO2003091219A1 (de)
ZA (1) ZA200408281B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
WO2004113330A1 (en) * 2003-05-19 2004-12-29 Irm Llc Immunosuppressant compounds and compositions
CN1787817B (zh) * 2003-05-19 2011-09-07 Irm责任有限公司 免疫抑制剂化合物及组合物
US7825109B2 (en) 2003-08-29 2010-11-02 Ono Pharmaceutical Co., Ltd. Compound capable of binding S1P receptor and pharmaceutical use thereof
BRPI0413923A (pt) * 2003-08-29 2006-11-07 Ono Pharmaceutical Co composto capaz de ligar o receptor de s1p e uso farmacêutico do mesmo
ATE411027T1 (de) * 2003-10-23 2008-10-15 Hoffmann La Roche Benzazepin-derivate als mao-b-hemmer
JP4094050B2 (ja) 2004-03-01 2008-06-04 アクテリオン ファーマシューティカルズ リミテッド 置換１，２，３，４−テトラヒドロイソキノリン誘導体
JP4318087B2 (ja) 2004-12-13 2009-08-19 小野薬品工業株式会社 アミノカルボン酸誘導体およびその医薬用途
EP1844033B1 (de) * 2005-01-28 2011-07-27 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur herstellung von isochroman und derivaten davon
NZ560232A (en) 2005-02-25 2010-11-26 Hoffmann La Roche Tablets with improved drug substance dispersibility
EP1963280B1 (de) 2005-12-22 2015-10-28 Newron Pharmaceuticals S.p.A. 2-phenylethylaminoderivate als calcium- und/oder natrium-kanalmodulatoren
EP1998774A1 (de) * 2006-03-15 2008-12-10 Actelion Pharmaceuticals Ltd. Tetrahydroisochinolin-derivate zur verstärkung der gedächtnisfunktion
ATE496051T1 (de) 2006-04-26 2011-02-15 Actelion Pharmaceuticals Ltd Pyrazolotetrahydropyridinderivate als orexinrezeptorantagonisten
KR101220182B1 (ko) 2009-02-25 2013-01-11 에스케이바이오팜 주식회사 치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법
CN105315204B (zh) * 2014-07-04 2018-02-09 中南大学 7‑氨基‑1,4‑二氢异喹啉‑3(2h)‑酮衍生物及其合成方法和用途
CN105461626B (zh) * 2015-12-17 2018-05-08 浙江工业大学 芳环或稠杂环联3,4-二氢异喹啉类共轭结构化合物及其应用
CN105585527B (zh) * 2015-12-17 2018-06-26 浙江工业大学 2-(3,4-二氢异喹啉-1(2h)-亚基)乙腈类化合物及其应用
JP7150745B2 (ja) * 2017-03-27 2022-10-11 ブリストル－マイヤーズ スクイブ カンパニー 免疫調節剤としての置換イソキノリン誘導体
US11992535B2 (en) * 2019-12-18 2024-05-28 Chdi Foundation, Inc. Compounds and probes for imaging huntingtin protein
CN114591238B (zh) * 2022-03-25 2022-11-15 邦恩泰(山东)生物医药科技集团股份有限公司 一种异喹啉类药物中间体的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448269B1 (en) * 1993-07-22 2002-09-10 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
IL110172A (en) * 1993-07-22 2001-10-31 Lilly Co Eli Bicyclic compounds and pharmaceutical compositions containing them
US5731324A (en) * 1993-07-22 1998-03-24 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
US6137002A (en) * 1993-07-22 2000-10-24 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
US5679715A (en) 1995-06-07 1997-10-21 Harris; Richard Y. Method for treating multiple sclerosis
AU709323B2 (en) 1996-03-15 1999-08-26 Somerset Pharmaceuticals, Inc. Method for preventing and treating peripheral neuropathy by administering selegiline
WO2001034172A2 (en) 1999-11-05 2001-05-17 Vela Pharmaceuticals Inc. Methods and compositions for treating reward deficiency syndrome

Also Published As

Publication number Publication date
PA8572001A1 (es) 2003-12-10
CN1310890C (zh) 2007-04-18
KR20040104628A (ko) 2004-12-10
JP2005533761A (ja) 2005-11-10
DE60328978D1 (de) 2009-10-08
US6818774B2 (en) 2004-11-16
JP4322685B2 (ja) 2009-09-02
HRP20040952A2 (en) 2005-06-30
PL373697A1 (en) 2005-09-05
MXPA04010537A (es) 2005-01-25
PT1501804E (pt) 2009-10-29
DK1501804T3 (da) 2009-10-12
EP1501804B1 (de) 2009-08-26
CA2483461C (en) 2010-12-21
HK1080836A1 (en) 2006-05-04
RU2318812C2 (ru) 2008-03-10
CA2483461A1 (en) 2003-11-06
RU2004134575A (ru) 2005-07-20
AU2003227614A1 (en) 2003-11-10
AU2003227614B2 (en) 2008-06-26
ZA200408281B (en) 2005-10-14
UY27786A1 (es) 2003-10-31
AR039651A1 (es) 2005-03-02
NZ535885A (en) 2007-05-31
CN1649844A (zh) 2005-08-03
ES2329354T3 (es) 2009-11-25
NO20044571L (no) 2004-10-22
TWI278451B (en) 2007-04-11
KR100681585B1 (ko) 2007-02-09
US20030225122A1 (en) 2003-12-04
GT200300095A (es) 2004-01-15
BR0309562A (pt) 2005-02-15
SI1501804T1 (sl) 2009-12-31
IL164677A0 (en) 2005-12-18
EP1501804A1 (de) 2005-02-02
MY133527A (en) 2007-11-30
PE20040594A1 (es) 2004-08-30
WO2003091219A1 (en) 2003-11-06
TW200307670A (en) 2003-12-16

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