ATE441628T1 - Tricyclische hydroxamat- und benzamidderivate, zusammensetzungen und verfahren - Google Patents

Tricyclische hydroxamat- und benzamidderivate, zusammensetzungen und verfahren

Info

Publication number
ATE441628T1
ATE441628T1 AT04806498T AT04806498T ATE441628T1 AT E441628 T1 ATE441628 T1 AT E441628T1 AT 04806498 T AT04806498 T AT 04806498T AT 04806498 T AT04806498 T AT 04806498T AT E441628 T1 ATE441628 T1 AT E441628T1
Authority
AT
Austria
Prior art keywords
compounds
compositions
methods
hydroxamat
tricyclic
Prior art date
Application number
AT04806498T
Other languages
English (en)
Inventor
Bertrand Leblond
Eric Beausoleil
Original Assignee
Exonhit Therapeutics Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exonhit Therapeutics Sa filed Critical Exonhit Therapeutics Sa
Application granted granted Critical
Publication of ATE441628T1 publication Critical patent/ATE441628T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT04806498T 2003-12-12 2004-12-10 Tricyclische hydroxamat- und benzamidderivate, zusammensetzungen und verfahren ATE441628T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03293143A EP1541549A1 (de) 2003-12-12 2003-12-12 Tricyclische Hydroxamat- und Benzamid-Derivate, Zusammensetzungen und Methoden
PCT/IB2004/004334 WO2005058803A1 (en) 2003-12-12 2004-12-10 Tricyclic hydroxamate and benzamide derivatives, compositions and methods

Publications (1)

Publication Number Publication Date
ATE441628T1 true ATE441628T1 (de) 2009-09-15

Family

ID=34486463

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04806498T ATE441628T1 (de) 2003-12-12 2004-12-10 Tricyclische hydroxamat- und benzamidderivate, zusammensetzungen und verfahren

Country Status (8)

Country Link
US (1) US7923579B2 (de)
EP (2) EP1541549A1 (de)
AT (1) ATE441628T1 (de)
DE (1) DE602004022974D1 (de)
DK (1) DK1692097T3 (de)
ES (1) ES2330749T3 (de)
PT (1) PT1692097E (de)
WO (1) WO2005058803A1 (de)

