ATE441115T1 - Markierungsreagens und anwendungsverfahren - Google Patents

Markierungsreagens und anwendungsverfahren

Info

Publication number: ATE441115T1
Authority: AT; Austria
Prior art keywords: lysine; labels; present; polypeptide; terminal
Prior art date: 2001-11-05

Application number

AT02803304T

Other languages

English (en)

Inventor

Eric Peters

Ansgar Brock

Christer Ericson

Original Assignee

Irm Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-05

Filing date

2002-11-05

Publication date

2009-09-15

2002-11-05 Application filed by Irm Llc filed Critical Irm Llc

2009-09-15 Application granted granted Critical

2009-09-15 Publication of ATE441115T1 publication Critical patent/ATE441115T1/de

Links

239000003153 chemical reaction reagent Substances 0.000 title 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 2
239000004472 Lysine Substances 0.000 abstract 2
239000012634 fragment Substances 0.000 abstract 2
150000002500 ions Chemical class 0.000 abstract 2
229920001184 polypeptide Polymers 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
210000004900 c-terminal fragment Anatomy 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052805 deuterium Inorganic materials 0.000 abstract 1
125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
238000013507 mapping Methods 0.000 abstract 1
238000001819 mass spectrum Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/13—Labelling of peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/36—Radio frequency spectrometers, e.g. Bennett-type spectrometers, Redhead-type spectrometers
- H01J49/38—Omegatrons ; using ion cyclotron resonance
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00158—Elements containing microarrays, i.e. "biochip"
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Bioinformatics & Computational Biology (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Spectroscopy & Molecular Physics (AREA)
Immunology (AREA)
Hematology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
General Physics & Mathematics (AREA)
Evolutionary Biology (AREA)
Medical Informatics (AREA)
Gastroenterology & Hepatology (AREA)
Theoretical Computer Science (AREA)
Food Science & Technology (AREA)
Cell Biology (AREA)
Pathology (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)
Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT02803304T 2001-11-05 2002-11-05 Markierungsreagens und anwendungsverfahren ATE441115T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US33298801P	2001-11-05	2001-11-05
US38583502P	2002-06-03	2002-06-03
US41038202P	2002-09-12	2002-09-12
PCT/US2002/035581 WO2003056299A2 (en)	2001-11-05	2002-11-05	Labeling reagent and methods of use

Publications (1)

Publication Number	Publication Date
ATE441115T1 true ATE441115T1 (de)	2009-09-15

Family

ID=27406887

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02803304T ATE441115T1 (de)	2001-11-05	2002-11-05	Markierungsreagens und anwendungsverfahren

Country Status (7)

