ATE441628T1 - Tricyclische hydroxamat- und benzamidderivate, zusammensetzungen und verfahren - Google Patents
Tricyclische hydroxamat- und benzamidderivate, zusammensetzungen und verfahrenInfo
- Publication number
- ATE441628T1 ATE441628T1 AT04806498T AT04806498T ATE441628T1 AT E441628 T1 ATE441628 T1 AT E441628T1 AT 04806498 T AT04806498 T AT 04806498T AT 04806498 T AT04806498 T AT 04806498T AT E441628 T1 ATE441628 T1 AT E441628T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- compositions
- methods
- hydroxamat
- tricyclic
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical class NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title 1
- 102000003964 Histone deacetylase Human genes 0.000 abstract 4
- 108090000353 Histone deacetylase Proteins 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03293143A EP1541549A1 (de) | 2003-12-12 | 2003-12-12 | Tricyclische Hydroxamat- und Benzamid-Derivate, Zusammensetzungen und Methoden |
| PCT/IB2004/004334 WO2005058803A1 (en) | 2003-12-12 | 2004-12-10 | Tricyclic hydroxamate and benzamide derivatives, compositions and methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE441628T1 true ATE441628T1 (de) | 2009-09-15 |
Family
ID=34486463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04806498T ATE441628T1 (de) | 2003-12-12 | 2004-12-10 | Tricyclische hydroxamat- und benzamidderivate, zusammensetzungen und verfahren |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7923579B2 (de) |
| EP (2) | EP1541549A1 (de) |
| AT (1) | ATE441628T1 (de) |
| DE (1) | DE602004022974D1 (de) |
| DK (1) | DK1692097T3 (de) |
| ES (1) | ES2330749T3 (de) |
| PT (1) | PT1692097E (de) |
| WO (1) | WO2005058803A1 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030129724A1 (en) | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7375228B2 (en) | 2003-03-17 | 2008-05-20 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| JP2008505969A (ja) * | 2004-07-12 | 2008-02-28 | メルク エンド カムパニー インコーポレーテッド | ヒストン脱アセチル化酵素の阻害剤 |
| US7642275B2 (en) | 2004-12-16 | 2010-01-05 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| SG171690A1 (en) | 2005-03-22 | 2011-06-29 | Harvard College | Treatment of protein degradation disorders |
| JP2008540574A (ja) | 2005-05-11 | 2008-11-20 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| CA2615105A1 (en) | 2005-07-14 | 2007-01-25 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| JP2010513326A (ja) * | 2006-12-19 | 2010-04-30 | メシルジーン インコーポレイテッド | ヒストンデアセチラーゼの阻害薬及びそのプロドラッグ |
| US8796330B2 (en) | 2006-12-19 | 2014-08-05 | Methylgene Inc. | Inhibitors of histone deacetylase and prodrugs thereof |
| WO2009018344A1 (en) * | 2007-07-30 | 2009-02-05 | Regents Of The University Of Minnesota | Anticancer agents |
| NZ586955A (en) | 2008-02-07 | 2012-06-29 | Generics Uk Ltd | Novel process for the preparation of vorinostat |
| WO2009117808A1 (en) * | 2008-03-25 | 2009-10-01 | Methylgene Inc. | Inhibitors of histone deacetylase |
| EP2321264B1 (de) | 2008-07-23 | 2016-05-04 | President and Fellows of Harvard College | Deacetylaseinhibitoren und anwendungen davon |
| AU2009289649B2 (en) | 2008-09-03 | 2016-05-05 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
| WO2010043904A2 (en) | 2008-10-15 | 2010-04-22 | Generics [Uk] Limited | Improved process |
| WO2010061219A2 (en) | 2008-11-26 | 2010-06-03 | Generics [Uk] Limited | Polymorphs |
| US8716344B2 (en) | 2009-08-11 | 2014-05-06 | President And Fellows Of Harvard College | Class- and isoform-specific HDAC inhibitors and uses thereof |
| WO2011084991A2 (en) * | 2010-01-08 | 2011-07-14 | President And Fellows Of Harvard College | Fluorinated hdac inhibitors and uses thereof |
| WO2012019772A1 (en) * | 2010-08-12 | 2012-02-16 | Institut De Recherche Pour Le Developpement (I.R.D) | Method for treating protozoan parasitic diseases |