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US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7169801B2 (en) 2003-03-17 2007-01-30 Takeda San Diego, Inc. Histone deacetylase inhibitors
CN1997626A (zh) * 2004-07-12 2007-07-11 默克公司 组蛋白脱乙酰基酶的抑制剂
EP1824831A2 (de) 2004-12-16 2007-08-29 Takeda San Diego, Inc. Histondeacetylase-inhibitoren
CA2937005A1 (en) 2005-03-22 2006-09-28 President And Fellows Of Harvard College Treatment of protein degradation disorders
JP2008540574A (ja) 2005-05-11 2008-11-20 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
JP2009501236A (ja) 2005-07-14 2009-01-15 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
CN101610996A (zh) * 2006-12-19 2009-12-23 梅特希尔基因公司 组蛋白脱乙酰酶抑制剂及其前体药物
US8796330B2 (en) 2006-12-19 2014-08-05 Methylgene Inc. Inhibitors of histone deacetylase and prodrugs thereof
WO2009018344A1 (en) * 2007-07-30 2009-02-05 Regents Of The University Of Minnesota Anticancer agents
CA2712858A1 (en) 2008-02-07 2009-08-13 Abhay Gaitonde Novel process for the preparation of vorinostat
WO2009117808A1 (en) * 2008-03-25 2009-10-01 Methylgene Inc. Inhibitors of histone deacetylase
CA2731730C (en) 2008-07-23 2017-06-13 President And Fellows Of Harvard College Deacetylase inhibitors and uses thereof
CA2735593C (en) 2008-09-03 2017-08-15 Repligen Corporation Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors
WO2010043904A2 (en) 2008-10-15 2010-04-22 Generics [Uk] Limited Improved process
EP2362869A2 (de) 2008-11-26 2011-09-07 Generics [UK] Limited Polymorphe
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
US20130040998A1 (en) * 2010-01-08 2013-02-14 Dana-Farber Cancer Institute, Inc. Fluorinated hdac inhibitors and uses thereof
WO2012019772A1 (en) * 2010-08-12 2012-02-16 Institut De Recherche Pour Le Developpement (I.R.D) Method for treating protozoan parasitic diseases
EP2486923B1 (de) * 2011-02-11 2015-09-09 Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG Histon-Deacetylase (HDAC) hemmende Verbindungen und Verfahren zu deren Herstellung
ES2712803T3 (es) 2011-02-28 2019-05-14 Biomarin Pharm Inc Inhibidores de histona desacetilasa
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
CN102329246B (zh) * 2011-07-04 2013-11-20 潍坊博创国际生物医药研究院 多靶点型他米巴罗汀衍生物、其制备方法和用途
US9573906B2 (en) 2011-09-15 2017-02-21 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University Therapeutic compounds
CN103664680A (zh) * 2012-09-26 2014-03-26 山东鲁北药业有限公司 一种他米巴罗汀合成的新工艺
NZ711585A (en) 2013-03-15 2020-05-29 Biomarin Pharm Inc Hdac inhibitors
WO2015109318A2 (en) 2014-01-17 2015-07-23 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Therapeutic methods
EP3152190B1 (de) * 2014-06-04 2024-07-31 Haro Pharmaceutical Inc. Bi-polycyclische verbindungen mit 18-20 elementen
CN107304172B (zh) 2016-04-20 2020-04-03 沈阳药科大学 八氢蒽类化合物及其制备方法和用途
CN106187818B (zh) * 2016-06-27 2017-12-08 刘美新 一种制备抗癌药物伏立诺他的方法
US10238655B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Dihydroindene and tetrahydronaphthalene compounds
US10238626B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
US10231947B2 (en) 2017-01-23 2019-03-19 Arizona Board Of Regents On Behalf Of Arizona State University Isochroman compounds and methods of use thereof
US20230096380A1 (en) * 2020-02-06 2023-03-30 Children's Hospital Medical Center Compounds, compositions, methods for treating diseases and nerve damage, and methods for preparing compounds
CN112479918B (zh) * 2020-12-11 2023-07-14 成都大学 一种维甲酸类衍生物Am580的合成方法

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LU86351A1 (fr) * 1986-03-12 1987-11-11 Oreal Composes benzopyrannyl et benzothiopyrannyl benzoiques,leur procede de preparation et leur utilisation en cosmetique et en medecine humaine et veterinaire
DE3903990A1 (de) * 1989-02-10 1990-08-30 Basf Ag Phenylhydrazone, ihre herstellung und daraus hergestellte arzneimittel und kosmetika
LU87821A1 (fr) * 1990-10-12 1992-05-25 Cird Galderma Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique
FR2746098B1 (fr) * 1996-03-14 1998-04-30 Composes propynyl biaromatiques
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US6376548B1 (en) * 2000-01-28 2002-04-23 Rohm And Haas Company Enhanced propertied pesticides
PE20020354A1 (es) * 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
AU2002312348A1 (en) * 2001-06-06 2002-12-16 Agouron Pharmaceuticals, Inc. Non-peptide gnrh agents, pharmaceutical compositions and methods for their uses, and processes for preparing them

Also Published As

Publication number Publication date
US7923579B2 (en) 2011-04-12
EP1541549A1 (de) 2005-06-15
DK1692097T3 (da) 2009-12-07
ES2330749T3 (es) 2009-12-15
US20070129368A1 (en) 2007-06-07
PT1692097E (pt) 2009-10-30
DE602004022974D1 (de) 2009-10-15
EP1692097A1 (de) 2006-08-23
WO2005058803A1 (en) 2005-06-30
EP1692097B1 (de) 2009-09-02

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