Country	Link
US (2)	US20030228700A1 (de)
EP (1)	EP1451207B1 (de)
JP (1)	JP4328625B2 (de)
AT (1)	ATE441115T1 (de)
AU (1)	AU2002365152A1 (de)
DE (1)	DE60233520D1 (de)
WO (1)	WO2003056299A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6977370B1 (en) *	2003-04-07	2005-12-20	Ciphergen Biosystems, Inc.	Off-resonance mid-IR laser desorption ionization
WO2005050226A1 (en) *	2003-11-14	2005-06-02	Irm Llc	Fluorous labeling for selective processing of biologically-derived samples
US20070054345A1 (en)	2004-05-19	2007-03-08	Hunter Christie L	Expression quantification using mass spectrometry
US20060172319A1 (en) *	2004-07-12	2006-08-03	Applera Corporation	Mass tags for quantitative analyses
US20070048752A1 (en)	2004-07-12	2007-03-01	Applera Corporation	Mass tags for quantitative analyses
US20060014293A1 (en) *	2004-07-16	2006-01-19	Joyce Timothy H	Lock mass ions for use with derivatized peptides for de novo sequencing using tandem mass spectrometry
US7371514B2 (en)	2004-07-16	2008-05-13	Agilent Technologies, Inc.	Serial derivatization of peptides for de novo sequencing using tandem mass spectrometry
US20060183238A1 (en)	2005-02-09	2006-08-17	Applera Corporation	Amine-containing compound analysis methods
CA2696167A1 (en) *	2007-08-21	2009-02-26	Mds Analytical Technologies, A Business Unit Of Mds Inc., Doing Business Through Its Sciex Division	Method for enhancing mass assignment accuracy
KR101081053B1 (ko)	2008-07-18	2011-11-07	포항공과대학교 산학협력단	가변질량 라벨링제와 이를 이용한 아미노산 서열 및 단백질정량 동시 분석방법
WO2010109022A1 (en)	2009-03-27	2010-09-30	Universitetet I Oslo	Quantitative proteomics method
WO2012178023A1 (en) *	2011-06-23	2012-12-27	Board Of Regents, The University Of Texas System	Identifying peptides at the single molecule level
US11435358B2 (en)	2011-06-23	2022-09-06	Board Of Regents, The University Of Texas System	Single molecule peptide sequencing
JP6281349B2 (ja) *	2014-03-19	2018-02-21	株式会社島津製作所	質量分析用ペプチド混合物試料の調製方法
CA2961493C (en)	2014-09-15	2023-10-03	Board Of Regents, The University Of Texas System	Improved single molecule peptide sequencing
CA2999331A1 (en) *	2015-10-14	2017-04-20	Wisconsin Alumni Research Foundation	Mass defect-based multiplex dimethyl pyrimidinyl ornithine (dipyro) tags for high-throughput quantitative proteomics and peptidomics
JP6857569B2 (ja) *	2017-07-26	2021-04-14	日本電子株式会社	質量分析システム及び質量スペクトル表示方法
CN112513269A (zh)	2018-07-12	2021-03-16	德克萨斯大学系统董事会	通过寡核苷酸进行分子邻域检测
EP3861009A4 (de)	2018-10-05	2023-01-11	Board of Regents, The University of Texas System	Erfassung und freisetzung von n-terminalem festphasenpeptid
CN116813693B (zh) *	2023-08-29	2023-12-01	苏州金顶生物有限公司	一种用于多肽合成的标签化合物及其在多肽合成中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB869977A (en) *	1957-12-26	1961-06-07	Pfizer & Co C	Diazacycloalkenes and the preparation thereof
FI832053L (fi) *	1982-06-10	1983-12-11	Syntex Inc	Nonapeptid- och dekapeptidanaloger av lhrh anvaendbara som lhrh-antagonister samt deras framstaellningsfoerfarande
US4530920A (en) *	1983-11-07	1985-07-23	Syntex (U.S.A.) Inc.	Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist
US4659693A (en) *	1984-04-30	1987-04-21	Syntex (U.S.A.) Inc.	N,N'-dialkyl substituted guanidino amino acyl residue substituted GRF-analog peptides
US5318899A (en) *	1989-06-16	1994-06-07	Cor Therapeutics, Inc.	Platelet aggregation inhibitors
WO1993024834A1 (en) *	1992-05-29	1993-12-09	The Rockefeller University	Method and product for the sequence determination of peptides using a mass spectrometer
US5859295A (en) *	1994-12-05	1999-01-12	University Of Kentucky Research Foundation	Canavanine analogs and their use as chemotherapeutic agents
EP1047107B1 (de) *	1999-04-06	2006-10-04	Micromass UK Limited	Verfahren zur Identifizierung von Peptiden und Proteinen mittels Massenspektromterie

