ATE440848T1 - Synthese von proteaseinhibitorvorstufen - Google Patents

Synthese von proteaseinhibitorvorstufen

Info

Publication number
ATE440848T1
ATE440848T1 AT06724879T AT06724879T ATE440848T1 AT E440848 T1 ATE440848 T1 AT E440848T1 AT 06724879 T AT06724879 T AT 06724879T AT 06724879 T AT06724879 T AT 06724879T AT E440848 T1 ATE440848 T1 AT E440848T1
Authority
AT
Austria
Prior art keywords
synthesis
protease inhibitor
inhibitor precursors
precursors
processes
Prior art date
Application number
AT06724879T
Other languages
English (en)
Inventor
Bruno Linclau
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Application granted granted Critical
Publication of ATE440848T1 publication Critical patent/ATE440848T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
AT06724879T 2005-02-25 2006-02-24 Synthese von proteaseinhibitorvorstufen ATE440848T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05101462 2005-02-25
US68369905P 2005-05-23 2005-05-23
PCT/EP2006/060246 WO2006089942A1 (en) 2005-02-25 2006-02-24 Protease inhibitor precursor synthesis

Publications (1)

Publication Number Publication Date
ATE440848T1 true ATE440848T1 (de) 2009-09-15

Family

ID=36646227

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06724879T ATE440848T1 (de) 2005-02-25 2006-02-24 Synthese von proteaseinhibitorvorstufen

Country Status (19)

Country Link
US (2) US8067463B2 (de)
EP (1) EP1856125B1 (de)
JP (1) JP5260965B2 (de)
KR (1) KR101333627B1 (de)
CN (1) CN101128469B (de)
AT (1) ATE440848T1 (de)
AU (1) AU2006217922B2 (de)
BR (1) BRPI0607827B8 (de)
CA (1) CA2595295C (de)
DE (1) DE602006008751D1 (de)
DK (1) DK1856125T3 (de)
ES (1) ES2331257T3 (de)
IL (1) IL184519A (de)
MX (1) MX2007010378A (de)
NO (1) NO20074880L (de)
PL (1) PL1856125T3 (de)
PT (1) PT1856125E (de)
RU (1) RU2421459C2 (de)
WO (1) WO2006089942A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5288153B2 (ja) * 2007-03-30 2013-09-11 日油株式会社 糖アルコール誘導体およびアルケニル基含有糖アルコール誘導体の製造方法
WO2012075122A2 (en) * 2010-11-30 2012-06-07 Purdue Research Foundation Processes and intermediates for preparing substituted hexahydrofuro [2,3-b] furans
CN116102569B (zh) * 2021-11-11 2025-02-18 深圳容金科技有限公司 一种展青霉素半抗原的合成方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2336134T (pt) 1998-06-23 2016-10-19 The Board Of Trustees Of The Univ Of Illionis Ensaio de aptidão e métodos para reduzir a resistência do hiv à terapia
AU4828199A (en) 1998-06-23 2000-01-10 Board Of Trustees Of The University Of Illinois, The Multi-drug resistant retroviral protease inhibitors and associated methods
EP1089328A1 (de) * 1999-09-29 2001-04-04 Infineon Technologies AG Verfahren zur Herstellung eines Halbleiterbauelementes
CA2386850C (en) 1999-10-06 2010-03-30 Piet Tom Bert Paul Wigerinck Hexahydrofuro[2,3-b]furan-3-yl-n-{3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl} carbamate as retroviral protease inhibitor
EP1370543B1 (de) 2001-02-14 2006-10-25 Tibotec Pharmaceuticals Ltd. Breitspektrum 2-(substituierte-amino)-benzothiazol-sulfonamide hiv protease inhibitoren
EP1397367A2 (de) 2001-04-09 2004-03-17 Tibotec Pharmaceuticals Ltd. Breitspektrum-2-(amino substituierte)-benzoxazol-sulfonamid-hiv-protease-inhibitoren für die entdeckung entfernter zellulärer signale durch nukleozytoplasmatisches zyklisieren
US7622490B2 (en) 2001-05-11 2009-11-24 Tibotec Pharmaceuticals, Ltd. Broadspecturm 2-amino-benzoxazole sulfonamide HIV protease inhibitors
EP1265073A3 (de) 2001-06-05 2003-11-26 Tibotec Pharmaceuticals Ltd. Verfahren zum Nachweis von der Plasmakonzentration von freien Arzneimitteln
AR037797A1 (es) 2001-12-12 2004-12-01 Tibotec Pharm Ltd Combinacion de inhibidores de proteasa dependientes del citocromo p450
US7763641B2 (en) 2001-12-21 2010-07-27 Tibotec Pharmaceuticals Ltd. Broadspectrum heterocyclic substituted phenyl containing sulfonamide HIV protease inhibitors
US7109230B2 (en) 2002-01-07 2006-09-19 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
CA2474671A1 (en) 2002-02-22 2003-08-28 Tibotec Bvba Methods for determining the influence of protein binding on antiretroviral activity
US7157489B2 (en) 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
MY142238A (en) 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
TW200408645A (en) 2002-04-26 2004-06-01 Gilead Sciences Inc Non nucleoside reverse transcriptase inhibitors
US7700645B2 (en) 2002-05-16 2010-04-20 Tibotec Pharmaceuticals Ltd. Pseudopolymorphic forms of a HIV protease inhibitor
CA2485903C (en) 2002-05-17 2011-08-16 Tibotec Pharmaceuticals Ltd. Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
EP1520247B1 (de) 2002-07-01 2009-05-27 Tibotec Pharmaceuticals Ltd. Mutationsprofile bei mit phänotypischer medikamentenresistenz korrelierter hiv-1-protease

Also Published As

Publication number Publication date
US8183394B2 (en) 2012-05-22
RU2007135345A (ru) 2009-03-27
PT1856125E (pt) 2009-11-06
AU2006217922B2 (en) 2012-04-05
RU2421459C2 (ru) 2011-06-20
US20090054668A1 (en) 2009-02-26
JP2008531522A (ja) 2008-08-14
WO2006089942A1 (en) 2006-08-31
CA2595295C (en) 2014-07-08
US8067463B2 (en) 2011-11-29
BRPI0607827B1 (pt) 2019-11-05
IL184519A0 (en) 2007-10-31
NO20074880L (no) 2007-09-25
US20120041215A1 (en) 2012-02-16
CA2595295A1 (en) 2006-08-31
KR20080005183A (ko) 2008-01-10
CN101128469A (zh) 2008-02-20
ES2331257T3 (es) 2009-12-28
KR101333627B1 (ko) 2013-11-27
DK1856125T3 (da) 2009-12-07
WO2006089942A8 (en) 2007-12-13
DE602006008751D1 (de) 2009-10-08
BRPI0607827B8 (pt) 2021-05-25
EP1856125B1 (de) 2009-08-26
CN101128469B (zh) 2012-11-14
JP5260965B2 (ja) 2013-08-14
BRPI0607827A2 (pt) 2009-10-06
MX2007010378A (es) 2007-09-25
EP1856125A1 (de) 2007-11-21
IL184519A (en) 2012-01-31
PL1856125T3 (pl) 2010-01-29
AU2006217922A1 (en) 2006-08-31

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