| EP2486923B1 (de) * | 2011-02-11 | 2015-09-09 | Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG | Histon-Deacetylase (HDAC) hemmende Verbindungen und Verfahren zu deren Herstellung |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| WO2012118782A1 (en) | 2011-02-28 | 2012-09-07 | Repligen Corporation | Histone deacetylase inhibitors |
| CN102329246B (zh) * | 2011-07-04 | 2013-11-20 | 潍坊博创国际生物医药研究院 | 多靶点型他米巴罗汀衍生物、其制备方法和用途 |
| JP2014527083A (ja) | 2011-09-15 | 2014-10-09 | アリゾナ ボード オブ リージェンツ， ア ボディー コーポレイト オブ ザ ステート オブ アリゾナ， アクティング フォー アンド オン ビハーフ オブ アリゾナ ステート ユニバーシティー | 治療用化合物 |
| CN103664680A (zh) * | 2012-09-26 | 2014-03-26 | 山东鲁北药业有限公司 | 一种他米巴罗汀合成的新工艺 |
| RU2665554C2 (ru) | 2013-03-15 | 2018-08-31 | Байомарин Фармасьютикал Инк. | Ингибиторы hdac |
| WO2015109318A2 (en) | 2014-01-17 | 2015-07-23 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Therapeutic methods |
| EP3152190B1 (de) * | 2014-06-04 | 2024-07-31 | Haro Pharmaceutical Inc. | Bi-polycyclische verbindungen mit 18-20 elementen |
| CN107304172B (zh) * | 2016-04-20 | 2020-04-03 | 沈阳药科大学 | 八氢蒽类化合物及其制备方法和用途 |
| CN106187818B (zh) * | 2016-06-27 | 2017-12-08 | 刘美新 | 一种制备抗癌药物伏立诺他的方法 |
| US10238655B2 (en) | 2017-01-23 | 2019-03-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Dihydroindene and tetrahydronaphthalene compounds |
| US10231947B2 (en) | 2017-01-23 | 2019-03-19 | Arizona Board Of Regents On Behalf Of Arizona State University | Isochroman compounds and methods of use thereof |
| US10238626B2 (en) | 2017-01-23 | 2019-03-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic compounds |
| US20230096380A1 (en) * | 2020-02-06 | 2023-03-30 | Children's Hospital Medical Center | Compounds, compositions, methods for treating diseases and nerve damage, and methods for preparing compounds |
| CN112479918B (zh) * | 2020-12-11 | 2023-07-14 | 成都大学 | 一种维甲酸类衍生物Am580的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU86351A1 (fr) * | 1986-03-12 | 1987-11-11 | Oreal | Composes benzopyrannyl et benzothiopyrannyl benzoiques,leur procede de preparation et leur utilisation en cosmetique et en medecine humaine et veterinaire |
| DE3903990A1 (de) * | 1989-02-10 | 1990-08-30 | Basf Ag | Phenylhydrazone, ihre herstellung und daraus hergestellte arzneimittel und kosmetika |
| LU87821A1 (fr) * | 1990-10-12 | 1992-05-25 | Cird Galderma | Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique |
| FR2746098B1 (fr) * | 1996-03-14 | 1998-04-30 | Composes propynyl biaromatiques | |
| KR20100035666A (ko) * | 1999-11-23 | 2010-04-05 | 메틸진 인크. | 히스톤 디아세틸라제의 억제제 |
| US6376548B1 (en) * | 2000-01-28 | 2002-04-23 | Rohm And Haas Company | Enhanced propertied pesticides |
| PE20020354A1 (es) * | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| EP1401427A4 (de) * | 2001-06-06 | 2004-12-01 | Agouron Pharma | Nicht-peptidische gnrh-agenzien, pharmazeutische zusammensetzungen und methoden zu ihrer verwendung sowie verfahren zu ihrer herstellung |
-
2003
- 2003-12-12 EP EP03293143A patent/EP1541549A1/de not_active Withdrawn
-
2004
- 2004-12-10 WO PCT/IB2004/004334 patent/WO2005058803A1/en not_active Ceased
- 2004-12-10 US US10/581,947 patent/US7923579B2/en not_active Expired - Fee Related
- 2004-12-10 DE DE602004022974T patent/DE602004022974D1/de not_active Expired - Lifetime
- 2004-12-10 EP EP04806498A patent/EP1692097B1/de not_active Expired - Lifetime
- 2004-12-10 DK DK04806498T patent/DK1692097T3/da active
- 2004-12-10 ES ES04806498T patent/ES2330749T3/es not_active Expired - Lifetime
- 2004-12-10 AT AT04806498T patent/ATE441628T1/de active
- 2004-12-10 PT PT04806498T patent/PT1692097E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1692097T3 (da) | 2009-12-07 |
| EP1541549A1 (de) | 2005-06-15 |
| US7923579B2 (en) | 2011-04-12 |
| US20070129368A1 (en) | 2007-06-07 |
| EP1692097B1 (de) | 2009-09-02 |
| EP1692097A1 (de) | 2006-08-23 |
| PT1692097E (pt) | 2009-10-30 |
| WO2005058803A1 (en) | 2005-06-30 |
| DE602004022974D1 (de) | 2009-10-15 |
| ES2330749T3 (es) | 2009-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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