2002
- 2002-11-05 AT AT02803304T patent/ATE441115T1/de not_active IP Right Cessation
- 2002-11-05 DE DE60233520T patent/DE60233520D1/de not_active Expired - Fee Related
- 2002-11-05 EP EP02803304A patent/EP1451207B1/de not_active Expired - Lifetime
- 2002-11-05 US US10/289,009 patent/US20030228700A1/en not_active Abandoned
- 2002-11-05 WO PCT/US2002/035581 patent/WO2003056299A2/en not_active Ceased
- 2002-11-05 JP JP2003556774A patent/JP4328625B2/ja not_active Expired - Fee Related
- 2002-11-05 AU AU2002365152A patent/AU2002365152A1/en not_active Abandoned
2007
- 2007-05-07 US US11/745,358 patent/US20080242838A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2003056299A2 (en)	2003-07-10
US20030228700A1 (en)	2003-12-11
EP1451207B1 (de)	2009-08-26
JP4328625B2 (ja)	2009-09-09
WO2003056299A3 (en)	2004-02-26
AU2002365152A8 (en)	2003-07-15
JP2005514404A (ja)	2005-05-19
EP1451207A2 (de)	2004-09-01
AU2002365152A1 (en)	2003-07-15
EP1451207A4 (de)	2005-08-24
US20080242838A1 (en)	2008-10-02
DE60233520D1 (de)	2009-10-08

Legal Events

Date	Code	Title	Description
2010-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE441115T1 (de)	2009-09-15	Markierungsreagens und anwendungsverfahren
Ostrom et al.	2000	New strategies for characterizing ancient proteins using matrix-assisted laser desorption ionization mass spectrometry
ATE479895T1 (de)	2010-09-15	Elektronentransferdissoziation zur biopolymer- sequenzanalyse
WO2009073505A3 (en)	2009-09-03	Methods for processing tandem mass spectral data for protein sequence analysis
ATE495447T1 (de)	2011-01-15	Peptidantikörperdepletion und anwendung zur probenvorbereitung für massenspektrometrie
WO2004042072A3 (en)	2004-12-29	Quantitative analysis of protein isoforms using matrix-assisted laser desorption/ionization time of flight mass spectrometry
AU2003263537A1 (en)	2004-05-04	Ionization source for mass spectrometry analysis
NO20082559L (no)	2008-07-07	Humane monoklonale antistoffer mot protein tyrosin kinase 7 (PTK7) og fremgangsmater for anvendelse av anti-PTK7 antistoffer
Medinas et al.	2010	A ditryptophan cross-link is responsible for the covalent dimerization of human superoxide dismutase 1 during its bicarbonate-dependent peroxidase activity
WO2001094935A3 (en)	2002-11-21	Labeling of proteomic samples during proteolysis for quantitation and sample multiplexing
MX2011012744A (es)	2012-05-22	Metodos novedosos para cuantificar proteinas mediante espectrometria de masas.
AU2002357699A1 (en)	2003-05-26	Methods for monitoring polypeptide production and purification using surface enhanced laser desorption/ionization mass spectrometry
WO2002008767A3 (en)	2003-08-28	Methods and kits for sequencing polypeptides
WO2006047614A3 (en)	2007-05-31	Compositions and methods for analyzing biomolecules using mass spectroscopy
Boersema et al.	2009	Straightforward and de novo peptide sequencing by MALDI-MS/MS using a Lys-N metalloendopeptidase
Pirondini et al.	2006	A 2-D liquid-phase chromatography for proteomic analysis in plant tissues
Kramer et al.	2011	Mass-spectrometric analysis of proteins cross-linked to 4-thio-uracil-and 5-bromo-uracil-substituted RNA
ATE321853T1 (de)	2006-04-15	Humanische pellino-polypeptide
IL144129A0 (en)	2002-05-23	Methods and kits for sequencing polypeptides
WO2004050845A3 (en)	2004-09-23	Methods of quantitation and identification of peptides and proteins
AU2174002A (en)	2002-05-15	Method for analyzing proteins
Zhu et al.	2004	Identification of low molecular weight proteins isolated by 2‐D liquid separations
DE69929183D1 (de)	2006-02-02	G-csf-rezeptoragonist-antikörper und methode zu ihrer isolierung mittels durchmusterung
SG127861A1 (en)	2006-12-29	in situ biomarker identification
Vijayasarathy et al.	2018	Mass spectrometric identification of bromotryptophan containing conotoxin sequences from the venom of C. áamadis