ATE442128T1 - Kombinierte chemo-immunotherapie mit liposomalen arzneistoffen und cytokinen - Google Patents

Kombinierte chemo-immunotherapie mit liposomalen arzneistoffen und cytokinen

Info

Publication number
ATE442128T1
ATE442128T1 AT98958388T AT98958388T ATE442128T1 AT E442128 T1 ATE442128 T1 AT E442128T1 AT 98958388 T AT98958388 T AT 98958388T AT 98958388 T AT98958388 T AT 98958388T AT E442128 T1 ATE442128 T1 AT E442128T1
Authority
AT
Austria
Prior art keywords
encapsulated
immunotherapy
cytokines
liposomes
administration
Prior art date
Application number
AT98958388T
Other languages
English (en)
Inventor
Alberto Gabizon
Eliezer Kedar
Yechezkel Barenholz
Original Assignee
Yissum Res Dev Co
Hadasit Med Res Service
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co, Hadasit Med Res Service filed Critical Yissum Res Dev Co
Application granted granted Critical
Publication of ATE442128T1 publication Critical patent/ATE442128T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT98958388T 1997-12-04 1998-12-01 Kombinierte chemo-immunotherapie mit liposomalen arzneistoffen und cytokinen ATE442128T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6769797P 1997-12-04 1997-12-04
PCT/IL1998/000586 WO1999027908A1 (en) 1997-12-04 1998-12-01 Combined chemo-immunotherapy with liposomal drugs and cytokines

Publications (1)

Publication Number Publication Date
ATE442128T1 true ATE442128T1 (de) 2009-09-15

Family

ID=22077764

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98958388T ATE442128T1 (de) 1997-12-04 1998-12-01 Kombinierte chemo-immunotherapie mit liposomalen arzneistoffen und cytokinen

Country Status (8)

Country Link
EP (1) EP1033971B1 (de)
JP (1) JP2001524512A (de)
AT (1) ATE442128T1 (de)
AU (1) AU756109B2 (de)
CA (1) CA2312778A1 (de)
DE (1) DE69841142D1 (de)
IL (1) IL136343A0 (de)
WO (1) WO1999027908A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002078672A2 (en) * 2001-03-30 2002-10-10 Alza Corporation Liposomal tumor necrosis factor compositions and methods
US8034791B2 (en) 2001-04-06 2011-10-11 The University Of Chicago Activation of Egr-1 promoter by DNA damaging chemotherapeutics
DE10157994A1 (de) * 2001-05-25 2003-01-02 G O T Therapeutics Gmbh Liposomal verkapselte hydrophobe Wirkstoffe mit hohem Wirkstoffgehalt >50% sowie Verfahren zur Herstellung pharmazeutischer Zubereitungen, die liposomal verkapselte hydrophobe Wirkstoffe umfassen
US20050118250A1 (en) 2001-11-13 2005-06-02 Paul Tardi Lipid carrier compositions with enhanced blood stability
AU2002360762A1 (en) * 2001-12-19 2003-07-09 Alza Corporation Liposomal tumor necrosis factor compositions
KR20060015534A (ko) 2003-04-25 2006-02-17 더 펜 스테이트 리서치 파운데이션 성장 억제, 지질 유래된 생활성 화합물의 전신 전달을 위한방법 및 시스템
BR112018067927A2 (pt) * 2016-03-09 2019-01-02 Technion Res & Development Found Ltd formulação, método de tratamento de plantas, método agrícola e kit
US11980636B2 (en) 2020-11-18 2024-05-14 Jazz Pharmaceuticals Ireland Limited Treatment of hematological disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0153955A1 (de) * 1983-09-06 1985-09-11 Health Research, Inc. Verfahren zum verabreichen von liposomen zum herabsetzen der toxizität eines antitumor-arzneimittels
JPS6348225A (ja) * 1986-08-19 1988-02-29 Green Cross Corp:The 制癌剤
EP0429585A4 (en) * 1989-04-28 1992-03-25 Syracuse University Cytochalasin compositions and therapeutic methods
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
IT1238231B (it) * 1989-12-18 1993-07-12 Consiglio Nazionale Ricerche Impiego di immunomodulanti come agenti sinergici di chemioterapici nella terapia dei tumori
EP0546951A1 (de) * 1991-12-13 1993-06-16 The Liposome Company, Inc. Kombination von im Liposomen verkapselten antineoplastischen Mitteln wie Doxorubicin, mit Kolonie-stimulierenden Faktoren
DE4430593C2 (de) * 1994-08-20 1999-01-14 Max Delbrueck Centrum Verfahren zur Herstellung von Liposomal verkapseltem Taxol

Also Published As

Publication number Publication date
AU1445199A (en) 1999-06-16
JP2001524512A (ja) 2001-12-04
EP1033971A1 (de) 2000-09-13
AU756109B2 (en) 2003-01-02
IL136343A0 (en) 2001-05-20
EP1033971B1 (de) 2009-09-09
CA2312778A1 (en) 1999-06-10
WO1999027908A1 (en) 1999-06-10
DE69841142D1 (de) 2009-10-22

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties